| 1 | Wed Nov 6 | vs UC San Diego | W63-58 | 1-0 | 1.000 | - | | Viejas Arena · San Diego, CA |
| 2 | Tue Nov 12 | vsTBD | W100-49 | 2-0 | 1.000 | - | | Viejas Arena · San Diego, CA |
| 3 | Mon Nov 18 | vs#3Gonzaga | L67-80 | 2-1 | .667 | - | CBS | Viejas Arena · San Diego, CA |
| 4 | Tue Nov 26 | vs#21Creighton | W71-53 | 3-1 | .750 | - | TBS | Viejas Arena · San Diego, CA |
| 5 | Wed Nov 27 | atOregon | L68-78 | 3-2 | .600 | - | TNT | Matthew Knight Arena · Eugene, OR |
| 6 | Sat Nov 30 | at#6Houston | W73-70 (OT) | 4-2 | .667 | - | TNT | Fertitta Center · Houston, TX |
| 7 | Wed Dec 4 | atFresno St | W84-62 | 5-2 | .714 | #24 | FS1 | Save Mart Center · Fresno, CA |
| 8 | Sat Dec 7 | vsSan Diego | W74-57 | 6-2 | .750 | #24 | | Viejas Arena · San Diego, CA |
| 9 | Wed Dec 11 | vsCA Baptist | W81-75 | 7-2 | .778 | #23 | | Viejas Arena · San Diego, CA |
| 10 | Sat Dec 21 | atCalifornia | W71-50 | 8-2 | .800 | #23 | ACC Network | Haas Pavilion · Berkeley, CA |
| 11 | Sat Dec 28 | vsUtah State | L66-67 | 8-3 | .727 | #20 | FOX | Viejas Arena · San Diego, CA |
| 12 | Sat Jan 4 | atBoise St | W76-68 | 9-3 | .750 | - | CBS | ExtraMile Arena · Boise, ID |
| 13 | Wed Jan 8 | vsAir Force | W67-38 | 10-3 | .769 | - | FS1 | Viejas Arena · San Diego, CA |
| 14 | Sat Jan 11 | atNew Mexico | L48-62 | 10-4 | .714 | - | CBS | The Pit · Albuquerque, NM |
| 15 | Tue Jan 14 | vsColorado St | W75-60 | 11-4 | .733 | - | CBS | Viejas Arena · San Diego, CA |
| 16 | Sat Jan 18 | vsUNLV | L68-76 | 11-5 | .688 | - | CBS | Viejas Arena · San Diego, CA |
| 17 | Wed Jan 22 | atAir Force | W77-76 (OT) | 12-5 | .706 | - | CBS | Clune Arena · Colorado Springs, CO |
| 18 | Sat Jan 25 | atNevada | W69-50 | 13-5 | .722 | - | CBS | Lawlor Events Center · Reno, NV |
| 19 | Tue Jan 28 | vsSan Jose St | W71-68 | 14-5 | .737 | - | FS1 | Viejas Arena · San Diego, CA |
| 20 | Sat Feb 1 | vsWyoming | W63-61 | 15-5 | .750 | - | CBS | Viejas Arena · San Diego, CA |
| 21 | Sat Feb 8 | atColorado St | L63-68 | 15-6 | .714 | - | CBS | Moby Arena · Fort Collins, CO |
| 22 | Tue Feb 11 | atSan Jose St | W69-66 | 16-6 | .727 | - | CBS | Provident Credit Union Event Center · San Jose, CA |
| 23 | Sat Feb 15 | vsBoise St | W64-47 | 17-6 | .739 | - | CBS | Viejas Arena · San Diego, CA |
| 24 | Tue Feb 18 | vsFresno St | W83-60 | 18-6 | .750 | - | CBS | Viejas Arena · San Diego, CA |
| 25 | Sat Feb 22 | atUtah State | L71-79 | 18-7 | .720 | - | CBS | Dee Glen Smith Spectrum · Logan, UT |
| 26 | Tue Feb 25 | vsNew Mexico | W73-65 | 19-7 | .731 | - | FS1 | Viejas Arena · San Diego, CA |
| 27 | Sat Mar 1 | atWyoming | W72-69 | 20-7 | .741 | - | CBS | Arena Auditorium · Laramie, WY |
| 28 | Tue Mar 4 | atUNLV | L67-74 | 20-8 | .714 | - | CBS | Thomas & Mack Center · Las Vegas, NV |
| 29 | Sat Mar 8 | vsNevada | W80-61 | 21-8 | .724 | - | FS1 | Viejas Arena · San Diego, CA |
| 30 | Thu Mar 13 | vsBoise St | L52-62 | 21-9 | .700 | - | CBS | Thomas & Mack Center · Las Vegas, NV |
| 31 | Tue Mar 18 | vs#11UNC | L68-95 | 21-10 | .677 | #11 | truTV | UD Arena · Dayton, OH |
