| 1 | Mon Nov 6 | vs TBD | W68-64 | - | 1-0 | 1.000 | - | | Jenny Craig Pavilion · San Diego, CA |
| 2 | Wed Nov 8 | vsJackson St | W87-61 | - | 2-0 | 1.000 | - | | Jenny Craig Pavilion · San Diego, CA |
| 3 | Sat Nov 11 | atUC San Diego | L63-69 | - | 2-1 | .667 | - | | University Credit Union Center · Davis, CA |
| 4 | Fri Nov 17 | vsLe Moyne | W80-71 | - | 3-1 | .750 | - | | Jenny Craig Pavilion · San Diego, CA |
| 5 | Mon Nov 20 | vsNavy | W67-59 | - | 4-1 | .800 | - | | Jenny Craig Pavilion · San Diego, CA |
| 6 | Fri Nov 24 | atArkansas St | W71-57 | - | 5-1 | .833 | - | | First National Bank Arena · Jonesboro, AR |
| 7 | Sat Nov 25 | atHawai'i | L66-77 | - | 5-2 | .714 | - | | Stan Sheriff Center · Honolulu, HI |
| 8 | Wed Nov 29 | vsN Colorado | W74-72 | - | 6-2 | .750 | - | | Jenny Craig Pavilion · San Diego, CA |
| 9 | Sun Dec 3 | atStanford | L64-88 | - | 6-3 | .667 | - | | Maples Pavilion · Stanford, CA |
| 10 | Wed Dec 6 | atUtah State | L81-108 | - | 6-4 | .600 | - | | Dee Glen Smith Spectrum · Logan, UT |
| 11 | Sat Dec 9 | vsArizona St | W89-84 | - | 7-4 | .636 | - | CBS Sports Network | Jenny Craig Pavilion · San Diego, CA |
| 12 | Fri Dec 15 | vsPortland St | W69-65 | - | 8-4 | .667 | - | | Jenny Craig Pavilion · San Diego, CA |
| 13 | Thu Dec 21 | vsSouth Dakota | W69-66 | - | 9-4 | .692 | - | | Jenny Craig Pavilion · San Diego, CA |
| 14 | Fri Dec 29 | vsFresno St | L67-71 | - | 9-5 | .643 | - | | Jenny Craig Pavilion · San Diego, CA |
| 15 | Sun Dec 31 | vsTBD | W78-65 | - | 10-5 | .667 | - | | Jenny Craig Pavilion · San Diego, CA |
| 16 | Thu Jan 4 | vsSaint Mary's | L70-81 | - | 10-6 | .625 | - | CBS Sports Network | Jenny Craig Pavilion · San Diego, CA |
| 17 | Sat Jan 6 | at24Gonzaga | L74-101 | - | 10-7 | .588 | - | | McCarthey Athletic Center · Spokane, WA |
| 18 | Thu Jan 11 | vsSan Francisco | L63-83 | - | 10-8 | .556 | - | | Jenny Craig Pavilion · San Diego, CA |
| 19 | Sat Jan 13 | vsPepperdine | L77-83 | - | 10-9 | .526 | - | | Jenny Craig Pavilion · San Diego, CA |
| 20 | Thu Jan 18 | atPortland | PPD | - | 18-15 | .545 | - | | Chiles Center · Portland, OR |
| 21 | Sat Jan 20 | vsGonzaga | L63-105 | - | 10-10 | .500 | - | | Jenny Craig Pavilion · San Diego, CA |
| 22 | Tue Jan 23 | atPortland | W85-81 | - | 11-10 | .524 | - | | Chiles Center · Portland, OR |
| 23 | Sat Jan 27 | atPepperdine | W69-67 | - | 12-10 | .545 | - | | Firestone Fieldhouse · Malibu, CA |
| 24 | Thu Feb 1 | atSan Francisco | L79-95 | - | 12-11 | .522 | - | CBS Sports Network | War Memorial at the Sobrato Center · San Francisco, CA |
| 25 | Sat Feb 3 | atSanta Clara | W70-59 | - | 13-11 | .542 | - | | Leavey Center · Santa Clara, CA |
| 26 | Wed Feb 7 | vsLMU | W79-77 | - | 14-11 | .560 | - | | Jenny Craig Pavilion · San Diego, CA |
| 27 | Sat Feb 10 | atPacific | W89-84 | - | 15-11 | .577 | - | | Alex G. Spanos Center · Stockton, CA |
| 28 | Thu Feb 15 | vsPortland | W71-66 | - | 16-11 | .593 | - | | Jenny Craig Pavilion · San Diego, CA |
| 29 | Sat Feb 17 | vsSanta Clara | L69-82 | - | 16-12 | .571 | - | | Jenny Craig Pavilion · San Diego, CA |
| 30 | Sat Feb 24 | at18Saint Mary's | L62-88 | - | 16-13 | .552 | - | ESPNU | University Credit Union Pavilion · Moraga, CA |
| 31 | Thu Feb 29 | atLMU | L62-96 | - | 16-14 | .533 | - | | Gersten Pavilion · Los Angeles, CA |
| 32 | Sat Mar 2 | vsPacific | W81-69 | - | 17-14 | .548 | - | | Jenny Craig Pavilion · San Diego, CA |
| 33 | Fri Mar 8 | vsPepperdine | W57-52 | - | 18-14 | .563 | - | | Orleans Arena · Las Vegas, NV |
| 34 | Sat Mar 9 | atSanta Clara | L79-104 | - | 18-15 | .545 | - | ESPN2 | Orleans Arena · Las Vegas, NV |
