| 1 | Tue Nov 4 | vs Long Beach St | W77-45 | 1-0 | 1.000 | - | | Viejas Arena · San Diego, CA |
| 2 | Sun Nov 9 | vsIdaho St | W73-57 | 2-0 | 1.000 | - | | Viejas Arena · San Diego, CA |
| 3 | Tue Nov 18 | vsTroy | L107-108 (2OT) | 2-1 | .667 | - | | Viejas Arena · San Diego, CA |
| 4 | Mon Nov 24 | at7Michigan | L54-94 | 2-2 | .500 | - | truTV | Crisler Center · Ann Arbor, MI |
| 5 | Tue Nov 25 | atOregon | W97-80 | 3-2 | .600 | - | TNT | Matthew Knight Arena · Eugene, OR |
| 6 | Wed Nov 26 | vsBaylor | L81-91 | 3-3 | .500 | - | truTV | Viejas Arena · San Diego, CA |
| 7 | Wed Dec 3 | vsUtah Valley | W77-66 | 4-3 | .571 | - | | Viejas Arena · San Diego, CA |
| 8 | Wed Dec 10 | vsLamar | W89-71 | 5-3 | .625 | - | | Viejas Arena · San Diego, CA |
| 9 | Wed Dec 17 | vsAir Force | W81-58 | 6-3 | .667 | - | CBSSN | Viejas Arena · San Diego, CA |
| 10 | Sat Dec 20 | at1Arizona | L45-68 | 6-4 | .600 | - | ESPN2 | Mortgage Matchup Center · Phoenix, AZ |
| 11 | Mon Dec 22 | vsTBD | W121-59 | 7-4 | .636 | - | | Viejas Arena · San Diego, CA |
| 12 | Tue Dec 30 | atSan Jose St | W81-68 | 8-4 | .667 | - | CBSSN | Provident Credit Union Event Center · San Jose, CA |
| 13 | Sat Jan 3 | vsBoise St | W110-107 (3OT) | 9-4 | .692 | - | CBSSN | Viejas Arena · San Diego, CA |
| 14 | Tue Jan 6 | atNevada | W73-68 | 10-4 | .714 | - | FS1 | Lawlor Events Center · Reno, NV |
| 15 | Sat Jan 10 | vsFresno St | W71-52 | 11-4 | .733 | - | CBSSN | Viejas Arena · San Diego, CA |
| 16 | Wed Jan 14 | atWyoming | W74-57 | 12-4 | .750 | - | CBSSN | Arena Auditorium · Laramie, WY |
| 17 | Sat Jan 17 | vsNew Mexico | W83-79 | 13-4 | .765 | - | CBSSN | Viejas Arena · San Diego, CA |
| 18 | Wed Jan 21 | atGrand Canyon | L69-70 | 13-5 | .722 | - | FS1 | GCU Arena · Phoenix, AZ |
| 19 | Sat Jan 24 | atUNLV | W82-71 | 14-5 | .737 | - | CBS | Thomas & Mack Center · Las Vegas, NV |
| 20 | Wed Jan 28 | vsColorado St | W73-50 | 15-5 | .750 | - | FS1 | Viejas Arena · San Diego, CA |
| 21 | Sat Jan 31 | atUtah State | L66-71 | 15-6 | .714 | - | CBS | Dee Glen Smith Spectrum · Logan, UT |
| 22 | Tue Feb 3 | vsWyoming | W72-63 | 16-6 | .727 | - | CBSSN | Viejas Arena · San Diego, CA |
| 23 | Sat Feb 7 | atAir Force | W88-54 | 17-6 | .739 | - | FS1 | Clune Arena · Colorado Springs, CO |
| 24 | Sat Feb 14 | vsNevada | W71-57 | 18-6 | .750 | - | CBSSN | Viejas Arena · San Diego, CA |
| 25 | Tue Feb 17 | vsGrand Canyon | L63-73 | 18-7 | .720 | - | CBSSN | Viejas Arena · San Diego, CA |
| 26 | Sat Feb 21 | atColorado St | L74-83 | 18-8 | .692 | - | CBSSN | Moby Arena · Fort Collins, CO |
| 27 | Wed Feb 25 | vsUtah State | W89-72 | 19-8 | .704 | - | FS1 | Viejas Arena · San Diego, CA |
| 28 | Sat Feb 28 | atNew Mexico | L76-81 | 19-9 | .679 | - | CBS | The Pit · Albuquerque, NM |
