| 1 | Mon Apr 1 | at Twins | W4-2 | 1-0 | 1.000 | Target Field · Minneapolis, MN |
| 2 | Wed Apr 3 | at Twins | L2-3 | 1-1 | .500 | Target Field · Minneapolis, MN |
| 3 | Thu Apr 4 | at Twins | L2-8 | 1-2 | .333 | Target Field · Minneapolis, MN |
| 4 | Fri Apr 5 | vs Yankees | W8-3 | 2-2 | .500 | Comerica Park · Detroit, MI |
| 5 | Sat Apr 6 | vs Yankees | W8-4 | 3-2 | .600 | Comerica Park · Detroit, MI |
| 6 | Sun Apr 7 | vs Yankees | L0-7 | 3-3 | .500 | Comerica Park · Detroit, MI |
| 7 | Tue Apr 9 | vs Blue Jays | W7-3 | 4-3 | .571 | Comerica Park · Detroit, MI |
| 8 | Wed Apr 10 | vs Blue Jays | L6-8 | 4-4 | .500 | Comerica Park · Detroit, MI |
| 9 | Thu Apr 11 | vs Blue Jays | W11-1 | 5-4 | .556 | Comerica Park · Detroit, MI |
| 10 | Fri Apr 12 | at Athletics | L3-4 (12) | 5-5 | .500 | RingCentral Coliseum · Oakland, CA |
| 11 | Sat Apr 13 | at Athletics | W7-3 | 6-5 | .545 | RingCentral Coliseum · Oakland, CA |
| 12 | Sun Apr 14 | at Athletics | W10-1 | 7-5 | .583 | RingCentral Coliseum · Oakland, CA |
| 13 | Tue Apr 16 | at Mariners | W6-2 | 8-5 | .615 | T-Mobile Park · Seattle, WA |
| 14 | Wed Apr 17 | at Mariners | W2-1 (14) | 9-5 | .643 | T-Mobile Park · Seattle, WA |
| 15 | Thu Apr 18 | at Mariners | L0-2 | 9-6 | .600 | T-Mobile Park · Seattle, WA |
| 16 | Fri Apr 19 | at Angels | L1-8 | 9-7 | .563 | Angel Stadium · Anaheim, CA |
| 17 | Sat Apr 20 | at Angels | L0-10 | 9-8 | .529 | Angel Stadium · Anaheim, CA |
| 18 | Sun Apr 21 | at Angels | L3-4 (13) | 9-9 | .500 | Angel Stadium · Anaheim, CA |
| 19 | Wed Apr 24 | vs Royals | W7-5 | 10-9 | .526 | Comerica Park · Detroit, MI |
| 20 | Thu Apr 25 | vs Royals | L3-8 (10) | 10-10 | .500 | Comerica Park · Detroit, MI |
| 21 | Fri Apr 26 | vs Braves | W10-0 | 11-10 | .524 | Comerica Park · Detroit, MI |
| 22 | Sat Apr 27 | vs Braves | W7-4 | 12-10 | .545 | Comerica Park · Detroit, MI |
| 23 | Sun Apr 28 | vs Braves | W8-3 | 13-10 | .565 | Comerica Park · Detroit, MI |
| 24 | Mon Apr 29 | vs Twins | W4-3 | 14-10 | .583 | Comerica Park · Detroit, MI |
| 25 | Tue Apr 30 | vs Twins | W6-1 | 15-10 | .600 | Comerica Park · Detroit, MI |
| 26 | Wed May 1 | vs Twins | L2-6 | 15-11 | .577 | Comerica Park · Detroit, MI |
| 27 | Thu May 2 | at Astros | W7-3 (14) | 16-11 | .593 | Minute Maid Park · Houston, TX |
| 28 | Fri May 3 | at Astros | W4-3 | 17-11 | .607 | Minute Maid Park · Houston, TX |
| 29 | Sat May 4 | at Astros | W17-2 | 18-11 | .621 | Minute Maid Park · Houston, TX |
| 30 | Sun May 5 | at Astros | W9-0 | 19-11 | .633 | Minute Maid Park · Houston, TX |
| 31 | Wed May 8 | at Nationals | L1-3 | 19-12 | .613 | Nationals Park · Washington, D.C. |
| 32 | Thu May 9 | at Nationals | L4-5 | 19-13 | .594 | Nationals Park · Washington, D.C. |
| 33 | Fri May 10 | vs Guardians | W10-4 | 20-13 | .606 | Comerica Park · Detroit, MI |
| 34 | Sat May 11 | vs Guardians | L6-7 | 20-14 | .588 | Comerica Park · Detroit, MI |
| 35 | Sun May 12 | vs Guardians | L3-4 (10) | 20-15 | .571 | Comerica Park · Detroit, MI |
| 36 | Mon May 13 | vs Astros | W7-2 | 21-15 | .583 | Comerica Park · Detroit, MI |
| 37 | Tue May 14 | vs Astros | W6-2 | 22-15 | .595 | Comerica Park · Detroit, MI |
| 38 | Wed May 15 | vs Astros | L5-7 | 22-16 | .579 | Comerica Park · Detroit, MI |
| 39 | Thu May 16 | at Rangers | L4-10 | 22-17 | .564 | Globe Life Field · Arlington, TX |
| 40 | Fri May 17 | at Rangers | W2-1 | 23-17 | .575 | Globe Life Field · Arlington, TX |
| 41 | Sat May 18 | at Rangers | L2-7 | 23-18 | .561 | Globe Life Field · Arlington, TX |
| 42 | Sun May 19 | at Rangers | L8-11 | 23-19 | .548 | Globe Life Field · Arlington, TX |
| 43 | Tue May 21 | at Guardians | W5-1 | 24-19 | .558 | Progressive Field · Cleveland, OH |
| 44 | Wed May 22 | at Guardians | W11-7 | 25-19 | .568 | Progressive Field · Cleveland, OH |
| 45 | Thu May 23 | vs Twins | W7-6 | 26-19 | .578 | Comerica Park · Detroit, MI |
| 46 | Fri May 24 | vs Twins | W6-0 | 27-19 | .587 | Comerica Park · Detroit, MI |
| 47 | Sat May 25 | vs Twins | L2-3 | 27-20 | .574 | Comerica Park · Detroit, MI |
| 48 | Sun May 26 | vs Twins | W6-1 | 28-20 | .583 | Comerica Park · Detroit, MI |
| 49 | Mon May 27 | vs Pirates | W6-5 | 29-20 | .592 | Comerica Park · Detroit, MI |
| 50 | Tue May 28 | vs Pirates | L0-1 (11) | 29-21 | .580 | Comerica Park · Detroit, MI |
| 51 | Wed May 29 | at Pirates | L3-5 | 29-22 | .569 | PNC Park · Pittsburgh, PA |
| 52 | Thu May 30 | at Pirates | L0-1 (11) | 29-23 | .558 | PNC Park · Pittsburgh, PA |
| 53 | Fri May 31 | at Orioles | L5-7 | 29-24 | .547 | Camden Yards · Baltimore, MD |
| 54 | Sat Jun 1 | at Orioles | W10-3 | 30-24 | .556 | Camden Yards · Baltimore, MD |
| 55 | Sun Jun 2 | at Orioles | L2-4 | 30-25 | .545 | Camden Yards · Baltimore, MD |
| 56 | Tue Jun 4 | vs Rays | W10-1 | 31-25 | .554 | Comerica Park · Detroit, MI |
| 57 | Wed Jun 5 | vs Rays | L0-3 | 31-26 | .544 | Comerica Park · Detroit, MI |
| 58 | Thu Jun 6 | vs Rays | W5-2 | 32-26 | .552 | Comerica Park · Detroit, MI |
| 59 | Fri Jun 7 | vs Guardians | W7-5 | 33-26 | .559 | Comerica Park · Detroit, MI |
| 60 | Sat Jun 8 | vs Guardians | W6-4 | 34-26 | .567 | Comerica Park · Detroit, MI |
| 61 | Sun Jun 9 | vs Guardians | W4-1 | 35-26 | .574 | Comerica Park · Detroit, MI |
| 62 | Mon Jun 10 | at Royals | L2-3 | 35-27 | .565 | Kauffman Stadium · Kansas City, MO |
| 63 | Tue Jun 11 | at Royals | W3-2 | 36-27 | .571 | Kauffman Stadium · Kansas City, MO |
| 64 | Wed Jun 12 | at Royals | L2-3 (10) | 36-28 | .563 | Kauffman Stadium · Kansas City, MO |
| 65 | Fri Jun 14 | at Twins | W4-0 | 37-28 | .569 | Target Field · Minneapolis, MN |
| 66 | Sat Jun 15 | at Twins | L3-6 | 37-29 | .561 | Target Field · Minneapolis, MN |
| 67 | Sun Jun 16 | at Twins | W5-2 | 38-29 | .567 | Target Field · Minneapolis, MN |
| 68 | Mon Jun 17 | vs Orioles | W5-1 | 39-29 | .574 | Comerica Park · Detroit, MI |
| 69 | Tue Jun 18 | vs Orioles | L2-5 | 39-30 | .565 | Comerica Park · Detroit, MI |
| 70 | Wed Jun 19 | vs Orioles | L3-13 | 39-31 | .557 | Comerica Park · Detroit, MI |
| 71 | Thu Jun 20 | vs Red Sox | W4-3 | 40-31 | .563 | Comerica Park · Detroit, MI |
| 72 | Fri Jun 21 | vs Red Sox | L6-10 | 40-32 | .556 | Comerica Park · Detroit, MI |
| 73 | Sat Jun 22 | vs Red Sox | W10-3 | 41-32 | .562 | Comerica Park · Detroit, MI |
| 74 | Sun Jun 23 | vs Red Sox | W7-5 | 42-32 | .568 | Comerica Park · Detroit, MI |
| 75 | Tue Jun 25 | vs Angels | L8-14 | 42-33 | .560 | Comerica Park · Detroit, MI |
| 76 | Wed Jun 26 | vs Angels | L4-7 | 42-34 | .553 | Comerica Park · Detroit, MI |
| 77 | Thu Jun 27 | vs Angels | L1-3 (10) | 42-35 | .545 | Comerica Park · Detroit, MI |
| 78 | Fri Jun 28 | at Rays | W6-3 | 43-35 | .551 | Tropicana Field · St. Petersburg, FL |
| 79 | Sat Jun 29 | at Rays | L3-4 (10) | 43-36 | .544 | Tropicana Field · St. Petersburg, FL |
| 80 | Sun Jun 30 | at Rays | L1-3 | 43-37 | .537 | Tropicana Field · St. Petersburg, FL |
| 81 | Mon Jul 1 | at Blue Jays | L3-8 | 43-38 | .531 | Rogers Centre · Toronto, ON |
| 82 | Tue Jul 2 | at Blue Jays | W7-6 | 44-38 | .537 | Rogers Centre · Toronto, ON |
| 83 | Wed Jul 3 | at Blue Jays | W6-2 | 45-38 | .542 | Rogers Centre · Toronto, ON |
| 84 | Thu Jul 4 | at Blue Jays | W11-1 | 46-38 | .548 | Rogers Centre · Toronto, ON |
| 85 | Fri Jul 5 | at Guardians | W7-0 | 47-38 | .553 | Progressive Field · Cleveland, OH |
| 86 | Sat Jul 6 | at Guardians | W9-4 | 48-38 | .558 | Progressive Field · Cleveland, OH |
| 87 | Sun Jul 7 | at Guardians | L6-9 | 48-39 | .552 | Progressive Field · Cleveland, OH |
| 88 | Mon Jul 8 | at Guardians | W4-2 (10) | 49-39 | .557 | Progressive Field · Cleveland, OH |
| 89 | Tue Jul 9 | vs White Sox | L4-11 | 49-40 | .551 | Comerica Park · Detroit, MI |
| 90 | Wed Jul 10 | vs White Sox | W8-5 | 50-40 | .556 | Comerica Park · Detroit, MI |
| 91 | Thu Jul 11 | vs White Sox | L3-6 | 50-41 | .549 | Comerica Park · Detroit, MI |
| 92 | Fri Jul 12 | vs Rangers | W7-2 | 51-41 | .554 | Comerica Park · Detroit, MI |
| 93 | Sat Jul 13 | vs Rangers | L1-7 | 51-42 | .548 | Comerica Park · Detroit, MI |
| 94 | Sun Jul 14 | vs Rangers | W5-0 | 52-42 | .553 | Comerica Park · Detroit, MI |
| 95 | Fri Jul 19 | at Royals | L0-1 | 52-43 | .547 | Kauffman Stadium · Kansas City, MO |
| 96 | Sat Jul 20 | at Royals | L5-6 | 52-44 | .542 | Kauffman Stadium · Kansas City, MO |
| 97 | Sun Jul 21 | at Royals | W4-1 | 53-44 | .546 | Kauffman Stadium · Kansas City, MO |
| 98 | Mon Jul 22 | at White Sox | W7-3 | 54-44 | .551 | Guaranteed Rate Field · Chicago, IL |
| 99 | Tue Jul 23 | at White Sox | W6-2 | 55-44 | .556 | Guaranteed Rate Field · Chicago, IL |
| 100 | Wed Jul 24 | at White Sox | W6-2 | 56-44 | .560 | Guaranteed Rate Field · Chicago, IL |
| 101 | Thu Jul 25 | at White Sox | L4-7 | 56-45 | .554 | Guaranteed Rate Field · Chicago, IL |
| 102 | Fri Jul 26 | vs Phillies | W2-1 | 57-45 | .559 | Comerica Park · Detroit, MI |
| 103 | Sat Jul 27 | vs Phillies | W10-0 | 58-45 | .563 | Comerica Park · Detroit, MI |
| 104 | Sun Jul 28 | vs Phillies | W12-4 | 59-45 | .567 | Comerica Park · Detroit, MI |
| 105 | Tue Jul 30 | vs Nationals | W5-1 | 60-45 | .571 | Comerica Park · Detroit, MI |
| 106 | Wed Jul 31 | vs Nationals | W11-1 | 61-45 | .575 | Comerica Park · Detroit, MI |
| 107 | Fri Aug 2 | vs White Sox | W2-1 | 62-45 | .579 | Comerica Park · Detroit, MI |
| 108 | Sat Aug 3 | vs White Sox | W3-0 | 63-45 | .583 | Comerica Park · Detroit, MI |
| 109 | Sun Aug 4 | vs White Sox | W3-2 (12) | 64-45 | .587 | Comerica Park · Detroit, MI |
| 110 | Mon Aug 5 | at Guardians | W4-2 | 65-45 | .591 | Progressive Field · Cleveland, OH |
| 111 | Tue Aug 6 | at Guardians | W5-1 | 66-45 | .595 | Progressive Field · Cleveland, OH |
| 112 | Wed Aug 7 | at Guardians | W6-5 (14) | 67-45 | .598 | Progressive Field · Cleveland, OH |
| 113 | Thu Aug 8 | at Guardians | W10-3 | 68-45 | .602 | Progressive Field · Cleveland, OH |
| 114 | Fri Aug 9 | at Yankees | L3-4 (10) | 68-46 | .596 | Yankee Stadium · The Bronx, NY |
| 115 | Sat Aug 10 | at Yankees | W9-3 | 69-46 | .600 | Yankee Stadium · The Bronx, NY |
| 116 | Sun Aug 11 | at Yankees | L4-5 | 69-47 | .595 | Yankee Stadium · The Bronx, NY |
| 117 | Mon Aug 12 | at White Sox | L2-6 | 69-48 | .590 | Guaranteed Rate Field · Chicago, IL |
| 118 | Tue Aug 13 | at White Sox | L3-4 (11) | 69-49 | .585 | Guaranteed Rate Field · Chicago, IL |
| 119 | Wed Aug 14 | at White Sox | W6-4 | 70-49 | .588 | Guaranteed Rate Field · Chicago, IL |
| 120 | Thu Aug 15 | vs Royals | W4-1 | 71-49 | .592 | Comerica Park · Detroit, MI |
| 121 | Fri Aug 16 | vs Royals | L1-2 | 71-50 | .587 | Comerica Park · Detroit, MI |
| 122 | Fri Aug 16 | vs Royals | L0-3 | 71-51 | .582 | Comerica Park · Detroit, MI |
| 123 | Sat Aug 17 | vs Royals | W6-5 | 72-51 | .585 | Comerica Park · Detroit, MI |
| 124 | Sun Aug 18 | vs Royals | W6-3 | 73-51 | .589 | Comerica Park · Detroit, MI |
| 125 | Tue Aug 20 | vs Twins | L3-6 | 73-52 | .584 | Comerica Park · Detroit, MI |
| 126 | Wed Aug 21 | vs Twins | W7-1 | 74-52 | .587 | Comerica Park · Detroit, MI |
| 127 | Thu Aug 22 | vs Twins | L6-7 | 74-53 | .583 | Comerica Park · Detroit, MI |
| 128 | Fri Aug 23 | at Mets | W6-1 | 75-53 | .586 | Citi Field · Queens, NY |
| 129 | Sat Aug 24 | at Mets | W3-0 | 76-53 | .589 | Citi Field · Queens, NY |
| 130 | Sun Aug 25 | at Mets | W11-3 | 77-53 | .592 | Citi Field · Queens, NY |
| 131 | Mon Aug 26 | vs Athletics | L6-8 | 77-54 | .588 | Comerica Park · Detroit, MI |
| 132 | Tue Aug 27 | vs Athletics | L3-6 | 77-55 | .583 | Comerica Park · Detroit, MI |
| 133 | Wed Aug 28 | vs Athletics | L4-14 | 77-56 | .579 | Comerica Park · Detroit, MI |
| 134 | Thu Aug 29 | vs Athletics | W7-6 | 78-56 | .582 | Comerica Park · Detroit, MI |
| 135 | Fri Aug 30 | vs Guardians | W7-2 | 79-56 | .585 | Comerica Park · Detroit, MI |
| 136 | Sat Aug 31 | vs Guardians | W10-5 | 80-56 | .588 | Comerica Park · Detroit, MI |
| 137 | Sun Sep 1 | vs Guardians | L0-4 | 80-57 | .584 | Comerica Park · Detroit, MI |
| 138 | Mon Sep 2 | at Red Sox | W3-0 | 81-57 | .587 | Fenway Park · Boston, MA |
| 139 | Tue Sep 3 | at Red Sox | L1-2 | 81-58 | .583 | Fenway Park · Boston, MA |
| 140 | Wed Sep 4 | at Red Sox | L4-20 | 81-59 | .579 | Fenway Park · Boston, MA |
| 141 | Fri Sep 6 | at Royals | W16-2 | 82-59 | .582 | Kauffman Stadium · Kansas City, MO |
| 142 | Sat Sep 7 | at Royals | L3-4 | 82-60 | .577 | Kauffman Stadium · Kansas City, MO |
| 143 | Sun Sep 8 | at Royals | L2-5 | 82-61 | .573 | Kauffman Stadium · Kansas City, MO |
| 144 | Mon Sep 9 | at White Sox | L1-5 | 82-62 | .569 | Guaranteed Rate Field · Chicago, IL |
| 145 | Tue Sep 10 | at White Sox | W9-1 | 83-62 | .572 | Guaranteed Rate Field · Chicago, IL |
| 146 | Wed Sep 11 | at White Sox | W1-0 | 84-62 | .575 | Guaranteed Rate Field · Chicago, IL |
| 147 | Fri Sep 13 | vs Royals | W6-3 | 85-62 | .578 | Comerica Park · Detroit, MI |
| 148 | Sat Sep 14 | vs Royals | L0-1 | 85-63 | .574 | Comerica Park · Detroit, MI |
| 149 | Sun Sep 15 | vs Royals | W3-2 | 86-63 | .577 | Comerica Park · Detroit, MI |
| 150 | Mon Sep 16 | vs Mariners | W4-2 | 87-63 | .580 | Comerica Park · Detroit, MI |
| 151 | Tue Sep 17 | vs Mariners | W6-2 | 88-63 | .583 | Comerica Park · Detroit, MI |
| 152 | Wed Sep 18 | vs Mariners | L0-8 | 88-64 | .579 | Comerica Park · Detroit, MI |
| 153 | Thu Sep 19 | vs Mariners | W5-4 | 89-64 | .582 | Comerica Park · Detroit, MI |
| 154 | Fri Sep 20 | vs White Sox | W12-5 | 90-64 | .584 | Comerica Park · Detroit, MI |
| 155 | Sat Sep 21 | vs White Sox | W7-6 (12) | 91-64 | .587 | Comerica Park · Detroit, MI |
| 156 | Sun Sep 22 | vs White Sox | L3-6 | 91-65 | .583 | Comerica Park · Detroit, MI |
| 157 | Mon Sep 23 | at Twins | L3-4 (11) | 91-66 | .580 | Target Field · Minneapolis, MN |
| 158 | Tue Sep 24 | at Twins | W4-2 | 92-66 | .582 | Target Field · Minneapolis, MN |
| 159 | Wed Sep 25 | at Twins | W1-0 | 93-66 | .585 | Target Field · Minneapolis, MN |
| 160 | Fri Sep 27 | at Marlins | L2-3 | 93-67 | .581 | LoanDepot Park · Miami, FL |
| 161 | Sat Sep 28 | at Marlins | L1-2 (10) | 93-68 | .578 | LoanDepot Park · Miami, FL |
| 162 | Sun Sep 29 | at Marlins | L0-1 | 93-69 | .574 | LoanDepot Park · Miami, FL |
| 163 | Fri Oct 4 | at Athletics | W3-2 | 1-0 | 1.000 | RingCentral Coliseum · Oakland, CA |
| 164 | Sat Oct 5 | at Athletics | L0-1 | 1-1 | .500 | RingCentral Coliseum · Oakland, CA |
| 165 | Mon Oct 7 | vs Athletics | L3-6 | 1-2 | .333 | Comerica Park · Detroit, MI |
| 166 | Tue Oct 8 | vs Athletics | W8-6 | 2-2 | .500 | Comerica Park · Detroit, MI |
| 167 | Thu Oct 10 | at Athletics | W3-0 | 3-2 | .600 | RingCentral Coliseum · Oakland, CA |
| 168 | Sat Oct 12 | at Red Sox | W1-0 | 1-0 | 1.000 | Fenway Park · Boston, MA |
| 169 | Sun Oct 13 | at Red Sox | L5-6 | 1-1 | .500 | Fenway Park · Boston, MA |
| 170 | Tue Oct 15 | vs Red Sox | L0-1 | 1-2 | .333 | Comerica Park · Detroit, MI |
| 171 | Wed Oct 16 | vs Red Sox | W7-3 | 2-2 | .500 | Comerica Park · Detroit, MI |
| 172 | Thu Oct 17 | vs Red Sox | L3-4 | 2-3 | .400 | Comerica Park · Detroit, MI |
| 173 | Sat Oct 19 | at Red Sox | L2-5 | 2-4 | .333 | Fenway Park · Boston, MA |