| 1 | Tue Nov 5 | vs UC Irvine | L73-76 | +5½ | 0-1 | .000 | - | | Jenny Craig Pavilion · San Diego, CA |
| 2 | Sat Nov 9 | atLong Beach St | L62-74 | -2½ | 0-2 | .000 | - | | Walter Pyramid · Long Beach, CA |
| 3 | Tue Nov 12 | vsFresno St | W72-66 (OT) | +2½ | 1-2 | .333 | - | | Jenny Craig Pavilion · San Diego, CA |
| 4 | Thu Nov 14 | atWeber St | W71-56 | +2½ | 2-2 | .500 | - | | Dee Events Center · Ogden, UT |
| 5 | Sat Nov 16 | at25Colorado | L53-71 | +18 | 2-3 | .400 | - | | CU Events Center · Boulder, CO |
| 6 | Wed Nov 20 | vsSDSU | L49-66 | +7½ | 2-4 | .333 | - | | Jenny Craig Pavilion · San Diego, CA |
| 7 | Sun Nov 24 | at25Washington | L69-88 | +15 | 2-5 | .286 | - | | Alaska Airlines Arena · Seattle, WA |
| 8 | Wed Nov 27 | vsHofstra | W79-69 | +1½ | 3-5 | .375 | - | | Jenny Craig Pavilion · San Diego, CA |
| 9 | Sun Dec 1 | vsSt Bonaventure | L61-70 | +3½ | 3-6 | .333 | - | | Jenny Craig Pavilion · San Diego, CA |
| 10 | Mon Dec 2 | atUIC | L83-89 | +3½ | 3-7 | .300 | - | | Credit Union 1 Arena · Chicago, IL |
| 11 | Sat Dec 7 | vsHoly Cross | W68-51 | -14½ | 4-7 | .364 | - | | Jenny Craig Pavilion · San Diego, CA |
| 12 | Wed Dec 11 | atFullerton | W66-54 | -2½ | 5-7 | .417 | - | | Titan Gym · Fullerton, CA |
| 13 | Sat Dec 14 | vsUC Davis | W58-54 | -7 | 6-7 | .462 | - | | Jenny Craig Pavilion · San Diego, CA |
| 14 | Sat Dec 21 | atStanford | L59-62 | -9 | 6-8 | .429 | - | | Chase Center · San Francisco, CA |
| 15 | Sun Dec 29 | vsTBD | W93-67 | - | 7-8 | .467 | - | | Jenny Craig Pavilion · San Diego, CA |
| 16 | Thu Jan 2 | atLMU | L58-64 | -2 | 7-9 | .438 | - | | Gersten Pavilion · Los Angeles, CA |
| 17 | Sat Jan 4 | atSanta Clara | L63-80 | +6½ | 7-10 | .412 | - | | Leavey Center · Santa Clara, CA |
| 18 | Thu Jan 9 | vs1Gonzaga | L50-94 | +15½ | 7-11 | .389 | - | | Jenny Craig Pavilion · San Diego, CA |
| 19 | Sat Jan 11 | vsPepperdine | L78-85 | +2 | 7-12 | .368 | - | | Jenny Craig Pavilion · San Diego, CA |
| 20 | Thu Jan 16 | atBYU | L70-93 | +15 | 7-13 | .350 | - | | Marriott Center · Provo, UT |
| 21 | Sat Jan 18 | atPortland | W77-67 | -1 | 8-13 | .381 | - | | Chiles Center · Portland, OR |
| 22 | Sat Jan 25 | vsSanta Clara | L52-65 | +2½ | 8-14 | .364 | - | | Jenny Craig Pavilion · San Diego, CA |
| 23 | Thu Jan 30 | vsSan Francisco | L44-69 | +5½ | 8-15 | .348 | - | | Jenny Craig Pavilion · San Diego, CA |
| 24 | Sat Feb 1 | atPacific | L58-66 | +9½ | 8-16 | .333 | - | | Alex G. Spanos Center · Stockton, CA |
| 25 | Thu Feb 6 | vsSaint Mary's | L60-66 | +11 | 8-17 | .320 | - | ESPNU | Jenny Craig Pavilion · San Diego, CA |
| 26 | Sat Feb 8 | vsPortland | W88-81 (2OT) | -7 | 9-17 | .346 | - | | Jenny Craig Pavilion · San Diego, CA |
| 27 | Thu Feb 13 | atPepperdine | L69-72 | +9 | 9-18 | .333 | - | | Firestone Fieldhouse · Malibu, CA |
| 28 | Sat Feb 15 | vsBYU | L71-72 | +13½ | 9-19 | .321 | - | CBS Sports Network | Jenny Craig Pavilion · San Diego, CA |
| 29 | Sat Feb 22 | atSaint Mary's | L63-92 | +15 | 9-20 | .310 | - | | University Credit Union Pavilion · Moraga, CA |
| 30 | Thu Feb 27 | at3Gonzaga | L59-94 | +25½ | 9-21 | .300 | - | | McCarthey Athletic Center · Spokane, WA |
| 31 | Sat Feb 29 | vsPacific | L64-71 | +4 | 9-22 | .290 | - | | Jenny Craig Pavilion · San Diego, CA |
| 32 | Thu Mar 5 | atLMU | L61-75 | +2 | 9-23 | .281 | - | | Orleans Arena · Las Vegas, NV |
