| 7 | Sat Oct 4 | at Man Utd | 10:00 AM | 2-1-2 | 7 PTS | Old Trafford · Manchester, England |
| 8 | Sat Oct 18 | vsWolves | 10:00 AM | 0-0-5 | 0 PTS | Stadium of Light · Sunderland, England |
| 9 | Sat Oct 25 | atChelsea | 10:00 AM | 2-2-1 | 8 PTS | Stamford Bridge · London, England |
| 10 | Mon Nov 3 | vsEverton | 3:00 PM | 2-1-2 | 7 PTS | Stadium of Light · Sunderland, England |
| 11 | Sat Nov 8 | vsArsenal | 12:30 PM | 3-1-1 | 10 PTS | Stadium of Light · Sunderland, England |
| 12 | Sat Nov 22 | atFulham | 10:00 AM | 2-2-1 | 8 PTS | Craven Cottage · London, England |
| 13 | Sat Nov 29 | vsB'mouth | 10:00 AM | 3-1-1 | 10 PTS | Stadium of Light · Sunderland, England |
| 14 | Wed Dec 3 | atLiverpool | 3:00 PM | 5-0-0 | 15 PTS | Anfield · Liverpool, England |
| 15 | Sat Dec 6 | atMan City | 10:00 AM | 2-1-2 | 7 PTS | Etihad Stadium · Manchester, England |
| 16 | Sat Dec 13 | vsNewcastle | 10:00 AM | 1-3-1 | 6 PTS | Stadium of Light · Sunderland, England |
| 17 | Sat Dec 20 | atBrighton | 10:00 AM | 1-2-2 | 5 PTS | Amex Stadium · Brighton, England |
| 18 | Sat Dec 27 | vsLeeds | 10:00 AM | 2-1-2 | 7 PTS | Stadium of Light · Sunderland, England |
| 19 | Tue Dec 30 | vsMan City | 3:00 PM | 2-1-2 | 7 PTS | Stadium of Light · Sunderland, England |
| 20 | Sat Jan 3 | atSpurs | 10:00 AM | 3-1-1 | 10 PTS | Tottenham Hotspur Stadium · London, England |
| 21 | Wed Jan 7 | atBrentford | 3:00 PM | 1-1-3 | 4 PTS | Gtech Community Stadium · Brentford, England |
| 22 | Sat Jan 17 | vsC Palace | 10:00 AM | 2-3-0 | 9 PTS | Stadium of Light · Sunderland, England |
| 23 | Sat Jan 24 | atWest Ham | 10:00 AM | 1-0-4 | 3 PTS | London Stadium · London, England |
| 24 | Sat Jan 31 | vsBurnley | 10:00 AM | 1-1-3 | 4 PTS | Stadium of Light · Sunderland, England |
| 25 | Sat Feb 7 | atArsenal | 10:00 AM | 3-1-1 | 10 PTS | Emirates Stadium · London, England |
| 26 | Wed Feb 11 | vsLiverpool | 3:00 PM | 5-0-0 | 15 PTS | Stadium of Light · Sunderland, England |
| 27 | Sat Feb 21 | vsFulham | 10:00 AM | 2-2-1 | 8 PTS | Stadium of Light · Sunderland, England |
| 28 | Sat Feb 28 | atB'mouth | 10:00 AM | 3-1-1 | 10 PTS | Vitality Stadium · Bournemouth, England |
| 29 | Wed Mar 4 | atLeeds | 3:00 PM | 2-1-2 | 7 PTS | Elland Road · Leeds, England |
| 30 | Sat Mar 14 | vsBrighton | 11:00 AM | 1-2-2 | 5 PTS | Stadium of Light · Sunderland, England |
| 31 | Sat Mar 21 | atNewcastle | 11:00 AM | 1-3-1 | 6 PTS | St. James' Park · Newcastle, England |
| 32 | Sat Apr 11 | vsSpurs | 10:00 AM | 3-1-1 | 10 PTS | Stadium of Light · Sunderland, England |
| 33 | Sat Apr 18 | atA Villa | 10:00 AM | 0-3-2 | 3 PTS | Villa Park · Birmingham, England |
| 34 | Sat Apr 25 | vsNott'm Forest | 10:00 AM | 1-2-2 | 5 PTS | Stadium of Light · Sunderland, England |
| 35 | Sat May 2 | atWolves | 10:00 AM | 0-0-5 | 0 PTS | Molineux Stadium · Wolverhampton, England |
| 36 | Sat May 9 | vsMan Utd | 10:00 AM | 2-1-2 | 7 PTS | Stadium of Light · Sunderland, England |
| 37 | Sun May 17 | atEverton | 10:00 AM | 2-1-2 | 7 PTS | Goodison Park · Liverpool, England |
| 38 | Sun May 24 | vsChelsea | 11:00 AM | 2-2-1 | 8 PTS | Stadium of Light · Sunderland, England |
