| 1 | Mon Nov 6 | vs Fullerton | W83-57 | 1-0 | 1.000 | #17 | FS1 | Viejas Arena · San Diego, CA |
| 2 | Fri Nov 10 | at BYU | L65-74 | 1-1 | .500 | #17 | | Marriott Center · Provo, UT |
| 3 | Tue Nov 14 | vs Long Beach St | W88-76 | 2-1 | .667 | - | | Viejas Arena · San Diego, CA |
| 4 | Fri Nov 17 | vs Saint Mary's | W79-54 | 3-1 | .750 | - | | Viejas Arena · San Diego, CA |
| 5 | Sun Nov 19 | vs Washington | W100-97 (OT) | 4-1 | .800 | - | ESPN2 | Viejas Arena · San Diego, CA |
| 6 | Sat Nov 25 | vs California | W76-67 (OT) | 5-1 | .833 | - | | Viejas Arena · San Diego, CA |
| 7 | Mon Nov 27 | vs TBD | W71-51 | 6-1 | .857 | - | | Viejas Arena · San Diego, CA |
| 8 | Fri Dec 1 | at UC San Diego | W63-62 | 7-1 | .875 | - | | University Credit Union Center · Davis, CA |
| 9 | Tue Dec 5 | at Grand Canyon | L73-79 | 7-2 | .778 | #25 | ESPNU | GCU Arena · Phoenix, AZ |
| 10 | Sat Dec 9 | vs UC Irvine | W63-62 | 8-2 | .800 | #25 | FS1 | Viejas Arena · San Diego, CA |
| 11 | Tue Dec 19 | vsTBD | W91-57 | 9-2 | .818 | - | | Viejas Arena · San Diego, CA |
| 12 | Thu Dec 21 | vs Stanford | W74-60 | 10-2 | .833 | - | CBS | Viejas Arena · San Diego, CA |
| 13 | Fri Dec 29 | at #13Gonzaga | W84-74 | 11-2 | .846 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 14 | Wed Jan 3 | vs Fresno St | W74-47 | 12-2 | .857 | - | FS1 | Viejas Arena · San Diego, CA |
| 15 | Sat Jan 6 | vs UNLV | W72-61 | 13-2 | .867 | - | CBS | Viejas Arena · San Diego, CA |
| 16 | Tue Jan 9 | at San Jose St | W81-78 | 14-2 | .875 | #19 | CBS | Provident Credit Union Event Center · San Jose, CA |
| 17 | Sat Jan 13 | at New Mexico | L70-88 | 14-3 | .824 | #19 | CBS | The Pit · Albuquerque, NM |
| 18 | Wed Jan 17 | vs Nevada | W71-59 | 15-3 | .833 | - | CBS | Viejas Arena · San Diego, CA |
| 19 | Sat Jan 20 | at Boise St | L66-67 | 15-4 | .789 | - | CBS | ExtraMile Arena · Boise, ID |
| 20 | Tue Jan 23 | vs Wyoming | W81-65 | 16-4 | .800 | - | CBS | Viejas Arena · San Diego, CA |
| 21 | Tue Jan 30 | at Colorado St | L71-79 | 16-5 | .762 | - | CBS | Moby Arena · Fort Collins, CO |
| 22 | Sat Feb 3 | vs #17Utah State | W81-67 | 17-5 | .773 | - | FOX | Viejas Arena · San Diego, CA |
| 23 | Tue Feb 6 | at Air Force | W77-64 | 18-5 | .783 | #24 | FS1 | Clune Arena · Colorado Springs, CO |
| 24 | Fri Feb 9 | atNevada | L66-70 (OT) | 18-6 | .750 | #24 | CBS | Lawlor Events Center · Reno, NV |
| 25 | Tue Feb 13 | vsColorado St | W71-55 | 19-6 | .760 | - | CBS | Viejas Arena · San Diego, CA |
| 26 | Fri Feb 16 | vsNew Mexico | W81-70 | 20-6 | .769 | - | FS1 | Viejas Arena · San Diego, CA |
| 27 | Tue Feb 20 | atUtah State | L63-68 | 20-7 | .741 | #19 | CBS | Dee Glen Smith Spectrum · Logan, UT |
| 28 | Sat Feb 24 | atFresno St | W73-41 | 21-7 | .750 | #19 | CBS | Save Mart Center · Fresno, CA |
| 29 | Tue Feb 27 | vsSan Jose St | W72-64 | 22-7 | .759 | #20 | CBS | Viejas Arena · San Diego, CA |
| 30 | Tue Mar 5 | atUNLV | L58-62 | 22-8 | .733 | #21 | CBS | Thomas & Mack Center · Las Vegas, NV |
| 31 | Fri Mar 8 | vsBoise St | L77-79 (OT) | 22-9 | .710 | #21 | FS1 | Viejas Arena · San Diego, CA |
| 32 | Thu Mar 14 | atUNLV | W74-71 (OT) | 23-9 | .719 | - | CBS | Thomas & Mack Center · Las Vegas, NV |
| 33 | Fri Mar 15 | at#18Utah State | W86-70 | 24-9 | .727 | - | | Dee Glen Smith Spectrum · Logan, UT |
| 34 | Sat Mar 16 | vsNew Mexico | L61-68 | 24-10 | .706 | - | CBS | Viejas Arena · San Diego, CA |
| 35 | Fri Mar 22 | vs #12UAB | W69-65 | 25-10 | .714 | #5 | TNT | Viejas Arena · San Diego, CA |
| 36 | Sun Mar 24 | vs #13Yale | W85-57 | 26-10 | .722 | #5 | TBS | Viejas Arena · San Diego, CA |
| 37 | Thu Mar 28 | at #1UConn | L52-82 | 26-11 | .703 | #5 | TBS | Gampel Pavilion · Storrs, CT |
