| 2 | Sun Aug 30 | at Chelsea | 9:00 AM | 1-0-0 | 3 PTS | Stamford Bridge · London, England |
| 3 | Sat Sep 5 | vsLeeds | 10:00 AM | 1-0-0 | 3 PTS | American Express Stadium · Brighton, England |
| 4 | Sun Sep 13 | atCoventry | 9:00 AM | 0-0-2 | 0 PTS | Coventry Building Society Arena · Coventry, England |
| 5 | Sat Sep 19 | vsArsenal | 10:00 AM | 1-0-0 | 3 PTS | American Express Stadium · Brighton, England |
| 6 | Sat Oct 10 | atSunderland | 10:00 AM | 0-0-1 | 0 PTS | Stadium of Light · Sunderland, England |
| 7 | Sun Oct 18 | vsC Palace | 9:00 AM | 0-0-2 | 0 PTS | American Express Stadium · Brighton, England |
| 8 | Sat Oct 24 | atLiverpool | 10:00 AM | 0-2-0 | 2 PTS | Nutter Center · Dayton, OH |
| 9 | Sat Oct 31 | atMan City | 11:00 AM | 2-0-0 | 6 PTS | Etihad Stadium · Manchester, England |
| 10 | Sat Nov 7 | vsBrentford | 10:00 AM | 1-0-0 | 3 PTS | American Express Stadium · Brighton, England |
| 11 | Sat Nov 21 | atHull | 10:00 AM | 2-0-0 | 6 PTS | Carter-Finley Stadium · Raleigh, NC |
| 12 | Sat Nov 28 | vsNewcastle | 10:00 AM | 1-1-0 | 4 PTS | American Express Stadium · Brighton, England |
| 13 | Wed Dec 2 | atB'mouth | 3:00 PM | 0-1-1 | 1 PTS | Vitality Stadium · Bournemouth, England |
| 14 | Sat Dec 5 | atNott'm Forest | 10:00 AM | 0-1-1 | 1 PTS | The City Ground · Nottingham, England |
| 15 | Sat Dec 12 | vsEverton | 10:00 AM | 1-1-0 | 4 PTS | American Express Stadium · Brighton, England |
| 16 | Sat Dec 19 | vsIpswich | 10:00 AM | 1-0-0 | 3 PTS | American Express Stadium · Brighton, England |
| 17 | Sat Dec 26 | atFulham | 10:00 AM | 0-0-1 | 0 PTS | Craven Cottage · London, England |
| 18 | Wed Dec 30 | atSpurs | 3:00 PM | 0-0-2 | 0 PTS | Tottenham Hotspur Stadium · London, England |
| 19 | Sat Jan 2 | vsMan Utd | 10:00 AM | 0-0-1 | 0 PTS | American Express Stadium · Brighton, England |
| 20 | Wed Jan 6 | vsB'mouth | 3:00 PM | 0-1-1 | 1 PTS | American Express Stadium · Brighton, England |
| 21 | Sat Jan 16 | atBrentford | 10:00 AM | 1-0-0 | 3 PTS | Gtech Community Stadium · Brentford, England |
| 22 | Sat Jan 23 | vsMan City | 10:00 AM | 2-0-0 | 6 PTS | American Express Stadium · Brighton, England |
| 23 | Sat Jan 30 | atNewcastle | 10:00 AM | 1-1-0 | 4 PTS | St. James' Park · Newcastle, England |
| 24 | Sat Feb 6 | vsHull | 10:00 AM | 2-0-0 | 6 PTS | American Express Stadium · Brighton, England |
| 25 | Wed Feb 10 | atMan Utd | 3:00 PM | 0-0-1 | 0 PTS | Old Trafford · Manchester, England |
| 26 | Sat Feb 20 | vsSpurs | 10:00 AM | 0-0-2 | 0 PTS | American Express Stadium · Brighton, England |
| 27 | Sat Feb 27 | atIpswich | 10:00 AM | 1-0-0 | 3 PTS | Portman Road · Ipswich, England |
| 28 | Wed Mar 3 | vsFulham | 3:00 PM | 0-0-1 | 0 PTS | American Express Stadium · Brighton, England |
| 29 | Sat Mar 13 | atLeeds | 10:00 AM | 1-0-0 | 3 PTS | Elland Road · Leeds, England |
| 30 | Sat Mar 20 | vsCoventry | 11:00 AM | 0-0-2 | 0 PTS | American Express Stadium · Brighton, England |
| 31 | Sat Apr 10 | atA Villa | 10:00 AM | 0-0-1 | 0 PTS | Villa Park · Birmingham, England |
| 32 | Sat Apr 17 | vsChelsea | 10:00 AM | 1-0-0 | 3 PTS | American Express Stadium · Brighton, England |
| 33 | Sat Apr 24 | atEverton | 10:00 AM | 1-1-0 | 4 PTS | Goodison Park · Liverpool, England |
| 34 | Sat May 1 | vsNott'm Forest | 10:00 AM | 0-1-1 | 1 PTS | American Express Stadium · Brighton, England |
| 35 | Sat May 8 | vsSunderland | 10:00 AM | 0-0-1 | 0 PTS | American Express Stadium · Brighton, England |
| 36 | Sat May 15 | atC Palace | 10:00 AM | 0-0-2 | 0 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 37 | Sun May 23 | vsLiverpool | 10:00 AM | 0-2-0 | 2 PTS | American Express Stadium · Brighton, England |
| 38 | Sun May 30 | atArsenal | 11:00 AM | 1-0-0 | 3 PTS | Emirates Stadium · London, England |
