| 1 | Sat Aug 16 | vs Fulham | D1-1 | 0-1-0 | 1 PTS | American Express Stadium · Brighton, England |
| 2 | Sun Aug 24 | atEverton | L0-2 | 0-1-1 | 1 PTS | Goodison Park · Liverpool, England |
| 3 | Sun Aug 31 | vsMan City | W2-1 | 1-1-1 | 4 PTS | American Express Stadium · Brighton, England |
| 4 | Sat Sep 13 | atB'mouth | L1-2 | 1-1-2 | 4 PTS | Vitality Stadium · Bournemouth, England |
| 5 | Sat Sep 20 | vsSpurs | D2-2 | 1-2-2 | 5 PTS | American Express Stadium · Brighton, England |
| 6 | Sat Sep 27 | atChelsea | W3-1 | 2-2-2 | 8 PTS | Stamford Bridge · London, England |
| 7 | Sun Oct 5 | atWolves | D1-1 | 2-3-2 | 9 PTS | Molineux Stadium · Wolverhampton, England |
| 8 | Sat Oct 18 | vsNewcastle | W2-1 | 3-3-2 | 12 PTS | American Express Stadium · Brighton, England |
| 9 | Sat Oct 25 | atMan Utd | L2-4 | 3-3-3 | 12 PTS | Old Trafford · Manchester, England |
| 10 | Sat Nov 1 | vsLeeds | W3-0 | 4-3-3 | 15 PTS | American Express Stadium · Brighton, England |
| 11 | Sun Nov 9 | atC Palace | D0-0 | 4-4-3 | 16 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 12 | Sat Nov 22 | vsBrentford | W2-1 | 5-4-3 | 19 PTS | American Express Stadium · Brighton, England |
| 13 | Sun Nov 30 | atNott'm Forest | W2-0 | 6-4-3 | 22 PTS | The City Ground · Nottingham, England |
| 14 | Wed Dec 3 | vsA Villa | L3-4 | 6-4-4 | 22 PTS | American Express Stadium · Brighton, England |
| 15 | Sun Dec 7 | vsWest Ham | D1-1 | 6-5-4 | 23 PTS | American Express Stadium · Brighton, England |
| 16 | Sat Dec 13 | atLiverpool | L0-2 | 6-5-5 | 23 PTS | Nutter Center · Dayton, OH |
| 17 | Sat Dec 20 | vsSunderland | D0-0 | 6-6-5 | 24 PTS | American Express Stadium · Brighton, England |
| 18 | Sat Dec 27 | atArsenal | L1-2 | 6-6-6 | 24 PTS | Emirates Stadium · London, England |
| 19 | Tue Dec 30 | atWest Ham | D2-2 | 6-7-6 | 25 PTS | London Stadium · London, England |
| 20 | Sat Jan 3 | vsBurnley | W2-0 | 7-7-6 | 28 PTS | American Express Stadium · Brighton, England |
| 21 | Wed Jan 7 | atMan City | D1-1 | 7-8-6 | 29 PTS | Etihad Stadium · Manchester, England |
| 22 | Mon Jan 19 | vsB'mouth | D1-1 | 7-9-6 | 30 PTS | American Express Stadium · Brighton, England |
| 23 | Sat Jan 24 | atFulham | L1-2 | 7-9-7 | 30 PTS | Craven Cottage · London, England |
| 24 | Sat Jan 31 | vsEverton | D1-1 | 7-10-7 | 31 PTS | American Express Stadium · Brighton, England |
| 25 | Sun Feb 8 | vsC Palace | L0-1 | 7-10-8 | 31 PTS | American Express Stadium · Brighton, England |
| 26 | Wed Feb 11 | atA Villa | L0-1 | 7-10-9 | 31 PTS | Villa Park · Birmingham, England |
| 27 | Sat Feb 21 | atBrentford | W2-0 | 8-10-9 | 34 PTS | Gtech Community Stadium · Brentford, England |
| 28 | Sun Mar 1 | vsNott'm Forest | W2-1 | 9-10-9 | 37 PTS | American Express Stadium · Brighton, England |
| 29 | Wed Mar 4 | vsArsenal | L0-1 | 9-10-10 | 37 PTS | American Express Stadium · Brighton, England |
| 30 | Sat Mar 14 | atSunderland | W1-0 | 10-10-10 | 40 PTS | Stadium of Light · Sunderland, England |
| 31 | Sat Mar 21 | vsLiverpool | W2-1 | 1-1-0 | 4 PTS | American Express Stadium · Brighton, England |
| 32 | Sat Apr 11 | atBurnley | W2-0 | 2-1-0 | 7 PTS | Turf Moor · Burnley, England |
