| 1 | Mon Apr 6 | vs Giants | L4-5 | 0-1 | .000 | Chase Field · Phoenix, AZ |
| 2 | Tue Apr 7 | vs Giants | W7-6 | 1-1 | .500 | Chase Field · Phoenix, AZ |
| 3 | Wed Apr 8 | vs Giants | L2-5 | 1-2 | .333 | Chase Field · Phoenix, AZ |
| 4 | Fri Apr 10 | vs Dodgers | W4-3 (10) | 2-2 | .500 | Chase Field · Phoenix, AZ |
| 5 | Sat Apr 11 | vs Dodgers | W6-0 | 3-2 | .600 | Chase Field · Phoenix, AZ |
| 6 | Sun Apr 12 | vs Dodgers | L4-7 | 3-3 | .500 | Chase Field · Phoenix, AZ |
| 7 | Mon Apr 13 | at Padres | W8-4 | 4-3 | .571 | Petco Park · San Diego, CA |
| 8 | Tue Apr 14 | at Padres | L1-5 | 4-4 | .500 | Petco Park · San Diego, CA |
| 9 | Wed Apr 15 | at Padres | L2-3 | 4-5 | .444 | Petco Park · San Diego, CA |
| 10 | Thu Apr 16 | at Giants | W7-6 (12) | 5-5 | .500 | Oracle Park · San Francisco, CA |
| 11 | Fri Apr 17 | at Giants | W9-0 | 6-5 | .545 | Oracle Park · San Francisco, CA |
| 12 | Sat Apr 18 | at Giants | L1-4 | 6-6 | .500 | Oracle Park · San Francisco, CA |
| 13 | Sun Apr 19 | at Giants | W5-1 | 7-6 | .538 | Oracle Park · San Francisco, CA |
| 14 | Tue Apr 21 | vs Rangers | L1-7 | 7-7 | .500 | Chase Field · Phoenix, AZ |
| 15 | Wed Apr 22 | vs Rangers | W8-5 | 8-7 | .533 | Chase Field · Phoenix, AZ |
| 16 | Fri Apr 24 | vs Pirates | L1-4 | 8-8 | .500 | Chase Field · Phoenix, AZ |
| 17 | Sat Apr 25 | vs Pirates | L1-2 | 8-9 | .471 | Chase Field · Phoenix, AZ |
| 18 | Sun Apr 26 | vs Pirates | L0-8 | 8-10 | .444 | Chase Field · Phoenix, AZ |
| 19 | Mon Apr 27 | vs Rockies | L4-5 | 8-11 | .421 | Chase Field · Phoenix, AZ |
| 20 | Tue Apr 28 | vs Rockies | W12-5 | 9-11 | .450 | Chase Field · Phoenix, AZ |
| 21 | Wed Apr 29 | vs Rockies | W9-1 | 10-11 | .476 | Chase Field · Phoenix, AZ |
| 22 | Fri May 1 | at Dodgers | L0-8 | 10-12 | .455 | Dodger Stadium · Los Angeles, CA |
| 23 | Sat May 2 | at Dodgers | L4-6 | 10-13 | .435 | Dodger Stadium · Los Angeles, CA |
| 24 | Sun May 3 | at Dodgers | L0-1 (13) | 10-14 | .417 | Dodger Stadium · Los Angeles, CA |
| 25 | Wed May 6 | at Rockies | W13-7 | 11-14 | .440 | Coors Field · Denver, CO |
| 26 | Wed May 6 | at Rockies | W5-1 | 12-14 | .462 | Coors Field · Denver, CO |
| 27 | Thu May 7 | vs Padres | W11-0 | 13-14 | .481 | Chase Field · Phoenix, AZ |
| 28 | Fri May 8 | vs Padres | L5-6 | 13-15 | .464 | Chase Field · Phoenix, AZ |
| 29 | Sat May 9 | vs Padres | L4-6 (12) | 13-16 | .448 | Chase Field · Phoenix, AZ |
| 30 | Sun May 10 | vs Padres | W2-1 | 14-16 | .467 | Chase Field · Phoenix, AZ |
| 31 | Mon May 11 | vs Nationals | L1-11 | 14-17 | .452 | Chase Field · Phoenix, AZ |
| 32 | Tue May 12 | vs Nationals | W14-6 | 15-17 | .469 | Chase Field · Phoenix, AZ |
| 33 | Wed May 13 | vs Nationals | L6-9 | 15-18 | .455 | Chase Field · Phoenix, AZ |
| 34 | Fri May 15 | at Phillies | L3-4 | 15-19 | .441 | Citizens Bank Park · Philadelphi, PA |
| 35 | Sat May 16 | at Phillies | L5-7 | 15-20 | .429 | Citizens Bank Park · Philadelphi, PA |
| 36 | Sun May 17 | at Phillies | L0-6 | 15-21 | .417 | Citizens Bank Park · Philadelphi, PA |
| 37 | Mon May 18 | at Marlins | W3-2 (13) | 16-21 | .432 | LoanDepot Park · Miami, FL |
| 38 | Tue May 19 | at Marlins | W4-2 | 17-21 | .447 | LoanDepot Park · Miami, FL |
| 39 | Wed May 20 | at Marlins | W6-1 | 18-21 | .462 | LoanDepot Park · Miami, FL |
| 40 | Thu May 21 | at Marlins | W7-6 | 19-21 | .475 | LoanDepot Park · Miami, FL |
| 41 | Fri May 22 | vs Cubs | W5-4 (13) | 20-21 | .488 | Chase Field · Phoenix, AZ |
| 42 | Sat May 23 | vs Cubs | L6-9 | 20-22 | .476 | Chase Field · Phoenix, AZ |
| 43 | Sun May 24 | vs Cubs | W4-3 | 21-22 | .488 | Chase Field · Phoenix, AZ |
| 44 | Mon May 25 | at Cardinals | L2-3 (10) | 21-23 | .477 | Busch Stadium · St. Louis, MO |
| 45 | Tue May 26 | at Cardinals | L4-6 | 21-24 | .467 | Busch Stadium · St. Louis, MO |
| 46 | Wed May 27 | at Cardinals | L3-4 | 21-25 | .457 | Busch Stadium · St. Louis, MO |
| 47 | Fri May 29 | at Brewers | W7-5 | 22-25 | .468 | American Family Field · Milwaukee, WI |
| 48 | Sat May 30 | at Brewers | W7-3 | 23-25 | .479 | American Family Field · Milwaukee, WI |
| 49 | Sun May 31 | at Brewers | L6-7 (17) | 23-26 | .469 | American Family Field · Milwaukee, WI |
| 50 | Mon Jun 1 | vs Braves | L1-8 | 23-27 | .460 | Chase Field · Phoenix, AZ |
| 51 | Tue Jun 2 | vs Braves | W7-6 | 24-27 | .471 | Chase Field · Phoenix, AZ |
| 52 | Wed Jun 3 | vs Braves | W9-8 | 25-27 | .481 | Chase Field · Phoenix, AZ |
| 53 | Thu Jun 4 | vs Mets | L2-6 | 25-28 | .472 | Chase Field · Phoenix, AZ |
| 54 | Fri Jun 5 | vs Mets | W7-2 | 26-28 | .481 | Chase Field · Phoenix, AZ |
| 55 | Sat Jun 6 | vs Mets | W2-1 | 27-28 | .491 | Chase Field · Phoenix, AZ |
| 56 | Sun Jun 7 | vs Mets | L3-6 | 27-29 | .482 | Chase Field · Phoenix, AZ |
| 57 | Mon Jun 8 | at Dodgers | L3-9 | 27-30 | .474 | Dodger Stadium · Los Angeles, CA |
| 58 | Tue Jun 9 | at Dodgers | L1-3 | 27-31 | .466 | Dodger Stadium · Los Angeles, CA |
| 59 | Wed Jun 10 | at Dodgers | L6-7 | 27-32 | .458 | Dodger Stadium · Los Angeles, CA |
| 60 | Fri Jun 12 | at Giants | W1-0 | 28-32 | .467 | Oracle Park · San Francisco, CA |
| 61 | Sat Jun 13 | at Giants | W4-2 | 29-32 | .475 | Oracle Park · San Francisco, CA |
| 62 | Sun Jun 14 | at Giants | W4-0 | 30-32 | .484 | Oracle Park · San Francisco, CA |
| 63 | Mon Jun 15 | at Angels | W7-3 | 31-32 | .492 | Angel Stadium · Anaheim, CA |
| 64 | Tue Jun 16 | at Angels | L1-4 | 31-33 | .484 | Angel Stadium · Anaheim, CA |
| 65 | Wed Jun 17 | vs Angels | W3-2 | 32-33 | .492 | Chase Field · Phoenix, AZ |
| 66 | Thu Jun 18 | vs Angels | L1-7 | 32-34 | .485 | Chase Field · Phoenix, AZ |
| 67 | Fri Jun 19 | vs Padres | W4-2 | 33-34 | .493 | Chase Field · Phoenix, AZ |
| 68 | Sat Jun 20 | vs Padres | L1-8 | 33-35 | .485 | Chase Field · Phoenix, AZ |
| 69 | Sun Jun 21 | vs Padres | W7-2 | 34-35 | .493 | Chase Field · Phoenix, AZ |
| 70 | Tue Jun 23 | at Rockies | L5-10 | 34-36 | .486 | Coors Field · Denver, CO |
| 71 | Wed Jun 24 | at Rockies | W8-7 | 35-36 | .493 | Coors Field · Denver, CO |
| 72 | Thu Jun 25 | at Rockies | L4-6 | 35-37 | .486 | Coors Field · Denver, CO |
| 73 | Fri Jun 26 | at Padres | L2-4 | 35-38 | .479 | Petco Park · San Diego, CA |
| 74 | Sat Jun 27 | at Padres | L2-7 | 35-39 | .473 | Petco Park · San Diego, CA |
| 75 | Sun Jun 28 | at Padres | W6-4 | 36-39 | .480 | Petco Park · San Diego, CA |
| 76 | Mon Jun 29 | vs Dodgers | W10-6 | 37-39 | .487 | Chase Field · Phoenix, AZ |
| 77 | Tue Jun 30 | vs Dodgers | L4-6 (10) | 37-40 | .481 | Chase Field · Phoenix, AZ |
| 78 | Wed Jul 1 | vs Dodgers | L3-4 | 37-41 | .474 | Chase Field · Phoenix, AZ |
| 79 | Thu Jul 2 | vs Rockies | W8-1 | 38-41 | .481 | Chase Field · Phoenix, AZ |
| 80 | Fri Jul 3 | vs Rockies | W4-3 (10) | 39-41 | .487 | Chase Field · Phoenix, AZ |
| 81 | Sat Jul 4 | vs Rockies | W7-3 | 40-41 | .494 | Chase Field · Phoenix, AZ |
| 82 | Sun Jul 5 | vs Rockies | L4-6 | 40-42 | .488 | Chase Field · Phoenix, AZ |
| 83 | Tue Jul 7 | at Rangers | W4-2 | 41-42 | .494 | Globe Life Field · Arlington, TX |
| 84 | Wed Jul 8 | at Rangers | W7-4 | 42-42 | .500 | Globe Life Field · Arlington, TX |
| 85 | Fri Jul 10 | at Mets | L2-4 | 42-43 | .494 | Citi Field · Queens, NY |
| 86 | Sat Jul 11 | at Mets | L2-4 | 42-44 | .488 | Citi Field · Queens, NY |
| 87 | Sun Jul 12 | at Mets | L3-5 | 42-45 | .483 | Citi Field · Queens, NY |
| 88 | Fri Jul 17 | vs Giants | L5-6 (12) | 42-46 | .477 | Chase Field · Phoenix, AZ |
| 89 | Sat Jul 18 | vs Giants | L4-8 | 42-47 | .472 | Chase Field · Phoenix, AZ |
| 90 | Sun Jul 19 | vs Giants | L1-2 | 42-48 | .467 | Chase Field · Phoenix, AZ |
| 91 | Mon Jul 20 | vs Marlins | W3-1 | 43-48 | .473 | Chase Field · Phoenix, AZ |
| 92 | Tue Jul 21 | vs Marlins | L0-3 | 43-49 | .467 | Chase Field · Phoenix, AZ |
| 93 | Wed Jul 22 | vs Marlins | L3-5 | 43-50 | .462 | Chase Field · Phoenix, AZ |
| 94 | Thu Jul 23 | vs Brewers | W8-3 | 44-50 | .468 | Chase Field · Phoenix, AZ |
| 95 | Fri Jul 24 | vs Brewers | L1-2 | 44-51 | .463 | Chase Field · Phoenix, AZ |
| 96 | Sat Jul 25 | vs Brewers | W2-0 | 45-51 | .469 | Chase Field · Phoenix, AZ |
| 97 | Sun Jul 26 | vs Brewers | W3-0 | 46-51 | .474 | Chase Field · Phoenix, AZ |
| 98 | Mon Jul 27 | at Mariners | W4-3 (10) | 47-51 | .480 | T-Mobile Park · Seattle, WA |
| 99 | Tue Jul 28 | at Mariners | W8-4 | 48-51 | .485 | T-Mobile Park · Seattle, WA |
| 100 | Wed Jul 29 | at Mariners | W8-2 | 49-51 | .490 | T-Mobile Park · Seattle, WA |
| 101 | Fri Jul 31 | at Astros | W6-4 (10) | 50-51 | .495 | Minute Maid Park · Houston, TX |
| 102 | Sat Aug 1 | at Astros | L2-9 | 50-52 | .490 | Minute Maid Park · Houston, TX |
| 103 | Sun Aug 2 | at Astros | L1-4 | 50-53 | .485 | Minute Maid Park · Houston, TX |
| 104 | Mon Aug 3 | at Nationals | W6-4 | 51-53 | .490 | Nationals Park · Washington, D.C. |
| 105 | Tue Aug 4 | at Nationals | L4-5 | 51-54 | .486 | Nationals Park · Washington, D.C. |
| 106 | Wed Aug 5 | at Nationals | W11-4 | 52-54 | .491 | Nationals Park · Washington, D.C. |
| 107 | Thu Aug 6 | at Nationals | L3-8 | 52-55 | .486 | Nationals Park · Washington, D.C. |
| 108 | Fri Aug 7 | vs Reds | W2-0 | 53-55 | .491 | Chase Field · Phoenix, AZ |
| 109 | Sat Aug 8 | vs Reds | L1-4 | 53-56 | .486 | Chase Field · Phoenix, AZ |
| 110 | Sun Aug 9 | vs Reds | W4-3 (10) | 54-56 | .491 | Chase Field · Phoenix, AZ |
| 111 | Mon Aug 10 | vs Phillies | W13-3 | 55-56 | .495 | Chase Field · Phoenix, AZ |
| 112 | Tue Aug 11 | vs Phillies | W13-1 | 56-56 | .500 | Chase Field · Phoenix, AZ |
| 113 | Wed Aug 12 | vs Phillies | L6-7 | 56-57 | .496 | Chase Field · Phoenix, AZ |
| 114 | Fri Aug 14 | at Braves | L2-3 | 56-58 | .491 | Truist Park · Cumberland, GA |
| 115 | Sat Aug 15 | at Braves | W8-4 | 57-58 | .496 | Truist Park · Cumberland, GA |
| 116 | Sun Aug 16 | at Braves | L1-2 (10) | 57-59 | .491 | Truist Park · Cumberland, GA |
| 117 | Mon Aug 17 | at Pirates | W4-1 | 58-59 | .496 | PNC Park · Pittsburgh, PA |
| 118 | Tue Aug 18 | at Pirates | L8-9 (15) | 58-60 | .492 | PNC Park · Pittsburgh, PA |
| 119 | Wed Aug 19 | at Pirates | L1-4 | 58-61 | .487 | PNC Park · Pittsburgh, PA |
| 120 | Thu Aug 20 | at Reds | W5-4 | 59-61 | .492 | Great American Ball Park · Cincinnati, OH |
| 121 | Fri Aug 21 | at Reds | W6-3 | 60-61 | .496 | Great American Ball Park · Cincinnati, OH |
| 122 | Sat Aug 22 | at Reds | W11-7 | 61-61 | .500 | Great American Ball Park · Cincinnati, OH |
| 123 | Sun Aug 23 | at Reds | W4-0 | 62-61 | .504 | Great American Ball Park · Cincinnati, OH |
| 124 | Mon Aug 24 | vs Cardinals | L3-5 | 62-62 | .500 | Chase Field · Phoenix, AZ |
| 125 | Tue Aug 25 | vs Cardinals | L1-9 | 62-63 | .496 | Chase Field · Phoenix, AZ |
| 126 | Wed Aug 26 | vs Cardinals | L1-3 | 62-64 | .492 | Chase Field · Phoenix, AZ |
| 127 | Thu Aug 27 | vs Cardinals | L3-5 | 62-65 | .488 | Chase Field · Phoenix, AZ |
| 128 | Fri Aug 28 | vs Athletics | W6-4 | 63-65 | .492 | Chase Field · Phoenix, AZ |
| 129 | Sat Aug 29 | vs Athletics | L2-3 | 63-66 | .488 | Chase Field · Phoenix, AZ |
| 130 | Sun Aug 30 | vs Athletics | L4-7 (11) | 63-67 | .485 | Chase Field · Phoenix, AZ |
| 131 | Mon Aug 31 | at Rockies | L4-5 | 63-68 | .481 | Coors Field · Denver, CO |
| 132 | Tue Sep 1 | at Rockies | W6-4 | 64-68 | .485 | Coors Field · Denver, CO |
| 133 | Tue Sep 1 | at Rockies | W5-3 | 65-68 | .489 | Coors Field · Denver, CO |
| 134 | Wed Sep 2 | at Rockies | L4-9 | 65-69 | .485 | Coors Field · Denver, CO |
| 135 | Fri Sep 4 | at Cubs | L5-14 | 65-70 | .481 | Wrigley Field · Chicago, IL |
| 136 | Sat Sep 5 | at Cubs | L0-2 | 65-71 | .478 | Wrigley Field · Chicago, IL |
| 137 | Sun Sep 6 | at Cubs | L4-6 | 65-72 | .474 | Wrigley Field · Chicago, IL |
| 138 | Mon Sep 7 | vs Giants | W6-1 | 66-72 | .478 | Chase Field · Phoenix, AZ |
| 139 | Tue Sep 8 | vs Giants | L2-6 | 66-73 | .475 | Chase Field · Phoenix, AZ |
| 140 | Wed Sep 9 | vs Giants | W2-1 | 67-73 | .479 | Chase Field · Phoenix, AZ |
| 141 | Fri Sep 11 | vs Dodgers | W12-4 | 68-73 | .482 | Chase Field · Phoenix, AZ |
| 142 | Sat Sep 12 | vs Dodgers | L5-9 | 68-74 | .479 | Chase Field · Phoenix, AZ |
| 143 | Sun Sep 13 | vs Dodgers | L3-4 | 68-75 | .476 | Chase Field · Phoenix, AZ |
| 144 | Mon Sep 14 | vs Padres | L3-10 | 68-76 | .472 | Chase Field · Phoenix, AZ |
| 145 | Tue Sep 15 | vs Padres | W6-4 | 69-76 | .476 | Chase Field · Phoenix, AZ |
| 146 | Wed Sep 16 | vs Padres | L3-4 | 69-77 | .473 | Chase Field · Phoenix, AZ |
| 147 | Fri Sep 18 | at Giants | W2-0 | 70-77 | .476 | Oracle Park · San Francisco, CA |
| 148 | Sat Sep 19 | at Giants | W6-0 | 71-77 | .480 | Oracle Park · San Francisco, CA |
| 149 | Sun Sep 20 | at Giants | L1-5 | 71-78 | .477 | Oracle Park · San Francisco, CA |
| 150 | Mon Sep 21 | at Dodgers | W8-4 | 72-78 | .480 | Dodger Stadium · Los Angeles, CA |
| 151 | Tue Sep 22 | at Dodgers | W8-0 | 73-78 | .483 | Dodger Stadium · Los Angeles, CA |
| 152 | Wed Sep 23 | at Dodgers | L1-4 | 73-79 | .480 | Dodger Stadium · Los Angeles, CA |
| 153 | Thu Sep 24 | at Dodgers | L3-6 | 73-80 | .477 | Dodger Stadium · Los Angeles, CA |
| 154 | Fri Sep 25 | at Padres | W6-3 | 74-80 | .481 | Petco Park · San Diego, CA |
| 155 | Sat Sep 26 | at Padres | L0-3 | 74-81 | .477 | Petco Park · San Diego, CA |
| 156 | Sun Sep 27 | at Padres | W4-2 | 75-81 | .481 | Petco Park · San Diego, CA |
| 157 | Tue Sep 29 | vs Rockies | W4-3 (11) | 76-81 | .484 | Chase Field · Phoenix, AZ |
| 158 | Wed Sep 30 | vs Rockies | W3-1 | 77-81 | .487 | Chase Field · Phoenix, AZ |
| 159 | Thu Oct 1 | vs Rockies | W8-6 | 78-81 | .491 | Chase Field · Phoenix, AZ |
| 160 | Fri Oct 2 | vs Astros | L5-21 | 78-82 | .487 | Chase Field · Phoenix, AZ |
| 161 | Sat Oct 3 | vs Astros | L2-6 | 78-83 | .484 | Chase Field · Phoenix, AZ |
| 162 | Sun Oct 4 | vs Astros | W5-3 | 79-83 | .488 | Chase Field · Phoenix, AZ |