| 1 | Tue Apr 4 | at White Sox | W6-3 | 1-0 | 1.000 | Guaranteed Rate Field · Chicago, IL |
| 2 | Thu Apr 6 | at White Sox | L2-11 | 1-1 | .500 | Guaranteed Rate Field · Chicago, IL |
| 3 | Fri Apr 7 | vs Red Sox | W6-5 | 2-1 | .667 | Comerica Park · Detroit, MI |
| 4 | Sat Apr 8 | vs Red Sox | W4-1 | 3-1 | .750 | Comerica Park · Detroit, MI |
| 5 | Sun Apr 9 | vs Red Sox | L5-7 | 3-2 | .600 | Comerica Park · Detroit, MI |
| 6 | Mon Apr 10 | vs Red Sox | W2-1 | 4-2 | .667 | Comerica Park · Detroit, MI |
| 7 | Tue Apr 11 | vs Twins | W2-1 | 5-2 | .714 | Comerica Park · Detroit, MI |
| 8 | Wed Apr 12 | vs Twins | W5-3 | 6-2 | .750 | Comerica Park · Detroit, MI |
| 9 | Thu Apr 13 | vs Twins | L5-11 | 6-3 | .667 | Comerica Park · Detroit, MI |
| 10 | Fri Apr 14 | at Guardians | W7-6 | 7-3 | .700 | Progressive Field · Cleveland, OH |
| 11 | Sat Apr 15 | at Guardians | L6-13 | 7-4 | .636 | Progressive Field · Cleveland, OH |
| 12 | Sun Apr 16 | at Guardians | W4-1 | 8-4 | .667 | Progressive Field · Cleveland, OH |
| 13 | Tue Apr 18 | at Rays | L1-5 | 8-5 | .615 | Tropicana Field · St. Petersburg, FL |
| 14 | Wed Apr 19 | at Rays | L7-8 | 8-6 | .571 | Tropicana Field · St. Petersburg, FL |
| 15 | Thu Apr 20 | at Rays | L1-8 | 8-7 | .533 | Tropicana Field · St. Petersburg, FL |
| 16 | Fri Apr 21 | at Twins | L3-6 | 8-8 | .500 | Target Field · Minneapolis, MN |
| 17 | Sat Apr 22 | at Twins | W5-4 | 9-8 | .529 | Target Field · Minneapolis, MN |
| 18 | Sun Apr 23 | at Twins | W13-4 | 10-8 | .556 | Target Field · Minneapolis, MN |
| 19 | Tue Apr 25 | vs Mariners | W19-9 | 11-8 | .579 | Comerica Park · Detroit, MI |
| 20 | Wed Apr 26 | vs Mariners | L0-8 | 11-9 | .550 | Comerica Park · Detroit, MI |
| 21 | Thu Apr 27 | vs Mariners | L1-2 | 11-10 | .524 | Comerica Park · Detroit, MI |
| 22 | Fri Apr 28 | vs White Sox | L3-7 | 11-11 | .500 | Comerica Park · Detroit, MI |
| 23 | Sat Apr 29 | vs White Sox | L4-6 (10) | 11-12 | .478 | Comerica Park · Detroit, MI |
| 24 | Sun Apr 30 | vs White Sox | W7-3 | 12-12 | .500 | Comerica Park · Detroit, MI |
| 25 | Mon May 1 | vs Guardians | W7-1 | 13-12 | .520 | Comerica Park · Detroit, MI |
| 26 | Tue May 2 | vs Guardians | W5-2 | 14-12 | .538 | Comerica Park · Detroit, MI |
| 27 | Wed May 3 | vs Guardians | L2-3 | 14-13 | .519 | Comerica Park · Detroit, MI |
| 28 | Fri May 5 | at Athletics | W7-2 | 15-13 | .536 | RingCentral Coliseum · Oakland, CA |
| 29 | Sat May 6 | at Athletics | L5-6 | 15-14 | .517 | RingCentral Coliseum · Oakland, CA |
| 30 | Sun May 7 | at Athletics | L6-8 | 15-15 | .500 | RingCentral Coliseum · Oakland, CA |
| 31 | Tue May 9 | at D-backs | W7-3 | 16-15 | .516 | Chase Field · Phoenix, AZ |
| 32 | Wed May 10 | at D-backs | L1-7 | 16-16 | .500 | Chase Field · Phoenix, AZ |
| 33 | Thu May 11 | at Angels | W7-1 | 17-16 | .515 | Angel Stadium · Anaheim, CA |
| 34 | Fri May 12 | at Angels | L0-7 | 17-17 | .500 | Angel Stadium · Anaheim, CA |
| 35 | Sat May 13 | at Angels | W4-3 | 18-17 | .514 | Angel Stadium · Anaheim, CA |
| 36 | Sun May 14 | at Angels | L1-4 | 18-18 | .500 | Angel Stadium · Anaheim, CA |
| 37 | Tue May 16 | vs Orioles | L11-13 (13) | 18-19 | .486 | Comerica Park · Detroit, MI |
| 38 | Wed May 17 | vs Orioles | W5-4 | 19-19 | .500 | Comerica Park · Detroit, MI |
| 39 | Thu May 18 | vs Orioles | W6-5 | 20-19 | .513 | Comerica Park · Detroit, MI |
| 40 | Fri May 19 | vs Rangers | L3-5 | 20-20 | .500 | Comerica Park · Detroit, MI |
| 41 | Sat May 20 | vs Rangers | W9-3 | 21-20 | .512 | Comerica Park · Detroit, MI |
| 42 | Sun May 21 | vs Rangers | L2-5 | 21-21 | .500 | Comerica Park · Detroit, MI |
| 43 | Mon May 22 | at Astros | L0-1 | 21-22 | .488 | Minute Maid Park · Houston, TX |
| 44 | Tue May 23 | at Astros | L2-6 | 21-23 | .477 | Minute Maid Park · Houston, TX |
| 45 | Wed May 24 | at Astros | W6-3 | 22-23 | .489 | Minute Maid Park · Houston, TX |
| 46 | Thu May 25 | at Astros | L6-7 | 22-24 | .478 | Minute Maid Park · Houston, TX |
| 47 | Fri May 26 | at White Sox | L2-8 | 22-25 | .468 | Guaranteed Rate Field · Chicago, IL |
| 48 | Sat May 27 | at White Sox | L0-3 | 22-26 | .458 | Guaranteed Rate Field · Chicago, IL |
| 49 | Sat May 27 | at White Sox | W4-3 | 23-26 | .469 | Guaranteed Rate Field · Chicago, IL |
| 50 | Sun May 28 | at White Sox | L3-7 | 23-27 | .460 | Guaranteed Rate Field · Chicago, IL |
| 51 | Mon May 29 | at Royals | W10-7 | 24-27 | .471 | Kauffman Stadium · Kansas City, MO |
| 52 | Tue May 30 | at Royals | L0-1 | 24-28 | .462 | Kauffman Stadium · Kansas City, MO |
| 53 | Wed May 31 | at Royals | W6-5 | 25-28 | .472 | Kauffman Stadium · Kansas City, MO |
| 54 | Fri Jun 2 | vs White Sox | W15-5 | 26-28 | .481 | Comerica Park · Detroit, MI |
| 55 | Sat Jun 3 | vs White Sox | W10-1 | 27-28 | .491 | Comerica Park · Detroit, MI |
| 56 | Sun Jun 4 | vs White Sox | W7-4 | 28-28 | .500 | Comerica Park · Detroit, MI |
| 57 | Tue Jun 6 | vs Angels | L3-5 | 28-29 | .491 | Comerica Park · Detroit, MI |
| 58 | Wed Jun 7 | vs Angels | W4-0 | 29-29 | .500 | Comerica Park · Detroit, MI |
| 59 | Thu Jun 8 | vs Angels | L4-11 | 29-30 | .492 | Comerica Park · Detroit, MI |
| 60 | Fri Jun 9 | at Red Sox | L3-5 | 29-31 | .483 | Fenway Park · Boston, MA |
| 61 | Sat Jun 10 | at Red Sox | L3-11 | 29-32 | .475 | Fenway Park · Boston, MA |
| 62 | Sun Jun 11 | at Red Sox | W8-3 | 30-32 | .484 | Fenway Park · Boston, MA |
| 63 | Tue Jun 13 | vs D-backs | L6-7 | 30-33 | .476 | Comerica Park · Detroit, MI |
| 64 | Wed Jun 14 | vs D-backs | L1-2 | 30-34 | .469 | Comerica Park · Detroit, MI |
| 65 | Thu Jun 15 | vs Rays | W5-3 | 31-34 | .477 | Comerica Park · Detroit, MI |
| 66 | Fri Jun 16 | vs Rays | W13-4 | 32-34 | .485 | Comerica Park · Detroit, MI |
| 67 | Sat Jun 17 | vs Rays | L2-3 | 32-35 | .478 | Comerica Park · Detroit, MI |
| 68 | Sun Jun 18 | vs Rays | L1-9 | 32-36 | .471 | Comerica Park · Detroit, MI |
| 69 | Mon Jun 19 | at Mariners | L2-6 | 32-37 | .464 | T-Mobile Park · Seattle, WA |
| 70 | Tue Jun 20 | at Mariners | L4-5 (10) | 32-38 | .457 | T-Mobile Park · Seattle, WA |
| 71 | Wed Jun 21 | at Mariners | L5-7 | 32-39 | .451 | T-Mobile Park · Seattle, WA |
| 72 | Thu Jun 22 | at Mariners | L6-9 | 32-40 | .444 | T-Mobile Park · Seattle, WA |
| 73 | Fri Jun 23 | at Padres | L0-1 | 32-41 | .438 | Petco Park · San Diego, CA |
| 74 | Sat Jun 24 | at Padres | L3-7 | 32-42 | .432 | Petco Park · San Diego, CA |
| 75 | Sun Jun 25 | at Padres | W7-5 | 33-42 | .440 | Petco Park · San Diego, CA |
| 76 | Tue Jun 27 | vs Royals | W5-3 | 34-42 | .447 | Comerica Park · Detroit, MI |
| 77 | Wed Jun 28 | vs Royals | L2-8 | 34-43 | .442 | Comerica Park · Detroit, MI |
| 78 | Thu Jun 29 | vs Royals | W7-3 | 35-43 | .449 | Comerica Park · Detroit, MI |
| 79 | Sat Jul 1 | vs Guardians | W7-4 | 36-43 | .456 | Comerica Park · Detroit, MI |
| 80 | Sat Jul 1 | vs Guardians | L1-4 | 36-44 | .450 | Comerica Park · Detroit, MI |
| 81 | Sun Jul 2 | vs Guardians | L8-11 | 36-45 | .444 | Comerica Park · Detroit, MI |
| 82 | Tue Jul 4 | vs Giants | W5-3 | 37-45 | .451 | Comerica Park · Detroit, MI |
| 83 | Wed Jul 5 | vs Giants | L4-5 | 37-46 | .446 | Comerica Park · Detroit, MI |
| 84 | Thu Jul 6 | vs Giants | W6-2 | 38-46 | .452 | Comerica Park · Detroit, MI |
| 85 | Fri Jul 7 | at Guardians | L2-11 | 38-47 | .447 | Progressive Field · Cleveland, OH |
| 86 | Sat Jul 8 | at Guardians | L0-4 | 38-48 | .442 | Progressive Field · Cleveland, OH |
| 87 | Sun Jul 9 | at Guardians | W5-3 | 39-48 | .448 | Progressive Field · Cleveland, OH |
| 88 | Fri Jul 14 | vs Blue Jays | L2-7 | 39-49 | .443 | Comerica Park · Detroit, MI |
| 89 | Sat Jul 15 | vs Blue Jays | W11-1 | 40-49 | .449 | Comerica Park · Detroit, MI |
| 90 | Sun Jul 16 | vs Blue Jays | W6-5 (11) | 41-49 | .456 | Comerica Park · Detroit, MI |
| 91 | Mon Jul 17 | at Royals | W10-2 | 42-49 | .462 | Kauffman Stadium · Kansas City, MO |
| 92 | Tue Jul 18 | at Royals | W9-3 | 43-49 | .467 | Kauffman Stadium · Kansas City, MO |
| 93 | Wed Jul 19 | at Royals | L3-4 | 43-50 | .462 | Kauffman Stadium · Kansas City, MO |
| 94 | Thu Jul 20 | at Royals | L4-16 | 43-51 | .457 | Kauffman Stadium · Kansas City, MO |
| 95 | Fri Jul 21 | at Twins | W6-3 | 44-51 | .463 | Target Field · Minneapolis, MN |
| 96 | Sat Jul 22 | at Twins | L5-6 | 44-52 | .458 | Target Field · Minneapolis, MN |
| 97 | Sun Jul 23 | at Twins | W9-6 | 45-52 | .464 | Target Field · Minneapolis, MN |
| 98 | Mon Jul 24 | vs Royals | L3-5 (12) | 45-53 | .459 | Comerica Park · Detroit, MI |
| 99 | Tue Jul 25 | vs Royals | L1-3 | 45-54 | .455 | Comerica Park · Detroit, MI |
| 100 | Wed Jul 26 | vs Royals | L2-16 | 45-55 | .450 | Comerica Park · Detroit, MI |
| 101 | Fri Jul 28 | vs Astros | L5-6 | 45-56 | .446 | Comerica Park · Detroit, MI |
| 102 | Sat Jul 29 | vs Astros | W5-3 | 46-56 | .451 | Comerica Park · Detroit, MI |
| 103 | Sun Jul 30 | vs Astros | W13-1 | 47-56 | .456 | Comerica Park · Detroit, MI |
| 104 | Mon Jul 31 | at Yankees | L3-7 | 47-57 | .452 | Yankee Stadium · The Bronx, NY |
| 105 | Tue Aug 1 | at Yankees | W4-3 | 48-57 | .457 | Yankee Stadium · The Bronx, NY |
| 106 | Wed Aug 2 | at Yankees | W2-0 | 49-57 | .462 | Yankee Stadium · The Bronx, NY |
| 107 | Thu Aug 3 | at Orioles | W7-5 | 50-57 | .467 | Camden Yards · Baltimore, MD |
| 108 | Fri Aug 4 | at Orioles | W5-2 | 51-57 | .472 | Camden Yards · Baltimore, MD |
| 109 | Sat Aug 5 | at Orioles | L2-5 | 51-58 | .468 | Camden Yards · Baltimore, MD |
| 110 | Sun Aug 6 | at Orioles | L3-12 | 51-59 | .464 | Camden Yards · Baltimore, MD |
| 111 | Mon Aug 7 | at Pirates | L0-3 | 51-60 | .459 | PNC Park · Pittsburgh, PA |
| 112 | Tue Aug 8 | at Pirates | L3-6 | 51-61 | .455 | PNC Park · Pittsburgh, PA |
| 113 | Wed Aug 9 | vs Pirates | W10-0 | 52-61 | .460 | Comerica Park · Detroit, MI |
| 114 | Thu Aug 10 | vs Pirates | L5-7 | 52-62 | .456 | Comerica Park · Detroit, MI |
| 115 | Fri Aug 11 | vs Twins | L4-9 | 52-63 | .452 | Comerica Park · Detroit, MI |
| 116 | Sat Aug 12 | vs Twins | W12-11 | 53-63 | .457 | Comerica Park · Detroit, MI |
| 117 | Sun Aug 13 | vs Twins | L4-6 | 53-64 | .453 | Comerica Park · Detroit, MI |
| 118 | Mon Aug 14 | at Rangers | L2-6 | 53-65 | .449 | Globe Life Field · Arlington, TX |
| 119 | Tue Aug 15 | at Rangers | L4-10 | 53-66 | .445 | Globe Life Field · Arlington, TX |
| 120 | Wed Aug 16 | at Rangers | L6-12 | 53-67 | .442 | Globe Life Field · Arlington, TX |
| 121 | Fri Aug 18 | vs Dodgers | L5-8 | 53-68 | .438 | Comerica Park · Detroit, MI |
| 122 | Sat Aug 19 | vs Dodgers | L0-3 | 53-69 | .434 | Comerica Park · Detroit, MI |
| 123 | Sun Aug 20 | vs Dodgers | W6-1 | 54-69 | .439 | Comerica Park · Detroit, MI |
| 124 | Tue Aug 22 | vs Yankees | L4-13 | 54-70 | .435 | Comerica Park · Detroit, MI |
| 125 | Wed Aug 23 | vs Yankees | L2-10 | 54-71 | .432 | Comerica Park · Detroit, MI |
| 126 | Thu Aug 24 | vs Yankees | W10-6 | 55-71 | .437 | Comerica Park · Detroit, MI |
| 127 | Fri Aug 25 | at White Sox | L2-3 | 55-72 | .433 | Guaranteed Rate Field · Chicago, IL |
| 128 | Sat Aug 26 | at White Sox | W6-3 | 56-72 | .438 | Guaranteed Rate Field · Chicago, IL |
| 129 | Sun Aug 27 | at White Sox | L1-7 | 56-73 | .434 | Guaranteed Rate Field · Chicago, IL |
| 130 | Mon Aug 28 | at Rockies | W4-3 | 57-73 | .438 | Coors Field · Denver, CO |
| 131 | Tue Aug 29 | at Rockies | L3-7 | 57-74 | .435 | Coors Field · Denver, CO |
| 132 | Wed Aug 30 | at Rockies | W6-2 | 58-74 | .439 | Coors Field · Denver, CO |
| 133 | Fri Sep 1 | vs Guardians | L2-3 | 58-75 | .436 | Comerica Park · Detroit, MI |
| 134 | Fri Sep 1 | vs Guardians | L0-10 | 58-76 | .433 | Comerica Park · Detroit, MI |
| 135 | Sat Sep 2 | vs Guardians | L2-5 | 58-77 | .430 | Comerica Park · Detroit, MI |
| 136 | Sun Sep 3 | vs Guardians | L1-11 | 58-78 | .426 | Comerica Park · Detroit, MI |
| 137 | Mon Sep 4 | vs Royals | L6-7 | 58-79 | .423 | Comerica Park · Detroit, MI |
| 138 | Tue Sep 5 | vs Royals | W13-2 | 59-79 | .428 | Comerica Park · Detroit, MI |
| 139 | Wed Sep 6 | vs Royals | L2-13 | 59-80 | .424 | Comerica Park · Detroit, MI |
| 140 | Fri Sep 8 | at Blue Jays | W5-4 | 60-80 | .429 | Rogers Centre · Toronto, ON |
| 141 | Sat Sep 9 | at Blue Jays | L4-5 | 60-81 | .426 | Rogers Centre · Toronto, ON |
| 142 | Sun Sep 10 | at Blue Jays | L2-8 | 60-82 | .423 | Rogers Centre · Toronto, ON |
| 143 | Mon Sep 11 | at Guardians | L0-11 | 60-83 | .420 | Progressive Field · Cleveland, OH |
| 144 | Tue Sep 12 | at Guardians | L0-2 | 60-84 | .417 | Progressive Field · Cleveland, OH |
| 145 | Wed Sep 13 | at Guardians | L3-5 | 60-85 | .414 | Progressive Field · Cleveland, OH |
| 146 | Thu Sep 14 | vs White Sox | L7-17 | 60-86 | .411 | Comerica Park · Detroit, MI |
| 147 | Fri Sep 15 | vs White Sox | W3-2 | 61-86 | .415 | Comerica Park · Detroit, MI |
| 148 | Sat Sep 16 | vs White Sox | L4-10 | 61-87 | .412 | Comerica Park · Detroit, MI |
| 149 | Sun Sep 17 | vs White Sox | W12-0 | 62-87 | .416 | Comerica Park · Detroit, MI |
| 150 | Mon Sep 18 | vs Athletics | L3-8 | 62-88 | .413 | Comerica Park · Detroit, MI |
| 151 | Tue Sep 19 | vs Athletics | L8-9 | 62-89 | .411 | Comerica Park · Detroit, MI |
| 152 | Wed Sep 20 | vs Athletics | L2-3 | 62-90 | .408 | Comerica Park · Detroit, MI |
| 153 | Thu Sep 21 | vs Twins | L1-12 | 62-91 | .405 | Comerica Park · Detroit, MI |
| 154 | Fri Sep 22 | vs Twins | L3-7 | 62-92 | .403 | Comerica Park · Detroit, MI |
| 155 | Sat Sep 23 | vs Twins | L4-10 | 62-93 | .400 | Comerica Park · Detroit, MI |
| 156 | Sun Sep 24 | vs Twins | L4-10 | 62-94 | .397 | Comerica Park · Detroit, MI |
| 157 | Tue Sep 26 | at Royals | L1-2 | 62-95 | .395 | Kauffman Stadium · Kansas City, MO |
| 158 | Wed Sep 27 | at Royals | L4-7 | 62-96 | .392 | Kauffman Stadium · Kansas City, MO |
| 159 | Thu Sep 28 | at Royals | W4-1 | 63-96 | .396 | Kauffman Stadium · Kansas City, MO |
| 160 | Fri Sep 29 | at Twins | L3-6 | 63-97 | .394 | Target Field · Minneapolis, MN |
| 161 | Sat Sep 30 | at Twins | W3-2 | 64-97 | .398 | Target Field · Minneapolis, MN |
| 162 | Sun Oct 1 | at Twins | L1-5 | 64-98 | .395 | Target Field · Minneapolis, MN |