| 1 | Thu Mar 31 | at Yankees | L3-6 | 0-1 | .000 | Yankee Stadium · The Bronx, NY |
| 2 | Sat Apr 2 | at Yankees | L6-10 | 0-2 | .000 | Yankee Stadium · The Bronx, NY |
| 3 | Sun Apr 3 | at Yankees | W10-7 | 1-2 | .333 | Yankee Stadium · The Bronx, NY |
| 4 | Mon Apr 4 | at Orioles | L1-5 | 1-3 | .250 | Camden Yards · Baltimore, MD |
| 5 | Wed Apr 6 | at Orioles | W7-3 | 2-3 | .400 | Camden Yards · Baltimore, MD |
| 6 | Thu Apr 7 | at Orioles | L5-9 | 2-4 | .333 | Camden Yards · Baltimore, MD |
| 7 | Fri Apr 8 | vs Royals | W5-2 | 3-4 | .429 | Comerica Park · Detroit, MI |
| 8 | Sat Apr 9 | vs Royals | L1-3 | 3-5 | .375 | Comerica Park · Detroit, MI |
| 9 | Sun Apr 10 | vs Royals | L5-9 | 3-6 | .333 | Comerica Park · Detroit, MI |
| 10 | Mon Apr 11 | vs Rangers | L0-2 | 3-7 | .300 | Comerica Park · Detroit, MI |
| 11 | Tue Apr 12 | vs Rangers | W5-4 | 4-7 | .364 | Comerica Park · Detroit, MI |
| 12 | Wed Apr 13 | vs Rangers | W3-2 | 5-7 | .417 | Comerica Park · Detroit, MI |
| 13 | Thu Apr 14 | at Athletics | W3-0 | 6-7 | .462 | RingCentral Coliseum · Oakland, CA |
| 14 | Fri Apr 15 | at Athletics | W8-4 (10) | 7-7 | .500 | RingCentral Coliseum · Oakland, CA |
| 15 | Sat Apr 16 | at Athletics | L2-6 | 7-8 | .467 | RingCentral Coliseum · Oakland, CA |
| 16 | Sun Apr 17 | at Athletics | L1-5 | 7-9 | .438 | RingCentral Coliseum · Oakland, CA |
| 17 | Mon Apr 18 | at Mariners | W8-3 | 8-9 | .471 | T-Mobile Park · Seattle, WA |
| 18 | Tue Apr 19 | at Mariners | L3-13 | 8-10 | .444 | T-Mobile Park · Seattle, WA |
| 19 | Wed Apr 20 | at Mariners | W3-2 | 9-10 | .474 | T-Mobile Park · Seattle, WA |
| 20 | Fri Apr 22 | vs White Sox | W9-3 | 10-10 | .500 | Comerica Park · Detroit, MI |
| 21 | Sat Apr 23 | vs White Sox | W9-0 | 11-10 | .524 | Comerica Park · Detroit, MI |
| 22 | Sun Apr 24 | vs White Sox | W3-0 | 12-10 | .545 | Comerica Park · Detroit, MI |
| 23 | Tue Apr 26 | vs Mariners | L3-7 | 12-11 | .522 | Comerica Park · Detroit, MI |
| 24 | Wed Apr 27 | vs Mariners | L1-10 | 12-12 | .500 | Comerica Park · Detroit, MI |
| 25 | Thu Apr 28 | vs Mariners | L2-7 | 12-13 | .480 | Comerica Park · Detroit, MI |
| 26 | Fri Apr 29 | at Guardians | L5-9 | 12-14 | .462 | Progressive Field · Cleveland, OH |
| 27 | Sat Apr 30 | at Guardians | L2-3 (13) | 12-15 | .444 | Progressive Field · Cleveland, OH |
| 28 | Sun May 1 | at Guardians | L4-5 | 12-16 | .429 | Progressive Field · Cleveland, OH |
| 29 | Mon May 2 | vs Yankees | L3-5 | 12-17 | .414 | Comerica Park · Detroit, MI |
| 30 | Tue May 3 | vs Yankees | W4-2 | 13-17 | .433 | Comerica Park · Detroit, MI |
| 31 | Wed May 4 | vs Yankees | W4-0 | 14-17 | .452 | Comerica Park · Detroit, MI |
| 32 | Thu May 5 | vs Yankees | W6-3 | 15-17 | .469 | Comerica Park · Detroit, MI |
| 33 | Fri May 6 | at Blue Jays | L4-7 | 15-18 | .455 | Rogers Centre · Toronto, ON |
| 34 | Sat May 7 | at Blue Jays | W9-0 | 16-18 | .471 | Rogers Centre · Toronto, ON |
| 35 | Sun May 8 | at Blue Jays | W5-2 | 17-18 | .486 | Rogers Centre · Toronto, ON |
| 36 | Mon May 9 | at Blue Jays | W10-5 | 18-18 | .500 | Rogers Centre · Toronto, ON |
| 37 | Tue May 10 | at Twins | W10-2 | 19-18 | .514 | Target Field · Minneapolis, MN |
| 38 | Wed May 11 | at Twins | W9-7 | 20-18 | .526 | Target Field · Minneapolis, MN |
| 39 | Fri May 13 | vs Royals | W3-1 | 21-18 | .538 | Comerica Park · Detroit, MI |
| 40 | Sat May 14 | vs Royals | W3-0 | 22-18 | .550 | Comerica Park · Detroit, MI |
| 41 | Mon May 16 | vs Blue Jays | L2-4 | 22-19 | .537 | Comerica Park · Detroit, MI |
| 42 | Wed May 18 | at Red Sox | L0-1 | 22-20 | .524 | Fenway Park · Boston, MA |
| 43 | Thu May 19 | at Red Sox | L3-4 | 22-21 | .512 | Fenway Park · Boston, MA |
| 44 | Fri May 20 | at Pirates | L1-10 | 22-22 | .500 | PNC Park · Pittsburgh, PA |
| 45 | Sat May 21 | at Pirates | L2-6 | 22-23 | .489 | PNC Park · Pittsburgh, PA |
| 46 | Sun May 22 | at Pirates | W2-0 | 23-23 | .500 | PNC Park · Pittsburgh, PA |
| 47 | Mon May 23 | vs Rays | W6-3 | 24-23 | .511 | Comerica Park · Detroit, MI |
| 48 | Tue May 24 | vs Rays | W7-6 | 25-23 | .521 | Comerica Park · Detroit, MI |
| 49 | Thu May 26 | vs Red Sox | L1-14 | 25-24 | .510 | Comerica Park · Detroit, MI |
| 50 | Fri May 27 | vs Red Sox | L3-6 | 25-25 | .500 | Comerica Park · Detroit, MI |
| 51 | Sun May 29 | vs Red Sox | L3-4 | 25-26 | .490 | Comerica Park · Detroit, MI |
| 52 | Sun May 29 | vs Red Sox | W3-0 | 26-26 | .500 | Comerica Park · Detroit, MI |
| 53 | Mon May 30 | vs Twins | W6-5 | 27-26 | .509 | Comerica Park · Detroit, MI |
| 54 | Tue May 31 | vs Twins | W8-7 | 28-26 | .519 | Comerica Park · Detroit, MI |
| 55 | Wed Jun 1 | vs Twins | W4-2 | 29-26 | .527 | Comerica Park · Detroit, MI |
| 56 | Fri Jun 3 | at White Sox | L4-6 | 29-27 | .518 | Guaranteed Rate Field · Chicago, IL |
| 57 | Sat Jun 4 | at White Sox | W4-2 | 30-27 | .526 | Guaranteed Rate Field · Chicago, IL |
| 58 | Sun Jun 5 | at White Sox | W7-3 | 31-27 | .534 | Guaranteed Rate Field · Chicago, IL |
| 59 | Mon Jun 6 | at Rangers | W13-7 | 32-27 | .542 | Globe Life Field · Arlington, TX |
| 60 | Tue Jun 7 | at Rangers | W8-1 | 33-27 | .550 | Globe Life Field · Arlington, TX |
| 61 | Wed Jun 8 | at Rangers | L3-7 | 33-28 | .541 | Globe Life Field · Arlington, TX |
| 62 | Thu Jun 9 | vs Mariners | W4-1 | 34-28 | .548 | Comerica Park · Detroit, MI |
| 63 | Fri Jun 10 | vs Mariners | L2-3 | 34-29 | .540 | Comerica Park · Detroit, MI |
| 64 | Sat Jun 11 | vs Mariners | W8-1 | 35-29 | .547 | Comerica Park · Detroit, MI |
| 65 | Sun Jun 12 | vs Mariners | L3-7 | 35-30 | .538 | Comerica Park · Detroit, MI |
| 66 | Mon Jun 13 | vs Rays | W2-1 (10) | 36-30 | .545 | Comerica Park · Detroit, MI |
| 67 | Tue Jun 14 | vs Guardians | W4-0 | 37-30 | .552 | Comerica Park · Detroit, MI |
| 68 | Wed Jun 15 | vs Guardians | L4-6 | 37-31 | .544 | Comerica Park · Detroit, MI |
| 69 | Thu Jun 16 | vs Guardians | W6-2 | 38-31 | .551 | Comerica Park · Detroit, MI |
| 70 | Fri Jun 17 | at Rockies | L6-13 | 38-32 | .543 | Coors Field · Denver, CO |
| 71 | Sat Jun 18 | at Rockies | L4-5 | 38-33 | .535 | Coors Field · Denver, CO |
| 72 | Sun Jun 19 | at Rockies | W9-1 | 39-33 | .542 | Coors Field · Denver, CO |
| 73 | Mon Jun 20 | at Dodgers | L0-4 | 39-34 | .534 | Dodger Stadium · Los Angeles, CA |
| 74 | Tue Jun 21 | at Dodgers | L1-6 | 39-35 | .527 | Dodger Stadium · Los Angeles, CA |
| 75 | Wed Jun 22 | at Dodgers | W7-5 | 40-35 | .533 | Dodger Stadium · Los Angeles, CA |
| 76 | Fri Jun 24 | vs D-backs | L6-7 | 40-36 | .526 | Comerica Park · Detroit, MI |
| 77 | Sat Jun 25 | vs D-backs | W6-0 | 41-36 | .532 | Comerica Park · Detroit, MI |
| 78 | Sun Jun 26 | vs D-backs | W8-3 | 42-36 | .538 | Comerica Park · Detroit, MI |
| 79 | Mon Jun 27 | vs Blue Jays | W4-2 | 43-36 | .544 | Comerica Park · Detroit, MI |
| 80 | Tue Jun 28 | vs Mets | L3-14 | 43-37 | .537 | Comerica Park · Detroit, MI |
| 81 | Wed Jun 29 | vs Mets | L9-16 | 43-38 | .531 | Comerica Park · Detroit, MI |
| 82 | Thu Jun 30 | vs Mets | W5-2 | 44-38 | .537 | Comerica Park · Detroit, MI |
| 83 | Fri Jul 1 | vs Giants | L3-4 | 44-39 | .530 | Comerica Park · Detroit, MI |
| 84 | Sat Jul 2 | vs Giants | L3-15 | 44-40 | .524 | Comerica Park · Detroit, MI |
| 85 | Sun Jul 3 | vs Giants | W6-3 | 45-40 | .529 | Comerica Park · Detroit, MI |
| 86 | Mon Jul 4 | at Angels | L1-5 | 45-41 | .523 | Angel Stadium · Anaheim, CA |
| 87 | Tue Jul 5 | at Angels | L0-1 | 45-42 | .517 | Angel Stadium · Anaheim, CA |
| 88 | Wed Jul 6 | at Angels | W5-4 | 46-42 | .523 | Angel Stadium · Anaheim, CA |
| 89 | Thu Jul 7 | at Royals | W3-1 | 47-42 | .528 | Kauffman Stadium · Kansas City, MO |
| 90 | Fri Jul 8 | at Royals | W6-4 | 48-42 | .533 | Kauffman Stadium · Kansas City, MO |
| 91 | Sat Jul 9 | at Royals | L6-13 | 48-43 | .527 | Kauffman Stadium · Kansas City, MO |
| 92 | Sun Jul 10 | at Royals | W2-1 | 49-43 | .533 | Kauffman Stadium · Kansas City, MO |
| 93 | Fri Jul 15 | vs White Sox | L2-8 | 49-44 | .527 | Comerica Park · Detroit, MI |
| 94 | Sat Jul 16 | vs White Sox | L0-5 | 49-45 | .521 | Comerica Park · Detroit, MI |
| 95 | Sun Jul 17 | vs White Sox | W4-3 | 50-45 | .526 | Comerica Park · Detroit, MI |
| 96 | Tue Jul 19 | vs Athletics | W8-3 | 51-45 | .531 | Comerica Park · Detroit, MI |
| 97 | Wed Jul 20 | vs Athletics | L5-7 | 51-46 | .526 | Comerica Park · Detroit, MI |
| 98 | Thu Jul 21 | at Twins | W6-2 | 52-46 | .531 | Target Field · Minneapolis, MN |
| 99 | Fri Jul 22 | at Twins | W8-2 | 53-46 | .535 | Target Field · Minneapolis, MN |
| 100 | Sat Jul 23 | at Twins | L1-4 | 53-47 | .530 | Target Field · Minneapolis, MN |
| 101 | Sun Jul 24 | at Twins | W5-2 | 54-47 | .535 | Target Field · Minneapolis, MN |
| 102 | Mon Jul 25 | at White Sox | L3-6 | 54-48 | .529 | Guaranteed Rate Field · Chicago, IL |
| 103 | Tue Jul 26 | at White Sox | W5-4 | 55-48 | .534 | Guaranteed Rate Field · Chicago, IL |
| 104 | Wed Jul 27 | at White Sox | L1-2 | 55-49 | .529 | Guaranteed Rate Field · Chicago, IL |
| 105 | Thu Jul 28 | vs Angels | L7-12 | 55-50 | .524 | Comerica Park · Detroit, MI |
| 106 | Fri Jul 29 | vs Angels | W12-2 | 56-50 | .528 | Comerica Park · Detroit, MI |
| 107 | Sat Jul 30 | vs Angels | L1-5 | 56-51 | .523 | Comerica Park · Detroit, MI |
| 108 | Sun Jul 31 | vs Angels | W3-2 | 57-51 | .528 | Comerica Park · Detroit, MI |
| 109 | Tue Aug 2 | vs Rangers | W6-5 | 58-51 | .532 | Comerica Park · Detroit, MI |
| 110 | Wed Aug 3 | vs Rangers | W5-4 | 59-51 | .536 | Comerica Park · Detroit, MI |
| 111 | Thu Aug 4 | vs Rangers | L2-5 | 59-52 | .532 | Comerica Park · Detroit, MI |
| 112 | Fri Aug 5 | at Royals | W4-3 (10) | 60-52 | .536 | Kauffman Stadium · Kansas City, MO |
| 113 | Sat Aug 6 | at Royals | W4-3 | 61-52 | .540 | Kauffman Stadium · Kansas City, MO |
| 114 | Sun Aug 7 | at Royals | L3-4 | 61-53 | .535 | Kauffman Stadium · Kansas City, MO |
| 115 | Tue Aug 9 | at Guardians | L2-3 (14) | 61-54 | .530 | Progressive Field · Cleveland, OH |
| 116 | Wed Aug 10 | at Guardians | L3-10 | 61-55 | .526 | Progressive Field · Cleveland, OH |
| 117 | Thu Aug 11 | at Guardians | W4-3 | 62-55 | .530 | Progressive Field · Cleveland, OH |
| 118 | Fri Aug 12 | at Orioles | W5-4 | 63-55 | .534 | Camden Yards · Baltimore, MD |
| 119 | Sat Aug 13 | at Orioles | W6-5 | 64-55 | .538 | Camden Yards · Baltimore, MD |
| 120 | Sun Aug 14 | at Orioles | L5-8 | 64-56 | .533 | Camden Yards · Baltimore, MD |
| 121 | Mon Aug 15 | vs Twins | L6-9 | 64-57 | .529 | Comerica Park · Detroit, MI |
| 122 | Tue Aug 16 | vs Twins | W7-1 | 65-57 | .533 | Comerica Park · Detroit, MI |
| 123 | Wed Aug 17 | vs Twins | L5-6 | 65-58 | .528 | Comerica Park · Detroit, MI |
| 124 | Fri Aug 19 | vs Guardians | W4-1 | 66-58 | .532 | Comerica Park · Detroit, MI |
| 125 | Sat Aug 20 | vs Guardians | W10-1 | 67-58 | .536 | Comerica Park · Detroit, MI |
| 126 | Sun Aug 21 | vs Guardians | W8-7 | 68-58 | .540 | Comerica Park · Detroit, MI |
| 127 | Mon Aug 22 | at Rays | W5-2 | 69-58 | .543 | Tropicana Field · St. Petersburg, FL |
| 128 | Tue Aug 23 | at Rays | W2-1 | 70-58 | .547 | Tropicana Field · St. Petersburg, FL |
| 129 | Wed Aug 24 | at Rays | L2-3 (10) | 70-59 | .543 | Tropicana Field · St. Petersburg, FL |
| 130 | Thu Aug 25 | at Rays | W2-0 | 71-59 | .546 | Tropicana Field · St. Petersburg, FL |
| 131 | Fri Aug 26 | at Twins | W8-1 | 72-59 | .550 | Target Field · Minneapolis, MN |
| 132 | Sat Aug 27 | at Twins | W6-4 | 73-59 | .553 | Target Field · Minneapolis, MN |
| 133 | Sun Aug 28 | at Twins | L4-11 | 73-60 | .549 | Target Field · Minneapolis, MN |
| 134 | Mon Aug 29 | vs Royals | L5-9 | 73-61 | .545 | Comerica Park · Detroit, MI |
| 135 | Tue Aug 30 | vs Royals | W2-1 (10) | 74-61 | .548 | Comerica Park · Detroit, MI |
| 136 | Wed Aug 31 | vs Royals | W5-4 | 75-61 | .551 | Comerica Park · Detroit, MI |
| 137 | Thu Sep 1 | vs Royals | L8-11 | 75-62 | .547 | Comerica Park · Detroit, MI |
| 138 | Fri Sep 2 | vs White Sox | W8-1 | 76-62 | .551 | Comerica Park · Detroit, MI |
| 139 | Sat Sep 3 | vs White Sox | W9-8 | 77-62 | .554 | Comerica Park · Detroit, MI |
| 140 | Sun Sep 4 | vs White Sox | W18-2 | 78-62 | .557 | Comerica Park · Detroit, MI |
| 141 | Mon Sep 5 | at Guardians | W4-2 | 79-62 | .560 | Progressive Field · Cleveland, OH |
| 142 | Tue Sep 6 | at Guardians | W10-1 | 80-62 | .563 | Progressive Field · Cleveland, OH |
| 143 | Wed Sep 7 | at Guardians | W8-6 | 81-62 | .566 | Progressive Field · Cleveland, OH |
| 144 | Fri Sep 9 | vs Twins | W8-4 | 82-62 | .569 | Comerica Park · Detroit, MI |
| 145 | Sat Sep 10 | vs Twins | W3-2 | 83-62 | .572 | Comerica Park · Detroit, MI |
| 146 | Sun Sep 11 | vs Twins | W2-1 | 84-62 | .575 | Comerica Park · Detroit, MI |
| 147 | Mon Sep 12 | at White Sox | W14-4 | 85-62 | .578 | Guaranteed Rate Field · Chicago, IL |
| 148 | Tue Sep 13 | at White Sox | W5-0 | 86-62 | .581 | Guaranteed Rate Field · Chicago, IL |
| 149 | Wed Sep 14 | at White Sox | W6-5 (10) | 87-62 | .584 | Guaranteed Rate Field · Chicago, IL |
| 150 | Thu Sep 15 | at Athletics | L1-6 | 87-63 | .580 | RingCentral Coliseum · Oakland, CA |
| 151 | Fri Sep 16 | at Athletics | W3-1 | 88-63 | .583 | RingCentral Coliseum · Oakland, CA |
| 152 | Sat Sep 17 | at Athletics | L3-5 | 88-64 | .579 | RingCentral Coliseum · Oakland, CA |
| 153 | Sun Sep 18 | at Athletics | W3-0 | 89-64 | .582 | RingCentral Coliseum · Oakland, CA |
| 154 | Tue Sep 20 | at Royals | L2-10 | 89-65 | .578 | Kauffman Stadium · Kansas City, MO |
| 155 | Wed Sep 21 | at Royals | W6-3 | 90-65 | .581 | Kauffman Stadium · Kansas City, MO |
| 156 | Thu Sep 22 | vs Orioles | L5-6 | 90-66 | .577 | Comerica Park · Detroit, MI |
| 157 | Fri Sep 23 | vs Orioles | W4-3 (11) | 91-66 | .580 | Comerica Park · Detroit, MI |
| 158 | Sat Sep 24 | vs Orioles | L5-6 | 91-67 | .576 | Comerica Park · Detroit, MI |
| 159 | Sun Sep 25 | vs Orioles | W10-6 | 92-67 | .579 | Comerica Park · Detroit, MI |
| 160 | Mon Sep 26 | vs Guardians | W14-0 | 93-67 | .581 | Comerica Park · Detroit, MI |
| 161 | Tue Sep 27 | vs Guardians | W9-6 | 94-67 | .584 | Comerica Park · Detroit, MI |
| 162 | Wed Sep 28 | vs Guardians | W5-4 | 95-67 | .586 | Comerica Park · Detroit, MI |
| 163 | Sat Oct 1 | at Yankees | L3-9 | 0-1 | .000 | Yankee Stadium · The Bronx, NY |
| 164 | Sun Oct 2 | at Yankees | W5-3 | 1-1 | .500 | Yankee Stadium · The Bronx, NY |
| 165 | Mon Oct 3 | vs Yankees | W5-4 | 2-1 | .667 | Comerica Park · Detroit, MI |
| 166 | Tue Oct 4 | vs Yankees | L1-10 | 2-2 | .500 | Comerica Park · Detroit, MI |
| 167 | Thu Oct 6 | at Yankees | W3-2 | 3-2 | .600 | Yankee Stadium · The Bronx, NY |
| 168 | Sat Oct 8 | at Rangers | L2-3 | 0-1 | .000 | Globe Life Field · Arlington, TX |
| 169 | Mon Oct 10 | at Rangers | L3-7 (11) | 0-2 | .000 | Globe Life Field · Arlington, TX |
| 170 | Tue Oct 11 | vs Rangers | W5-2 | 1-2 | .333 | Comerica Park · Detroit, MI |
| 171 | Wed Oct 12 | vs Rangers | L3-7 (11) | 1-3 | .250 | Comerica Park · Detroit, MI |
| 172 | Thu Oct 13 | vs Rangers | W7-5 | 2-3 | .400 | Comerica Park · Detroit, MI |
| 173 | Sat Oct 15 | at Rangers | L5-15 | 2-4 | .333 | Globe Life Field · Arlington, TX |