| 1 | Thu Mar 28 | at White Sox | W1-0 | 1-0 | 1.000 | Guaranteed Rate Field · Chicago, IL |
| 2 | Sat Mar 30 | at White Sox | W7-6 (10) | 2-0 | 1.000 | Guaranteed Rate Field · Chicago, IL |
| 3 | Sun Mar 31 | at White Sox | W3-2 | 3-0 | 1.000 | Guaranteed Rate Field · Chicago, IL |
| 4 | Mon Apr 1 | at Mets | W5-0 (10) | 4-0 | 1.000 | Citi Field · Queens, NY |
| 5 | Thu Apr 4 | at Mets | W6-3 (11) | 5-0 | 1.000 | Citi Field · Queens, NY |
| 6 | Thu Apr 4 | at Mets | L1-2 | 5-1 | .833 | Citi Field · Queens, NY |
| 7 | Fri Apr 5 | vs Athletics | W5-4 | 6-1 | .857 | Comerica Park · Detroit, MI |
| 8 | Sat Apr 6 | vs Athletics | L0-4 | 6-2 | .750 | Comerica Park · Detroit, MI |
| 9 | Sun Apr 7 | vs Athletics | L1-7 | 6-3 | .667 | Comerica Park · Detroit, MI |
| 10 | Mon Apr 8 | at Pirates | L4-7 | 6-4 | .600 | PNC Park · Pittsburgh, PA |
| 11 | Tue Apr 9 | at Pirates | W5-3 | 7-4 | .636 | PNC Park · Pittsburgh, PA |
| 12 | Fri Apr 12 | vs Twins | W8-2 | 8-4 | .667 | Comerica Park · Detroit, MI |
| 13 | Sat Apr 13 | vs Twins | L5-11 (12) | 8-5 | .615 | Comerica Park · Detroit, MI |
| 14 | Sat Apr 13 | vs Twins | L1-4 | 8-6 | .571 | Comerica Park · Detroit, MI |
| 15 | Sun Apr 14 | vs Twins | W4-3 | 9-6 | .600 | Comerica Park · Detroit, MI |
| 16 | Mon Apr 15 | vs Rangers | L0-1 | 9-7 | .563 | Comerica Park · Detroit, MI |
| 17 | Tue Apr 16 | vs Rangers | W4-2 | 10-7 | .588 | Comerica Park · Detroit, MI |
| 18 | Wed Apr 17 | vs Rangers | L4-5 | 10-8 | .556 | Comerica Park · Detroit, MI |
| 19 | Thu Apr 18 | vs Rangers | L7-9 | 10-9 | .526 | Comerica Park · Detroit, MI |
| 20 | Fri Apr 19 | at Twins | W5-4 | 11-9 | .550 | Target Field · Minneapolis, MN |
| 21 | Sat Apr 20 | at Twins | L3-4 | 11-10 | .524 | Target Field · Minneapolis, MN |
| 22 | Sun Apr 21 | at Twins | W6-1 | 12-10 | .545 | Target Field · Minneapolis, MN |
| 23 | Mon Apr 22 | at Rays | W7-1 | 13-10 | .565 | Tropicana Field · St. Petersburg, FL |
| 24 | Tue Apr 23 | at Rays | W4-2 | 14-10 | .583 | Tropicana Field · St. Petersburg, FL |
| 25 | Wed Apr 24 | at Rays | L5-7 | 14-11 | .560 | Tropicana Field · St. Petersburg, FL |
| 26 | Fri Apr 26 | vs Royals | L0-8 | 14-12 | .538 | Comerica Park · Detroit, MI |
| 27 | Sat Apr 27 | vs Royals | W6-5 | 15-12 | .556 | Comerica Park · Detroit, MI |
| 28 | Sun Apr 28 | vs Royals | W4-1 | 16-12 | .571 | Comerica Park · Detroit, MI |
| 29 | Tue Apr 30 | vs Cardinals | L1-2 | 16-13 | .552 | Comerica Park · Detroit, MI |
| 30 | Tue Apr 30 | vs Cardinals | W11-6 | 17-13 | .567 | Comerica Park · Detroit, MI |
| 31 | Wed May 1 | vs Cardinals | W4-1 | 18-13 | .581 | Comerica Park · Detroit, MI |
| 32 | Fri May 3 | at Yankees | L1-2 | 18-14 | .563 | Yankee Stadium · The Bronx, NY |
| 33 | Sat May 4 | at Yankees | L3-5 | 18-15 | .545 | Yankee Stadium · The Bronx, NY |
| 34 | Sun May 5 | at Yankees | L2-5 | 18-16 | .529 | Yankee Stadium · The Bronx, NY |
| 35 | Mon May 6 | at Guardians | L1-2 | 18-17 | .514 | Progressive Field · Cleveland, OH |
| 36 | Tue May 7 | at Guardians | W11-7 | 19-17 | .528 | Progressive Field · Cleveland, OH |
| 37 | Wed May 8 | at Guardians | L4-5 (10) | 19-18 | .514 | Progressive Field · Cleveland, OH |
| 38 | Fri May 10 | vs Astros | L2-5 | 19-19 | .500 | Comerica Park · Detroit, MI |
| 39 | Sat May 11 | vs Astros | W8-2 | 20-19 | .513 | Comerica Park · Detroit, MI |
| 40 | Sun May 12 | vs Astros | L3-9 | 20-20 | .500 | Comerica Park · Detroit, MI |
| 41 | Mon May 13 | vs Marlins | W6-5 | 21-20 | .512 | Comerica Park · Detroit, MI |
| 42 | Tue May 14 | vs Marlins | L0-1 (10) | 21-21 | .500 | Comerica Park · Detroit, MI |
| 43 | Wed May 15 | vs Marlins | L0-2 | 21-22 | .488 | Comerica Park · Detroit, MI |
| 44 | Fri May 17 | at D-backs | W13-0 | 22-22 | .500 | Chase Field · Phoenix, AZ |
| 45 | Sat May 18 | at D-backs | W8-3 | 23-22 | .511 | Chase Field · Phoenix, AZ |
| 46 | Sun May 19 | at D-backs | L4-6 | 23-23 | .500 | Chase Field · Phoenix, AZ |
| 47 | Mon May 20 | at Royals | L3-8 | 23-24 | .489 | Kauffman Stadium · Kansas City, MO |
| 48 | Tue May 21 | at Royals | L3-10 | 23-25 | .479 | Kauffman Stadium · Kansas City, MO |
| 49 | Wed May 22 | at Royals | L3-8 | 23-26 | .469 | Kauffman Stadium · Kansas City, MO |
| 50 | Thu May 23 | vs Blue Jays | L1-9 | 23-27 | .460 | Comerica Park · Detroit, MI |
| 51 | Fri May 24 | vs Blue Jays | W6-2 | 24-27 | .471 | Comerica Park · Detroit, MI |
| 52 | Sat May 25 | vs Blue Jays | W2-1 | 25-27 | .481 | Comerica Park · Detroit, MI |
| 53 | Sun May 26 | vs Blue Jays | W14-11 | 26-27 | .491 | Comerica Park · Detroit, MI |
| 54 | Wed May 29 | vs Pirates | W8-0 | 27-27 | .500 | Comerica Park · Detroit, MI |
| 55 | Wed May 29 | vs Pirates | L2-10 | 27-28 | .491 | Comerica Park · Detroit, MI |
| 56 | Thu May 30 | at Red Sox | W5-0 | 28-28 | .500 | Fenway Park · Boston, MA |
| 57 | Fri May 31 | at Red Sox | L3-7 | 28-29 | .491 | Fenway Park · Boston, MA |
| 58 | Sat Jun 1 | at Red Sox | L3-6 | 28-30 | .483 | Fenway Park · Boston, MA |
| 59 | Sun Jun 2 | at Red Sox | W8-4 (10) | 29-30 | .492 | Fenway Park · Boston, MA |
| 60 | Mon Jun 3 | at Rangers | W2-1 | 30-30 | .500 | Globe Life Field · Arlington, TX |
| 61 | Tue Jun 4 | at Rangers | W3-1 | 31-30 | .508 | Globe Life Field · Arlington, TX |
| 62 | Wed Jun 5 | at Rangers | L1-9 | 31-31 | .500 | Globe Life Field · Arlington, TX |
| 63 | Fri Jun 7 | vs Brewers | L0-10 | 31-32 | .492 | Comerica Park · Detroit, MI |
| 64 | Sat Jun 8 | vs Brewers | L4-5 | 31-33 | .484 | Comerica Park · Detroit, MI |
| 65 | Sun Jun 9 | vs Brewers | W10-2 | 32-33 | .492 | Comerica Park · Detroit, MI |
| 66 | Tue Jun 11 | vs Nationals | L4-5 (10) | 32-34 | .485 | Comerica Park · Detroit, MI |
| 67 | Wed Jun 12 | vs Nationals | L5-7 | 32-35 | .478 | Comerica Park · Detroit, MI |
| 68 | Thu Jun 13 | vs Nationals | W7-2 | 33-35 | .485 | Comerica Park · Detroit, MI |
| 69 | Fri Jun 14 | at Astros | L0-4 | 33-36 | .478 | Minute Maid Park · Houston, TX |
| 70 | Sat Jun 15 | at Astros | W13-5 | 34-36 | .486 | Minute Maid Park · Houston, TX |
| 71 | Sun Jun 16 | at Astros | L1-4 | 34-37 | .479 | Minute Maid Park · Houston, TX |
| 72 | Mon Jun 17 | at Braves | L1-2 | 34-38 | .472 | Truist Park · Cumberland, GA |
| 73 | Tue Jun 18 | at Braves | L1-2 | 34-39 | .466 | Truist Park · Cumberland, GA |
| 74 | Wed Jun 19 | at Braves | L0-7 | 34-40 | .459 | Truist Park · Cumberland, GA |
| 75 | Fri Jun 21 | vs White Sox | W2-1 | 35-40 | .467 | Comerica Park · Detroit, MI |
| 76 | Sat Jun 22 | vs White Sox | L1-5 | 35-41 | .461 | Comerica Park · Detroit, MI |
| 77 | Sun Jun 23 | vs White Sox | W11-2 | 36-41 | .468 | Comerica Park · Detroit, MI |
| 78 | Mon Jun 24 | vs Phillies | L1-8 | 36-42 | .462 | Comerica Park · Detroit, MI |
| 79 | Tue Jun 25 | vs Phillies | W4-1 | 37-42 | .468 | Comerica Park · Detroit, MI |
| 80 | Wed Jun 26 | vs Phillies | L2-6 | 37-43 | .463 | Comerica Park · Detroit, MI |
| 81 | Thu Jun 27 | at Angels | L0-5 | 37-44 | .457 | Angel Stadium · Anaheim, CA |
| 82 | Fri Jun 28 | at Angels | L2-5 | 37-45 | .451 | Angel Stadium · Anaheim, CA |
| 83 | Sat Jun 29 | at Angels | L5-6 (10) | 37-46 | .446 | Angel Stadium · Anaheim, CA |
| 84 | Sun Jun 30 | at Angels | W7-6 | 38-46 | .452 | Angel Stadium · Anaheim, CA |
| 85 | Tue Jul 2 | at Twins | L3-5 | 38-47 | .447 | Target Field · Minneapolis, MN |
| 86 | Wed Jul 3 | at Twins | W9-2 | 39-47 | .453 | Target Field · Minneapolis, MN |
| 87 | Thu Jul 4 | at Twins | L3-12 | 39-48 | .448 | Target Field · Minneapolis, MN |
| 88 | Fri Jul 5 | at Reds | W5-4 | 40-48 | .455 | Great American Ball Park · Cincinnati, OH |
| 89 | Sat Jul 6 | at Reds | W5-3 | 41-48 | .461 | Great American Ball Park · Cincinnati, OH |
| 90 | Sun Jul 7 | at Reds | W5-1 | 42-48 | .467 | Great American Ball Park · Cincinnati, OH |
| 91 | Mon Jul 8 | vs Guardians | W1-0 | 43-48 | .473 | Comerica Park · Detroit, MI |
| 92 | Tue Jul 9 | vs Guardians | L8-9 (10) | 43-49 | .467 | Comerica Park · Detroit, MI |
| 93 | Wed Jul 10 | vs Guardians | W5-4 | 44-49 | .473 | Comerica Park · Detroit, MI |
| 94 | Thu Jul 11 | vs Guardians | W10-1 | 45-49 | .479 | Comerica Park · Detroit, MI |
| 95 | Fri Jul 12 | vs Dodgers | L3-4 | 45-50 | .474 | Comerica Park · Detroit, MI |
| 96 | Sat Jul 13 | vs Dodgers | W11-9 (10) | 46-50 | .479 | Comerica Park · Detroit, MI |
| 97 | Sun Jul 14 | vs Dodgers | W4-3 | 47-50 | .485 | Comerica Park · Detroit, MI |
| 98 | Fri Jul 19 | at Blue Jays | W5-4 | 48-50 | .490 | Rogers Centre · Toronto, ON |
| 99 | Sat Jul 20 | at Blue Jays | W7-3 | 49-50 | .495 | Rogers Centre · Toronto, ON |
| 100 | Sun Jul 21 | at Blue Jays | L4-5 | 49-51 | .490 | Rogers Centre · Toronto, ON |
| 101 | Mon Jul 22 | at Guardians | W8-2 | 50-51 | .495 | Progressive Field · Cleveland, OH |
| 102 | Tue Jul 23 | at Guardians | L4-5 | 50-52 | .490 | Progressive Field · Cleveland, OH |
| 103 | Wed Jul 24 | at Guardians | L1-2 | 50-53 | .485 | Progressive Field · Cleveland, OH |
| 104 | Thu Jul 25 | at Guardians | W3-0 | 51-53 | .490 | Progressive Field · Cleveland, OH |
| 105 | Fri Jul 26 | vs Twins | L3-9 | 51-54 | .486 | Comerica Park · Detroit, MI |
| 106 | Sat Jul 27 | vs Twins | W7-2 | 52-54 | .491 | Comerica Park · Detroit, MI |
| 107 | Sun Jul 28 | vs Twins | L0-5 | 52-55 | .486 | Comerica Park · Detroit, MI |
| 108 | Mon Jul 29 | vs Guardians | L4-8 | 52-56 | .481 | Comerica Park · Detroit, MI |
| 109 | Tue Jul 30 | vs Guardians | L0-5 | 52-57 | .477 | Comerica Park · Detroit, MI |
| 110 | Thu Aug 1 | vs Royals | L1-7 | 52-58 | .473 | Comerica Park · Detroit, MI |
| 111 | Fri Aug 2 | vs Royals | L2-9 | 52-59 | .468 | Comerica Park · Detroit, MI |
| 112 | Sat Aug 3 | vs Royals | W6-5 (11) | 53-59 | .473 | Comerica Park · Detroit, MI |
| 113 | Sun Aug 4 | vs Royals | L2-3 | 53-60 | .469 | Comerica Park · Detroit, MI |
| 114 | Tue Aug 6 | at Mariners | W4-2 | 54-60 | .474 | T-Mobile Park · Seattle, WA |
| 115 | Wed Aug 7 | at Mariners | W6-2 | 55-60 | .478 | T-Mobile Park · Seattle, WA |
| 116 | Thu Aug 8 | at Mariners | L3-4 | 55-61 | .474 | T-Mobile Park · Seattle, WA |
| 117 | Fri Aug 9 | at Giants | L2-3 | 55-62 | .470 | Oracle Park · San Francisco, CA |
| 118 | Sat Aug 10 | at Giants | L1-3 | 55-63 | .466 | Oracle Park · San Francisco, CA |
| 119 | Sun Aug 11 | at Giants | W5-4 | 56-63 | .471 | Oracle Park · San Francisco, CA |
| 120 | Tue Aug 13 | vs Mariners | W15-1 | 57-63 | .475 | Comerica Park · Detroit, MI |
| 121 | Wed Aug 14 | vs Mariners | W3-2 (10) | 58-63 | .479 | Comerica Park · Detroit, MI |
| 122 | Thu Aug 15 | vs Mariners | W2-1 | 59-63 | .484 | Comerica Park · Detroit, MI |
| 123 | Fri Aug 16 | vs Yankees | L0-3 | 59-64 | .480 | Comerica Park · Detroit, MI |
| 124 | Sat Aug 17 | vs Yankees | W4-0 | 60-64 | .484 | Comerica Park · Detroit, MI |
| 125 | Sun Aug 18 | vs Yankees | W3-2 (10) | 61-64 | .488 | Comerica Park · Detroit, MI |
| 126 | Tue Aug 20 | at Cubs | L1-3 | 61-65 | .484 | Wrigley Field · Chicago, IL |
| 127 | Wed Aug 21 | at Cubs | W8-2 | 62-65 | .488 | Wrigley Field · Chicago, IL |
| 128 | Thu Aug 22 | at Cubs | L2-10 | 62-66 | .484 | Wrigley Field · Chicago, IL |
| 129 | Fri Aug 23 | at White Sox | W5-2 | 63-66 | .488 | Guaranteed Rate Field · Chicago, IL |
| 130 | Sat Aug 24 | at White Sox | W13-4 | 64-66 | .492 | Guaranteed Rate Field · Chicago, IL |
| 131 | Sun Aug 25 | at White Sox | W9-4 | 65-66 | .496 | Guaranteed Rate Field · Chicago, IL |
| 132 | Mon Aug 26 | at White Sox | W6-3 | 66-66 | .500 | Guaranteed Rate Field · Chicago, IL |
| 133 | Tue Aug 27 | vs Angels | W6-2 | 67-66 | .504 | Comerica Park · Detroit, MI |
| 134 | Wed Aug 28 | vs Angels | W3-2 | 68-66 | .507 | Comerica Park · Detroit, MI |
| 135 | Thu Aug 29 | vs Angels | L0-3 | 68-67 | .504 | Comerica Park · Detroit, MI |
| 136 | Fri Aug 30 | vs Red Sox | L5-7 (10) | 68-68 | .500 | Comerica Park · Detroit, MI |
| 137 | Sat Aug 31 | vs Red Sox | W2-1 | 69-68 | .504 | Comerica Park · Detroit, MI |
| 138 | Sun Sep 1 | vs Red Sox | W4-1 | 70-68 | .507 | Comerica Park · Detroit, MI |
| 139 | Mon Sep 2 | at Padres | L0-3 | 70-69 | .504 | Petco Park · San Diego, CA |
| 140 | Wed Sep 4 | at Padres | L5-6 (10) | 70-70 | .500 | Petco Park · San Diego, CA |
| 141 | Thu Sep 5 | at Padres | W4-3 | 71-70 | .504 | Petco Park · San Diego, CA |
| 142 | Fri Sep 6 | at Athletics | L6-7 (13) | 71-71 | .500 | RingCentral Coliseum · Oakland, CA |
| 143 | Sat Sep 7 | at Athletics | W2-1 | 72-71 | .503 | RingCentral Coliseum · Oakland, CA |
| 144 | Sun Sep 8 | at Athletics | W9-1 | 73-71 | .507 | RingCentral Coliseum · Oakland, CA |
| 145 | Tue Sep 10 | vs Rockies | W11-0 | 74-71 | .510 | Comerica Park · Detroit, MI |
| 146 | Wed Sep 11 | vs Rockies | W7-4 | 75-71 | .514 | Comerica Park · Detroit, MI |
| 147 | Thu Sep 12 | vs Rockies | L2-4 | 75-72 | .510 | Comerica Park · Detroit, MI |
| 148 | Fri Sep 13 | vs Orioles | W1-0 | 76-72 | .514 | Comerica Park · Detroit, MI |
| 149 | Sat Sep 14 | vs Orioles | L2-4 | 76-73 | .510 | Comerica Park · Detroit, MI |
| 150 | Sun Sep 15 | vs Orioles | W4-2 | 77-73 | .513 | Comerica Park · Detroit, MI |
| 151 | Mon Sep 16 | at Royals | W7-6 | 78-73 | .517 | Kauffman Stadium · Kansas City, MO |
| 152 | Tue Sep 17 | at Royals | W3-1 (10) | 79-73 | .520 | Kauffman Stadium · Kansas City, MO |
| 153 | Wed Sep 18 | at Royals | W4-2 | 80-73 | .523 | Kauffman Stadium · Kansas City, MO |
| 154 | Fri Sep 20 | at Orioles | L1-7 | 80-74 | .519 | Camden Yards · Baltimore, MD |
| 155 | Sat Sep 21 | at Orioles | W6-4 (10) | 81-74 | .523 | Camden Yards · Baltimore, MD |
| 156 | Sun Sep 22 | at Orioles | W4-3 | 82-74 | .526 | Camden Yards · Baltimore, MD |
| 157 | Tue Sep 24 | vs Rays | W2-1 | 83-74 | .529 | Comerica Park · Detroit, MI |
| 158 | Wed Sep 25 | vs Rays | W7-1 | 84-74 | .532 | Comerica Park · Detroit, MI |
| 159 | Thu Sep 26 | vs Rays | W4-3 | 85-74 | .535 | Comerica Park · Detroit, MI |
| 160 | Fri Sep 27 | vs White Sox | W4-1 | 86-74 | .537 | Comerica Park · Detroit, MI |
| 161 | Sat Sep 28 | vs White Sox | L0-4 | 86-75 | .534 | Comerica Park · Detroit, MI |
| 162 | Sun Sep 29 | vs White Sox | L5-9 | 86-76 | .531 | Comerica Park · Detroit, MI |
| 163 | Tue Oct 1 | at Astros | W3-1 | 1-0 | 1.000 | Minute Maid Park · Houston, TX |
| 164 | Wed Oct 2 | at Astros | W5-2 | 2-0 | 1.000 | Minute Maid Park · Houston, TX |
| 165 | Sat Oct 5 | at Guardians | L0-7 | 0-1 | .000 | Progressive Field · Cleveland, OH |
| 166 | Mon Oct 7 | at Guardians | W3-0 | 1-1 | .500 | Progressive Field · Cleveland, OH |
| 167 | Wed Oct 9 | vs Guardians | W3-0 | 2-1 | .667 | Comerica Park · Detroit, MI |
| 168 | Thu Oct 10 | vs Guardians | L4-5 | 2-2 | .500 | Comerica Park · Detroit, MI |
| 169 | Sat Oct 12 | at Guardians | L3-7 | 2-3 | .400 | Progressive Field · Cleveland, OH |