| 1 | Wed Nov 10 | vs Detroit Mercy | W85-47 | 1-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 2 | Sun Nov 14 | vs AR-Pine Bluff | W85-45 | 2-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 3 | Thu Nov 18 | at Washington | W77-72 (OT) | 3-0 | 1.000 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 4 | Mon Nov 22 | at Grand Canyon | W68-61 | 4-0 | 1.000 | - | | GCU Arena · Phoenix, AZ |
| 5 | Fri Nov 26 | vs TBD | W108-59 | 5-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 6 | Mon Nov 29 | at Fullerton | W79-66 | 6-0 | 1.000 | - | | Titan Gym · Fullerton, CA |
| 7 | Thu Dec 2 | vs Denver | W77-64 | 7-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 8 | Sat Dec 4 | vs McNeese | W79-58 | 8-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 9 | Wed Dec 8 | at #11Arizona | L65-94 | 8-1 | .889 | - | PACN | McKale Center · Tucson, AZ |
| 10 | Sat Dec 11 | vs Utah Valley | W74-62 | 9-1 | .900 | - | | Arena Auditorium · Laramie, WY |
| 11 | Wed Dec 22 | at Stanford | L63-66 | 9-2 | .818 | - | ESPNU | Maples Pavilion · Stanford, CA |
| 12 | Thu Dec 23 | vs Northern Iowa | W71-69 | 10-2 | .833 | - | ESPNU | Arena Auditorium · Laramie, WY |
| 13 | Sat Dec 25 | at South Florida | W77-57 | 11-2 | .846 | - | ESPNU | Yuengling Center · Tampa, FL |
| 14 | Sat Jan 1 | vs Boise St | PPD | 25-9 | .735 | - | | Arena Auditorium · Laramie, WY |
| 15 | Tue Jan 4 | at Nevada | PPD | 25-9 | .735 | - | | Lawlor Events Center · Reno, NV |
| 16 | Sat Jan 8 | at Fresno St | PPD | 25-9 | .735 | - | | Save Mart Center · Fresno, CA |
| 17 | Wed Jan 12 | vs SDSU | PPD | 25-9 | .735 | - | | Arena Auditorium · Laramie, WY |
| 18 | Sat Jan 15 | at Utah State | W71-69 | 12-2 | .857 | - | | Dee Glen Smith Spectrum · Logan, UT |
| 19 | Mon Jan 17 | atNevada | W77-67 | 13-2 | .867 | - | | Lawlor Events Center · Reno, NV |
| 20 | Wed Jan 19 | vs San Jose St | W84-69 | 14-2 | .875 | - | | Arena Auditorium · Laramie, WY |
| 21 | Sat Jan 22 | vs New Mexico | W93-91 | 15-2 | .882 | - | CBS | Arena Auditorium · Laramie, WY |
| 22 | Tue Jan 25 | atBoise St | L62-65 | 15-3 | .833 | - | | ExtraMile Arena · Boise, ID |
| 23 | Fri Jan 28 | at Air Force | W63-61 | 16-3 | .842 | - | | Clune Arena · Colorado Springs, CO |
| 24 | Mon Jan 31 | vs Colorado St | W84-78 (OT) | 17-3 | .850 | - | FS1 | Arena Auditorium · Laramie, WY |
| 25 | Thu Feb 3 | vsBoise St | W72-65 | 18-3 | .857 | - | | Arena Auditorium · Laramie, WY |
| 26 | Sun Feb 6 | atFresno St | W61-59 | 19-3 | .864 | - | FS1 | Save Mart Center · Fresno, CA |
| 27 | Tue Feb 8 | vsUtah State | W78-76 (OT) | 20-3 | .870 | - | | Arena Auditorium · Laramie, WY |
| 28 | Sat Feb 12 | atSan Jose St | W74-52 | 21-3 | .875 | - | | Provident Credit Union Event Center · San Jose, CA |
| 29 | Tue Feb 15 | atNew Mexico | L66-75 | 21-4 | .840 | #22 | | The Pit · Albuquerque, NM |
| 30 | Sat Feb 19 | vsAir Force | W75-67 | 22-4 | .846 | #22 | | Arena Auditorium · Laramie, WY |
| 31 | Wed Feb 23 | atColorado St | L55-61 | 22-5 | .815 | - | CBS | Moby Arena · Fort Collins, CO |
| 32 | Sat Feb 26 | vsNevada | W74-61 | 23-5 | .821 | - | CBS | Arena Auditorium · Laramie, WY |
| 33 | Mon Feb 28 | vsSDSU | L66-73 | 23-6 | .793 | - | CBS | Arena Auditorium · Laramie, WY |
| 34 | Wed Mar 2 | at UNLV | L57-64 | 23-7 | .767 | - | FS1 | Thomas & Mack Center · Las Vegas, NV |
| 35 | Sat Mar 5 | vsFresno St | W68-64 (OT) | 24-7 | .774 | - | | Arena Auditorium · Laramie, WY |
| 36 | Thu Mar 10 | vsUNLV | W59-56 | 25-7 | .781 | - | CBS | Arena Auditorium · Laramie, WY |
| 37 | Fri Mar 11 | atBoise St | L61-68 | 25-8 | .758 | - | CBS | ExtraMile Arena · Boise, ID |
| 38 | Tue Mar 15 | vs #12Indiana | L58-66 | 25-9 | .735 | #12 | truTV | Arena Auditorium · Laramie, WY |
