| 8 | Fri Dec 5 | at San Jose St | 10:00 PM | 3-5 | .375 | - | | Provident Credit Union Event Center · San Jose, CA |
| 9 | Tue Dec 9 | vs#24USC | 9:00 PM | 8-0 | 1.000 | - | ESPN2 | Jenny Craig Pavilion · San Diego, CA |
| 10 | Sat Dec 13 | vsN Arizona | 6:00 PM | 4-3 | .571 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 11 | Fri Dec 19 | atUC San Diego | 10:00 PM | 7-1 | .875 | - | ESPN+ | University Credit Union Center · Davis, CA |
| 12 | Mon Dec 22 | atWashington | 10:00 PM | 5-3 | .625 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 13 | Sun Dec 28 | vsPacific | 6:00 PM | 7-2 | .778 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 14 | Tue Dec 30 | vs#11Gonzaga | 9:30 PM | 7-1 | .875 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 15 | Fri Jan 2 | atSan Francisco | 10:00 PM | 5-4 | .556 | - | ESPN+ | War Memorial at the Sobrato Center · San Francisco, CA |
| 16 | Sun Jan 4 | atSanta Clara | 7:00 PM | 8-1 | .889 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 17 | Thu Jan 8 | vsPepperdine | 9:30 PM | 3-6 | .333 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 18 | Sat Jan 10 | atPacific | 7:00 PM | 7-2 | .778 | - | ESPN+ | Alex G. Spanos Center · Stockton, CA |
| 19 | Thu Jan 15 | atSeattle U | 10:00 PM | 6-2 | .750 | - | ESPN+ | Redhawk Center · Seattle, WA |
| 20 | Sat Jan 17 | vsTBD | 8:00 PM | 0-0 | .000 | - | | Jenny Craig Pavilion · San Diego, CA |
| 21 | Wed Jan 21 | vsWashington St | 9:30 PM | 3-6 | .333 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 22 | Sat Jan 24 | vsSanta Clara | 6:30 PM | 8-1 | .889 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 23 | Wed Jan 28 | atPepperdine | 9:00 PM | 3-6 | .333 | - | ESPN+ | Firestone Fieldhouse · Malibu, CA |
| 24 | Sat Jan 31 | vsOregon St | 6:00 PM | 4-5 | .444 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 25 | Wed Feb 4 | atSaint Mary's | 10:00 PM | 8-1 | .889 | - | ESPN+ | University Credit Union Pavilion · Moraga, CA |
| 26 | Sat Feb 7 | atLMU | 9:00 PM | 7-3 | .700 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 27 | Wed Feb 11 | vsPortland | 9:30 PM | 5-4 | .556 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 28 | Sun Feb 15 | vsSan Francisco | 6:00 PM | 5-4 | .556 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 29 | Sat Feb 21 | vsLMU | 6:00 PM | 7-3 | .700 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 30 | Wed Feb 25 | atOregon St | 10:00 PM | 4-5 | .444 | - | ESPN+ | Gill Coliseum · Corvallis, OR |
| 31 | Sat Feb 28 | atPortland | 5:00 PM | 5-4 | .556 | - | ESPN+ | Chiles Center · Portland, OR |
