| 1 | Fri Apr 2 | vs Orioles | L0-3 | 0-1 | .000 | Fenway Park · Boston, MA |
| 2 | Sat Apr 3 | vs Orioles | L2-4 | 0-2 | .000 | Fenway Park · Boston, MA |
| 3 | Sun Apr 4 | vs Orioles | L3-11 | 0-3 | .000 | Fenway Park · Boston, MA |
| 4 | Mon Apr 5 | vs Rays | W11-2 | 1-3 | .250 | Fenway Park · Boston, MA |
| 5 | Tue Apr 6 | vs Rays | W6-5 (12) | 2-3 | .400 | Fenway Park · Boston, MA |
| 6 | Wed Apr 7 | vs Rays | W9-2 | 3-3 | .500 | Fenway Park · Boston, MA |
| 7 | Thu Apr 8 | at Orioles | W7-3 | 4-3 | .571 | Camden Yards · Baltimore, MD |
| 8 | Sat Apr 10 | at Orioles | W6-4 (10) | 5-3 | .625 | Camden Yards · Baltimore, MD |
| 9 | Sun Apr 11 | at Orioles | W14-9 | 6-3 | .667 | Camden Yards · Baltimore, MD |
| 10 | Tue Apr 13 | at Twins | W4-2 | 7-3 | .700 | Target Field · Minneapolis, MN |
| 11 | Wed Apr 14 | at Twins | W3-2 | 8-3 | .727 | Target Field · Minneapolis, MN |
| 12 | Wed Apr 14 | at Twins | W7-1 | 9-3 | .750 | Target Field · Minneapolis, MN |
| 13 | Thu Apr 15 | at Twins | L3-4 | 9-4 | .692 | Target Field · Minneapolis, MN |
| 14 | Sat Apr 17 | vs White Sox | W7-4 | 10-4 | .714 | Fenway Park · Boston, MA |
| 15 | Sun Apr 18 | vs White Sox | L2-3 | 10-5 | .667 | Fenway Park · Boston, MA |
| 16 | Sun Apr 18 | vs White Sox | L1-5 | 10-6 | .625 | Fenway Park · Boston, MA |
| 17 | Mon Apr 19 | vs White Sox | W11-4 | 11-6 | .647 | Fenway Park · Boston, MA |
| 18 | Tue Apr 20 | vs Blue Jays | W4-2 | 12-6 | .667 | Fenway Park · Boston, MA |
| 19 | Wed Apr 21 | vs Blue Jays | L3-6 | 12-7 | .632 | Fenway Park · Boston, MA |
| 20 | Thu Apr 22 | vs Mariners | L3-7 (10) | 12-8 | .600 | Fenway Park · Boston, MA |
| 21 | Fri Apr 23 | vs Mariners | W6-5 | 13-8 | .619 | Fenway Park · Boston, MA |
| 22 | Sat Apr 24 | vs Mariners | L2-8 | 13-9 | .591 | Fenway Park · Boston, MA |
| 23 | Sun Apr 25 | vs Mariners | W5-3 | 14-9 | .609 | Fenway Park · Boston, MA |
| 24 | Tue Apr 27 | at Mets | W2-1 | 15-9 | .625 | Citi Field · Queens, NY |
| 25 | Wed Apr 28 | at Mets | W1-0 | 16-9 | .640 | Citi Field · Queens, NY |
| 26 | Thu Apr 29 | at Rangers | L1-4 | 16-10 | .615 | Globe Life Field · Arlington, TX |
| 27 | Fri Apr 30 | at Rangers | W6-1 | 17-10 | .630 | Globe Life Field · Arlington, TX |
| 28 | Sat May 1 | at Rangers | L6-8 | 17-11 | .607 | Globe Life Field · Arlington, TX |
| 29 | Sun May 2 | at Rangers | L3-5 | 17-12 | .586 | Globe Life Field · Arlington, TX |
| 30 | Tue May 4 | vs Tigers | W11-7 | 18-12 | .600 | Fenway Park · Boston, MA |
| 31 | Wed May 5 | vs Tigers | L5-6 (10) | 18-13 | .581 | Fenway Park · Boston, MA |
| 32 | Thu May 6 | vs Tigers | W12-9 | 19-13 | .594 | Fenway Park · Boston, MA |
| 33 | Fri May 7 | at Orioles | W6-2 | 20-13 | .606 | Camden Yards · Baltimore, MD |
| 34 | Sat May 8 | at Orioles | W11-6 | 21-13 | .618 | Camden Yards · Baltimore, MD |
| 35 | Sun May 9 | at Orioles | W4-3 | 22-13 | .629 | Camden Yards · Baltimore, MD |
| 36 | Mon May 10 | at Orioles | L1-4 | 22-14 | .611 | Camden Yards · Baltimore, MD |
| 37 | Tue May 11 | vs Athletics | L2-3 | 22-15 | .595 | Fenway Park · Boston, MA |
| 38 | Wed May 12 | vs Athletics | L1-4 | 22-16 | .579 | Fenway Park · Boston, MA |
| 39 | Thu May 13 | vs Athletics | W8-1 | 23-16 | .590 | Fenway Park · Boston, MA |
| 40 | Fri May 14 | vs Angels | W4-3 | 24-16 | .600 | Fenway Park · Boston, MA |
| 41 | Sat May 15 | vs Angels | W9-0 | 25-16 | .610 | Fenway Park · Boston, MA |
| 42 | Sun May 16 | vs Angels | L5-6 | 25-17 | .595 | Fenway Park · Boston, MA |
| 43 | Tue May 18 | at Blue Jays | L0-8 | 25-18 | .581 | Rogers Centre · Toronto, ON |
| 44 | Wed May 19 | at Blue Jays | W7-3 | 26-18 | .591 | Rogers Centre · Toronto, ON |
| 45 | Thu May 20 | at Blue Jays | W8-7 | 27-18 | .600 | Rogers Centre · Toronto, ON |
| 46 | Fri May 21 | at Phillies | W11-3 | 28-18 | .609 | Citizens Bank Park · Philadelphi, PA |
| 47 | Sat May 22 | at Phillies | W4-3 | 29-18 | .617 | Citizens Bank Park · Philadelphi, PA |
| 48 | Sun May 23 | at Phillies | L2-6 | 29-19 | .604 | Citizens Bank Park · Philadelphi, PA |
| 49 | Tue May 25 | vs Braves | L1-3 | 29-20 | .592 | Fenway Park · Boston, MA |
| 50 | Wed May 26 | vs Braves | W9-5 | 30-20 | .600 | Fenway Park · Boston, MA |
| 51 | Fri May 28 | vs Marlins | W5-2 | 31-20 | .608 | Fenway Park · Boston, MA |
| 52 | Sat May 29 | vs Marlins | W3-1 | 32-20 | .615 | Fenway Park · Boston, MA |
| 53 | Mon May 31 | at Astros | L2-11 | 32-21 | .604 | Minute Maid Park · Houston, TX |
| 54 | Tue Jun 1 | at Astros | L1-5 | 32-22 | .593 | Minute Maid Park · Houston, TX |
| 55 | Wed Jun 2 | at Astros | L1-2 | 32-23 | .582 | Minute Maid Park · Houston, TX |
| 56 | Thu Jun 3 | at Astros | W5-1 | 33-23 | .589 | Minute Maid Park · Houston, TX |
| 57 | Fri Jun 4 | at Yankees | W5-2 | 34-23 | .596 | Yankee Stadium · The Bronx, NY |
| 58 | Sat Jun 5 | at Yankees | W7-3 | 35-23 | .603 | Yankee Stadium · The Bronx, NY |
| 59 | Sun Jun 6 | at Yankees | W6-5 (10) | 36-23 | .610 | Yankee Stadium · The Bronx, NY |
| 60 | Mon Jun 7 | vs Marlins | W5-3 | 37-23 | .617 | Fenway Park · Boston, MA |
| 61 | Tue Jun 8 | vs Astros | L1-7 | 37-24 | .607 | Fenway Park · Boston, MA |
| 62 | Wed Jun 9 | vs Astros | L3-8 | 37-25 | .597 | Fenway Park · Boston, MA |
| 63 | Thu Jun 10 | vs Astros | W12-8 | 38-25 | .603 | Fenway Park · Boston, MA |
| 64 | Fri Jun 11 | vs Blue Jays | W6-5 | 39-25 | .609 | Fenway Park · Boston, MA |
| 65 | Sat Jun 12 | vs Blue Jays | L2-7 | 39-26 | .600 | Fenway Park · Boston, MA |
| 66 | Sun Jun 13 | vs Blue Jays | L4-18 | 39-27 | .591 | Fenway Park · Boston, MA |
| 67 | Mon Jun 14 | vs Blue Jays | W2-1 | 40-27 | .597 | Fenway Park · Boston, MA |
| 68 | Tue Jun 15 | at Braves | W10-8 | 41-27 | .603 | Truist Park · Cumberland, GA |
| 69 | Wed Jun 16 | at Braves | W10-8 | 42-27 | .609 | Truist Park · Cumberland, GA |
| 70 | Fri Jun 18 | at Royals | L3-5 | 42-28 | .600 | Kauffman Stadium · Kansas City, MO |
| 71 | Sat Jun 19 | at Royals | W7-1 | 43-28 | .606 | Kauffman Stadium · Kansas City, MO |
| 72 | Sun Jun 20 | at Royals | L3-7 | 43-29 | .597 | Kauffman Stadium · Kansas City, MO |
| 73 | Tue Jun 22 | at Rays | W9-5 (11) | 44-29 | .603 | Tropicana Field · St. Petersburg, FL |
| 74 | Wed Jun 23 | at Rays | L2-8 | 44-30 | .595 | Tropicana Field · St. Petersburg, FL |
| 75 | Thu Jun 24 | at Rays | L0-1 | 44-31 | .587 | Tropicana Field · St. Petersburg, FL |
| 76 | Fri Jun 25 | vs Yankees | W5-3 | 45-31 | .592 | Fenway Park · Boston, MA |
| 77 | Sat Jun 26 | vs Yankees | W4-2 | 46-31 | .597 | Fenway Park · Boston, MA |
| 78 | Sun Jun 27 | vs Yankees | W9-2 | 47-31 | .603 | Fenway Park · Boston, MA |
| 79 | Mon Jun 28 | vs Royals | W6-5 | 48-31 | .608 | Fenway Park · Boston, MA |
| 80 | Tue Jun 29 | vs Royals | W7-6 | 49-31 | .613 | Fenway Park · Boston, MA |
| 81 | Wed Jun 30 | vs Royals | W6-2 | 50-31 | .617 | Fenway Park · Boston, MA |
| 82 | Thu Jul 1 | vs Royals | W15-1 | 51-31 | .622 | Fenway Park · Boston, MA |
| 83 | Fri Jul 2 | at Athletics | W3-2 (10) | 52-31 | .627 | RingCentral Coliseum · Oakland, CA |
| 84 | Sat Jul 3 | at Athletics | L6-7 (12) | 52-32 | .619 | RingCentral Coliseum · Oakland, CA |
| 85 | Sun Jul 4 | at Athletics | W1-0 | 53-32 | .624 | RingCentral Coliseum · Oakland, CA |
| 86 | Mon Jul 5 | at Angels | W5-4 | 54-32 | .628 | Angel Stadium · Anaheim, CA |
| 87 | Tue Jul 6 | at Angels | L3-5 | 54-33 | .621 | Angel Stadium · Anaheim, CA |
| 88 | Wed Jul 7 | at Angels | L4-5 | 54-34 | .614 | Angel Stadium · Anaheim, CA |
| 89 | Fri Jul 9 | vs Phillies | W11-5 | 55-34 | .618 | Fenway Park · Boston, MA |
| 90 | Sat Jul 10 | vs Phillies | L2-11 | 55-35 | .611 | Fenway Park · Boston, MA |
| 91 | Sun Jul 11 | vs Phillies | L4-5 | 55-36 | .604 | Fenway Park · Boston, MA |
| 92 | Fri Jul 16 | at Yankees | W4-0 | 56-36 | .609 | Yankee Stadium · The Bronx, NY |
| 93 | Sat Jul 17 | at Yankees | L1-3 | 56-37 | .602 | Yankee Stadium · The Bronx, NY |
| 94 | Sun Jul 18 | at Yankees | L1-9 | 56-38 | .596 | Yankee Stadium · The Bronx, NY |
| 95 | Mon Jul 19 | at Blue Jays | W13-4 | 57-38 | .600 | Rogers Centre · Toronto, ON |
| 96 | Wed Jul 21 | at Blue Jays | W7-4 | 58-38 | .604 | Rogers Centre · Toronto, ON |
| 97 | Thu Jul 22 | vs Yankees | W5-4 (10) | 59-38 | .608 | Fenway Park · Boston, MA |
| 98 | Fri Jul 23 | vs Yankees | W6-2 | 60-38 | .612 | Fenway Park · Boston, MA |
| 99 | Sat Jul 24 | vs Yankees | L3-4 | 60-39 | .606 | Fenway Park · Boston, MA |
| 100 | Sun Jul 25 | vs Yankees | W5-4 | 61-39 | .610 | Fenway Park · Boston, MA |
| 101 | Mon Jul 26 | vs Blue Jays | W5-4 | 62-39 | .614 | Fenway Park · Boston, MA |
| 102 | Wed Jul 28 | vs Blue Jays | L1-4 | 62-40 | .608 | Fenway Park · Boston, MA |
| 103 | Wed Jul 28 | vs Blue Jays | W4-1 | 63-40 | .612 | Fenway Park · Boston, MA |
| 104 | Thu Jul 29 | vs Blue Jays | L1-13 | 63-41 | .606 | Fenway Park · Boston, MA |
| 105 | Fri Jul 30 | at Rays | L3-7 | 63-42 | .600 | Tropicana Field · St. Petersburg, FL |
| 106 | Sat Jul 31 | at Rays | L5-9 | 63-43 | .594 | Tropicana Field · St. Petersburg, FL |
| 107 | Sun Aug 1 | at Rays | L2-3 | 63-44 | .589 | Tropicana Field · St. Petersburg, FL |
| 108 | Tue Aug 3 | at Tigers | L2-4 | 63-45 | .583 | Comerica Park · Detroit, MI |
| 109 | Wed Aug 4 | at Tigers | W4-1 | 64-45 | .587 | Comerica Park · Detroit, MI |
| 110 | Thu Aug 5 | at Tigers | L1-8 | 64-46 | .582 | Comerica Park · Detroit, MI |
| 111 | Fri Aug 6 | at Blue Jays | L4-12 | 64-47 | .577 | Rogers Centre · Toronto, ON |
| 112 | Sat Aug 7 | at Blue Jays | L0-1 | 64-48 | .571 | Rogers Centre · Toronto, ON |
| 113 | Sat Aug 7 | at Blue Jays | W2-1 (8) | 65-48 | .575 | Rogers Centre · Toronto, ON |
| 114 | Sun Aug 8 | at Blue Jays | L8-9 | 65-49 | .570 | Rogers Centre · Toronto, ON |
| 115 | Tue Aug 10 | vs Rays | L4-8 | 65-50 | .565 | Fenway Park · Boston, MA |
| 116 | Wed Aug 11 | vs Rays | W20-8 | 66-50 | .569 | Fenway Park · Boston, MA |
| 117 | Thu Aug 12 | vs Rays | L1-8 | 66-51 | .564 | Fenway Park · Boston, MA |
| 118 | Fri Aug 13 | vs Orioles | W8-1 | 67-51 | .568 | Fenway Park · Boston, MA |
| 119 | Sat Aug 14 | vs Orioles | W16-2 | 68-51 | .571 | Fenway Park · Boston, MA |
| 120 | Sun Aug 15 | vs Orioles | W6-2 | 69-51 | .575 | Fenway Park · Boston, MA |
| 121 | Tue Aug 17 | at Yankees | L3-5 | 69-52 | .570 | Yankee Stadium · The Bronx, NY |
| 122 | Tue Aug 17 | at Yankees | L0-2 | 69-53 | .566 | Yankee Stadium · The Bronx, NY |
| 123 | Wed Aug 18 | at Yankees | L2-5 | 69-54 | .561 | Yankee Stadium · The Bronx, NY |
| 124 | Fri Aug 20 | vs Rangers | W6-0 | 70-54 | .565 | Fenway Park · Boston, MA |
| 125 | Sat Aug 21 | vs Rangers | L1-10 | 70-55 | .560 | Fenway Park · Boston, MA |
| 126 | Mon Aug 23 | vs Rangers | W8-4 (11) | 71-55 | .563 | Fenway Park · Boston, MA |
| 127 | Tue Aug 24 | vs Twins | W11-9 | 72-55 | .567 | Fenway Park · Boston, MA |
| 128 | Wed Aug 25 | vs Twins | L6-9 (10) | 72-56 | .563 | Fenway Park · Boston, MA |
| 129 | Thu Aug 26 | vs Twins | W12-2 | 73-56 | .566 | Fenway Park · Boston, MA |
| 130 | Fri Aug 27 | at Guardians | W4-3 | 74-56 | .569 | Progressive Field · Cleveland, OH |
| 131 | Sat Aug 28 | at Guardians | W5-3 (10) | 75-56 | .573 | Progressive Field · Cleveland, OH |
| 132 | Sun Aug 29 | at Guardians | L5-7 | 75-57 | .568 | Progressive Field · Cleveland, OH |
| 133 | Mon Aug 30 | at Rays | L1-6 | 75-58 | .564 | Tropicana Field · St. Petersburg, FL |
| 134 | Tue Aug 31 | at Rays | L5-8 | 75-59 | .560 | Tropicana Field · St. Petersburg, FL |
| 135 | Wed Sep 1 | at Rays | W3-2 | 76-59 | .563 | Tropicana Field · St. Petersburg, FL |
| 136 | Thu Sep 2 | at Rays | W4-0 | 77-59 | .566 | Tropicana Field · St. Petersburg, FL |
| 137 | Fri Sep 3 | vs Guardians | W8-5 | 78-59 | .569 | Fenway Park · Boston, MA |
| 138 | Sat Sep 4 | vs Guardians | W4-3 | 79-59 | .572 | Fenway Park · Boston, MA |
| 139 | Sun Sep 5 | vs Guardians | L5-11 | 79-60 | .568 | Fenway Park · Boston, MA |
| 140 | Mon Sep 6 | vs Rays | L10-11 (10) | 79-61 | .564 | Fenway Park · Boston, MA |
| 141 | Tue Sep 7 | vs Rays | L7-12 | 79-62 | .560 | Fenway Park · Boston, MA |
| 142 | Wed Sep 8 | vs Rays | W2-1 | 80-62 | .563 | Fenway Park · Boston, MA |
| 143 | Fri Sep 10 | at White Sox | L3-4 | 80-63 | .559 | Guaranteed Rate Field · Chicago, IL |
| 144 | Sat Sep 11 | at White Sox | W9-8 (10) | 81-63 | .563 | Guaranteed Rate Field · Chicago, IL |
| 145 | Sun Sep 12 | at White Sox | L1-2 | 81-64 | .559 | Guaranteed Rate Field · Chicago, IL |
| 146 | Mon Sep 13 | at Mariners | L4-5 | 81-65 | .555 | T-Mobile Park · Seattle, WA |
| 147 | Tue Sep 14 | at Mariners | W8-4 | 82-65 | .558 | T-Mobile Park · Seattle, WA |
| 148 | Wed Sep 15 | at Mariners | W9-4 (10) | 83-65 | .561 | T-Mobile Park · Seattle, WA |
| 149 | Fri Sep 17 | vs Orioles | W7-1 | 84-65 | .564 | Fenway Park · Boston, MA |
| 150 | Sat Sep 18 | vs Orioles | W9-3 | 85-65 | .567 | Fenway Park · Boston, MA |
| 151 | Sun Sep 19 | vs Orioles | W8-6 | 86-65 | .570 | Fenway Park · Boston, MA |
| 152 | Tue Sep 21 | vs Mets | W6-3 | 87-65 | .572 | Fenway Park · Boston, MA |
| 153 | Wed Sep 22 | vs Mets | W12-5 | 88-65 | .575 | Fenway Park · Boston, MA |
| 154 | Fri Sep 24 | vs Yankees | L3-8 | 88-66 | .571 | Fenway Park · Boston, MA |
| 155 | Sat Sep 25 | vs Yankees | L3-5 | 88-67 | .568 | Fenway Park · Boston, MA |
| 156 | Sun Sep 26 | vs Yankees | L3-6 | 88-68 | .564 | Fenway Park · Boston, MA |
| 157 | Tue Sep 28 | at Orioles | L2-4 | 88-69 | .561 | Camden Yards · Baltimore, MD |
| 158 | Wed Sep 29 | at Orioles | W6-0 | 89-69 | .563 | Camden Yards · Baltimore, MD |
| 159 | Thu Sep 30 | at Orioles | L2-6 | 89-70 | .560 | Camden Yards · Baltimore, MD |
| 160 | Fri Oct 1 | at Nationals | W4-2 | 90-70 | .563 | Nationals Park · Washington, D.C. |
| 161 | Sat Oct 2 | at Nationals | W5-3 | 91-70 | .565 | Nationals Park · Washington, D.C. |
| 162 | Sun Oct 3 | at Nationals | W7-5 | 92-70 | .568 | Nationals Park · Washington, D.C. |
| 163 | Tue Oct 5 | vs Yankees | W6-2 | 1-0 | 1.000 | Fenway Park · Boston, MA |
| 164 | Thu Oct 7 | at Rays | L0-5 | 0-1 | .000 | Tropicana Field · St. Petersburg, FL |
| 165 | Fri Oct 8 | at Rays | W14-6 | 1-1 | .500 | Tropicana Field · St. Petersburg, FL |
| 166 | Sun Oct 10 | vs Rays | W6-4 (13) | 2-1 | .667 | Fenway Park · Boston, MA |
| 167 | Mon Oct 11 | vs Rays | W6-5 | 3-1 | .750 | Fenway Park · Boston, MA |
| 168 | Fri Oct 15 | at Astros | L4-5 | 0-1 | .000 | Minute Maid Park · Houston, TX |
| 169 | Sat Oct 16 | at Astros | W9-5 | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 170 | Mon Oct 18 | vs Astros | W12-3 | 2-1 | .667 | Fenway Park · Boston, MA |
| 171 | Tue Oct 19 | vs Astros | L2-9 | 2-2 | .500 | Fenway Park · Boston, MA |
| 172 | Wed Oct 20 | vs Astros | L1-9 | 2-3 | .400 | Fenway Park · Boston, MA |
| 173 | Fri Oct 22 | at Astros | L0-5 | 2-4 | .333 | Minute Maid Park · Houston, TX |