| 1 | Sun Aug 17 | vs Arsenal | L0-1 | 0-0-1 | 0 PTS | Old Trafford · Manchester, England |
| 2 | Sun Aug 24 | atFulham | D1-1 | 0-1-1 | 1 PTS | Craven Cottage · London, England |
| 3 | Sat Aug 30 | vsBurnley | W3-2 | 1-1-1 | 4 PTS | Old Trafford · Manchester, England |
| 4 | Sun Sep 14 | atMan City | L0-3 | 1-1-2 | 4 PTS | Etihad Stadium · Manchester, England |
| 5 | Sat Sep 20 | vsChelsea | W2-1 | 2-1-2 | 7 PTS | Old Trafford · Manchester, England |
| 6 | Sat Sep 27 | atBrentford | L1-3 | 2-1-3 | 7 PTS | Gtech Community Stadium · Brentford, England |
| 7 | Sat Oct 4 | vsSunderland | W2-0 | 3-1-3 | 10 PTS | Old Trafford · Manchester, England |
| 8 | Sun Oct 19 | atLiverpool | W2-1 | 4-1-3 | 13 PTS | Anfield · Liverpool, England |
| 9 | Sat Oct 25 | vsBrighton | W4-2 | 5-1-3 | 16 PTS | Old Trafford · Manchester, England |
| 10 | Sat Nov 1 | atNott'm Forest | D2-2 | 5-2-3 | 17 PTS | The City Ground · Nottingham, England |
| 11 | Sat Nov 8 | atSpurs | D2-2 | 5-3-3 | 18 PTS | Tottenham Hotspur Stadium · London, England |
| 12 | Mon Nov 24 | vsEverton | L0-1 | 5-3-4 | 18 PTS | Old Trafford · Manchester, England |
| 13 | Sun Nov 30 | atC Palace | W2-1 | 6-3-4 | 21 PTS | Selhurst Park · London, England |
| 14 | Thu Dec 4 | vsWest Ham | D1-1 | 6-4-4 | 22 PTS | Old Trafford · Manchester, England |
| 15 | Mon Dec 8 | atWolves | W4-1 | 7-4-4 | 25 PTS | Molineux Stadium · Wolverhampton, England |
| 16 | Mon Dec 15 | vsB'mouth | D4-4 | 7-5-4 | 26 PTS | Old Trafford · Manchester, England |
| 17 | Sun Dec 21 | atA Villa | L1-2 | 7-5-5 | 26 PTS | Villa Park · Birmingham, England |
| 18 | Fri Dec 26 | vsNewcastle | W1-0 | 8-5-5 | 29 PTS | Old Trafford · Manchester, England |
| 19 | Tue Dec 30 | vsWolves | D1-1 | 8-6-5 | 30 PTS | Old Trafford · Manchester, England |
| 20 | Sun Jan 4 | atLeeds | D1-1 | 8-7-5 | 31 PTS | Elland Road · Leeds, England |
| 21 | Wed Jan 7 | atBurnley | D2-2 | 8-8-5 | 32 PTS | Turf Moor · Burnley, England |
| 22 | Sat Jan 17 | vsMan City | W2-0 | 9-8-5 | 35 PTS | Old Trafford · Manchester, England |
| 23 | Sun Jan 25 | atArsenal | W3-2 | 10-8-5 | 38 PTS | Emirates Stadium · London, England |
| 24 | Sun Feb 1 | vsFulham | W3-2 | 11-8-5 | 41 PTS | Old Trafford · Manchester, England |
| 25 | Sat Feb 7 | vsSpurs | W2-0 | 12-8-5 | 44 PTS | Old Trafford · Manchester, England |
| 26 | Tue Feb 10 | atWest Ham | D1-1 | 12-9-5 | 45 PTS | London Stadium · London, England |
| 27 | Mon Feb 23 | atEverton | W1-0 | 13-9-5 | 48 PTS | Goodison Park · Liverpool, England |
| 28 | Sun Mar 1 | vsC Palace | W2-1 | 14-9-5 | 51 PTS | Old Trafford · Manchester, England |
