| 1 | Tue Nov 9 | vs UC Riverside | W66-53 | 1-0 | 1.000 | - | | Viejas Arena · San Diego, CA |
| 2 | Fri Nov 12 | at BYU | L60-66 | 1-1 | .500 | - | | Marriott Center · Provo, UT |
| 3 | Thu Nov 18 | vs Arizona St | W65-63 | 2-1 | .667 | - | CBS | Viejas Arena · San Diego, CA |
| 4 | Sat Nov 20 | vs UT Arlington | W68-62 | 3-1 | .750 | - | | Viejas Arena · San Diego, CA |
| 5 | Thu Nov 25 | vs Georgetown | W73-56 | 4-1 | .800 | - | ESPN2 | Viejas Arena · San Diego, CA |
| 6 | Fri Nov 26 | vs USC | L43-58 | 4-2 | .667 | - | ESPN2 | Viejas Arena · San Diego, CA |
| 7 | Tue Nov 30 | vs Long Beach St | W72-47 | 5-2 | .714 | - | | Viejas Arena · San Diego, CA |
| 8 | Sat Dec 4 | at #24Michigan | L58-72 | 5-3 | .625 | - | CBS | Crisler Center · Ann Arbor, MI |
| 9 | Wed Dec 8 | vs Fullerton | W66-56 | 6-3 | .667 | - | | Viejas Arena · San Diego, CA |
| 10 | Fri Dec 17 | at Saint Mary's | W63-53 | 7-3 | .700 | - | | University Credit Union Pavilion · Moraga, CA |
| 11 | Wed Dec 22 | vs UC San Diego | W78-57 | 8-3 | .727 | - | | Viejas Arena · San Diego, CA |
| 12 | Sat Jan 1 | at UNLV | W62-55 | 9-3 | .750 | - | | Thomas & Mack Center · Las Vegas, NV |
| 13 | Wed Jan 5 | vs Fresno St | PPD | 23-9 | .719 | - | | Viejas Arena · San Diego, CA |
| 14 | Sat Jan 8 | vs #20Colorado St | W79-49 | 10-3 | .769 | - | CBS | Viejas Arena · San Diego, CA |
| 15 | Wed Jan 12 | at Wyoming | PPD | 23-9 | .719 | - | | Arena Auditorium · Laramie, WY |
| 16 | Tue Jan 18 | vsUNLV | PPD | 23-9 | .719 | - | | Viejas Arena · San Diego, CA |
| 17 | Sat Jan 22 | vs Boise St | L37-42 | 10-4 | .714 | - | CBS | Viejas Arena · San Diego, CA |
| 18 | Mon Jan 24 | vsUNLV | W80-55 | 11-4 | .733 | - | CBS | Viejas Arena · San Diego, CA |
| 19 | Wed Jan 26 | at Utah State | L57-75 | 11-5 | .688 | - | FS1 | Dee Glen Smith Spectrum · Logan, UT |
| 20 | Mon Jan 31 | vs New Mexico | W72-47 | 12-5 | .706 | - | FS1 | Viejas Arena · San Diego, CA |
| 21 | Fri Feb 4 | atColorado St | L57-58 | 12-6 | .667 | - | FS1 | Moby Arena · Fort Collins, CO |
| 22 | Sun Feb 6 | vs Nevada | W65-63 | 13-6 | .684 | - | CBS | Viejas Arena · San Diego, CA |
| 23 | Wed Feb 9 | at San Jose St | W72-62 | 14-6 | .700 | - | CBS | Provident Credit Union Event Center · San Jose, CA |
| 24 | Sat Feb 12 | vs Air Force | W76-64 | 15-6 | .714 | - | CBS | Viejas Arena · San Diego, CA |
| 25 | Tue Feb 15 | vsUtah State | W75-56 | 16-6 | .727 | - | CBS | Viejas Arena · San Diego, CA |
| 26 | Sat Feb 19 | atFresno St | W61-44 | 17-6 | .739 | - | CBS | Save Mart Center · Fresno, CA |
| 27 | Tue Feb 22 | atBoise St | L57-58 | 17-7 | .708 | - | CBS | ExtraMile Arena · Boise, ID |
| 28 | Fri Feb 25 | vsSan Jose St | W77-52 | 18-7 | .720 | - | | Viejas Arena · San Diego, CA |
| 29 | Mon Feb 28 | atWyoming | W73-66 | 19-7 | .731 | - | CBS | Arena Auditorium · Laramie, WY |
| 30 | Thu Mar 3 | vsFresno St | W65-64 (2OT) | 20-7 | .741 | - | CBS | Viejas Arena · San Diego, CA |
| 31 | Sat Mar 5 | atNevada | W79-78 | 21-7 | .750 | - | CBS | Lawlor Events Center · Reno, NV |
| 32 | Thu Mar 10 | vsFresno St | W53-46 | 22-7 | .759 | - | CBS | Viejas Arena · San Diego, CA |
| 33 | Fri Mar 11 | atColorado St | W63-58 | 23-7 | .767 | - | CBS | Moby Arena · Fort Collins, CO |
| 34 | Sat Mar 12 | atBoise St | L52-53 | 23-8 | .742 | - | CBS | ExtraMile Arena · Boise, ID |
| 35 | Thu Mar 17 | vs #9Creighton | L69-72 (OT) | 23-9 | .719 | #8 | truTV | Viejas Arena · San Diego, CA |
