| 1 | Tue Nov 5 | vs Texas So | W77-42 | 1-0 | 1.000 | - | | Viejas Arena · San Diego, CA |
| 2 | Sat Nov 9 | at BYU | W76-71 | 2-0 | 1.000 | - | | Marriott Center · Provo, UT |
| 3 | Wed Nov 13 | vs Grand Canyon | W86-61 | 3-0 | 1.000 | - | | Viejas Arena · San Diego, CA |
| 4 | Wed Nov 20 | at San Diego | W66-49 | 4-0 | 1.000 | - | | Jenny Craig Pavilion · San Diego, CA |
| 5 | Fri Nov 22 | vs Long Island | W81-64 | 5-0 | 1.000 | - | | Viejas Arena · San Diego, CA |
| 6 | Mon Nov 25 | vs Tennessee St | W62-49 | 6-0 | 1.000 | - | | Viejas Arena · San Diego, CA |
| 7 | Thu Nov 28 | at Creighton | W83-52 | 7-0 | 1.000 | - | | CHI Health Center Omaha · Omaha, NE |
| 8 | Fri Nov 29 | at Iowa | W83-73 | 8-0 | 1.000 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 9 | Wed Dec 4 | at Colorado St | W79-57 | 9-0 | 1.000 | - | | Moby Arena · Fort Collins, CO |
| 10 | Sun Dec 8 | vs San Jose St | W59-57 | 10-0 | 1.000 | - | | Viejas Arena · San Diego, CA |
| 11 | Wed Dec 18 | vs TBD | W92-48 | 11-0 | 1.000 | #20 | | Viejas Arena · San Diego, CA |
| 12 | Sat Dec 21 | vs Utah | W80-52 | 12-0 | 1.000 | - | PACN | Viejas Arena · San Diego, CA |
| 13 | Sat Dec 28 | vs Cal Poly | W73-57 | 13-0 | 1.000 | #15 | | Viejas Arena · San Diego, CA |
| 14 | Wed Jan 1 | vs Fresno St | W61-52 | 14-0 | 1.000 | #13 | | Viejas Arena · San Diego, CA |
| 15 | Sat Jan 4 | at Utah State | W77-68 | 15-0 | 1.000 | #13 | CBS | Dee Glen Smith Spectrum · Logan, UT |
| 16 | Wed Jan 8 | at Wyoming | W72-52 | 16-0 | 1.000 | #7 | | Arena Auditorium · Laramie, WY |
| 17 | Sat Jan 11 | vs Boise St | W83-65 | 17-0 | 1.000 | #7 | | Viejas Arena · San Diego, CA |
| 18 | Tue Jan 14 | atFresno St | W64-55 | 18-0 | 1.000 | #7 | ESPN2 | Save Mart Center · Fresno, CA |
| 19 | Sat Jan 18 | vs Nevada | W68-55 | 19-0 | 1.000 | #7 | CBS | Viejas Arena · San Diego, CA |
| 20 | Tue Jan 21 | vsWyoming | W72-55 | 20-0 | 1.000 | #4 | CBS | Viejas Arena · San Diego, CA |
| 21 | Sun Jan 26 | at UNLV | W71-67 | 21-0 | 1.000 | #4 | CBS | Thomas & Mack Center · Las Vegas, NV |
| 22 | Wed Jan 29 | at New Mexico | W85-57 | 22-0 | 1.000 | #4 | CBS | The Pit · Albuquerque, NM |
| 23 | Sat Feb 1 | vsUtah State | W80-68 | 23-0 | 1.000 | #4 | CBS | Viejas Arena · San Diego, CA |
| 24 | Sat Feb 8 | at Air Force | W89-74 | 24-0 | 1.000 | #4 | CBS | Clune Arena · Colorado Springs, CO |
| 25 | Tue Feb 11 | vsNew Mexico | W82-59 | 25-0 | 1.000 | #4 | ESPN2 | Viejas Arena · San Diego, CA |
| 26 | Sun Feb 16 | atBoise St | W72-55 | 26-0 | 1.000 | #4 | CBS | ExtraMile Arena · Boise, ID |
| 27 | Sat Feb 22 | vsUNLV | L63-66 | 26-1 | .963 | #4 | CBS | Viejas Arena · San Diego, CA |
| 28 | Tue Feb 25 | vsColorado St | W66-60 | 27-1 | .964 | #5 | CBS | Viejas Arena · San Diego, CA |
| 29 | Sat Feb 29 | atNevada | W83-76 | 28-1 | .966 | #5 | ESPN2 | Lawlor Events Center · Reno, NV |
| 30 | Thu Mar 5 | vsAir Force | W73-60 | 29-1 | .967 | - | CBS | Viejas Arena · San Diego, CA |
| 31 | Fri Mar 6 | vsBoise St | W81-68 | 30-1 | .968 | - | CBS | Viejas Arena · San Diego, CA |
| 32 | Sat Mar 7 | vsUtah State | L56-59 | 30-2 | .938 | - | CBS | Viejas Arena · San Diego, CA |
