| 1 | Sat Aug 16 | vs Burnley | W3-0 | 1-0-0 | 3 PTS | Tottenham Hotspur Stadium · London, England |
| 2 | Sat Aug 23 | atMan City | W2-0 | 2-0-0 | 6 PTS | Etihad Stadium · Manchester, England |
| 3 | Sat Aug 30 | vsB'mouth | L0-1 | 2-0-1 | 6 PTS | Tottenham Hotspur Stadium · London, England |
| 4 | Sat Sep 13 | atWest Ham | W3-0 | 3-0-1 | 9 PTS | London Stadium · London, England |
| 5 | Sat Sep 20 | atBrighton | D2-2 | 3-1-1 | 10 PTS | American Express Stadium · Brighton, England |
| 6 | Sat Sep 27 | vsWolves | D1-1 | 3-2-1 | 11 PTS | Tottenham Hotspur Stadium · London, England |
| 7 | Sat Oct 4 | atLeeds | W2-1 | 4-2-1 | 14 PTS | Elland Road · Leeds, England |
| 8 | Sun Oct 19 | vsA Villa | L1-2 | 4-2-2 | 14 PTS | Tottenham Hotspur Stadium · London, England |
| 9 | Sun Oct 26 | atEverton | W3-0 | 5-2-2 | 17 PTS | Goodison Park · Liverpool, England |
| 10 | Sat Nov 1 | vsChelsea | L0-1 | 5-2-3 | 17 PTS | Tottenham Hotspur Stadium · London, England |
| 11 | Sat Nov 8 | vsMan Utd | D2-2 | 5-3-3 | 18 PTS | Tottenham Hotspur Stadium · London, England |
| 12 | Sun Nov 23 | atArsenal | L1-4 | 5-3-4 | 18 PTS | Emirates Stadium · London, England |
| 13 | Sat Nov 29 | vsFulham | L1-2 | 5-3-5 | 18 PTS | Tottenham Hotspur Stadium · London, England |
| 14 | Tue Dec 2 | atNewcastle | D2-2 | 5-4-5 | 19 PTS | St. James' Park · Newcastle, England |
| 15 | Sat Dec 6 | vsBrentford | W2-0 | 6-4-5 | 22 PTS | Tottenham Hotspur Stadium · London, England |
| 16 | Sun Dec 14 | atNott'm Forest | L0-3 | 6-4-6 | 22 PTS | The City Ground · Nottingham, England |
| 17 | Sat Dec 20 | vsLiverpool | L1-2 | 6-4-7 | 22 PTS | Tottenham Hotspur Stadium · London, England |
| 18 | Sun Dec 28 | atC Palace | W1-0 | 7-4-7 | 25 PTS | Silvio O. Conte Forum · Chestnut Hill, MA |
| 19 | Thu Jan 1 | atBrentford | D0-0 | 7-5-7 | 26 PTS | Gtech Community Stadium · Brentford, England |
| 20 | Sun Jan 4 | vsSunderland | D1-1 | 7-6-7 | 27 PTS | Tottenham Hotspur Stadium · London, England |
| 21 | Wed Jan 7 | atB'mouth | L2-3 | 7-6-8 | 27 PTS | Vitality Stadium · Bournemouth, England |
| 22 | Sat Jan 17 | vsWest Ham | L1-2 | 7-6-9 | 27 PTS | Tottenham Hotspur Stadium · London, England |
| 23 | Sat Jan 24 | atBurnley | D2-2 | 7-7-9 | 28 PTS | Turf Moor · Burnley, England |
| 24 | Sun Feb 1 | vsMan City | D2-2 | 7-8-9 | 29 PTS | Tottenham Hotspur Stadium · London, England |
| 25 | Sat Feb 7 | atMan Utd | L0-2 | 7-8-10 | 29 PTS | Old Trafford · Manchester, England |
| 26 | Tue Feb 10 | vsNewcastle | L1-2 | 7-8-11 | 29 PTS | Tottenham Hotspur Stadium · London, England |
| 27 | Sun Feb 22 | vsArsenal | L1-4 | 7-8-12 | 29 PTS | Tottenham Hotspur Stadium · London, England |
| 28 | Sun Mar 1 | atFulham | L1-2 | 7-8-13 | 29 PTS | Craven Cottage · London, England |
| 29 | Thu Mar 5 | vsC Palace | L1-3 | 7-8-14 | 29 PTS | Tottenham Hotspur Stadium · London, England |
| 30 | Sun Mar 15 | atLiverpool | D1-1 | 7-9-14 | 30 PTS | Nutter Center · Dayton, OH |
| 31 | Sun Mar 22 | vsNott'm Forest | L0-3 | 1-0-1 | 3 PTS | Tottenham Hotspur Stadium · London, England |
| 32 | Sun Apr 12 | atSunderland | L0-1 | 1-0-2 | 3 PTS | Stadium of Light · Sunderland, England |
