| 1 | Sat Aug 16 | at Wolves | W4-0 | 1-0-0 | 3 PTS | Molineux Stadium · Wolverhampton, England |
| 2 | Sat Aug 23 | vsSpurs | L0-2 | 1-0-1 | 3 PTS | Etihad Stadium · Manchester, England |
| 3 | Sun Aug 31 | atBrighton | L1-2 | 1-0-2 | 3 PTS | American Express Stadium · Brighton, England |
| 4 | Sun Sep 14 | vsMan Utd | W3-0 | 2-0-2 | 6 PTS | Etihad Stadium · Manchester, England |
| 5 | Sun Sep 21 | atArsenal | D1-1 | 2-1-2 | 7 PTS | Emirates Stadium · London, England |
| 6 | Sat Sep 27 | vsBurnley | W5-1 | 3-1-2 | 10 PTS | Etihad Stadium · Manchester, England |
| 7 | Sun Oct 5 | atBrentford | W1-0 | 4-1-2 | 13 PTS | Gtech Community Stadium · Brentford, England |
| 8 | Sat Oct 18 | vsEverton | W2-0 | 5-1-2 | 16 PTS | Etihad Stadium · Manchester, England |
| 9 | Sun Oct 26 | atA Villa | L0-1 | 5-1-3 | 16 PTS | Villa Park · Birmingham, England |
| 10 | Sun Nov 2 | vsB'mouth | W3-1 | 6-1-3 | 19 PTS | Etihad Stadium · Manchester, England |
| 11 | Sun Nov 9 | vsLiverpool | W3-0 | 7-1-3 | 22 PTS | Etihad Stadium · Manchester, England |
| 12 | Sat Nov 22 | atNewcastle | L1-2 | 7-1-4 | 22 PTS | St. James' Park · Newcastle, England |
| 13 | Sat Nov 29 | vsLeeds | W3-2 | 8-1-4 | 25 PTS | Etihad Stadium · Manchester, England |
| 14 | Tue Dec 2 | atFulham | W5-4 | 9-1-4 | 28 PTS | Craven Cottage · London, England |
| 15 | Sat Dec 6 | vsSunderland | W3-0 | 10-1-4 | 31 PTS | Etihad Stadium · Manchester, England |
| 16 | Sun Dec 14 | atC Palace | W3-0 | 11-1-4 | 34 PTS | Selhurst Park · London, England |
| 17 | Sat Dec 20 | vsWest Ham | W3-0 | 12-1-4 | 37 PTS | Etihad Stadium · Manchester, England |
| 18 | Sat Dec 27 | atNott'm Forest | W2-1 | 13-1-4 | 40 PTS | The City Ground · Nottingham, England |
| 19 | Thu Jan 1 | atSunderland | D0-0 | 13-2-4 | 41 PTS | Stadium of Light · Sunderland, England |
| 20 | Sun Jan 4 | vsChelsea | D1-1 | 13-3-4 | 42 PTS | Etihad Stadium · Manchester, England |
| 21 | Wed Jan 7 | vsBrighton | D1-1 | 13-4-4 | 43 PTS | Etihad Stadium · Manchester, England |
| 22 | Sat Jan 17 | atMan Utd | L0-2 | 13-4-5 | 43 PTS | Old Trafford · Manchester, England |
| 23 | Sat Jan 24 | vsWolves | W2-0 | 14-4-5 | 46 PTS | Etihad Stadium · Manchester, England |
| 24 | Sun Feb 1 | atSpurs | D2-2 | 14-5-5 | 47 PTS | Tottenham Hotspur Stadium · London, England |
| 25 | Sun Feb 8 | atLiverpool | W2-1 | 15-5-5 | 50 PTS | Anfield · Liverpool, England |
| 26 | Wed Feb 11 | vsFulham | W3-0 | 16-5-5 | 53 PTS | Etihad Stadium · Manchester, England |
| 27 | Sat Feb 21 | vsNewcastle | W2-1 | 17-5-5 | 56 PTS | Etihad Stadium · Manchester, England |
| 28 | Sat Feb 28 | atLeeds | W1-0 | 18-5-5 | 59 PTS | Elland Road · Leeds, England |
