| 1 | Fri Apr 8 | at Yankees | L5-6 (11) | 0-1 | .000 | Yankee Stadium · The Bronx, NY |
| 2 | Sat Apr 9 | at Yankees | L2-4 | 0-2 | .000 | Yankee Stadium · The Bronx, NY |
| 3 | Sun Apr 10 | at Yankees | W4-3 | 1-2 | .333 | Yankee Stadium · The Bronx, NY |
| 4 | Mon Apr 11 | at Tigers | L1-3 | 1-3 | .250 | Comerica Park · Detroit, MI |
| 5 | Tue Apr 12 | at Tigers | W5-3 | 2-3 | .400 | Comerica Park · Detroit, MI |
| 6 | Wed Apr 13 | at Tigers | W9-7 | 3-3 | .500 | Comerica Park · Detroit, MI |
| 7 | Fri Apr 15 | vs Twins | L4-8 | 3-4 | .429 | Fenway Park · Boston, MA |
| 8 | Sat Apr 16 | vs Twins | W4-0 | 4-4 | .500 | Fenway Park · Boston, MA |
| 9 | Sun Apr 17 | vs Twins | W8-1 | 5-4 | .556 | Fenway Park · Boston, MA |
| 10 | Mon Apr 18 | vs Twins | L3-8 | 5-5 | .500 | Fenway Park · Boston, MA |
| 11 | Tue Apr 19 | vs Blue Jays | W2-1 | 6-5 | .545 | Fenway Park · Boston, MA |
| 12 | Wed Apr 20 | vs Blue Jays | L1-6 | 6-6 | .500 | Fenway Park · Boston, MA |
| 13 | Thu Apr 21 | vs Blue Jays | L2-3 | 6-7 | .462 | Fenway Park · Boston, MA |
| 14 | Fri Apr 22 | at Rays | W4-3 | 7-7 | .500 | Tropicana Field · St. Petersburg, FL |
| 15 | Sat Apr 23 | at Rays | L2-3 (10) | 7-8 | .467 | Tropicana Field · St. Petersburg, FL |
| 16 | Sun Apr 24 | at Rays | L2-5 | 7-9 | .438 | Tropicana Field · St. Petersburg, FL |
| 17 | Mon Apr 25 | at Blue Jays | L2-6 | 7-10 | .412 | Rogers Centre · Toronto, ON |
| 18 | Tue Apr 26 | at Blue Jays | L5-6 (10) | 7-11 | .389 | Rogers Centre · Toronto, ON |
| 19 | Wed Apr 27 | at Blue Jays | W7-1 | 8-11 | .421 | Rogers Centre · Toronto, ON |
| 20 | Thu Apr 28 | at Blue Jays | L0-1 | 8-12 | .400 | Rogers Centre · Toronto, ON |
| 21 | Fri Apr 29 | at Orioles | W3-1 | 9-12 | .429 | Camden Yards · Baltimore, MD |
| 22 | Sat Apr 30 | at Orioles | L1-2 (10) | 9-13 | .409 | Camden Yards · Baltimore, MD |
| 23 | Sun May 1 | at Orioles | L5-9 | 9-14 | .391 | Camden Yards · Baltimore, MD |
| 24 | Tue May 3 | vs Angels | W4-0 | 10-14 | .417 | Fenway Park · Boston, MA |
| 25 | Wed May 4 | vs Angels | L5-10 (10) | 10-15 | .400 | Fenway Park · Boston, MA |
| 26 | Thu May 5 | vs Angels | L0-8 | 10-16 | .385 | Fenway Park · Boston, MA |
| 27 | Fri May 6 | vs White Sox | L2-4 | 10-17 | .370 | Fenway Park · Boston, MA |
| 28 | Sat May 7 | vs White Sox | L1-3 (10) | 10-18 | .357 | Fenway Park · Boston, MA |
| 29 | Sun May 8 | vs White Sox | L2-3 | 10-19 | .345 | Fenway Park · Boston, MA |
| 30 | Tue May 10 | at Braves | W9-4 | 11-19 | .367 | Truist Park · Cumberland, GA |
| 31 | Wed May 11 | at Braves | L3-5 | 11-20 | .355 | Truist Park · Cumberland, GA |
| 32 | Fri May 13 | at Rangers | W7-1 | 12-20 | .375 | Globe Life Field · Arlington, TX |
| 33 | Sat May 14 | at Rangers | W11-3 | 13-20 | .394 | Globe Life Field · Arlington, TX |
| 34 | Sun May 15 | at Rangers | L1-7 | 13-21 | .382 | Globe Life Field · Arlington, TX |
| 35 | Mon May 16 | vs Astros | W6-3 | 14-21 | .400 | Fenway Park · Boston, MA |
| 36 | Tue May 17 | vs Astros | L4-13 | 14-22 | .389 | Fenway Park · Boston, MA |
| 37 | Wed May 18 | vs Astros | W5-1 | 15-22 | .405 | Fenway Park · Boston, MA |
| 38 | Thu May 19 | vs Mariners | W12-6 | 16-22 | .421 | Fenway Park · Boston, MA |
| 39 | Fri May 20 | vs Mariners | W7-3 | 17-22 | .436 | Fenway Park · Boston, MA |
| 40 | Sat May 21 | vs Mariners | W6-5 | 18-22 | .450 | Fenway Park · Boston, MA |
| 41 | Sun May 22 | vs Mariners | W8-4 (10) | 19-22 | .463 | Fenway Park · Boston, MA |
| 42 | Tue May 24 | at White Sox | W16-3 | 20-22 | .476 | Guaranteed Rate Field · Chicago, IL |
| 43 | Wed May 25 | at White Sox | L1-3 | 20-23 | .465 | Guaranteed Rate Field · Chicago, IL |
| 44 | Thu May 26 | at White Sox | W16-7 | 21-23 | .477 | Guaranteed Rate Field · Chicago, IL |
| 45 | Fri May 27 | vs Orioles | L8-12 | 21-24 | .467 | Fenway Park · Boston, MA |
| 46 | Sat May 28 | vs Orioles | W5-3 | 22-24 | .478 | Fenway Park · Boston, MA |
| 47 | Sat May 28 | vs Orioles | L2-4 | 22-25 | .468 | Fenway Park · Boston, MA |
| 48 | Sun May 29 | vs Orioles | W12-2 | 23-25 | .479 | Fenway Park · Boston, MA |
| 49 | Mon May 30 | vs Orioles | L0-10 | 23-26 | .469 | Fenway Park · Boston, MA |
| 50 | Tue May 31 | vs Reds | L1-2 | 23-27 | .460 | Fenway Park · Boston, MA |
| 51 | Wed Jun 1 | vs Reds | W7-1 | 24-27 | .471 | Fenway Park · Boston, MA |
| 52 | Fri Jun 3 | at Athletics | W7-2 | 25-27 | .481 | RingCentral Coliseum · Oakland, CA |
| 53 | Sat Jun 4 | at Athletics | W8-0 | 26-27 | .491 | RingCentral Coliseum · Oakland, CA |
| 54 | Sun Jun 5 | at Athletics | W5-2 | 27-27 | .500 | RingCentral Coliseum · Oakland, CA |
| 55 | Mon Jun 6 | at Angels | W1-0 | 28-27 | .509 | Angel Stadium · Anaheim, CA |
| 56 | Tue Jun 7 | at Angels | W6-5 (10) | 29-27 | .518 | Angel Stadium · Anaheim, CA |
| 57 | Wed Jun 8 | at Angels | W1-0 | 30-27 | .526 | Angel Stadium · Anaheim, CA |
| 58 | Thu Jun 9 | at Angels | L2-5 | 30-28 | .517 | Angel Stadium · Anaheim, CA |
| 59 | Fri Jun 10 | at Mariners | W4-3 | 31-28 | .525 | T-Mobile Park · Seattle, WA |
| 60 | Sat Jun 11 | at Mariners | L6-7 | 31-29 | .517 | T-Mobile Park · Seattle, WA |
| 61 | Sun Jun 12 | at Mariners | W2-0 | 32-29 | .525 | T-Mobile Park · Seattle, WA |
| 62 | Tue Jun 14 | vs Athletics | W6-1 | 33-29 | .532 | Fenway Park · Boston, MA |
| 63 | Wed Jun 15 | vs Athletics | W10-1 | 34-29 | .540 | Fenway Park · Boston, MA |
| 64 | Thu Jun 16 | vs Athletics | L3-4 | 34-30 | .531 | Fenway Park · Boston, MA |
| 65 | Fri Jun 17 | vs Cardinals | W6-5 | 35-30 | .538 | Fenway Park · Boston, MA |
| 66 | Sat Jun 18 | vs Cardinals | L2-11 | 35-31 | .530 | Fenway Park · Boston, MA |
| 67 | Sun Jun 19 | vs Cardinals | W6-4 | 36-31 | .537 | Fenway Park · Boston, MA |
| 68 | Mon Jun 20 | vs Tigers | W5-2 | 37-31 | .544 | Fenway Park · Boston, MA |
| 69 | Tue Jun 21 | vs Tigers | W5-4 | 38-31 | .551 | Fenway Park · Boston, MA |
| 70 | Wed Jun 22 | vs Tigers | W6-2 | 39-31 | .557 | Fenway Park · Boston, MA |
| 71 | Fri Jun 24 | at Guardians | W6-3 | 40-31 | .563 | Progressive Field · Cleveland, OH |
| 72 | Sat Jun 25 | at Guardians | W4-2 | 41-31 | .569 | Progressive Field · Cleveland, OH |
| 73 | Sun Jun 26 | at Guardians | W8-3 | 42-31 | .575 | Progressive Field · Cleveland, OH |
| 74 | Mon Jun 27 | at Blue Jays | L2-7 | 42-32 | .568 | Rogers Centre · Toronto, ON |
| 75 | Tue Jun 28 | at Blue Jays | L5-6 | 42-33 | .560 | Rogers Centre · Toronto, ON |
| 76 | Wed Jun 29 | at Blue Jays | W6-5 (10) | 43-33 | .566 | Rogers Centre · Toronto, ON |
| 77 | Fri Jul 1 | at Cubs | L5-6 | 43-34 | .558 | Wrigley Field · Chicago, IL |
| 78 | Sat Jul 2 | at Cubs | L1-3 | 43-35 | .551 | Wrigley Field · Chicago, IL |
| 79 | Sun Jul 3 | at Cubs | W4-2 (11) | 44-35 | .557 | Wrigley Field · Chicago, IL |
| 80 | Mon Jul 4 | vs Rays | W4-0 | 45-35 | .563 | Fenway Park · Boston, MA |
| 81 | Tue Jul 5 | vs Rays | L4-8 | 45-36 | .556 | Fenway Park · Boston, MA |
| 82 | Wed Jul 6 | vs Rays | L1-7 | 45-37 | .549 | Fenway Park · Boston, MA |
| 83 | Thu Jul 7 | vs Yankees | L5-6 | 45-38 | .542 | Fenway Park · Boston, MA |
| 84 | Fri Jul 8 | vs Yankees | L5-12 | 45-39 | .536 | Fenway Park · Boston, MA |
| 85 | Sat Jul 9 | vs Yankees | W6-5 (10) | 46-39 | .541 | Fenway Park · Boston, MA |
| 86 | Sun Jul 10 | vs Yankees | W11-6 | 47-39 | .547 | Fenway Park · Boston, MA |
| 87 | Mon Jul 11 | at Rays | L5-10 | 47-40 | .540 | Tropicana Field · St. Petersburg, FL |
| 88 | Tue Jul 12 | at Rays | L2-3 | 47-41 | .534 | Tropicana Field · St. Petersburg, FL |
| 89 | Wed Jul 13 | at Rays | L1-4 | 47-42 | .528 | Tropicana Field · St. Petersburg, FL |
| 90 | Thu Jul 14 | at Rays | L4-5 | 47-43 | .522 | Tropicana Field · St. Petersburg, FL |
| 91 | Fri Jul 15 | at Yankees | W5-4 (11) | 48-43 | .527 | Yankee Stadium · The Bronx, NY |
| 92 | Sat Jul 16 | at Yankees | L1-14 | 48-44 | .522 | Yankee Stadium · The Bronx, NY |
| 93 | Sun Jul 17 | at Yankees | L2-13 | 48-45 | .516 | Yankee Stadium · The Bronx, NY |
| 94 | Fri Jul 22 | vs Blue Jays | L5-28 | 48-46 | .511 | Fenway Park · Boston, MA |
| 95 | Sat Jul 23 | vs Blue Jays | L1-4 | 48-47 | .505 | Fenway Park · Boston, MA |
| 96 | Sun Jul 24 | vs Blue Jays | L4-8 | 48-48 | .500 | Fenway Park · Boston, MA |
| 97 | Mon Jul 25 | vs Guardians | W3-1 | 49-48 | .505 | Fenway Park · Boston, MA |
| 98 | Tue Jul 26 | vs Guardians | L3-8 | 49-49 | .500 | Fenway Park · Boston, MA |
| 99 | Wed Jul 27 | vs Guardians | L6-7 | 49-50 | .495 | Fenway Park · Boston, MA |
| 100 | Thu Jul 28 | vs Guardians | W4-2 | 50-50 | .500 | Fenway Park · Boston, MA |
| 101 | Fri Jul 29 | vs Brewers | L1-4 | 50-51 | .495 | Fenway Park · Boston, MA |
| 102 | Sat Jul 30 | vs Brewers | L4-9 | 50-52 | .490 | Fenway Park · Boston, MA |
| 103 | Sun Jul 31 | vs Brewers | W7-2 | 51-52 | .495 | Fenway Park · Boston, MA |
| 104 | Mon Aug 1 | at Astros | W3-2 | 52-52 | .500 | Minute Maid Park · Houston, TX |
| 105 | Tue Aug 2 | at Astros | W2-1 | 53-52 | .505 | Minute Maid Park · Houston, TX |
| 106 | Wed Aug 3 | at Astros | L1-6 | 53-53 | .500 | Minute Maid Park · Houston, TX |
| 107 | Thu Aug 4 | at Royals | L3-7 | 53-54 | .495 | Kauffman Stadium · Kansas City, MO |
| 108 | Fri Aug 5 | at Royals | W7-4 | 54-54 | .500 | Kauffman Stadium · Kansas City, MO |
| 109 | Sat Aug 6 | at Royals | L4-5 | 54-55 | .495 | Kauffman Stadium · Kansas City, MO |
| 110 | Sun Aug 7 | at Royals | L5-13 | 54-56 | .491 | Kauffman Stadium · Kansas City, MO |
| 111 | Tue Aug 9 | vs Braves | L7-9 (11) | 54-57 | .486 | Fenway Park · Boston, MA |
| 112 | Wed Aug 10 | vs Braves | L4-8 | 54-58 | .482 | Fenway Park · Boston, MA |
| 113 | Thu Aug 11 | vs Orioles | W4-3 | 55-58 | .487 | Fenway Park · Boston, MA |
| 114 | Fri Aug 12 | vs Yankees | W3-2 (10) | 56-58 | .491 | Fenway Park · Boston, MA |
| 115 | Sat Aug 13 | vs Yankees | L2-3 | 56-59 | .487 | Fenway Park · Boston, MA |
| 116 | Sun Aug 14 | vs Yankees | W3-0 | 57-59 | .491 | Fenway Park · Boston, MA |
| 117 | Tue Aug 16 | at Pirates | W5-3 | 58-59 | .496 | PNC Park · Pittsburgh, PA |
| 118 | Wed Aug 17 | at Pirates | W8-3 | 59-59 | .500 | PNC Park · Pittsburgh, PA |
| 119 | Thu Aug 18 | at Pirates | L2-8 | 59-60 | .496 | PNC Park · Pittsburgh, PA |
| 120 | Fri Aug 19 | at Orioles | L10-15 | 59-61 | .492 | Camden Yards · Baltimore, MD |
| 121 | Sat Aug 20 | at Orioles | W4-3 | 60-61 | .496 | Camden Yards · Baltimore, MD |
| 122 | Sun Aug 21 | at Orioles | L3-5 | 60-62 | .492 | Camden Yards · Baltimore, MD |
| 123 | Tue Aug 23 | vs Blue Jays | L3-9 | 60-63 | .488 | Fenway Park · Boston, MA |
| 124 | Wed Aug 24 | vs Blue Jays | L2-3 (10) | 60-64 | .484 | Fenway Park · Boston, MA |
| 125 | Thu Aug 25 | vs Blue Jays | L5-6 (10) | 60-65 | .480 | Fenway Park · Boston, MA |
| 126 | Fri Aug 26 | vs Rays | W9-8 | 61-65 | .484 | Fenway Park · Boston, MA |
| 127 | Sat Aug 27 | vs Rays | W5-1 | 62-65 | .488 | Fenway Park · Boston, MA |
| 128 | Sun Aug 28 | vs Rays | L4-12 | 62-66 | .484 | Fenway Park · Boston, MA |
| 129 | Mon Aug 29 | at Twins | L2-4 | 62-67 | .481 | Target Field · Minneapolis, MN |
| 130 | Tue Aug 30 | at Twins | L5-10 | 62-68 | .477 | Target Field · Minneapolis, MN |
| 131 | Wed Aug 31 | at Twins | W6-5 | 63-68 | .481 | Target Field · Minneapolis, MN |
| 132 | Thu Sep 1 | vs Rangers | W9-8 | 64-68 | .485 | Fenway Park · Boston, MA |
| 133 | Fri Sep 2 | vs Rangers | W9-1 | 65-68 | .489 | Fenway Park · Boston, MA |
| 134 | Sat Sep 3 | vs Rangers | W5-3 | 66-68 | .493 | Fenway Park · Boston, MA |
| 135 | Sun Sep 4 | vs Rangers | W5-2 | 67-68 | .496 | Fenway Park · Boston, MA |
| 136 | Mon Sep 5 | at Rays | L3-4 | 67-69 | .493 | Tropicana Field · St. Petersburg, FL |
| 137 | Tue Sep 6 | at Rays | L4-8 | 67-70 | .489 | Tropicana Field · St. Petersburg, FL |
| 138 | Wed Sep 7 | at Rays | L0-1 | 67-71 | .486 | Tropicana Field · St. Petersburg, FL |
| 139 | Fri Sep 9 | at Orioles | L2-3 | 67-72 | .482 | Camden Yards · Baltimore, MD |
| 140 | Sat Sep 10 | at Orioles | W17-4 | 68-72 | .486 | Camden Yards · Baltimore, MD |
| 141 | Sun Sep 11 | at Orioles | W1-0 | 69-72 | .489 | Camden Yards · Baltimore, MD |
| 142 | Tue Sep 13 | vs Yankees | L6-7 (10) | 69-73 | .486 | Fenway Park · Boston, MA |
| 143 | Wed Sep 14 | vs Yankees | L3-5 | 69-74 | .483 | Fenway Park · Boston, MA |
| 144 | Fri Sep 16 | vs Royals | W2-1 | 70-74 | .486 | Fenway Park · Boston, MA |
| 145 | Sat Sep 17 | vs Royals | L0-9 | 70-75 | .483 | Fenway Park · Boston, MA |
| 146 | Sun Sep 18 | vs Royals | W13-3 | 71-75 | .486 | Fenway Park · Boston, MA |
| 147 | Tue Sep 20 | at Reds | W5-3 | 72-75 | .490 | Great American Ball Park · Cincinnati, OH |
| 148 | Wed Sep 21 | at Reds | L1-5 | 72-76 | .486 | Great American Ball Park · Cincinnati, OH |
| 149 | Thu Sep 22 | at Yankees | L4-5 (10) | 72-77 | .483 | Yankee Stadium · The Bronx, NY |
| 150 | Fri Sep 23 | at Yankees | L4-5 | 72-78 | .480 | Yankee Stadium · The Bronx, NY |
| 151 | Sat Sep 24 | at Yankees | L5-7 | 72-79 | .477 | Yankee Stadium · The Bronx, NY |
| 152 | Sun Sep 25 | at Yankees | L0-2 | 72-80 | .474 | Yankee Stadium · The Bronx, NY |
| 153 | Mon Sep 26 | vs Orioles | L8-14 | 72-81 | .471 | Fenway Park · Boston, MA |
| 154 | Tue Sep 27 | vs Orioles | W13-9 | 73-81 | .474 | Fenway Park · Boston, MA |
| 155 | Wed Sep 28 | vs Orioles | W3-1 | 74-81 | .477 | Fenway Park · Boston, MA |
| 156 | Thu Sep 29 | vs Orioles | W5-3 | 75-81 | .481 | Fenway Park · Boston, MA |
| 157 | Fri Sep 30 | at Blue Jays | L0-9 | 75-82 | .478 | Rogers Centre · Toronto, ON |
| 158 | Sat Oct 1 | at Blue Jays | L0-10 | 75-83 | .475 | Rogers Centre · Toronto, ON |
| 159 | Sun Oct 2 | at Blue Jays | L3-6 | 75-84 | .472 | Rogers Centre · Toronto, ON |
| 160 | Mon Oct 3 | vs Rays | W4-3 | 76-84 | .475 | Fenway Park · Boston, MA |
| 161 | Tue Oct 4 | vs Rays | W6-0 | 77-84 | .478 | Fenway Park · Boston, MA |
| 162 | Wed Oct 5 | vs Rays | W6-3 | 78-84 | .481 | Fenway Park · Boston, MA |