| 1 | Tue Nov 9 | vs TBD | W103-38 | 1-0 | 1.000 | - | | Jenny Craig Pavilion · San Diego, CA |
| 2 | Fri Nov 12 | atNevada | W75-68 | 2-0 | 1.000 | - | | Lawlor Events Center · Reno, NV |
| 3 | Mon Nov 15 | atCalifornia | L70-75 | 2-1 | .667 | - | PACN | Haas Pavilion · Berkeley, CA |
| 4 | Wed Nov 17 | vsUC Riverside | W74-62 | 3-1 | .750 | - | | Jenny Craig Pavilion · San Diego, CA |
| 5 | Fri Nov 19 | vsFullerton | L55-57 | 3-2 | .600 | - | | Jenny Craig Pavilion · San Diego, CA |
| 6 | Thu Nov 25 | vsSouth Alabama | L67-68 | 3-3 | .500 | - | | Jenny Craig Pavilion · San Diego, CA |
| 7 | Fri Nov 26 | vsUIC | W64-52 | 4-3 | .571 | - | | Jenny Craig Pavilion · San Diego, CA |
| 8 | Sun Nov 28 | vsCSU Northridge | L52-56 | 4-4 | .500 | - | | Jenny Craig Pavilion · San Diego, CA |
| 9 | Wed Dec 1 | atFresno St | L43-63 | 4-5 | .444 | - | | Save Mart Center · Fresno, CA |
| 10 | Sun Dec 5 | vsCal Poly | W52-51 | 5-5 | .500 | - | | Jenny Craig Pavilion · San Diego, CA |
| 11 | Sat Dec 11 | vsTBD | W84-55 | 6-5 | .545 | - | | Jenny Craig Pavilion · San Diego, CA |
| 12 | Sat Dec 18 | atN Arizona | W69-59 | 7-5 | .583 | - | | J. Lawrence Walkup Skydome · Flagstaff, AZ |
| 14 | Wed Dec 22 | atUNLV | L57-80 | 7-6 | .538 | - | | Thomas & Mack Center · Las Vegas, NV |
| 15 | Thu Dec 30 | vs#4Gonzaga | PPD | 15-16 | .484 | - | | Jenny Craig Pavilion · San Diego, CA |
| 16 | Sat Jan 1 | atSanta Clara | PPD | 15-16 | .484 | - | | Leavey Center · Santa Clara, CA |
| 17 | Sat Jan 8 | atSan Francisco | L73-88 | 7-7 | .500 | - | | War Memorial at the Sobrato Center · San Francisco, CA |
| 18 | Mon Jan 10 | atPepperdine | W72-62 | 8-7 | .533 | - | | Firestone Fieldhouse · Malibu, CA |
| 19 | Thu Jan 13 | vsPortland | W68-63 (OT) | 9-7 | .563 | - | | Jenny Craig Pavilion · San Diego, CA |
| 20 | Sat Jan 15 | vsLMU | W70-65 | 10-7 | .588 | - | | Jenny Craig Pavilion · San Diego, CA |
| 21 | Thu Jan 20 | atBYU | L71-79 | 10-8 | .556 | - | | Marriott Center · Provo, UT |
| 22 | Sat Jan 22 | atPacific | W73-65 | 11-8 | .579 | - | | Alex G. Spanos Center · Stockton, CA |
| 23 | Mon Jan 24 | atSanta Clara | L74-78 (OT) | 11-9 | .550 | - | | Leavey Center · Santa Clara, CA |
| 24 | Thu Jan 27 | vsPepperdine | W64-56 | 12-9 | .571 | - | | Jenny Craig Pavilion · San Diego, CA |
| 25 | Sat Jan 29 | atLMU | W69-65 | 13-9 | .591 | - | | Gersten Pavilion · Los Angeles, CA |
| 26 | Thu Feb 3 | vs#2Gonzaga | L62-92 | 13-10 | .565 | - | ESPN2 | Jenny Craig Pavilion · San Diego, CA |
| 27 | Sat Feb 5 | vsSanta Clara | L66-79 | 13-11 | .542 | - | | Jenny Craig Pavilion · San Diego, CA |
| 28 | Thu Feb 10 | at#22Saint Mary's | L57-86 | 13-12 | .520 | - | | University Credit Union Pavilion · Moraga, CA |
| 29 | Sat Feb 12 | vsPacific | W60-54 | 14-12 | .538 | - | | Jenny Craig Pavilion · San Diego, CA |
| 30 | Thu Feb 17 | atPortland | L60-92 | 14-13 | .519 | - | | Chiles Center · Portland, OR |
| 31 | Thu Feb 24 | vs#23Saint Mary's | L46-60 | 14-14 | .500 | - | | Jenny Craig Pavilion · San Diego, CA |
| 32 | Sat Feb 26 | vsSan Francisco | L62-78 | 14-15 | .483 | - | | Jenny Craig Pavilion · San Diego, CA |
| 33 | Thu Mar 3 | vsPepperdine | W74-67 | 15-15 | .500 | - | | Jenny Craig Pavilion · San Diego, CA |
| 34 | Fri Mar 4 | atPortland | L55-73 | 15-16 | .484 | - | | Chiles Center · Portland, OR |
