| 1 | Fri Apr 1 | at Rangers | L5-9 | 0-1 | .000 | Globe Life Field · Arlington, TX |
| 2 | Sat Apr 2 | at Rangers | L5-12 | 0-2 | .000 | Globe Life Field · Arlington, TX |
| 3 | Sun Apr 3 | at Rangers | L1-5 | 0-3 | .000 | Globe Life Field · Arlington, TX |
| 4 | Tue Apr 5 | at Guardians | L1-3 | 0-4 | .000 | Progressive Field · Cleveland, OH |
| 5 | Wed Apr 6 | at Guardians | L4-8 | 0-5 | .000 | Progressive Field · Cleveland, OH |
| 6 | Thu Apr 7 | at Guardians | L0-1 | 0-6 | .000 | Progressive Field · Cleveland, OH |
| 7 | Fri Apr 8 | vs Yankees | W9-6 | 1-6 | .143 | Fenway Park · Boston, MA |
| 8 | Sat Apr 9 | vs Yankees | L4-9 | 1-7 | .125 | Fenway Park · Boston, MA |
| 9 | Sun Apr 10 | vs Yankees | W4-0 | 2-7 | .222 | Fenway Park · Boston, MA |
| 10 | Mon Apr 11 | vs Rays | L5-16 | 2-8 | .200 | Fenway Park · Boston, MA |
| 11 | Tue Apr 12 | vs Rays | L2-3 | 2-9 | .182 | Fenway Park · Boston, MA |
| 12 | Fri Apr 15 | vs Blue Jays | L6-7 | 2-10 | .167 | Fenway Park · Boston, MA |
| 13 | Sat Apr 16 | vs Blue Jays | W4-1 | 3-10 | .231 | Fenway Park · Boston, MA |
| 14 | Sun Apr 17 | vs Blue Jays | W8-1 | 4-10 | .286 | Fenway Park · Boston, MA |
| 15 | Mon Apr 18 | vs Blue Jays | W9-1 | 5-10 | .333 | Fenway Park · Boston, MA |
| 16 | Tue Apr 19 | at Athletics | L0-5 | 5-11 | .313 | RingCentral Coliseum · Oakland, CA |
| 17 | Wed Apr 20 | at Athletics | W5-3 | 6-11 | .353 | RingCentral Coliseum · Oakland, CA |
| 18 | Thu Apr 21 | at Angels | W4-2 (11) | 7-11 | .389 | Angel Stadium · Anaheim, CA |
| 19 | Fri Apr 22 | at Angels | W4-3 | 8-11 | .421 | Angel Stadium · Anaheim, CA |
| 20 | Sat Apr 23 | at Angels | W5-0 | 9-11 | .450 | Angel Stadium · Anaheim, CA |
| 21 | Sun Apr 24 | at Angels | W7-0 | 10-11 | .476 | Angel Stadium · Anaheim, CA |
| 22 | Tue Apr 26 | at Orioles | L1-4 | 10-12 | .455 | Camden Yards · Baltimore, MD |
| 23 | Wed Apr 27 | at Orioles | L4-5 | 10-13 | .435 | Camden Yards · Baltimore, MD |
| 24 | Thu Apr 28 | at Orioles | W6-2 | 11-13 | .458 | Camden Yards · Baltimore, MD |
| 25 | Fri Apr 29 | vs Mariners | L4-5 | 11-14 | .440 | Fenway Park · Boston, MA |
| 26 | Sat Apr 30 | vs Mariners | L0-2 | 11-15 | .423 | Fenway Park · Boston, MA |
| 27 | Sun May 1 | vs Mariners | W3-2 | 12-15 | .444 | Fenway Park · Boston, MA |
| 28 | Mon May 2 | vs Angels | W9-5 | 13-15 | .464 | Fenway Park · Boston, MA |
| 29 | Tue May 3 | vs Angels | W7-3 | 14-15 | .483 | Fenway Park · Boston, MA |
| 30 | Wed May 4 | vs Angels | L3-5 (13) | 14-16 | .467 | Fenway Park · Boston, MA |
| 31 | Thu May 5 | vs Angels | L0-11 | 14-17 | .452 | Fenway Park · Boston, MA |
| 32 | Fri May 6 | vs Twins | L2-9 | 14-18 | .438 | Fenway Park · Boston, MA |
| 33 | Sat May 7 | vs Twins | W4-0 | 15-18 | .455 | Fenway Park · Boston, MA |
| 34 | Sun May 8 | vs Twins | W9-5 | 16-18 | .471 | Fenway Park · Boston, MA |
| 35 | Mon May 9 | vs Twins | W2-1 (11) | 17-18 | .486 | Fenway Park · Boston, MA |
| 36 | Tue May 10 | at Blue Jays | L6-7 (10) | 17-19 | .472 | Rogers Centre · Toronto, ON |
| 37 | Wed May 11 | at Blue Jays | L3-9 | 17-20 | .459 | Rogers Centre · Toronto, ON |
| 38 | Fri May 13 | at Yankees | W5-4 | 18-20 | .474 | Yankee Stadium · The Bronx, NY |
| 39 | Sat May 14 | at Yankees | W6-0 | 19-20 | .487 | Yankee Stadium · The Bronx, NY |
| 40 | Sun May 15 | at Yankees | W7-5 | 20-20 | .500 | Yankee Stadium · The Bronx, NY |
| 41 | Mon May 16 | vs Orioles | W8-7 | 21-20 | .512 | Fenway Park · Boston, MA |
| 42 | Wed May 18 | vs Tigers | W1-0 | 22-20 | .524 | Fenway Park · Boston, MA |
| 43 | Thu May 19 | vs Tigers | W4-3 | 23-20 | .535 | Fenway Park · Boston, MA |
| 44 | Fri May 20 | vs Cubs | W15-5 | 24-20 | .545 | Fenway Park · Boston, MA |
| 45 | Sat May 21 | vs Cubs | L3-9 | 24-21 | .533 | Fenway Park · Boston, MA |
| 46 | Sun May 22 | vs Cubs | W5-1 | 25-21 | .543 | Fenway Park · Boston, MA |
| 47 | Mon May 23 | at Guardians | L2-3 | 25-22 | .532 | Progressive Field · Cleveland, OH |
| 48 | Tue May 24 | at Guardians | W4-2 | 26-22 | .542 | Progressive Field · Cleveland, OH |
| 49 | Wed May 25 | at Guardians | W14-2 | 27-22 | .551 | Progressive Field · Cleveland, OH |
| 50 | Thu May 26 | at Tigers | W14-1 | 28-22 | .560 | Comerica Park · Detroit, MI |
| 51 | Fri May 27 | at Tigers | W6-3 | 29-22 | .569 | Comerica Park · Detroit, MI |
| 52 | Sun May 29 | at Tigers | W4-3 | 30-22 | .577 | Comerica Park · Detroit, MI |
| 53 | Sun May 29 | at Tigers | L0-3 | 30-23 | .566 | Comerica Park · Detroit, MI |
| 54 | Mon May 30 | vs White Sox | L3-7 | 30-24 | .556 | Fenway Park · Boston, MA |
| 55 | Tue May 31 | vs White Sox | L7-10 | 30-25 | .545 | Fenway Park · Boston, MA |
| 56 | Wed Jun 1 | vs White Sox | L4-7 | 30-26 | .536 | Fenway Park · Boston, MA |
| 57 | Fri Jun 3 | vs Athletics | W8-6 | 31-26 | .544 | Fenway Park · Boston, MA |
| 58 | Sat Jun 4 | vs Athletics | W9-8 (14) | 32-26 | .552 | Fenway Park · Boston, MA |
| 59 | Sun Jun 5 | vs Athletics | W6-3 | 33-26 | .559 | Fenway Park · Boston, MA |
| 60 | Tue Jun 7 | at Yankees | W6-4 | 34-26 | .567 | Yankee Stadium · The Bronx, NY |
| 61 | Wed Jun 8 | at Yankees | W11-6 | 35-26 | .574 | Yankee Stadium · The Bronx, NY |
| 62 | Thu Jun 9 | at Yankees | W8-3 | 36-26 | .581 | Yankee Stadium · The Bronx, NY |
| 63 | Fri Jun 10 | at Blue Jays | W5-1 | 37-26 | .587 | Rogers Centre · Toronto, ON |
| 64 | Sat Jun 11 | at Blue Jays | W16-4 | 38-26 | .594 | Rogers Centre · Toronto, ON |
| 65 | Sun Jun 12 | at Blue Jays | W14-1 | 39-26 | .600 | Rogers Centre · Toronto, ON |
| 66 | Tue Jun 14 | at Rays | L0-4 | 39-27 | .591 | Tropicana Field · St. Petersburg, FL |
| 67 | Wed Jun 15 | at Rays | W3-0 | 40-27 | .597 | Tropicana Field · St. Petersburg, FL |
| 68 | Thu Jun 16 | at Rays | W4-2 | 41-27 | .603 | Tropicana Field · St. Petersburg, FL |
| 69 | Fri Jun 17 | vs Brewers | W10-4 | 42-27 | .609 | Fenway Park · Boston, MA |
| 70 | Sat Jun 18 | vs Brewers | L2-4 | 42-28 | .600 | Fenway Park · Boston, MA |
| 71 | Sun Jun 19 | vs Brewers | W12-3 | 43-28 | .606 | Fenway Park · Boston, MA |
| 72 | Mon Jun 20 | vs Padres | W14-5 | 44-28 | .611 | Fenway Park · Boston, MA |
| 73 | Tue Jun 21 | vs Padres | L4-5 | 44-29 | .603 | Fenway Park · Boston, MA |
| 74 | Wed Jun 22 | vs Padres | L1-5 | 44-30 | .595 | Fenway Park · Boston, MA |
| 75 | Fri Jun 24 | at Pirates | L1-3 | 44-31 | .587 | PNC Park · Pittsburgh, PA |
| 76 | Sat Jun 25 | at Pirates | L4-6 | 44-32 | .579 | PNC Park · Pittsburgh, PA |
| 77 | Sun Jun 26 | at Pirates | W4-2 | 45-32 | .584 | PNC Park · Pittsburgh, PA |
| 78 | Tue Jun 28 | at Phillies | L0-5 | 45-33 | .577 | Citizens Bank Park · Philadelphi, PA |
| 79 | Wed Jun 29 | at Phillies | L1-2 | 45-34 | .570 | Citizens Bank Park · Philadelphi, PA |
| 80 | Thu Jun 30 | at Phillies | W5-2 | 46-34 | .575 | Citizens Bank Park · Philadelphi, PA |
| 81 | Fri Jul 1 | at Astros | W7-5 | 47-34 | .580 | Minute Maid Park · Houston, TX |
| 82 | Sat Jul 2 | at Astros | W10-4 | 48-34 | .585 | Minute Maid Park · Houston, TX |
| 83 | Sun Jul 3 | at Astros | W2-1 | 49-34 | .590 | Minute Maid Park · Houston, TX |
| 84 | Mon Jul 4 | vs Blue Jays | L7-9 | 49-35 | .583 | Fenway Park · Boston, MA |
| 85 | Tue Jul 5 | vs Blue Jays | W3-2 | 50-35 | .588 | Fenway Park · Boston, MA |
| 86 | Wed Jul 6 | vs Blue Jays | W6-4 | 51-35 | .593 | Fenway Park · Boston, MA |
| 87 | Thu Jul 7 | vs Orioles | W10-4 | 52-35 | .598 | Fenway Park · Boston, MA |
| 88 | Fri Jul 8 | vs Orioles | W10-3 | 53-35 | .602 | Fenway Park · Boston, MA |
| 89 | Sat Jul 9 | vs Orioles | W4-0 | 54-35 | .607 | Fenway Park · Boston, MA |
| 90 | Sun Jul 10 | vs Orioles | W8-6 | 55-35 | .611 | Fenway Park · Boston, MA |
| 91 | Fri Jul 15 | at Rays | L6-9 | 55-36 | .604 | Tropicana Field · St. Petersburg, FL |
| 92 | Sat Jul 16 | at Rays | W9-5 | 56-36 | .609 | Tropicana Field · St. Petersburg, FL |
| 93 | Sun Jul 17 | at Rays | W1-0 (16) | 57-36 | .613 | Tropicana Field · St. Petersburg, FL |
| 94 | Mon Jul 18 | at Orioles | W15-10 | 58-36 | .617 | Camden Yards · Baltimore, MD |
| 95 | Tue Jul 19 | at Orioles | L2-6 | 58-37 | .611 | Camden Yards · Baltimore, MD |
| 96 | Wed Jul 20 | at Orioles | W4-0 | 59-37 | .615 | Camden Yards · Baltimore, MD |
| 97 | Fri Jul 22 | vs Mariners | W7-4 | 60-37 | .619 | Fenway Park · Boston, MA |
| 98 | Sat Jul 23 | vs Mariners | W3-1 | 61-37 | .622 | Fenway Park · Boston, MA |
| 99 | Sun Jul 24 | vs Mariners | W12-8 | 62-37 | .626 | Fenway Park · Boston, MA |
| 100 | Mon Jul 25 | vs Royals | L1-3 (14) | 62-38 | .620 | Fenway Park · Boston, MA |
| 101 | Tue Jul 26 | vs Royals | W13-9 | 63-38 | .624 | Fenway Park · Boston, MA |
| 102 | Wed Jul 27 | vs Royals | W12-5 | 64-38 | .627 | Fenway Park · Boston, MA |
| 103 | Thu Jul 28 | vs Royals | L3-4 | 64-39 | .621 | Fenway Park · Boston, MA |
| 104 | Fri Jul 29 | at White Sox | L1-3 | 64-40 | .615 | Guaranteed Rate Field · Chicago, IL |
| 105 | Sat Jul 30 | at White Sox | W10-2 | 65-40 | .619 | Guaranteed Rate Field · Chicago, IL |
| 106 | Sun Jul 31 | at White Sox | W5-3 | 66-40 | .623 | Guaranteed Rate Field · Chicago, IL |
| 107 | Mon Aug 1 | vs Guardians | L6-9 | 66-41 | .617 | Fenway Park · Boston, MA |
| 108 | Tue Aug 2 | vs Guardians | W3-2 | 67-41 | .620 | Fenway Park · Boston, MA |
| 109 | Wed Aug 3 | vs Guardians | W4-3 | 68-41 | .624 | Fenway Park · Boston, MA |
| 110 | Thu Aug 4 | vs Guardians | L3-7 | 68-42 | .618 | Fenway Park · Boston, MA |
| 111 | Fri Aug 5 | vs Yankees | L2-3 | 68-43 | .613 | Fenway Park · Boston, MA |
| 112 | Sat Aug 6 | vs Yankees | W10-4 | 69-43 | .616 | Fenway Park · Boston, MA |
| 113 | Sun Aug 7 | vs Yankees | W3-2 (10) | 70-43 | .619 | Fenway Park · Boston, MA |
| 114 | Mon Aug 8 | at Twins | W8-6 | 71-43 | .623 | Target Field · Minneapolis, MN |
| 115 | Tue Aug 9 | at Twins | W4-3 | 72-43 | .626 | Target Field · Minneapolis, MN |
| 116 | Wed Aug 10 | at Twins | L2-5 | 72-44 | .621 | Target Field · Minneapolis, MN |
| 117 | Fri Aug 12 | at Mariners | W6-4 | 73-44 | .624 | T-Mobile Park · Seattle, WA |
| 118 | Sat Aug 13 | at Mariners | L4-5 | 73-45 | .619 | T-Mobile Park · Seattle, WA |
| 119 | Sun Aug 14 | at Mariners | L3-5 | 73-46 | .613 | T-Mobile Park · Seattle, WA |
| 120 | Tue Aug 16 | vs Rays | W3-1 | 74-46 | .617 | Fenway Park · Boston, MA |
| 121 | Tue Aug 16 | vs Rays | L2-6 | 74-47 | .612 | Fenway Park · Boston, MA |
| 122 | Wed Aug 17 | vs Rays | L0-4 | 74-48 | .607 | Fenway Park · Boston, MA |
| 123 | Thu Aug 18 | at Royals | W4-3 | 75-48 | .610 | Kauffman Stadium · Kansas City, MO |
| 124 | Fri Aug 19 | at Royals | W7-1 | 76-48 | .613 | Kauffman Stadium · Kansas City, MO |
| 125 | Sat Aug 20 | at Royals | L4-9 | 76-49 | .608 | Kauffman Stadium · Kansas City, MO |
| 126 | Sun Aug 21 | at Royals | W6-1 | 77-49 | .611 | Kauffman Stadium · Kansas City, MO |
| 127 | Mon Aug 22 | at Rangers | L0-4 | 77-50 | .606 | Globe Life Field · Arlington, TX |
| 128 | Tue Aug 23 | at Rangers | W11-5 | 78-50 | .609 | Globe Life Field · Arlington, TX |
| 129 | Wed Aug 24 | at Rangers | W13-2 | 79-50 | .612 | Globe Life Field · Arlington, TX |
| 130 | Thu Aug 25 | at Rangers | W6-0 | 80-50 | .615 | Globe Life Field · Arlington, TX |
| 131 | Fri Aug 26 | vs Athletics | L5-15 | 80-51 | .611 | Fenway Park · Boston, MA |
| 132 | Sat Aug 27 | vs Athletics | W9-3 | 81-51 | .614 | Fenway Park · Boston, MA |
| 133 | Sat Aug 27 | vs Athletics | W4-0 | 82-51 | .617 | Fenway Park · Boston, MA |
| 134 | Tue Aug 30 | vs Yankees | L2-5 | 82-52 | .612 | Fenway Park · Boston, MA |
| 135 | Wed Aug 31 | vs Yankees | W9-5 | 83-52 | .615 | Fenway Park · Boston, MA |
| 136 | Thu Sep 1 | vs Yankees | L2-4 | 83-53 | .610 | Fenway Park · Boston, MA |
| 137 | Fri Sep 2 | vs Rangers | L0-10 | 83-54 | .606 | Fenway Park · Boston, MA |
| 138 | Sat Sep 3 | vs Rangers | W12-7 | 84-54 | .609 | Fenway Park · Boston, MA |
| 139 | Sun Sep 4 | vs Rangers | L4-11 | 84-55 | .604 | Fenway Park · Boston, MA |
| 140 | Mon Sep 5 | at Blue Jays | L0-1 (11) | 84-56 | .600 | Rogers Centre · Toronto, ON |
| 141 | Tue Sep 6 | at Blue Jays | W14-0 | 85-56 | .603 | Rogers Centre · Toronto, ON |
| 142 | Wed Sep 7 | at Blue Jays | L10-11 | 85-57 | .599 | Rogers Centre · Toronto, ON |
| 143 | Thu Sep 8 | at Blue Jays | L4-7 | 85-58 | .594 | Rogers Centre · Toronto, ON |
| 144 | Fri Sep 9 | at Rays | L2-7 | 85-59 | .590 | Tropicana Field · St. Petersburg, FL |
| 145 | Sat Sep 10 | at Rays | L5-6 (11) | 85-60 | .586 | Tropicana Field · St. Petersburg, FL |
| 146 | Sun Sep 11 | at Rays | L1-9 | 85-61 | .582 | Tropicana Field · St. Petersburg, FL |
| 147 | Tue Sep 13 | vs Blue Jays | W18-6 | 86-61 | .585 | Fenway Park · Boston, MA |
| 148 | Wed Sep 14 | vs Blue Jays | L4-5 | 86-62 | .581 | Fenway Park · Boston, MA |
| 149 | Thu Sep 15 | vs Rays | L2-9 | 86-63 | .577 | Fenway Park · Boston, MA |
| 150 | Fri Sep 16 | vs Rays | W4-3 | 87-63 | .580 | Fenway Park · Boston, MA |
| 151 | Sat Sep 17 | vs Rays | L3-4 | 87-64 | .576 | Fenway Park · Boston, MA |
| 152 | Sun Sep 18 | vs Rays | L5-8 | 87-65 | .572 | Fenway Park · Boston, MA |
| 153 | Mon Sep 19 | vs Orioles | L5-6 | 87-66 | .569 | Fenway Park · Boston, MA |
| 154 | Mon Sep 19 | vs Orioles | W18-9 | 88-66 | .571 | Fenway Park · Boston, MA |
| 155 | Tue Sep 20 | vs Orioles | L5-7 | 88-67 | .568 | Fenway Park · Boston, MA |
| 156 | Wed Sep 21 | vs Orioles | L4-6 | 88-68 | .564 | Fenway Park · Boston, MA |
| 157 | Sat Sep 24 | at Yankees | L1-9 | 88-69 | .561 | Yankee Stadium · The Bronx, NY |
| 158 | Sun Sep 25 | at Yankees | L2-6 | 88-70 | .557 | Yankee Stadium · The Bronx, NY |
| 159 | Sun Sep 25 | at Yankees | W7-4 (14) | 89-70 | .560 | Yankee Stadium · The Bronx, NY |
| 160 | Mon Sep 26 | at Orioles | L3-6 | 89-71 | .556 | Camden Yards · Baltimore, MD |
| 161 | Tue Sep 27 | at Orioles | W8-7 | 90-71 | .559 | Camden Yards · Baltimore, MD |
| 162 | Wed Sep 28 | at Orioles | L3-4 | 90-72 | .556 | Camden Yards · Baltimore, MD |