| 1 | Thu Mar 27 | at Rangers | W5-2 | 1-0 | 1.000 | Globe Life Field · Arlington, TX |
| 2 | Fri Mar 28 | at Rangers | L1-4 | 1-1 | .500 | Globe Life Field · Arlington, TX |
| 3 | Sat Mar 29 | at Rangers | L3-4 | 1-2 | .333 | Globe Life Field · Arlington, TX |
| 4 | Sun Mar 30 | at Rangers | L2-3 | 1-3 | .250 | Globe Life Field · Arlington, TX |
| 5 | Mon Mar 31 | at Orioles | L5-8 | 1-4 | .200 | Camden Yards · Baltimore, MD |
| 6 | Wed Apr 2 | at Orioles | W3-0 | 2-4 | .333 | Camden Yards · Baltimore, MD |
| 7 | Thu Apr 3 | at Orioles | W8-4 | 3-4 | .429 | Camden Yards · Baltimore, MD |
| 8 | Fri Apr 4 | vs Cardinals | W13-9 | 4-4 | .500 | Fenway Park · Boston, MA |
| 9 | Sun Apr 6 | vs Cardinals | W5-4 (10) | 5-4 | .556 | Fenway Park · Boston, MA |
| 10 | Sun Apr 6 | vs Cardinals | W18-7 | 6-4 | .600 | Fenway Park · Boston, MA |
| 11 | Mon Apr 7 | vs Blue Jays | L2-6 | 6-5 | .545 | Fenway Park · Boston, MA |
| 12 | Tue Apr 8 | vs Blue Jays | L1-6 | 6-6 | .500 | Fenway Park · Boston, MA |
| 13 | Wed Apr 9 | vs Blue Jays | L1-2 (11) | 6-7 | .462 | Fenway Park · Boston, MA |
| 14 | Thu Apr 10 | vs Blue Jays | W4-3 (10) | 7-7 | .500 | Fenway Park · Boston, MA |
| 15 | Fri Apr 11 | at White Sox | L1-11 | 7-8 | .467 | Guaranteed Rate Field · Chicago, IL |
| 16 | Sat Apr 12 | at White Sox | L2-3 | 7-9 | .438 | Guaranteed Rate Field · Chicago, IL |
| 17 | Sun Apr 13 | at White Sox | W3-1 | 8-9 | .471 | Guaranteed Rate Field · Chicago, IL |
| 18 | Mon Apr 14 | at Rays | L1-16 | 8-10 | .444 | Tropicana Field · St. Petersburg, FL |
| 19 | Tue Apr 15 | at Rays | W7-4 | 9-10 | .474 | Tropicana Field · St. Petersburg, FL |
| 20 | Wed Apr 16 | at Rays | W1-0 | 10-10 | .500 | Tropicana Field · St. Petersburg, FL |
| 21 | Fri Apr 18 | vs White Sox | W10-3 | 11-10 | .524 | Fenway Park · Boston, MA |
| 22 | Sat Apr 19 | vs White Sox | W4-3 (10) | 12-10 | .545 | Fenway Park · Boston, MA |
| 23 | Sun Apr 20 | vs White Sox | L4-8 | 12-11 | .522 | Fenway Park · Boston, MA |
| 24 | Mon Apr 21 | vs White Sox | W4-2 | 13-11 | .542 | Fenway Park · Boston, MA |
| 25 | Tue Apr 22 | vs Mariners | W8-3 | 14-11 | .560 | Fenway Park · Boston, MA |
| 26 | Wed Apr 23 | vs Mariners | L5-8 | 14-12 | .538 | Fenway Park · Boston, MA |
| 27 | Thu Apr 24 | vs Mariners | L3-4 | 14-13 | .519 | Fenway Park · Boston, MA |
| 28 | Sat Apr 26 | at Guardians | L4-5 | 14-14 | .500 | Progressive Field · Cleveland, OH |
| 29 | Sat Apr 26 | at Guardians | W7-3 | 15-14 | .517 | Progressive Field · Cleveland, OH |
| 30 | Sun Apr 27 | at Guardians | W13-3 | 16-14 | .533 | Progressive Field · Cleveland, OH |
| 31 | Tue Apr 29 | at Blue Jays | W10-2 | 17-14 | .548 | Rogers Centre · Toronto, ON |
| 32 | Wed Apr 30 | at Blue Jays | L6-7 (10) | 17-15 | .531 | Rogers Centre · Toronto, ON |
| 33 | Thu May 1 | at Blue Jays | L2-4 | 17-16 | .515 | Rogers Centre · Toronto, ON |
| 34 | Fri May 2 | vs Twins | W6-1 | 18-16 | .529 | Fenway Park · Boston, MA |
| 35 | Sat May 3 | vs Twins | L3-4 | 18-17 | .514 | Fenway Park · Boston, MA |
| 36 | Sun May 4 | vs Twins | L4-5 | 18-18 | .500 | Fenway Park · Boston, MA |
| 37 | Tue May 6 | vs Rangers | L1-6 | 18-19 | .486 | Fenway Park · Boston, MA |
| 38 | Wed May 7 | vs Rangers | W6-4 | 19-19 | .500 | Fenway Park · Boston, MA |
| 39 | Thu May 8 | vs Rangers | W5-0 | 20-19 | .513 | Fenway Park · Boston, MA |
| 40 | Fri May 9 | at Royals | L1-2 (12) | 20-20 | .500 | Kauffman Stadium · Kansas City, MO |
| 41 | Sat May 10 | at Royals | W10-1 | 21-20 | .512 | Kauffman Stadium · Kansas City, MO |
| 42 | Sun May 11 | at Royals | W3-1 | 22-20 | .524 | Kauffman Stadium · Kansas City, MO |
| 43 | Mon May 12 | at Tigers | L2-14 | 22-21 | .512 | Comerica Park · Detroit, MI |
| 44 | Tue May 13 | at Tigers | L9-10 (11) | 22-22 | .500 | Comerica Park · Detroit, MI |
| 45 | Wed May 14 | at Tigers | L5-6 | 22-23 | .489 | Comerica Park · Detroit, MI |
| 46 | Fri May 16 | vs Braves | L2-4 | 22-24 | .478 | Fenway Park · Boston, MA |
| 47 | Sat May 17 | vs Braves | W7-6 | 23-24 | .489 | Fenway Park · Boston, MA |
| 48 | Sun May 18 | vs Braves | L4-10 | 23-25 | .479 | Fenway Park · Boston, MA |
| 49 | Mon May 19 | vs Mets | W3-1 | 24-25 | .490 | Fenway Park · Boston, MA |
| 50 | Tue May 20 | vs Mets | W2-0 | 25-25 | .500 | Fenway Park · Boston, MA |
| 51 | Wed May 21 | vs Mets | L1-5 | 25-26 | .490 | Fenway Park · Boston, MA |
| 52 | Fri May 23 | vs Orioles | W19-5 | 26-26 | .500 | Fenway Park · Boston, MA |
| 53 | Sat May 24 | vs Orioles | W6-5 (10) | 27-26 | .509 | Fenway Park · Boston, MA |
| 54 | Sat May 24 | vs Orioles | L1-2 | 27-27 | .500 | Fenway Park · Boston, MA |
| 55 | Sun May 25 | vs Orioles | L1-5 | 27-28 | .491 | Fenway Park · Boston, MA |
| 56 | Mon May 26 | at Brewers | L2-3 | 27-29 | .482 | American Family Field · Milwaukee, WI |
| 57 | Tue May 27 | at Brewers | L1-5 (10) | 27-30 | .474 | American Family Field · Milwaukee, WI |
| 58 | Wed May 28 | at Brewers | L5-6 (10) | 27-31 | .466 | American Family Field · Milwaukee, WI |
| 59 | Fri May 30 | at Braves | W5-1 | 28-31 | .475 | Truist Park · Cumberland, GA |
| 60 | Sat May 31 | at Braves | L0-5 | 28-32 | .467 | Truist Park · Cumberland, GA |
| 61 | Sun Jun 1 | at Braves | W3-1 | 29-32 | .475 | Truist Park · Cumberland, GA |
| 62 | Mon Jun 2 | vs Angels | L6-7 | 29-33 | .468 | Fenway Park · Boston, MA |
| 63 | Tue Jun 3 | vs Angels | L3-4 (10) | 29-34 | .460 | Fenway Park · Boston, MA |
| 64 | Wed Jun 4 | vs Angels | W11-9 | 30-34 | .469 | Fenway Park · Boston, MA |
| 65 | Fri Jun 6 | at Yankees | L6-9 | 30-35 | .462 | Yankee Stadium · The Bronx, NY |
| 66 | Sat Jun 7 | at Yankees | W10-7 | 31-35 | .470 | Yankee Stadium · The Bronx, NY |
| 67 | Sun Jun 8 | at Yankees | W11-7 | 32-35 | .478 | Yankee Stadium · The Bronx, NY |
| 68 | Mon Jun 9 | vs Rays | L8-10 (11) | 32-36 | .471 | Fenway Park · Boston, MA |
| 69 | Tue Jun 10 | vs Rays | W3-1 | 33-36 | .478 | Fenway Park · Boston, MA |
| 70 | Wed Jun 11 | vs Rays | W4-3 | 34-36 | .486 | Fenway Park · Boston, MA |
| 71 | Fri Jun 13 | vs Yankees | W2-1 (10) | 35-36 | .493 | Fenway Park · Boston, MA |
| 72 | Sat Jun 14 | vs Yankees | W4-3 | 36-36 | .500 | Fenway Park · Boston, MA |
| 73 | Sun Jun 15 | vs Yankees | W2-0 | 37-36 | .507 | Fenway Park · Boston, MA |
| 74 | Mon Jun 16 | at Mariners | W2-0 | 38-36 | .514 | T-Mobile Park · Seattle, WA |
| 75 | Tue Jun 17 | at Mariners | L0-8 | 38-37 | .507 | T-Mobile Park · Seattle, WA |
| 76 | Wed Jun 18 | at Mariners | W3-1 | 39-37 | .513 | T-Mobile Park · Seattle, WA |
| 77 | Fri Jun 20 | at Giants | W7-5 | 40-37 | .519 | Oracle Park · San Francisco, CA |
| 78 | Sat Jun 21 | at Giants | L2-3 | 40-38 | .513 | Oracle Park · San Francisco, CA |
| 79 | Sun Jun 22 | at Giants | L5-9 | 40-39 | .506 | Oracle Park · San Francisco, CA |
| 80 | Mon Jun 23 | at Angels | L5-9 | 40-40 | .500 | Angel Stadium · Anaheim, CA |
| 81 | Tue Jun 24 | at Angels | L2-3 (10) | 40-41 | .494 | Angel Stadium · Anaheim, CA |
| 82 | Wed Jun 25 | at Angels | L2-5 | 40-42 | .488 | Angel Stadium · Anaheim, CA |
| 83 | Fri Jun 27 | vs Blue Jays | L0-9 | 40-43 | .482 | Fenway Park · Boston, MA |
| 84 | Sat Jun 28 | vs Blue Jays | W15-1 | 41-43 | .488 | Fenway Park · Boston, MA |
| 85 | Sun Jun 29 | vs Blue Jays | L3-5 | 41-44 | .482 | Fenway Park · Boston, MA |
| 86 | Mon Jun 30 | vs Reds | W13-6 | 42-44 | .488 | Fenway Park · Boston, MA |
| 87 | Wed Jul 2 | vs Reds | W5-3 | 43-44 | .494 | Fenway Park · Boston, MA |
| 88 | Wed Jul 2 | vs Reds | L4-8 | 43-45 | .489 | Fenway Park · Boston, MA |
| 89 | Fri Jul 4 | at Nationals | W11-2 | 44-45 | .494 | Nationals Park · Washington, D.C. |
| 90 | Sat Jul 5 | at Nationals | W10-3 | 45-45 | .500 | Nationals Park · Washington, D.C. |
| 91 | Sun Jul 6 | at Nationals | W6-4 | 46-45 | .505 | Nationals Park · Washington, D.C. |
| 92 | Mon Jul 7 | vs Rockies | W9-3 | 47-45 | .511 | Fenway Park · Boston, MA |
| 93 | Tue Jul 8 | vs Rockies | W10-2 | 48-45 | .516 | Fenway Park · Boston, MA |
| 94 | Wed Jul 9 | vs Rockies | W10-2 | 49-45 | .521 | Fenway Park · Boston, MA |
| 95 | Thu Jul 10 | vs Rays | W4-3 | 50-45 | .526 | Fenway Park · Boston, MA |
| 96 | Fri Jul 11 | vs Rays | W5-4 | 51-45 | .531 | Fenway Park · Boston, MA |
| 97 | Sat Jul 12 | vs Rays | W1-0 | 52-45 | .536 | Fenway Park · Boston, MA |
| 98 | Sun Jul 13 | vs Rays | W4-1 | 53-45 | .541 | Fenway Park · Boston, MA |
| 99 | Fri Jul 18 | at Cubs | L1-4 | 53-46 | .535 | Wrigley Field · Chicago, IL |
| 100 | Sat Jul 19 | at Cubs | L0-6 | 53-47 | .530 | Wrigley Field · Chicago, IL |
| 101 | Sun Jul 20 | at Cubs | W6-1 | 54-47 | .535 | Wrigley Field · Chicago, IL |
| 102 | Mon Jul 21 | at Phillies | L2-3 (10) | 54-48 | .529 | Citizens Bank Park · Philadelphi, PA |
| 103 | Tue Jul 22 | at Phillies | L1-4 | 54-49 | .524 | Citizens Bank Park · Philadelphi, PA |
| 104 | Wed Jul 23 | at Phillies | W9-8 (11) | 55-49 | .529 | Citizens Bank Park · Philadelphi, PA |
| 105 | Fri Jul 25 | vs Dodgers | L2-5 | 55-50 | .524 | Fenway Park · Boston, MA |
| 106 | Sat Jul 26 | vs Dodgers | W4-2 | 56-50 | .528 | Fenway Park · Boston, MA |
| 107 | Sun Jul 27 | vs Dodgers | W4-3 | 57-50 | .533 | Fenway Park · Boston, MA |
| 108 | Mon Jul 28 | at Twins | L4-5 | 57-51 | .528 | Target Field · Minneapolis, MN |
| 109 | Tue Jul 29 | at Twins | W8-5 | 58-51 | .532 | Target Field · Minneapolis, MN |
| 110 | Wed Jul 30 | at Twins | W13-1 | 59-51 | .536 | Target Field · Minneapolis, MN |
| 111 | Fri Aug 1 | vs Astros | W2-1 (10) | 60-51 | .541 | Fenway Park · Boston, MA |
| 112 | Sat Aug 2 | vs Astros | W7-3 | 61-51 | .545 | Fenway Park · Boston, MA |
| 113 | Sun Aug 3 | vs Astros | W6-1 | 62-51 | .549 | Fenway Park · Boston, MA |
| 114 | Mon Aug 4 | vs Royals | W8-5 | 63-51 | .553 | Fenway Park · Boston, MA |
| 115 | Tue Aug 5 | vs Royals | W6-2 | 64-51 | .557 | Fenway Park · Boston, MA |
| 116 | Wed Aug 6 | vs Royals | L3-7 | 64-52 | .552 | Fenway Park · Boston, MA |
| 117 | Fri Aug 8 | at Padres | W10-2 | 65-52 | .556 | Petco Park · San Diego, CA |
| 118 | Sat Aug 9 | at Padres | L4-5 (10) | 65-53 | .551 | Petco Park · San Diego, CA |
| 119 | Sun Aug 10 | at Padres | L2-6 | 65-54 | .546 | Petco Park · San Diego, CA |
| 120 | Mon Aug 11 | at Astros | L6-7 | 65-55 | .542 | Minute Maid Park · Houston, TX |
| 121 | Tue Aug 12 | at Astros | W14-1 | 66-55 | .545 | Minute Maid Park · Houston, TX |
| 122 | Wed Aug 13 | at Astros | L1-4 | 66-56 | .541 | Minute Maid Park · Houston, TX |
| 123 | Fri Aug 15 | vs Marlins | W2-1 | 67-56 | .545 | Fenway Park · Boston, MA |
| 124 | Sat Aug 16 | vs Marlins | W7-5 | 68-56 | .548 | Fenway Park · Boston, MA |
| 125 | Sun Aug 17 | vs Marlins | L3-5 | 68-57 | .544 | Fenway Park · Boston, MA |
| 126 | Mon Aug 18 | vs Orioles | L3-6 | 68-58 | .540 | Fenway Park · Boston, MA |
| 127 | Tue Aug 19 | vs Orioles | L3-4 (11) | 68-59 | .535 | Fenway Park · Boston, MA |
| 128 | Thu Aug 21 | at Yankees | W6-3 | 69-59 | .539 | Yankee Stadium · The Bronx, NY |
| 129 | Fri Aug 22 | at Yankees | W1-0 | 70-59 | .543 | Yankee Stadium · The Bronx, NY |
| 130 | Sat Aug 23 | at Yankees | W12-1 | 71-59 | .546 | Yankee Stadium · The Bronx, NY |
| 131 | Sun Aug 24 | at Yankees | L2-7 | 71-60 | .542 | Yankee Stadium · The Bronx, NY |
| 132 | Mon Aug 25 | at Orioles | W4-3 | 72-60 | .545 | Camden Yards · Baltimore, MD |
| 133 | Tue Aug 26 | at Orioles | W5-0 | 73-60 | .549 | Camden Yards · Baltimore, MD |
| 134 | Wed Aug 27 | at Orioles | W3-2 | 74-60 | .552 | Camden Yards · Baltimore, MD |
| 135 | Thu Aug 28 | at Orioles | W3-2 | 75-60 | .556 | Camden Yards · Baltimore, MD |
| 136 | Fri Aug 29 | vs Pirates | L2-4 | 75-61 | .551 | Fenway Park · Boston, MA |
| 137 | Sat Aug 30 | vs Pirates | L3-10 | 75-62 | .547 | Fenway Park · Boston, MA |
| 138 | Sun Aug 31 | vs Pirates | W5-2 | 76-62 | .551 | Fenway Park · Boston, MA |
| 139 | Mon Sep 1 | vs Guardians | W6-4 | 77-62 | .554 | Fenway Park · Boston, MA |
| 140 | Tue Sep 2 | vs Guardians | W11-7 | 78-62 | .557 | Fenway Park · Boston, MA |
| 141 | Wed Sep 3 | vs Guardians | L1-8 | 78-63 | .553 | Fenway Park · Boston, MA |
| 142 | Fri Sep 5 | at D-backs | L5-10 | 78-64 | .549 | Chase Field · Phoenix, AZ |
| 143 | Sat Sep 6 | at D-backs | L1-5 | 78-65 | .545 | Chase Field · Phoenix, AZ |
| 144 | Sun Sep 7 | at D-backs | W7-4 | 79-65 | .549 | Chase Field · Phoenix, AZ |
| 145 | Mon Sep 8 | at Athletics | W7-0 | 80-65 | .552 | Sutter Health Park · West Sacramento, CA |
| 146 | Tue Sep 9 | at Athletics | W6-0 | 81-65 | .555 | Sutter Health Park · West Sacramento, CA |
| 147 | Wed Sep 10 | at Athletics | L4-5 | 81-66 | .551 | Sutter Health Park · West Sacramento, CA |
| 148 | Fri Sep 12 | vs Yankees | L1-4 | 81-67 | .547 | Fenway Park · Boston, MA |
| 149 | Sat Sep 13 | vs Yankees | L3-5 | 81-68 | .544 | Fenway Park · Boston, MA |
| 150 | Sun Sep 14 | vs Yankees | W6-4 | 82-68 | .547 | Fenway Park · Boston, MA |
| 151 | Tue Sep 16 | vs Athletics | L1-2 | 82-69 | .543 | Fenway Park · Boston, MA |
| 152 | Wed Sep 17 | vs Athletics | W5-4 (10) | 83-69 | .546 | Fenway Park · Boston, MA |
| 153 | Thu Sep 18 | vs Athletics | L3-5 | 83-70 | .542 | Fenway Park · Boston, MA |
| 154 | Fri Sep 19 | at Rays | W11-7 | 84-70 | .545 | Tropicana Field · St. Petersburg, FL |
| 155 | Sat Sep 20 | at Rays | W6-3 | 85-70 | .548 | Tropicana Field · St. Petersburg, FL |
| 156 | Sun Sep 21 | at Rays | L3-7 | 85-71 | .545 | Tropicana Field · St. Petersburg, FL |
| 157 | Tue Sep 23 | at Blue Jays | W4-1 | 86-71 | .548 | Rogers Centre · Toronto, ON |
| 158 | Wed Sep 24 | at Blue Jays | W7-1 | 87-71 | .551 | Rogers Centre · Toronto, ON |
| 159 | Thu Sep 25 | at Blue Jays | L1-6 | 87-72 | .547 | Rogers Centre · Toronto, ON |
| 160 | Fri Sep 26 | vs Tigers | W4-3 | 88-72 | .550 | Fenway Park · Boston, MA |
| 161 | Sat Sep 27 | vs Tigers | L1-2 | 88-73 | .547 | Fenway Park · Boston, MA |
| 162 | Sun Sep 28 | vs Tigers | W4-3 | 89-73 | .549 | Fenway Park · Boston, MA |
| 163 | Tue Sep 30 | at Yankees | W3-1 | 1-0 | 1.000 | Yankee Stadium · The Bronx, NY |
| 164 | Wed Oct 1 | at Yankees | L3-4 | 1-1 | .500 | Yankee Stadium · The Bronx, NY |
| 165 | Thu Oct 2 | at Yankees | L0-4 | 1-2 | .333 | Yankee Stadium · The Bronx, NY |