| 1 | Mon Nov 6 | vs TBD | W89-66 | 1-0 | 1.000 | - | | William Nicks Building · Prairie View, TX |
| 2 | Wed Nov 8 | at Seattle U | L60-71 | 1-1 | .500 | - | | Redhawk Center · Seattle, WA |
| 3 | Fri Nov 10 | at Washington St | L65-83 | 1-2 | .333 | - | | Friel Court at Beasley Coliseum · Pullman, WA |
| 4 | Tue Nov 14 | at Abilene Chrstn | W79-74 | 2-2 | .500 | - | | Moody Coliseum (Abilene) · Abilene, TX |
| 5 | Sun Nov 19 | vs UT Martin | W78-66 | 3-2 | .600 | - | | William Nicks Building · Prairie View, TX |
| 6 | Tue Nov 21 | at E Kentucky | W76-64 | 4-2 | .667 | - | | McBrayer Arena · Richmond, KY |
| 7 | Wed Nov 29 | at Tulane | L77-98 | 4-3 | .571 | - | | Devlin Fieldhouse · New Orleans, LA |
| 8 | Sun Dec 10 | at Iowa State | L56-107 | 4-4 | .500 | - | | James H. Hilton Coliseum · Ames, IA |
| 9 | Tue Dec 12 | at Northern Iowa | L55-74 | 4-5 | .444 | - | | McLeod Center · Cedar Falls, IA |
| 10 | Mon Dec 18 | vsTBD | W92-61 | 5-5 | .500 | - | | William Nicks Building · Prairie View, TX |
| 11 | Wed Dec 20 | at Rice | L56-82 | 5-6 | .455 | - | | Tudor Fieldhouse · Houston, TX |
| 12 | Thu Dec 28 | at UTSA | L89-103 | 5-7 | .417 | - | | UTSA Convocation Center · San Antonio, TX |
| 13 | Sat Dec 30 | at Texas A&M | L54-79 | 5-8 | .385 | - | SEC Network | Reed Arena · College Station, TX |
| 14 | Sat Jan 6 | at Grambling | L63-69 | 5-9 | .357 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 15 | Mon Jan 8 | at Southern | L58-79 | 5-10 | .333 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 16 | Sat Jan 13 | vs Miss Valley St | W71-60 | 6-10 | .375 | - | | William Nicks Building · Prairie View, TX |
| 17 | Mon Jan 15 | vs AR-Pine Bluff | PPD | 10-21 | .323 | - | | William Nicks Building · Prairie View, TX |
| 18 | Sat Jan 20 | at Jackson St | W71-62 | 7-10 | .412 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 19 | Mon Jan 22 | at Alcorn St | L78-90 | 7-11 | .389 | - | | Davey L. Whitney Complex · Lorman, MS |
| 20 | Sat Jan 27 | vs Alabama St | L67-74 | 7-12 | .368 | - | | William Nicks Building · Prairie View, TX |
| 21 | Mon Jan 29 | vs Alabama A&M | W87-76 | 8-12 | .400 | - | | William Nicks Building · Prairie View, TX |
| 22 | Sat Feb 3 | vs Texas So | L69-80 | 8-13 | .381 | - | | William Nicks Building · Prairie View, TX |
| 23 | Mon Feb 5 | vsAR-Pine Bluff | W75-74 | 9-13 | .409 | - | | William Nicks Building · Prairie View, TX |
| 24 | Sat Feb 10 | at Bethune | L78-84 | 9-14 | .391 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 25 | Mon Feb 12 | at FAMU | W61-58 | 10-14 | .417 | - | ESPNU | Al Lawson Center · Tallahassee, FL |
| 26 | Sat Feb 17 | vsSouthern | L71-77 | 10-15 | .400 | - | | William Nicks Building · Prairie View, TX |
| 27 | Mon Feb 19 | vsGrambling | L74-83 | 10-16 | .385 | - | | William Nicks Building · Prairie View, TX |
| 28 | Sat Feb 24 | atAR-Pine Bluff | L59-72 | 10-17 | .370 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 29 | Mon Feb 26 | atMiss Valley St | L51-57 | 10-18 | .357 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 30 | Sat Mar 2 | vsAlcorn St | L65-73 | 10-19 | .345 | - | | William Nicks Building · Prairie View, TX |
| 31 | Mon Mar 4 | vsJackson St | L74-79 | 10-20 | .333 | - | | William Nicks Building · Prairie View, TX |
| 32 | Sat Mar 9 | atTexas So | L78-93 | 10-21 | .323 | - | | H&PE Arena · Houston, TX |
