| 1 | Tue Nov 4 | vs TBD | W88-59 | 1-0 | 1.000 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 2 | Fri Nov 7 | vsIdaho St | L68-71 | 1-1 | .500 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 3 | Wed Nov 12 | vsIdaho | W78-74 | 2-1 | .667 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 4 | Tue Nov 18 | vsGrambling | W78-68 | 3-1 | .750 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 5 | Fri Nov 21 | vsUC Riverside | L71-85 | 3-2 | .600 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 6 | Tue Nov 25 | atCA Baptist | L61-76 | 3-3 | .500 | - | CBSSN | CBU Events Center · Riverside, CA |
| 7 | Sun Nov 30 | atLong Beach St | L72-76 | 3-4 | .429 | - | ESPN+ | Walter Pyramid · Long Beach, CA |
| 8 | Fri Dec 5 | atSan Jose St | L69-86 | 3-5 | .375 | - | | Provident Credit Union Event Center · San Jose, CA |
| 9 | Tue Dec 9 | vsUSC | L81-94 | 3-6 | .333 | - | ESPN2 | Jenny Craig Pavilion · San Diego, CA |
| 10 | Sat Dec 13 | vsN Arizona | W78-69 | 4-6 | .400 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 11 | Fri Dec 19 | atUC San Diego | W82-80 | 5-6 | .455 | - | ESPN+ | University Credit Union Center · Davis, CA |
| 12 | Mon Dec 22 | atWashington | L56-86 | 5-7 | .417 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 13 | Sun Dec 28 | vsPacific | W66-54 | 6-7 | .462 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 14 | Tue Dec 30 | vs7Gonzaga | L93-99 | 6-8 | .429 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 15 | Fri Jan 2 | atSan Francisco | L64-74 | 6-9 | .400 | - | ESPN+ | War Memorial at the Sobrato Center · San Francisco, CA |
| 16 | Sun Jan 4 | atSanta Clara | L70-98 | 6-10 | .375 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 17 | Thu Jan 8 | vsPepperdine | W83-63 | 7-10 | .412 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 18 | Sat Jan 10 | atPacific | L70-77 | 7-11 | .389 | - | ESPN+ | Alex G. Spanos Center · Stockton, CA |
| 19 | Thu Jan 15 | atSeattle U | L64-75 | 7-12 | .368 | - | ESPN+ | Redhawk Center · Seattle, WA |
| 20 | Sat Jan 17 | vsTBD | W113-67 | 8-12 | .400 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 21 | Wed Jan 21 | vsWashington St | W96-92 | 9-12 | .429 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 22 | Sat Jan 24 | vsSanta Clara | L73-85 | 9-13 | .409 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 23 | Wed Jan 28 | atPepperdine | W92-88 (OT) | 10-13 | .435 | - | ESPN+ | Firestone Fieldhouse · Malibu, CA |
| 24 | Sat Jan 31 | vsOregon St | L76-78 (OT) | 10-14 | .417 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 25 | Wed Feb 4 | atSaint Mary's | L60-87 | 10-15 | .400 | - | ESPN+ | University Credit Union Pavilion · Moraga, CA |
| 26 | Sat Feb 7 | atLMU | L63-83 | 10-16 | .385 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 27 | Wed Feb 11 | vsPortland | W71-58 | 11-16 | .407 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 28 | Sun Feb 15 | vsSan Francisco | L79-92 | 11-17 | .393 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 29 | Sat Feb 21 | vsLMU | L65-77 | 11-18 | .379 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 30 | Wed Feb 25 | atOregon St | L82-92 (OT) | 11-19 | .367 | - | ESPN+ | Gill Coliseum · Corvallis, OR |
| 31 | Sat Feb 28 | atPortland | L74-87 | 11-20 | .355 | - | ESPN+ | Chiles Center · Portland, OR |
