| 7 | Sun Oct 18 | at Leeds | 9:00 AM | 2-2-0 | 8 PTS | Elland Road · Leeds, England |
| 8 | Sun Oct 25 | vsB'mouth | 10:00 AM | 0-3-1 | 3 PTS | Old Trafford · Manchester, England |
| 9 | Sat Oct 31 | atChelsea | 8:30 AM | 2-1-1 | 7 PTS | Stamford Bridge · London, England |
| 10 | Sun Nov 8 | vsA Villa | 11:30 AM | 0-1-3 | 1 PTS | Old Trafford · Manchester, England |
| 11 | Sun Nov 22 | atLiverpool | 11:30 AM | 1-3-0 | 6 PTS | Anfield · Liverpool, England |
| 12 | Sat Nov 28 | vsBrentford | 10:00 AM | 1-3-0 | 6 PTS | Old Trafford · Manchester, England |
| 13 | Wed Dec 2 | atNewcastle | 3:00 PM | 1-2-1 | 5 PTS | St. James' Park · Newcastle, England |
| 14 | Sat Dec 5 | vsCoventry | 10:00 AM | 0-0-4 | 0 PTS | Old Trafford · Manchester, England |
| 15 | Sat Dec 12 | atC Palace | 10:00 AM | 1-0-3 | 3 PTS | Selhurst Park · London, England |
| 16 | Sat Dec 19 | atArsenal | 10:00 AM | 4-0-0 | 12 PTS | Emirates Stadium · London, England |
| 17 | Sun Dec 27 | vsNott'm Forest | 11:30 AM | 1-2-1 | 5 PTS | Old Trafford · Manchester, England |
| 18 | Wed Dec 30 | vsSunderland | 2:30 PM | 1-1-2 | 4 PTS | Old Trafford · Manchester, England |
| 19 | Sat Jan 2 | atBrighton | 7:30 AM | 2-1-1 | 7 PTS | American Express Stadium · Brighton, England |
| 20 | Thu Jan 7 | vsNewcastle | 3:00 PM | 1-2-1 | 5 PTS | Old Trafford · Manchester, England |
| 21 | Sat Jan 16 | atA Villa | 10:00 AM | 0-1-3 | 1 PTS | Villa Park · Birmingham, England |
| 22 | Sat Jan 23 | vsLiverpool | 10:00 AM | 1-3-0 | 6 PTS | Old Trafford · Manchester, England |
| 23 | Sat Jan 30 | atBrentford | 10:00 AM | 1-3-0 | 6 PTS | Gtech Community Stadium · Brentford, England |
| 24 | Sat Feb 6 | vsChelsea | 10:00 AM | 2-1-1 | 7 PTS | Old Trafford · Manchester, England |
| 25 | Wed Feb 10 | vsBrighton | 3:00 PM | 2-1-1 | 7 PTS | Old Trafford · Manchester, England |
| 26 | Sat Feb 20 | atNott'm Forest | 10:00 AM | 1-2-1 | 5 PTS | The City Ground · Nottingham, England |
| 27 | Sat Feb 27 | vsArsenal | 10:00 AM | 4-0-0 | 12 PTS | Old Trafford · Manchester, England |
| 28 | Wed Mar 3 | atSunderland | 3:00 PM | 1-1-2 | 4 PTS | Stadium of Light · Sunderland, England |
| 29 | Sat Mar 13 | vsEverton | 10:00 AM | 1-3-0 | 6 PTS | Old Trafford · Manchester, England |
| 30 | Sat Mar 20 | atMan City | 11:00 AM | 4-0-0 | 12 PTS | Etihad Stadium · Manchester, England |
| 31 | Sat Apr 10 | vsHull | 10:00 AM | 2-2-0 | 8 PTS | Old Trafford · Manchester, England |
| 32 | Sat Apr 17 | atIpswich | 10:00 AM | 2-0-2 | 6 PTS | Portman Road · Ipswich, England |
| 33 | Sat Apr 24 | vsC Palace | 10:00 AM | 1-0-3 | 3 PTS | Old Trafford · Manchester, England |
| 34 | Sat May 1 | atCoventry | 10:00 AM | 0-0-4 | 0 PTS | Coventry Building Society Arena · Coventry, England |
| 35 | Sat May 8 | atB'mouth | 10:00 AM | 0-3-1 | 3 PTS | Vitality Stadium · Bournemouth, England |
| 36 | Sat May 15 | vsLeeds | 10:00 AM | 2-2-0 | 8 PTS | Old Trafford · Manchester, England |
| 37 | Sun May 23 | atSpurs | 10:00 AM | 0-2-2 | 2 PTS | Tottenham Hotspur Stadium · London, England |
| 38 | Sun May 30 | vsFulham | 11:00 AM | 0-1-3 | 1 PTS | Old Trafford · Manchester, England |
