| 1 | Sat Aug 17 | vs A Villa | L1-2 | 0-0-1 | 0 PTS | London Stadium · London, England |
| 2 | Sat Aug 24 | at C Palace | W2-0 | 1-0-1 | 3 PTS | Selhurst Park · London, England |
| 3 | Sat Aug 31 | vs Man City | L1-3 | 1-0-2 | 3 PTS | London Stadium · London, England |
| 4 | Sat Sep 14 | at Fulham | D1-1 | 1-1-2 | 4 PTS | Craven Cottage · London, England |
| 5 | Sat Sep 21 | vs Chelsea | L0-3 | 1-1-3 | 4 PTS | London Stadium · London, England |
| 6 | Sat Sep 28 | at Brentford | D1-1 | 1-2-3 | 5 PTS | Gtech Community Stadium · Brentford, England |
| 7 | Sat Oct 5 | vs Ipswich | W4-1 | 2-2-3 | 8 PTS | London Stadium · London, England |
| 8 | Sat Oct 19 | at Spurs | L1-4 | 2-2-4 | 8 PTS | Tottenham Hotspur Stadium · London, England |
| 9 | Sun Oct 27 | vs Man Utd | W2-1 | 3-2-4 | 11 PTS | London Stadium · London, England |
| 10 | Sat Nov 2 | at Nott'm Forest | L0-3 | 3-2-5 | 11 PTS | The City Ground · Nottingham, England |
| 11 | Sat Nov 9 | vs Everton | D0-0 | 3-3-5 | 12 PTS | London Stadium · London, England |
| 12 | Mon Nov 25 | at Newcastle | W2-0 | 4-3-5 | 15 PTS | St. James' Park · Newcastle, England |
| 13 | Sat Nov 30 | vs Arsenal | L2-5 | 4-3-6 | 15 PTS | London Stadium · London, England |
| 14 | Tue Dec 3 | at Leicester | L1-3 | 4-3-7 | 15 PTS | King Power Stadium · Leicester, England |
| 15 | Mon Dec 9 | vs Wolves | W2-1 | 5-3-7 | 18 PTS | London Stadium · London, England |
| 16 | Mon Dec 16 | at B'mouth | D1-1 | 5-4-7 | 19 PTS | Vitality Stadium · Bournemouth, England |
| 17 | Sat Dec 21 | vs Brighton | D1-1 | 5-5-7 | 20 PTS | London Stadium · London, England |
| 18 | Thu Dec 26 | at Southampton | W1-0 | 6-5-7 | 23 PTS | St. Mary's Stadium · Southampton, England |
| 19 | Sun Dec 29 | vs Liverpool | L0-5 | 6-5-8 | 23 PTS | London Stadium · London, England |
| 20 | Sat Jan 4 | atMan City | L1-4 | 6-5-9 | 23 PTS | Etihad Stadium · Manchester, England |
| 21 | Tue Jan 14 | vsFulham | W3-2 | 7-5-9 | 26 PTS | London Stadium · London, England |
| 22 | Sat Jan 18 | vsC Palace | L0-2 | 7-5-10 | 26 PTS | London Stadium · London, England |
| 23 | Sun Jan 26 | atA Villa | D1-1 | 7-6-10 | 27 PTS | Villa Park · Birmingham, England |
| 24 | Mon Feb 3 | atChelsea | L1-2 | 7-6-11 | 27 PTS | Stamford Bridge · London, England |
| 25 | Sat Feb 15 | vsBrentford | L0-1 | 7-6-12 | 27 PTS | London Stadium · London, England |
| 26 | Sat Feb 22 | atArsenal | W1-0 | 8-6-12 | 30 PTS | Emirates Stadium · London, England |
| 27 | Thu Feb 27 | vsLeicester | W2-0 | 9-6-12 | 33 PTS | London Stadium · London, England |
| 28 | Mon Mar 10 | vsNewcastle | L0-1 | 9-6-13 | 33 PTS | London Stadium · London, England |
| 29 | Sat Mar 15 | atEverton | D1-1 | 9-7-13 | 34 PTS | Goodison Park · Liverpool, England |
| 30 | Tue Apr 1 | atWolves | L0-1 | 9-7-14 | 34 PTS | Molineux Stadium · Wolverhampton, England |
| 31 | Sat Apr 5 | vsB'mouth | D2-2 | 9-8-14 | 35 PTS | London Stadium · London, England |
| 32 | Sun Apr 13 | atLiverpool | L1-2 | 9-8-15 | 35 PTS | Anfield · Liverpool, England |
| 33 | Sat Apr 19 | vsSouthampton | D1-1 | 9-9-15 | 36 PTS | London Stadium · London, England |
| 34 | Sat Apr 26 | atBrighton | L2-3 | 9-9-16 | 36 PTS | Amex Stadium · Brighton, England |
| 35 | Sun May 4 | vsSpurs | D1-1 | 9-10-16 | 37 PTS | London Stadium · London, England |
