| 1 | Fri Aug 15 | at Liverpool | L2-4 | 0-0-1 | 0 PTS | Nutter Center · Dayton, OH |
| 2 | Sat Aug 23 | vsWolves | W1-0 | 1-0-1 | 3 PTS | Vitality Stadium · Bournemouth, England |
| 3 | Sat Aug 30 | atSpurs | W1-0 | 2-0-1 | 6 PTS | Tottenham Hotspur Stadium · London, England |
| 4 | Sat Sep 13 | vsBrighton | W2-1 | 3-0-1 | 9 PTS | Vitality Stadium · Bournemouth, England |
| 5 | Sun Sep 21 | vsNewcastle | D0-0 | 3-1-1 | 10 PTS | Vitality Stadium · Bournemouth, England |
| 6 | Sat Sep 27 | atLeeds | D2-2 | 3-2-1 | 11 PTS | Elland Road · Leeds, England |
| 7 | Fri Oct 3 | vsFulham | W3-1 | 4-2-1 | 14 PTS | Vitality Stadium · Bournemouth, England |
| 8 | Sat Oct 18 | atC Palace | D3-3 | 4-3-1 | 15 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 9 | Sun Oct 26 | vsNott'm Forest | W2-0 | 5-3-1 | 18 PTS | Vitality Stadium · Bournemouth, England |
| 10 | Sun Nov 2 | atMan City | L1-3 | 5-3-2 | 18 PTS | Etihad Stadium · Manchester, England |
| 11 | Sun Nov 9 | atA Villa | L0-4 | 5-3-3 | 18 PTS | Villa Park · Birmingham, England |
| 12 | Sat Nov 22 | vsWest Ham | D2-2 | 5-4-3 | 19 PTS | Vitality Stadium · Bournemouth, England |
| 13 | Sat Nov 29 | atSunderland | L2-3 | 5-4-4 | 19 PTS | Stadium of Light · Sunderland, England |
| 14 | Tue Dec 2 | vsEverton | L0-1 | 5-4-5 | 19 PTS | Vitality Stadium · Bournemouth, England |
| 15 | Sat Dec 6 | vsChelsea | D0-0 | 5-5-5 | 20 PTS | Vitality Stadium · Bournemouth, England |
| 16 | Mon Dec 15 | atMan Utd | D4-4 | 5-6-5 | 21 PTS | Old Trafford · Manchester, England |
| 17 | Sat Dec 20 | vsBurnley | D1-1 | 5-7-5 | 22 PTS | Vitality Stadium · Bournemouth, England |
| 18 | Sat Dec 27 | atBrentford | L1-4 | 5-7-6 | 22 PTS | Gtech Community Stadium · Brentford, England |
| 19 | Tue Dec 30 | atChelsea | D2-2 | 5-8-6 | 23 PTS | Stamford Bridge · London, England |
| 20 | Sat Jan 3 | vsArsenal | L2-3 | 5-8-7 | 23 PTS | Vitality Stadium · Bournemouth, England |
| 21 | Wed Jan 7 | vsSpurs | W3-2 | 6-8-7 | 26 PTS | Vitality Stadium · Bournemouth, England |
| 22 | Mon Jan 19 | atBrighton | D1-1 | 6-9-7 | 27 PTS | American Express Stadium · Brighton, England |
| 23 | Sat Jan 24 | vsLiverpool | W3-2 | 7-9-7 | 30 PTS | Vitality Stadium · Bournemouth, England |
| 24 | Sat Jan 31 | atWolves | W2-0 | 8-9-7 | 33 PTS | Molineux Stadium · Wolverhampton, England |
| 25 | Sat Feb 7 | vsA Villa | D1-1 | 8-10-7 | 34 PTS | Vitality Stadium · Bournemouth, England |
| 26 | Tue Feb 10 | atEverton | W2-1 | 9-10-7 | 37 PTS | Goodison Park · Liverpool, England |
| 27 | Sat Feb 21 | atWest Ham | D0-0 | 9-11-7 | 38 PTS | London Stadium · London, England |
| 28 | Sat Feb 28 | vsSunderland | D1-1 | 9-12-7 | 39 PTS | Vitality Stadium · Bournemouth, England |
| 29 | Tue Mar 3 | vsBrentford | D0-0 | 9-13-7 | 40 PTS | Vitality Stadium · Bournemouth, England |
| 30 | Sat Mar 14 | atBurnley | D0-0 | 9-14-7 | 41 PTS | Turf Moor · Burnley, England |
| 31 | Fri Mar 20 | vsMan Utd | D2-2 | 0-1-1 | 1 PTS | Vitality Stadium · Bournemouth, England |
