| 1 | Mon Nov 7 | vs TBD | W102-69 | 1-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 2 | Thu Nov 10 | vs Nicholls | W79-68 | 2-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 3 | Sun Nov 13 | vs SE Louisiana | L72-76 | 2-1 | .667 | - | | Arena Auditorium · Laramie, WY |
| 4 | Fri Nov 18 | vs Howard | W78-71 | 3-1 | .750 | - | | Arena Auditorium · Laramie, WY |
| 5 | Sun Nov 20 | vs Drake | L56-61 | 3-2 | .600 | - | | Arena Auditorium · Laramie, WY |
| 6 | Mon Nov 21 | at Boston College | L48-59 | 3-3 | .500 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 7 | Wed Nov 30 | vs Santa Clara | L85-89 (OT) | 3-4 | .429 | - | | Arena Auditorium · Laramie, WY |
| 8 | Sat Dec 3 | vs Grand Canyon | L58-66 | 3-5 | .375 | - | | Arena Auditorium · Laramie, WY |
| 9 | Tue Dec 6 | vs E Texas A&M | W91-76 | 4-5 | .444 | - | | Arena Auditorium · Laramie, WY |
| 10 | Sat Dec 10 | vs Louisiana Tech | W92-65 | 5-5 | .500 | - | | Arena Auditorium · Laramie, WY |
| 11 | Sat Dec 17 | at Dayton | L49-66 | 5-6 | .455 | - | CBS | UD Arena · Dayton, OH |
| 12 | Wed Dec 21 | vs Saint Mary's | L54-66 | 5-7 | .417 | - | | Arena Auditorium · Laramie, WY |
| 13 | Wed Dec 28 | at Fresno St | L53-58 | 5-8 | .385 | - | CBS | Save Mart Center · Fresno, CA |
| 14 | Sat Dec 31 | vs #22New Mexico | L75-76 | 5-9 | .357 | - | FS1 | Arena Auditorium · Laramie, WY |
| 15 | Sat Jan 7 | vs SDSU | L75-80 | 5-10 | .333 | - | CBS | Arena Auditorium · Laramie, WY |
| 16 | Tue Jan 10 | at Utah State | L63-83 | 5-11 | .313 | - | FS1 | Dee Glen Smith Spectrum · Logan, UT |
| 17 | Sat Jan 14 | vs Boise St | L68-85 | 5-12 | .294 | - | FS1 | Arena Auditorium · Laramie, WY |
| 18 | Tue Jan 17 | at Air Force | L74-82 | 5-13 | .278 | - | | Clune Arena · Colorado Springs, CO |
| 19 | Sat Jan 21 | vs Colorado St | W58-57 | 6-13 | .316 | - | FS1 | Arena Auditorium · Laramie, WY |
| 20 | Tue Jan 24 | at UNLV | L72-86 | 6-14 | .300 | - | CBS | Thomas & Mack Center · Las Vegas, NV |
| 21 | Tue Jan 31 | vsFresno St | W85-62 | 7-14 | .333 | - | FS1 | Arena Auditorium · Laramie, WY |
| 22 | Sat Feb 4 | at San Jose St | L64-84 | 7-15 | .318 | - | CBS | Provident Credit Union Event Center · San Jose, CA |
| 23 | Wed Feb 8 | vsUNLV | L59-69 | 7-16 | .304 | - | FS1 | Arena Auditorium · Laramie, WY |
| 24 | Sat Feb 11 | atBoise St | L63-75 | 7-17 | .292 | - | CBS | ExtraMile Arena · Boise, ID |
| 25 | Tue Feb 14 | atNew Mexico | W70-56 | 8-17 | .320 | - | CBS | The Pit · Albuquerque, NM |
| 26 | Fri Feb 17 | vsAir Force | L69-75 | 8-18 | .308 | - | FS1 | Arena Auditorium · Laramie, WY |
| 27 | Tue Feb 21 | vsUtah State | L55-65 | 8-19 | .296 | - | CBS | Arena Auditorium · Laramie, WY |
| 28 | Fri Feb 24 | atColorado St | L71-84 | 8-20 | .286 | - | FS1 | Moby Arena · Fort Collins, CO |
| 29 | Mon Feb 27 | vs Nevada | W80-71 | 9-20 | .310 | - | CBS | Arena Auditorium · Laramie, WY |
| 30 | Sat Mar 4 | at#18SDSU | L50-67 | 9-21 | .300 | - | CBS | Viejas Arena · San Diego, CA |
| 31 | Wed Mar 8 | atNew Mexico | L76-87 | 9-22 | .290 | - | | The Pit · Albuquerque, NM |
