| 1 | Mon Nov 3 | vs TBD | W99-75 | 1-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 2 | Sat Nov 8 | vsFullerton | W92-82 | 2-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 3 | Tue Nov 11 | vsAustin Peay | W79-65 | 3-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 4 | Sat Nov 15 | vsPortland | W93-56 | 4-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 5 | Wed Nov 19 | atSam Houston | L70-78 | 4-1 | .800 | - | ESPN+ | Bernard G. Johnson Coliseum · Huntsville, TX |
| 6 | Sun Nov 23 | vsNorfolk St | W75-67 | 5-1 | .833 | - | | Arena Auditorium · Laramie, WY |
| 7 | Wed Nov 26 | vsDenver | W101-59 | 6-1 | .857 | - | | Arena Auditorium · Laramie, WY |
| 8 | Sun Nov 30 | at20Texas Tech | L72-76 | 6-2 | .750 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 9 | Sat Dec 6 | vsDartmouth | W93-80 | 7-2 | .778 | - | | Arena Auditorium · Laramie, WY |
| 10 | Tue Dec 9 | vsSouth Dakota | W106-79 | 8-2 | .800 | - | | Arena Auditorium · Laramie, WY |
| 11 | Mon Dec 15 | atS Dakota St | W87-72 | 9-2 | .818 | - | | Frost Arena · Brookings, SD |
| 12 | Sat Dec 20 | vsGrand Canyon | L70-82 | 9-3 | .750 | - | | Arena Auditorium · Laramie, WY |
| 13 | Tue Dec 30 | atAir Force | W68-56 | 10-3 | .769 | - | | Clune Arena · Colorado Springs, CO |
| 14 | Sat Jan 3 | atNew Mexico | L58-78 | 10-4 | .714 | - | CBSSN | The Pit · Albuquerque, NM |
| 15 | Tue Jan 6 | vsUNLV | W98-66 | 11-4 | .733 | - | CBSSN | Arena Auditorium · Laramie, WY |
| 16 | Sat Jan 10 | atNevada | L83-92 | 11-5 | .688 | - | | Lawlor Events Center · Reno, NV |
| 17 | Wed Jan 14 | vsSDSU | L57-74 | 11-6 | .647 | - | CBSSN | Arena Auditorium · Laramie, WY |
| 18 | Sat Jan 17 | atFresno St | L60-63 | 11-7 | .611 | - | | Save Mart Center · Fresno, CA |
| 19 | Tue Jan 20 | vsBoise St | L65-81 | 11-8 | .579 | - | | Arena Auditorium · Laramie, WY |
| 20 | Sat Jan 24 | vsSan Jose St | W66-62 | 12-8 | .600 | - | | Arena Auditorium · Laramie, WY |
| 21 | Wed Jan 28 | atUtah State | L62-94 | 12-9 | .571 | - | CBSSN | Dee Glen Smith Spectrum · Logan, UT |
| 22 | Sat Jan 31 | vsColorado St | W68-57 | 13-9 | .591 | - | FS1 | Arena Auditorium · Laramie, WY |
| 23 | Tue Feb 3 | atSDSU | L63-72 | 13-10 | .565 | - | CBSSN | Viejas Arena · San Diego, CA |
| 24 | Sat Feb 7 | vsUtah State | L83-85 | 13-11 | .542 | - | CBSSN | Arena Auditorium · Laramie, WY |
| 25 | Sat Feb 14 | atColorado St | L68-79 | 13-12 | .520 | - | | Moby Arena · Fort Collins, CO |
| 26 | Tue Feb 17 | vsFresno St | W92-82 | 14-12 | .538 | - | | Arena Auditorium · Laramie, WY |
| 27 | Sat Feb 21 | atGrand Canyon | W70-65 | 15-12 | .556 | - | | GCU Arena · Phoenix, AZ |
| 28 | Tue Feb 24 | atBoise St | L62-72 | 15-13 | .536 | - | | ExtraMile Arena · Boise, ID |
| 29 | Sat Feb 28 | vsAir Force | W66-62 | 16-13 | .552 | - | | Arena Auditorium · Laramie, WY |
