| 1 | Sat Aug 16 | at A Villa | D0-0 | 0-1-0 | 1 PTS | Villa Park · Birmingham, England |
| 2 | Mon Aug 25 | vsLiverpool | L2-3 | 0-1-1 | 1 PTS | St. James' Park · Newcastle, England |
| 3 | Sat Aug 30 | atLeeds | D0-0 | 0-2-1 | 2 PTS | Elland Road · Leeds, England |
| 4 | Sat Sep 13 | vsWolves | W1-0 | 1-2-1 | 5 PTS | St. James' Park · Newcastle, England |
| 5 | Sun Sep 21 | atB'mouth | D0-0 | 1-3-1 | 6 PTS | Vitality Stadium · Bournemouth, England |
| 6 | Sun Sep 28 | vsArsenal | L1-2 | 1-3-2 | 6 PTS | St. James' Park · Newcastle, England |
| 7 | Sun Oct 5 | vsNott'm Forest | W2-0 | 2-3-2 | 9 PTS | St. James' Park · Newcastle, England |
| 8 | Sat Oct 18 | atBrighton | L1-2 | 2-3-3 | 9 PTS | American Express Stadium · Brighton, England |
| 9 | Sat Oct 25 | vsFulham | W2-1 | 3-3-3 | 12 PTS | St. James' Park · Newcastle, England |
| 10 | Sun Nov 2 | atWest Ham | L1-3 | 3-3-4 | 12 PTS | London Stadium · London, England |
| 11 | Sun Nov 9 | atBrentford | L1-3 | 3-3-5 | 12 PTS | Gtech Community Stadium · Brentford, England |
| 12 | Sat Nov 22 | vsMan City | W2-1 | 4-3-5 | 15 PTS | St. James' Park · Newcastle, England |
| 13 | Sat Nov 29 | atEverton | W4-1 | 5-3-5 | 18 PTS | Goodison Park · Liverpool, England |
| 14 | Tue Dec 2 | vsSpurs | D2-2 | 5-4-5 | 19 PTS | St. James' Park · Newcastle, England |
| 15 | Sat Dec 6 | vsBurnley | W2-1 | 6-4-5 | 22 PTS | St. James' Park · Newcastle, England |
| 16 | Sun Dec 14 | atSunderland | L0-1 | 6-4-6 | 22 PTS | Stadium of Light · Sunderland, England |
| 17 | Sat Dec 20 | vsChelsea | D2-2 | 6-5-6 | 23 PTS | St. James' Park · Newcastle, England |
| 18 | Fri Dec 26 | atMan Utd | L0-1 | 6-5-7 | 23 PTS | Old Trafford · Manchester, England |
| 19 | Tue Dec 30 | atBurnley | W3-1 | 7-5-7 | 26 PTS | Turf Moor · Burnley, England |
| 20 | Sun Jan 4 | vsC Palace | W2-0 | 8-5-7 | 29 PTS | St. James' Park · Newcastle, England |
| 21 | Wed Jan 7 | vsLeeds | W4-3 | 9-5-7 | 32 PTS | St. James' Park · Newcastle, England |
| 22 | Sun Jan 18 | atWolves | D0-0 | 9-6-7 | 33 PTS | Molineux Stadium · Wolverhampton, England |
| 23 | Sun Jan 25 | vsA Villa | L0-2 | 9-6-8 | 33 PTS | St. James' Park · Newcastle, England |
| 24 | Sat Jan 31 | atLiverpool | L1-4 | 9-6-9 | 33 PTS | Anfield · Liverpool, England |
| 25 | Sat Feb 7 | vsBrentford | L2-3 | 9-6-10 | 33 PTS | St. James' Park · Newcastle, England |
| 26 | Tue Feb 10 | atSpurs | W2-1 | 10-6-10 | 36 PTS | Tottenham Hotspur Stadium · London, England |
| 27 | Sat Feb 21 | atMan City | L1-2 | 10-6-11 | 36 PTS | Etihad Stadium · Manchester, England |
| 28 | Sat Feb 28 | vsEverton | L2-3 | 10-6-12 | 36 PTS | St. James' Park · Newcastle, England |
