| 4 | Sat Sep 13 | vs Wolves | 10:00 AM | 0-0-3 | 0 PTS | St. James' Park · Newcastle, England |
| 5 | Sun Sep 21 | at B'mouth | 9:00 AM | 2-0-1 | 6 PTS | Vitality Stadium · Bournemouth, England |
| 6 | Sun Sep 28 | vs Arsenal | 11:30 AM | 2-0-1 | 6 PTS | St. James' Park · Newcastle, England |
| 7 | Sun Oct 5 | vs Nott'm Forest | 9:00 AM | 1-1-1 | 4 PTS | St. James' Park · Newcastle, England |
| 8 | Sat Oct 18 | at Brighton | 10:00 AM | 1-1-1 | 4 PTS | Amex Stadium · Brighton, England |
| 9 | Sat Oct 25 | vs Fulham | 10:00 AM | 0-2-1 | 2 PTS | St. James' Park · Newcastle, England |
| 10 | Sat Nov 1 | at West Ham | 11:00 AM | 1-0-2 | 3 PTS | London Stadium · London, England |
| 11 | Sat Nov 8 | at Brentford | 10:00 AM | 1-0-2 | 3 PTS | Gtech Community Stadium · Brentford, England |
| 12 | Sat Nov 22 | vs Man City | 10:00 AM | 1-0-2 | 3 PTS | St. James' Park · Newcastle, England |
| 13 | Sat Nov 29 | at Everton | 10:00 AM | 2-0-1 | 6 PTS | Goodison Park · Liverpool, England |
| 14 | Wed Dec 3 | vs Spurs | 3:00 PM | 2-0-1 | 6 PTS | St. James' Park · Newcastle, England |
| 15 | Sat Dec 6 | vs Burnley | 10:00 AM | 1-0-2 | 3 PTS | St. James' Park · Newcastle, England |
| 16 | Sat Dec 13 | at Sunderland | 10:00 AM | 2-0-1 | 6 PTS | Stadium of Light · Sunderland, England |
| 17 | Sat Dec 20 | vs Chelsea | 10:00 AM | 2-1-0 | 7 PTS | St. James' Park · Newcastle, England |
| 18 | Sat Dec 27 | at Man Utd | 10:00 AM | 1-1-1 | 4 PTS | Old Trafford · Manchester, England |
| 19 | Tue Dec 30 | atBurnley | 3:00 PM | 1-0-2 | 3 PTS | Turf Moor · Burnley, England |
| 20 | Sat Jan 3 | vs C Palace | 10:00 AM | 1-2-0 | 5 PTS | St. James' Park · Newcastle, England |
| 21 | Wed Jan 7 | vs Leeds | 3:00 PM | 1-1-1 | 4 PTS | St. James' Park · Newcastle, England |
| 22 | Sat Jan 17 | atWolves | 10:00 AM | 0-0-3 | 0 PTS | Molineux Stadium · Wolverhampton, England |
| 23 | Sat Jan 24 | vs A Villa | 10:00 AM | 0-1-2 | 1 PTS | St. James' Park · Newcastle, England |
| 24 | Sat Jan 31 | at Liverpool | 10:00 AM | 3-0-0 | 9 PTS | Anfield · Liverpool, England |
| 25 | Sat Feb 7 | vsBrentford | 10:00 AM | 1-0-2 | 3 PTS | St. James' Park · Newcastle, England |
| 26 | Wed Feb 11 | atSpurs | 3:00 PM | 2-0-1 | 6 PTS | Tottenham Hotspur Stadium · London, England |
| 27 | Sat Feb 21 | atMan City | 10:00 AM | 1-0-2 | 3 PTS | Etihad Stadium · Manchester, England |
| 28 | Sat Feb 28 | vsEverton | 10:00 AM | 2-0-1 | 6 PTS | St. James' Park · Newcastle, England |
| 29 | Wed Mar 4 | vsMan Utd | 3:00 PM | 1-1-1 | 4 PTS | St. James' Park · Newcastle, England |
| 30 | Sat Mar 14 | atChelsea | 11:00 AM | 2-1-0 | 7 PTS | Stamford Bridge · London, England |
| 31 | Sat Mar 21 | vsSunderland | 11:00 AM | 2-0-1 | 6 PTS | St. James' Park · Newcastle, England |
| 32 | Sat Apr 11 | atC Palace | 10:00 AM | 1-2-0 | 5 PTS | Selhurst Park · London, England |
| 33 | Sat Apr 18 | vsB'mouth | 10:00 AM | 2-0-1 | 6 PTS | St. James' Park · Newcastle, England |
| 34 | Sat Apr 25 | atArsenal | 10:00 AM | 2-0-1 | 6 PTS | Emirates Stadium · London, England |
| 35 | Sat May 2 | vsBrighton | 10:00 AM | 1-1-1 | 4 PTS | St. James' Park · Newcastle, England |
| 36 | Sat May 9 | atNott'm Forest | 10:00 AM | 1-1-1 | 4 PTS | The City Ground · Nottingham, England |
| 37 | Sun May 17 | vsWest Ham | 10:00 AM | 1-0-2 | 3 PTS | St. James' Park · Newcastle, England |
| 38 | Sun May 24 | atFulham | 11:00 AM | 0-2-1 | 2 PTS | Craven Cottage · London, England |
