| 1 | Wed Nov 6 | vs Rider | L67-68 | 0-1 | .000 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 2 | Fri Nov 8 | vsBoston Univ | W74-60 | 1-1 | .500 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 3 | Tue Nov 12 | vsPortland St | L76-85 | 1-2 | .333 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 4 | Sat Nov 16 | vsIdaho St | L66-78 | 1-3 | .250 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 5 | Fri Nov 22 | vsSouthern Utah | L67-72 | 1-4 | .200 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 6 | Sun Nov 24 | vsIdaho | W68-61 | 2-4 | .333 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 7 | Wed Nov 27 | vsTBD | W69-64 | 3-4 | .429 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 8 | Tue Dec 3 | atArizona St | L53-90 | 3-5 | .375 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 9 | Sat Dec 7 | at24SDSU | L57-74 | 3-6 | .333 | - | | Viejas Arena · San Diego, CA |
| 10 | Tue Dec 10 | vsLong Beach St | L70-76 | 3-7 | .300 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 11 | Sat Dec 14 | atFresno St | L65-73 | 3-8 | .273 | - | | Save Mart Center · Fresno, CA |
| 12 | Sat Dec 21 | vsUC San Diego | L71-77 | 3-9 | .250 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 13 | Sat Dec 28 | vsGrand Canyon | L55-68 | 3-10 | .231 | - | | Intuit Dome · Inglewood, CA |
| 14 | Mon Dec 30 | vsPacific | W75-65 | 4-10 | .286 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 15 | Thu Jan 2 | vsSanta Clara | L80-81 | 4-11 | .267 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 16 | Sat Jan 4 | atOregon St | L54-81 | 4-12 | .250 | - | ESPN+ | Gill Coliseum · Corvallis, OR |
| 17 | Wed Jan 8 | at18Gonzaga | L80-93 | 4-13 | .235 | - | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 18 | Sat Jan 11 | vsSaint Mary's | L56-103 | 4-14 | .222 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 19 | Thu Jan 16 | vsWashington St | L61-65 | 4-15 | .211 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 20 | Sat Jan 18 | atLMU | L70-77 | 4-16 | .200 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 21 | Thu Jan 23 | atPortland | L82-92 | 4-17 | .190 | - | ESPN+ | Chiles Center · Portland, OR |
| 22 | Sat Jan 25 | atSan Francisco | L69-81 | 4-18 | .182 | - | ESPN+ | War Memorial at the Sobrato Center · San Francisco, CA |
| 23 | Thu Jan 30 | vsPepperdine | L90-98 | 4-19 | .174 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 24 | Sat Feb 1 | vsLMU | L62-78 | 4-20 | .167 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 25 | Thu Feb 6 | atPacific | L69-71 | 4-21 | .160 | - | ESPN+ | Alex G. Spanos Center · Stockton, CA |
| 26 | Sat Feb 8 | atSanta Clara | L70-93 | 4-22 | .154 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 27 | Thu Feb 13 | atPepperdine | L81-88 | 4-23 | .148 | - | ESPN+ | Firestone Fieldhouse · Malibu, CA |
| 28 | Sat Feb 15 | vsSan Francisco | L61-84 | 4-24 | .143 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 29 | Sat Feb 22 | vsOregon St | L73-83 | 4-25 | .138 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 30 | Thu Feb 27 | atWashington St | L86-93 | 4-26 | .133 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 31 | Sat Mar 1 | vsPortland | W82-80 | 5-26 | .161 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 32 | Thu Mar 6 | atPacific | W81-77 | 6-26 | .188 | - | ESPN+ | Orleans Arena · Las Vegas, NV |
| 33 | Fri Mar 7 | atLMU | L74-100 | 6-27 | .182 | - | ESPN+ | Orleans Arena · Las Vegas, NV |
