| 1 | Tue Nov 7 | vs TBD | W104-56 | 1-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 2 | Sat Nov 11 | vs Cal Poly | W80-66 | 2-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 3 | Thu Nov 16 | vs Saint Louis | L69-79 | 2-1 | .667 | - | ESPN2 | Arena Auditorium · Laramie, WY |
| 4 | Fri Nov 17 | vs Charleston | W67-60 | 3-1 | .750 | - | ESPNU | Arena Auditorium · Laramie, WY |
| 5 | Sun Nov 19 | at Furman | W78-71 | 4-1 | .800 | - | ESPNU | Timmons Arena · Greenville, SC |
| 6 | Sun Nov 26 | at #15Texas | L63-86 | 4-2 | .667 | - | LHN | Moody Center · Austin, TX |
| 7 | Fri Dec 1 | at Portland | L70-81 | 4-3 | .571 | - | | Chiles Center · Portland, OR |
| 8 | Tue Dec 5 | vsTBD | W80-59 | 5-3 | .625 | - | | Arena Auditorium · Laramie, WY |
| 9 | Sat Dec 9 | vs SF Austin | W78-70 | 6-3 | .667 | - | | Arena Auditorium · Laramie, WY |
| 10 | Sat Dec 16 | vs Weber St | L71-84 | 6-4 | .600 | - | | Arena Auditorium · Laramie, WY |
| 11 | Wed Dec 20 | at S Dakota St | W78-65 | 7-4 | .636 | - | | Frost Arena · Brookings, SD |
| 12 | Thu Dec 21 | at UTEP | L67-78 | 7-5 | .583 | - | | Don Haskins Center · El Paso, TX |
| 13 | Sat Dec 30 | at #14BYU | L68-94 | 7-6 | .538 | - | | Marriott Center · Provo, UT |
| 14 | Tue Jan 2 | vs San Jose St | W75-73 | 8-6 | .571 | - | | Arena Auditorium · Laramie, WY |
| 15 | Sat Jan 6 | at New Mexico | L60-77 | 8-7 | .533 | - | CBS | The Pit · Albuquerque, NM |
| 16 | Tue Jan 9 | at #20Utah State | L59-83 | 8-8 | .500 | - | | Dee Glen Smith Spectrum · Logan, UT |
| 17 | Sat Jan 13 | vs Fresno St | W68-67 | 9-8 | .529 | - | | Arena Auditorium · Laramie, WY |
| 18 | Sat Jan 20 | vs Nevada | W98-93 | 10-8 | .556 | - | | Arena Auditorium · Laramie, WY |
| 19 | Tue Jan 23 | at SDSU | L65-81 | 10-9 | .526 | - | CBS | Viejas Arena · San Diego, CA |
| 20 | Sat Jan 27 | vs #24Colorado St | W79-76 (OT) | 11-9 | .550 | - | | Arena Auditorium · Laramie, WY |
| 21 | Tue Jan 30 | at Air Force | W83-72 | 12-9 | .571 | - | | Clune Arena · Colorado Springs, CO |
| 22 | Sat Feb 3 | at UNLV | L48-62 | 12-10 | .545 | - | CBS | Thomas & Mack Center · Las Vegas, NV |
| 23 | Tue Feb 6 | vs#25New Mexico | L73-91 | 12-11 | .522 | - | | Arena Auditorium · Laramie, WY |
| 24 | Wed Feb 14 | vsUtah State | L76-84 | 12-12 | .500 | - | FS1 | Arena Auditorium · Laramie, WY |
| 25 | Sat Feb 17 | atSan Jose St | W80-75 | 13-12 | .520 | - | | Provident Credit Union Event Center · San Jose, CA |
| 26 | Tue Feb 20 | atNevada | L58-76 | 13-13 | .500 | - | CBS | Lawlor Events Center · Reno, NV |
| 27 | Sat Feb 24 | vs Boise St | L72-92 | 13-14 | .481 | - | | Arena Auditorium · Laramie, WY |
| 28 | Tue Feb 27 | vsUNLV | L69-75 (OT) | 13-15 | .464 | - | CBS | Arena Auditorium · Laramie, WY |
| 29 | Sat Mar 2 | atColorado St | L62-70 | 13-16 | .448 | - | | Moby Arena · Fort Collins, CO |
| 30 | Tue Mar 5 | vsAir Force | W74-63 | 14-16 | .467 | - | | Arena Auditorium · Laramie, WY |
| 31 | Sat Mar 9 | atFresno St | W86-47 | 15-16 | .484 | - | | Save Mart Center · Fresno, CA |
| 32 | Wed Mar 13 | vsFresno St | L73-77 | 15-17 | .469 | - | | Arena Auditorium · Laramie, WY |
