| 1 | Thu Mar 29 | vs Rockies | W8-2 | 1-0 | 1.000 | Chase Field · Phoenix, AZ |
| 2 | Fri Mar 30 | vs Rockies | W9-8 | 2-0 | 1.000 | Chase Field · Phoenix, AZ |
| 3 | Sat Mar 31 | vs Rockies | L1-2 | 2-1 | .667 | Chase Field · Phoenix, AZ |
| 4 | Mon Apr 2 | vs Dodgers | W8-7 (15) | 3-1 | .750 | Chase Field · Phoenix, AZ |
| 5 | Tue Apr 3 | vs Dodgers | W6-1 | 4-1 | .800 | Chase Field · Phoenix, AZ |
| 6 | Wed Apr 4 | vs Dodgers | W3-0 | 5-1 | .833 | Chase Field · Phoenix, AZ |
| 7 | Thu Apr 5 | at Cardinals | W3-1 | 6-1 | .857 | Busch Stadium · St. Louis, MO |
| 8 | Sat Apr 7 | at Cardinals | L3-5 | 6-2 | .750 | Busch Stadium · St. Louis, MO |
| 9 | Sun Apr 8 | at Cardinals | W4-1 | 7-2 | .778 | Busch Stadium · St. Louis, MO |
| 10 | Mon Apr 9 | at Giants | W2-1 | 8-2 | .800 | Oracle Park · San Francisco, CA |
| 11 | Tue Apr 10 | at Giants | L4-5 | 8-3 | .727 | Oracle Park · San Francisco, CA |
| 12 | Wed Apr 11 | at Giants | W7-3 | 9-3 | .750 | Oracle Park · San Francisco, CA |
| 13 | Fri Apr 13 | at Dodgers | W8-7 | 10-3 | .769 | Dodger Stadium · Los Angeles, CA |
| 14 | Sat Apr 14 | at Dodgers | W9-1 | 11-3 | .786 | Dodger Stadium · Los Angeles, CA |
| 15 | Sun Apr 15 | at Dodgers | L2-7 | 11-4 | .733 | Dodger Stadium · Los Angeles, CA |
| 16 | Tue Apr 17 | vs Giants | W1-0 | 12-4 | .750 | Chase Field · Phoenix, AZ |
| 17 | Wed Apr 18 | vs Giants | L3-4 (10) | 12-5 | .706 | Chase Field · Phoenix, AZ |
| 18 | Thu Apr 19 | vs Giants | W3-1 | 13-5 | .722 | Chase Field · Phoenix, AZ |
| 19 | Fri Apr 20 | vs Padres | L1-4 | 13-6 | .684 | Chase Field · Phoenix, AZ |
| 20 | Sat Apr 21 | vs Padres | W6-2 | 14-6 | .700 | Chase Field · Phoenix, AZ |
| 21 | Sun Apr 22 | vs Padres | W4-2 | 15-6 | .714 | Chase Field · Phoenix, AZ |
| 22 | Tue Apr 24 | at Phillies | W8-4 | 16-6 | .727 | Citizens Bank Park · Philadelphi, PA |
| 23 | Wed Apr 25 | at Phillies | L3-5 | 16-7 | .696 | Citizens Bank Park · Philadelphi, PA |
| 24 | Thu Apr 26 | at Phillies | W8-2 | 17-7 | .708 | Citizens Bank Park · Philadelphi, PA |
| 25 | Fri Apr 27 | at Nationals | W5-4 | 18-7 | .720 | Nationals Park · Washington, D.C. |
| 26 | Sat Apr 28 | at Nationals | W4-3 (10) | 19-7 | .731 | Nationals Park · Washington, D.C. |
| 27 | Sun Apr 29 | at Nationals | L1-3 | 19-8 | .704 | Nationals Park · Washington, D.C. |
| 28 | Mon Apr 30 | vs Dodgers | W8-5 | 20-8 | .714 | Chase Field · Phoenix, AZ |
| 29 | Tue May 1 | vs Dodgers | W4-3 | 21-8 | .724 | Chase Field · Phoenix, AZ |
| 30 | Wed May 2 | vs Dodgers | L1-2 | 21-9 | .700 | Chase Field · Phoenix, AZ |
| 31 | Thu May 3 | vs Dodgers | L2-5 | 21-10 | .677 | Chase Field · Phoenix, AZ |
| 32 | Fri May 4 | vs Astros | L0-8 | 21-11 | .656 | Chase Field · Phoenix, AZ |
| 33 | Sat May 5 | vs Astros | W4-3 | 22-11 | .667 | Chase Field · Phoenix, AZ |
| 34 | Sun May 6 | vs Astros | W3-1 | 23-11 | .676 | Chase Field · Phoenix, AZ |
| 35 | Tue May 8 | at Dodgers | W8-5 (12) | 24-11 | .686 | Dodger Stadium · Los Angeles, CA |
| 36 | Wed May 9 | at Dodgers | L3-6 | 24-12 | .667 | Dodger Stadium · Los Angeles, CA |
| 37 | Thu May 10 | vs Nationals | L1-2 (11) | 24-13 | .649 | Chase Field · Phoenix, AZ |
| 38 | Fri May 11 | vs Nationals | L1-3 | 24-14 | .632 | Chase Field · Phoenix, AZ |
| 39 | Sat May 12 | vs Nationals | L1-2 | 24-15 | .615 | Chase Field · Phoenix, AZ |
| 40 | Sun May 13 | vs Nationals | L4-6 | 24-16 | .600 | Chase Field · Phoenix, AZ |
| 41 | Mon May 14 | vs Brewers | L2-7 | 24-17 | .585 | Chase Field · Phoenix, AZ |
| 42 | Tue May 15 | vs Brewers | W2-1 | 25-17 | .595 | Chase Field · Phoenix, AZ |
| 43 | Wed May 16 | vs Brewers | L2-8 | 25-18 | .581 | Chase Field · Phoenix, AZ |
| 44 | Fri May 18 | at Mets | L1-3 | 25-19 | .568 | Citi Field · Queens, NY |
| 45 | Sat May 19 | at Mets | L4-5 | 25-20 | .556 | Citi Field · Queens, NY |
| 46 | Sun May 20 | at Mets | L1-4 | 25-21 | .543 | Citi Field · Queens, NY |
| 47 | Mon May 21 | at Brewers | L2-4 | 25-22 | .532 | American Family Field · Milwaukee, WI |
| 48 | Tue May 22 | at Brewers | L0-1 | 25-23 | .521 | American Family Field · Milwaukee, WI |
| 49 | Wed May 23 | at Brewers | L2-9 | 25-24 | .510 | American Family Field · Milwaukee, WI |
| 50 | Fri May 25 | at Athletics | W7-1 | 26-24 | .520 | RingCentral Coliseum · Oakland, CA |
| 51 | Sat May 26 | at Athletics | L0-3 | 26-25 | .510 | RingCentral Coliseum · Oakland, CA |
| 52 | Sun May 27 | at Athletics | L1-2 | 26-26 | .500 | RingCentral Coliseum · Oakland, CA |
| 53 | Mon May 28 | vs Reds | W12-5 | 27-26 | .509 | Chase Field · Phoenix, AZ |
| 54 | Tue May 29 | vs Reds | W5-2 | 28-26 | .519 | Chase Field · Phoenix, AZ |
| 55 | Wed May 30 | vs Reds | L4-7 | 28-27 | .509 | Chase Field · Phoenix, AZ |
| 56 | Fri Jun 1 | vs Marlins | W9-1 | 29-27 | .518 | Chase Field · Phoenix, AZ |
| 57 | Sat Jun 2 | vs Marlins | W6-2 | 30-27 | .526 | Chase Field · Phoenix, AZ |
| 58 | Sun Jun 3 | vs Marlins | W6-1 | 31-27 | .534 | Chase Field · Phoenix, AZ |
| 59 | Mon Jun 4 | at Giants | L3-10 | 31-28 | .525 | Oracle Park · San Francisco, CA |
| 60 | Tue Jun 5 | at Giants | W3-2 | 32-28 | .533 | Oracle Park · San Francisco, CA |
| 61 | Wed Jun 6 | at Giants | L4-5 (10) | 32-29 | .525 | Oracle Park · San Francisco, CA |
| 62 | Fri Jun 8 | at Rockies | W9-4 | 33-29 | .532 | Coors Field · Denver, CO |
| 63 | Sat Jun 9 | at Rockies | W12-7 | 34-29 | .540 | Coors Field · Denver, CO |
| 64 | Sun Jun 10 | at Rockies | W8-3 | 35-29 | .547 | Coors Field · Denver, CO |
| 65 | Mon Jun 11 | vs Pirates | W9-5 | 36-29 | .554 | Chase Field · Phoenix, AZ |
| 66 | Tue Jun 12 | vs Pirates | W13-8 | 37-29 | .561 | Chase Field · Phoenix, AZ |
| 67 | Wed Jun 13 | vs Pirates | L4-5 | 37-30 | .552 | Chase Field · Phoenix, AZ |
| 68 | Thu Jun 14 | vs Mets | W6-3 | 38-30 | .559 | Chase Field · Phoenix, AZ |
| 69 | Fri Jun 15 | vs Mets | W7-3 | 39-30 | .565 | Chase Field · Phoenix, AZ |
| 70 | Sat Jun 16 | vs Mets | L1-5 | 39-31 | .557 | Chase Field · Phoenix, AZ |
| 71 | Sun Jun 17 | vs Mets | L3-5 | 39-32 | .549 | Chase Field · Phoenix, AZ |
| 72 | Mon Jun 18 | at Angels | W7-4 | 40-32 | .556 | Angel Stadium · Anaheim, CA |
| 73 | Tue Jun 19 | at Angels | L4-5 | 40-33 | .548 | Angel Stadium · Anaheim, CA |
| 74 | Thu Jun 21 | at Pirates | W9-3 | 41-33 | .554 | PNC Park · Pittsburgh, PA |
| 75 | Fri Jun 22 | at Pirates | W2-1 (13) | 42-33 | .560 | PNC Park · Pittsburgh, PA |
| 76 | Sat Jun 23 | at Pirates | W7-2 | 43-33 | .566 | PNC Park · Pittsburgh, PA |
| 77 | Sun Jun 24 | at Pirates | W3-0 | 44-33 | .571 | PNC Park · Pittsburgh, PA |
| 78 | Mon Jun 25 | at Marlins | L5-9 | 44-34 | .564 | LoanDepot Park · Miami, FL |
| 79 | Tue Jun 26 | at Marlins | W5-3 | 45-34 | .570 | LoanDepot Park · Miami, FL |
| 80 | Wed Jun 27 | at Marlins | W2-1 | 46-34 | .575 | LoanDepot Park · Miami, FL |
| 81 | Thu Jun 28 | at Marlins | W4-0 | 47-34 | .580 | LoanDepot Park · Miami, FL |
| 82 | Fri Jun 29 | vs Giants | L1-2 | 47-35 | .573 | Chase Field · Phoenix, AZ |
| 83 | Sat Jun 30 | vs Giants | L0-7 | 47-36 | .566 | Chase Field · Phoenix, AZ |
| 84 | Sun Jul 1 | vs Giants | L6-9 | 47-37 | .560 | Chase Field · Phoenix, AZ |
| 85 | Mon Jul 2 | vs Cardinals | L3-6 | 47-38 | .553 | Chase Field · Phoenix, AZ |
| 86 | Tue Jul 3 | vs Cardinals | W4-2 | 48-38 | .558 | Chase Field · Phoenix, AZ |
| 87 | Wed Jul 4 | vs Cardinals | L4-8 | 48-39 | .552 | Chase Field · Phoenix, AZ |
| 88 | Thu Jul 5 | vs Padres | L3-6 | 48-40 | .545 | Chase Field · Phoenix, AZ |
| 89 | Fri Jul 6 | vs Padres | W3-1 | 49-40 | .551 | Chase Field · Phoenix, AZ |
| 90 | Sat Jul 7 | vs Padres | W20-5 | 50-40 | .556 | Chase Field · Phoenix, AZ |
| 91 | Sun Jul 8 | vs Padres | L3-4 (16) | 50-41 | .549 | Chase Field · Phoenix, AZ |
| 92 | Tue Jul 10 | at Rockies | W5-3 | 51-41 | .554 | Coors Field · Denver, CO |
| 93 | Wed Jul 11 | at Rockies | L2-19 | 51-42 | .548 | Coors Field · Denver, CO |
| 94 | Thu Jul 12 | at Rockies | L1-5 | 51-43 | .543 | Coors Field · Denver, CO |
| 95 | Fri Jul 13 | at Braves | W2-1 | 52-43 | .547 | Truist Park · Cumberland, GA |
| 96 | Sat Jul 14 | at Braves | W3-0 | 53-43 | .552 | Truist Park · Cumberland, GA |
| 97 | Sun Jul 15 | at Braves | L1-5 | 53-44 | .546 | Truist Park · Cumberland, GA |
| 98 | Fri Jul 20 | vs Rockies | L10-11 | 53-45 | .541 | Chase Field · Phoenix, AZ |
| 99 | Sat Jul 21 | vs Rockies | L5-6 | 53-46 | .535 | Chase Field · Phoenix, AZ |
| 100 | Sun Jul 22 | vs Rockies | W6-1 | 54-46 | .540 | Chase Field · Phoenix, AZ |
| 101 | Mon Jul 23 | at Cubs | W7-1 | 55-46 | .545 | Wrigley Field · Chicago, IL |
| 102 | Tue Jul 24 | at Cubs | W5-1 | 56-46 | .549 | Wrigley Field · Chicago, IL |
| 103 | Wed Jul 25 | at Cubs | L1-2 | 56-47 | .544 | Wrigley Field · Chicago, IL |
| 104 | Thu Jul 26 | at Cubs | L6-7 | 56-48 | .538 | Wrigley Field · Chicago, IL |
| 105 | Fri Jul 27 | at Padres | W6-2 | 57-48 | .543 | Petco Park · San Diego, CA |
| 106 | Sat Jul 28 | at Padres | W9-4 | 58-48 | .547 | Petco Park · San Diego, CA |
| 107 | Sun Jul 29 | at Padres | W5-4 | 59-48 | .551 | Petco Park · San Diego, CA |
| 108 | Mon Jul 30 | vs Rangers | L5-9 | 59-49 | .546 | Chase Field · Phoenix, AZ |
| 109 | Tue Jul 31 | vs Rangers | W6-0 | 60-49 | .550 | Chase Field · Phoenix, AZ |
| 110 | Thu Aug 2 | vs Giants | L1-8 | 60-50 | .545 | Chase Field · Phoenix, AZ |
| 111 | Fri Aug 3 | vs Giants | W6-3 | 61-50 | .550 | Chase Field · Phoenix, AZ |
| 112 | Sat Aug 4 | vs Giants | W9-3 | 62-50 | .554 | Chase Field · Phoenix, AZ |
| 113 | Sun Aug 5 | vs Giants | L2-3 | 62-51 | .549 | Chase Field · Phoenix, AZ |
| 114 | Mon Aug 6 | vs Phillies | W3-2 (14) | 63-51 | .553 | Chase Field · Phoenix, AZ |
| 115 | Tue Aug 7 | vs Phillies | L2-5 | 63-52 | .548 | Chase Field · Phoenix, AZ |
| 116 | Wed Aug 8 | vs Phillies | W6-0 | 64-52 | .552 | Chase Field · Phoenix, AZ |
| 117 | Fri Aug 10 | at Reds | L0-3 | 64-53 | .547 | Great American Ball Park · Cincinnati, OH |
| 118 | Sat Aug 11 | at Reds | L3-6 | 64-54 | .542 | Great American Ball Park · Cincinnati, OH |
| 119 | Sun Aug 12 | at Reds | W9-2 | 65-54 | .546 | Great American Ball Park · Cincinnati, OH |
| 120 | Mon Aug 13 | at Rangers | L3-5 | 65-55 | .542 | Globe Life Field · Arlington, TX |
| 121 | Tue Aug 14 | at Rangers | W6-4 | 66-55 | .545 | Globe Life Field · Arlington, TX |
| 122 | Thu Aug 16 | at Padres | W5-1 | 67-55 | .549 | Petco Park · San Diego, CA |
| 123 | Fri Aug 17 | at Padres | W9-4 | 68-55 | .553 | Petco Park · San Diego, CA |
| 124 | Sat Aug 18 | at Padres | L6-7 | 68-56 | .548 | Petco Park · San Diego, CA |
| 125 | Sun Aug 19 | at Padres | W4-3 | 69-56 | .552 | Petco Park · San Diego, CA |
| 126 | Tue Aug 21 | vs Angels | W5-4 | 70-56 | .556 | Chase Field · Phoenix, AZ |
| 127 | Wed Aug 22 | vs Angels | W5-1 | 71-56 | .559 | Chase Field · Phoenix, AZ |
| 128 | Fri Aug 24 | vs Mariners | L3-6 | 71-57 | .555 | Chase Field · Phoenix, AZ |
| 129 | Sat Aug 25 | vs Mariners | L3-4 (10) | 71-58 | .550 | Chase Field · Phoenix, AZ |
| 130 | Sun Aug 26 | vs Mariners | W5-2 | 72-58 | .554 | Chase Field · Phoenix, AZ |
| 131 | Mon Aug 27 | at Giants | L0-2 | 72-59 | .550 | Oracle Park · San Francisco, CA |
| 132 | Tue Aug 28 | at Giants | L0-1 | 72-60 | .545 | Oracle Park · San Francisco, CA |
| 133 | Wed Aug 29 | at Giants | W3-1 | 73-60 | .549 | Oracle Park · San Francisco, CA |
| 134 | Thu Aug 30 | at Dodgers | W3-1 | 74-60 | .552 | Dodger Stadium · Los Angeles, CA |
| 135 | Fri Aug 31 | at Dodgers | L2-3 | 74-61 | .548 | Dodger Stadium · Los Angeles, CA |
| 136 | Sat Sep 1 | at Dodgers | L2-3 | 74-62 | .544 | Dodger Stadium · Los Angeles, CA |
| 137 | Sun Sep 2 | at Dodgers | L2-3 | 74-63 | .540 | Dodger Stadium · Los Angeles, CA |
| 138 | Mon Sep 3 | vs Padres | L2-6 | 74-64 | .536 | Chase Field · Phoenix, AZ |
| 139 | Tue Sep 4 | vs Padres | W6-0 | 75-64 | .540 | Chase Field · Phoenix, AZ |
| 140 | Thu Sep 6 | vs Braves | L6-7 (10) | 75-65 | .536 | Chase Field · Phoenix, AZ |
| 141 | Fri Sep 7 | vs Braves | W5-3 | 76-65 | .539 | Chase Field · Phoenix, AZ |
| 142 | Sat Sep 8 | vs Braves | L4-5 (10) | 76-66 | .535 | Chase Field · Phoenix, AZ |
| 143 | Sun Sep 9 | vs Braves | L5-9 | 76-67 | .531 | Chase Field · Phoenix, AZ |
| 144 | Mon Sep 10 | at Rockies | L2-13 | 76-68 | .528 | Coors Field · Denver, CO |
| 145 | Tue Sep 11 | at Rockies | W6-3 | 77-68 | .531 | Coors Field · Denver, CO |
| 146 | Wed Sep 12 | at Rockies | L4-5 | 77-69 | .527 | Coors Field · Denver, CO |
| 147 | Thu Sep 13 | at Rockies | L3-10 | 77-70 | .524 | Coors Field · Denver, CO |
| 148 | Fri Sep 14 | at Astros | W4-2 | 78-70 | .527 | Minute Maid Park · Houston, TX |
| 149 | Sat Sep 15 | at Astros | L4-10 | 78-71 | .523 | Minute Maid Park · Houston, TX |
| 150 | Sun Sep 16 | at Astros | L4-5 | 78-72 | .520 | Minute Maid Park · Houston, TX |
| 151 | Mon Sep 17 | vs Cubs | L1-5 | 78-73 | .517 | Chase Field · Phoenix, AZ |
| 152 | Tue Sep 18 | vs Cubs | L1-9 | 78-74 | .513 | Chase Field · Phoenix, AZ |
| 153 | Wed Sep 19 | vs Cubs | W9-0 | 79-74 | .516 | Chase Field · Phoenix, AZ |
| 154 | Fri Sep 21 | vs Rockies | L2-6 | 79-75 | .513 | Chase Field · Phoenix, AZ |
| 155 | Sat Sep 22 | vs Rockies | L1-5 | 79-76 | .510 | Chase Field · Phoenix, AZ |
| 156 | Sun Sep 23 | vs Rockies | L0-2 | 79-77 | .506 | Chase Field · Phoenix, AZ |
| 157 | Mon Sep 24 | vs Dodgers | L4-7 | 79-78 | .503 | Chase Field · Phoenix, AZ |
| 158 | Tue Sep 25 | vs Dodgers | W4-3 | 80-78 | .506 | Chase Field · Phoenix, AZ |
| 159 | Wed Sep 26 | vs Dodgers | W7-2 | 81-78 | .509 | Chase Field · Phoenix, AZ |
| 160 | Fri Sep 28 | at Padres | L2-3 (15) | 81-79 | .506 | Petco Park · San Diego, CA |
| 161 | Sat Sep 29 | at Padres | W5-4 | 82-79 | .509 | Petco Park · San Diego, CA |
| 162 | Sun Sep 30 | at Padres | L3-4 (10) | 82-80 | .506 | Petco Park · San Diego, CA |