| 1 | Sun Aug 17 | at Chelsea | D0-0 | 0-1-0 | 1 PTS | Stamford Bridge · London, England |
| 2 | Sun Aug 24 | vsNott'm Forest | D1-1 | 0-2-0 | 2 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 3 | Sun Aug 31 | atA Villa | W3-0 | 1-2-0 | 5 PTS | Villa Park · Birmingham, England |
| 4 | Sat Sep 13 | vsSunderland | D0-0 | 1-3-0 | 6 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 5 | Sat Sep 20 | atWest Ham | W2-1 | 2-3-0 | 9 PTS | London Stadium · London, England |
| 6 | Sat Sep 27 | vsLiverpool | W2-1 | 3-3-0 | 12 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 7 | Sun Oct 5 | atEverton | L1-2 | 3-3-1 | 12 PTS | Goodison Park · Liverpool, England |
| 8 | Sat Oct 18 | vsB'mouth | D3-3 | 3-4-1 | 13 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 9 | Sun Oct 26 | atArsenal | L0-1 | 3-4-2 | 13 PTS | Emirates Stadium · London, England |
| 10 | Sat Nov 1 | vsBrentford | W2-0 | 4-4-2 | 16 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 11 | Sun Nov 9 | vsBrighton | D0-0 | 4-5-2 | 17 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 12 | Sat Nov 22 | atWolves | W2-0 | 5-5-2 | 20 PTS | Molineux Stadium · Wolverhampton, England |
| 13 | Sun Nov 30 | vsMan Utd | L1-2 | 5-5-3 | 20 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 14 | Wed Dec 3 | atBurnley | W1-0 | 6-5-3 | 23 PTS | Turf Moor · Burnley, England |
| 15 | Sun Dec 7 | atFulham | W2-1 | 7-5-3 | 26 PTS | Craven Cottage · London, England |
| 16 | Sun Dec 14 | vsMan City | L0-3 | 7-5-4 | 26 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 17 | Sat Dec 20 | atLeeds | L1-4 | 7-5-5 | 26 PTS | Elland Road · Leeds, England |
| 18 | Sun Dec 28 | vsSpurs | L0-1 | 7-5-6 | 26 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 19 | Thu Jan 1 | vsFulham | D1-1 | 7-6-6 | 27 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 20 | Sun Jan 4 | atNewcastle | L0-2 | 7-6-7 | 27 PTS | St. James' Park · Newcastle, England |
| 21 | Wed Jan 7 | vsA Villa | D0-0 | 7-7-7 | 28 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 22 | Sat Jan 17 | atSunderland | L1-2 | 7-7-8 | 28 PTS | Stadium of Light · Sunderland, England |
| 23 | Sun Jan 25 | vsChelsea | L1-3 | 7-7-9 | 28 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 24 | Sun Feb 1 | atNott'm Forest | D1-1 | 7-8-9 | 29 PTS | The City Ground · Nottingham, England |
| 25 | Sun Feb 8 | atBrighton | W1-0 | 8-8-9 | 32 PTS | American Express Stadium · Brighton, England |
| 26 | Wed Feb 11 | vsBurnley | L2-3 | 8-8-10 | 32 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 27 | Sun Feb 22 | vsWolves | W1-0 | 9-8-10 | 35 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 28 | Sun Mar 1 | atMan Utd | L1-2 | 9-8-11 | 35 PTS | Old Trafford · Manchester, England |
| 29 | Thu Mar 5 | atSpurs | W3-1 | 10-8-11 | 38 PTS | Tottenham Hotspur Stadium · London, England |
| 30 | Sun Mar 15 | vsLeeds | D0-0 | 10-9-11 | 39 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 32 | Sun Apr 12 | vsNewcastle | W2-1 | 1-1-0 | 4 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
