| 1 | Sun Aug 18 | at Chelsea | W2-0 | 1-0-0 | 3 PTS | Stamford Bridge · London, England |
| 2 | Sat Aug 24 | vs Ipswich | W4-1 | 2-0-0 | 6 PTS | Etihad Stadium · Manchester, England |
| 3 | Sat Aug 31 | at West Ham | W3-1 | 3-0-0 | 9 PTS | London Stadium · London, England |
| 4 | Sat Sep 14 | vs Brentford | W2-1 | 4-0-0 | 12 PTS | Etihad Stadium · Manchester, England |
| 5 | Sun Sep 22 | vs Arsenal | D2-2 | 4-1-0 | 13 PTS | Etihad Stadium · Manchester, England |
| 6 | Sat Sep 28 | at Newcastle | D1-1 | 4-2-0 | 14 PTS | St. James' Park · Newcastle, England |
| 7 | Sat Oct 5 | vs Fulham | W3-2 | 5-2-0 | 17 PTS | Etihad Stadium · Manchester, England |
| 8 | Sun Oct 20 | at Wolves | W2-1 | 6-2-0 | 20 PTS | Molineux Stadium · Wolverhampton, England |
| 9 | Sat Oct 26 | vs Southampton | W1-0 | 7-2-0 | 23 PTS | Etihad Stadium · Manchester, England |
| 10 | Sat Nov 2 | at B'mouth | L1-2 | 7-2-1 | 23 PTS | Vitality Stadium · Bournemouth, England |
| 11 | Sat Nov 9 | at Brighton | L1-2 | 7-2-2 | 23 PTS | Amex Stadium · Brighton, England |
| 12 | Sat Nov 23 | vs Spurs | L0-4 | 7-2-3 | 23 PTS | Etihad Stadium · Manchester, England |
| 13 | Sun Dec 1 | at Liverpool | L0-2 | 7-2-4 | 23 PTS | Anfield · Liverpool, England |
| 14 | Wed Dec 4 | vs Nott'm Forest | W3-0 | 8-2-4 | 26 PTS | Etihad Stadium · Manchester, England |
| 15 | Sat Dec 7 | at C Palace | D2-2 | 8-3-4 | 27 PTS | Selhurst Park · London, England |
| 16 | Sun Dec 15 | vs Man Utd | L1-2 | 8-3-5 | 27 PTS | Etihad Stadium · Manchester, England |
| 17 | Sat Dec 21 | at A Villa | L1-2 | 8-3-6 | 27 PTS | Villa Park · Birmingham, England |
| 18 | Thu Dec 26 | vs Everton | D1-1 | 8-4-6 | 28 PTS | Etihad Stadium · Manchester, England |
| 19 | Sun Dec 29 | at Leicester | W2-0 | 9-4-6 | 31 PTS | King Power Stadium · Leicester, England |
| 20 | Sat Jan 4 | vsWest Ham | W4-1 | 10-4-6 | 34 PTS | Etihad Stadium · Manchester, England |
| 21 | Tue Jan 14 | atBrentford | D2-2 | 10-5-6 | 35 PTS | Gtech Community Stadium · Brentford, England |
| 22 | Sun Jan 19 | atIpswich | W6-0 | 11-5-6 | 38 PTS | Portman Road · Ipswich, England |
| 23 | Sat Jan 25 | vsChelsea | W3-1 | 12-5-6 | 41 PTS | Etihad Stadium · Manchester, England |
| 24 | Sun Feb 2 | atArsenal | L1-5 | 12-5-7 | 41 PTS | Emirates Stadium · London, England |
| 25 | Sat Feb 15 | vsNewcastle | W4-0 | 13-5-7 | 44 PTS | Etihad Stadium · Manchester, England |
| 26 | Sun Feb 23 | vsLiverpool | L0-2 | 13-5-8 | 44 PTS | Etihad Stadium · Manchester, England |
| 27 | Wed Feb 26 | atSpurs | W1-0 | 14-5-8 | 47 PTS | Tottenham Hotspur Stadium · London, England |
| 28 | Sat Mar 8 | atNott'm Forest | L0-1 | 14-5-9 | 47 PTS | The City Ground · Nottingham, England |
| 29 | Sat Mar 15 | vsBrighton | D2-2 | 14-6-9 | 48 PTS | Etihad Stadium · Manchester, England |
