| 1 | Fri Apr 8 | vs White Sox | W5-4 | 1-0 | 1.000 | Comerica Park · Detroit, MI |
| 2 | Sat Apr 9 | vs White Sox | L2-5 | 1-1 | .500 | Comerica Park · Detroit, MI |
| 3 | Sun Apr 10 | vs White Sox | L1-10 | 1-2 | .333 | Comerica Park · Detroit, MI |
| 4 | Mon Apr 11 | vs Red Sox | W3-1 | 2-2 | .500 | Comerica Park · Detroit, MI |
| 5 | Tue Apr 12 | vs Red Sox | L3-5 | 2-3 | .400 | Comerica Park · Detroit, MI |
| 6 | Wed Apr 13 | vs Red Sox | L7-9 | 2-4 | .333 | Comerica Park · Detroit, MI |
| 7 | Thu Apr 14 | at Royals | W4-2 | 3-4 | .429 | Kauffman Stadium · Kansas City, MO |
| 8 | Fri Apr 15 | at Royals | W2-1 | 4-4 | .500 | Kauffman Stadium · Kansas City, MO |
| 9 | Sat Apr 16 | at Royals | L1-3 | 4-5 | .444 | Kauffman Stadium · Kansas City, MO |
| 10 | Tue Apr 19 | vs Yankees | L2-4 | 4-6 | .400 | Comerica Park · Detroit, MI |
| 11 | Wed Apr 20 | vs Yankees | L3-5 | 4-7 | .364 | Comerica Park · Detroit, MI |
| 12 | Thu Apr 21 | vs Yankees | W3-0 | 5-7 | .417 | Comerica Park · Detroit, MI |
| 13 | Sat Apr 23 | vs Rockies | W13-0 | 6-7 | .462 | Comerica Park · Detroit, MI |
| 14 | Sat Apr 23 | vs Rockies | L2-3 | 6-8 | .429 | Comerica Park · Detroit, MI |
| 15 | Sun Apr 24 | vs Rockies | L2-6 | 6-9 | .400 | Comerica Park · Detroit, MI |
| 16 | Tue Apr 26 | at Twins | L4-5 | 6-10 | .375 | Target Field · Minneapolis, MN |
| 17 | Wed Apr 27 | at Twins | L0-5 | 6-11 | .353 | Target Field · Minneapolis, MN |
| 18 | Thu Apr 28 | at Twins | L1-7 | 6-12 | .333 | Target Field · Minneapolis, MN |
| 19 | Fri Apr 29 | at Dodgers | L1-5 | 6-13 | .316 | Dodger Stadium · Los Angeles, CA |
| 20 | Sat Apr 30 | at Dodgers | W5-1 | 7-13 | .350 | Dodger Stadium · Los Angeles, CA |
| 21 | Sun May 1 | at Dodgers | L3-6 | 7-14 | .333 | Dodger Stadium · Los Angeles, CA |
| 22 | Wed May 4 | vs Pirates | W3-2 | 8-14 | .364 | Comerica Park · Detroit, MI |
| 23 | Wed May 4 | vs Pirates | L2-7 | 8-15 | .348 | Comerica Park · Detroit, MI |
| 24 | Thu May 5 | at Astros | L2-3 | 8-16 | .333 | Minute Maid Park · Houston, TX |
| 25 | Fri May 6 | at Astros | L2-3 | 8-17 | .320 | Minute Maid Park · Houston, TX |
| 26 | Sat May 7 | at Astros | L2-3 | 8-18 | .308 | Minute Maid Park · Houston, TX |
| 27 | Sun May 8 | at Astros | L0-5 | 8-19 | .296 | Minute Maid Park · Houston, TX |
| 28 | Mon May 9 | vs Athletics | L0-2 | 8-20 | .286 | Comerica Park · Detroit, MI |
| 29 | Tue May 10 | at Athletics | W6-0 | 9-20 | .310 | Comerica Park · Detroit, MI |
| 30 | Tue May 10 | vs Athletics | L1-4 | 9-21 | .300 | Comerica Park · Detroit, MI |
| 31 | Wed May 11 | vs Athletics | L0-9 | 9-22 | .290 | Comerica Park · Detroit, MI |
| 32 | Thu May 12 | vs Athletics | L3-5 | 9-23 | .281 | Comerica Park · Detroit, MI |
| 33 | Fri May 13 | vs Orioles | W4-2 | 10-23 | .303 | Comerica Park · Detroit, MI |
| 34 | Sat May 14 | vs Orioles | W3-0 | 11-23 | .324 | Comerica Park · Detroit, MI |
| 35 | Sun May 15 | vs Orioles | W5-1 | 12-23 | .343 | Comerica Park · Detroit, MI |
| 36 | Mon May 16 | at Rays | W3-2 | 13-23 | .361 | Tropicana Field · St. Petersburg, FL |
| 37 | Tue May 17 | at Rays | L1-8 | 13-24 | .351 | Tropicana Field · St. Petersburg, FL |
| 38 | Wed May 18 | at Rays | L1-6 | 13-25 | .342 | Tropicana Field · St. Petersburg, FL |
| 39 | Fri May 20 | at Guardians | L1-6 | 13-26 | .333 | Progressive Field · Cleveland, OH |
| 40 | Sun May 22 | at Guardians | W4-2 | 14-26 | .350 | Progressive Field · Cleveland, OH |
| 41 | Mon May 23 | at Twins | L4-5 | 14-27 | .341 | Target Field · Minneapolis, MN |
| 42 | Tue May 24 | at Twins | L0-2 | 14-28 | .333 | Target Field · Minneapolis, MN |
| 43 | Wed May 25 | at Twins | W4-2 (10) | 15-28 | .349 | Target Field · Minneapolis, MN |
| 44 | Thu May 26 | vs Guardians | W4-3 | 16-28 | .364 | Comerica Park · Detroit, MI |
| 45 | Sat May 28 | vs Guardians | L1-8 | 16-29 | .356 | Comerica Park · Detroit, MI |
| 46 | Sun May 29 | vs Guardians | W2-1 | 17-29 | .370 | Comerica Park · Detroit, MI |
| 47 | Mon May 30 | vs Twins | W7-5 | 18-29 | .383 | Comerica Park · Detroit, MI |
| 48 | Tue May 31 | vs Twins | L2-8 | 18-30 | .375 | Comerica Park · Detroit, MI |
| 49 | Tue May 31 | vs Twins | W4-0 | 19-30 | .388 | Comerica Park · Detroit, MI |
| 50 | Wed Jun 1 | vs Twins | W5-0 | 20-30 | .400 | Comerica Park · Detroit, MI |
| 51 | Thu Jun 2 | vs Twins | W3-2 | 21-30 | .412 | Comerica Park · Detroit, MI |
| 52 | Fri Jun 3 | at Yankees | L0-13 | 21-31 | .404 | Yankee Stadium · The Bronx, NY |
| 53 | Sat Jun 4 | at Yankees | L0-3 | 21-32 | .396 | Yankee Stadium · The Bronx, NY |
| 54 | Sun Jun 5 | at Yankees | L4-5 (10) | 21-33 | .389 | Yankee Stadium · The Bronx, NY |
| 55 | Tue Jun 7 | at Pirates | W5-3 | 22-33 | .400 | PNC Park · Pittsburgh, PA |
| 56 | Wed Jun 8 | at Pirates | W3-1 | 23-33 | .411 | PNC Park · Pittsburgh, PA |
| 57 | Fri Jun 10 | vs Blue Jays | L1-10 | 23-34 | .404 | Comerica Park · Detroit, MI |
| 58 | Sat Jun 11 | vs Blue Jays | W3-1 | 24-34 | .414 | Comerica Park · Detroit, MI |
| 59 | Sun Jun 12 | vs Blue Jays | L0-6 | 24-35 | .407 | Comerica Park · Detroit, MI |
| 60 | Mon Jun 13 | vs White Sox | L5-9 | 24-36 | .400 | Comerica Park · Detroit, MI |
| 61 | Tue Jun 14 | vs White Sox | L1-5 | 24-37 | .393 | Comerica Park · Detroit, MI |
| 62 | Wed Jun 15 | vs White Sox | L0-13 | 24-38 | .387 | Comerica Park · Detroit, MI |
| 63 | Thu Jun 16 | vs Rangers | L1-3 | 24-39 | .381 | Comerica Park · Detroit, MI |
| 64 | Fri Jun 17 | vs Rangers | L0-7 | 24-40 | .375 | Comerica Park · Detroit, MI |
| 65 | Sat Jun 18 | vs Rangers | W14-7 | 25-40 | .385 | Comerica Park · Detroit, MI |
| 66 | Sun Jun 19 | vs Rangers | W7-3 | 26-40 | .394 | Comerica Park · Detroit, MI |
| 67 | Mon Jun 20 | at Red Sox | L2-5 | 26-41 | .388 | Fenway Park · Boston, MA |
| 68 | Tue Jun 21 | at Red Sox | L4-5 | 26-42 | .382 | Fenway Park · Boston, MA |
| 69 | Wed Jun 22 | at Red Sox | L2-6 | 26-43 | .377 | Fenway Park · Boston, MA |
| 70 | Fri Jun 24 | at D-backs | W5-1 | 27-43 | .386 | Chase Field · Phoenix, AZ |
| 71 | Sat Jun 25 | at D-backs | W6-3 | 28-43 | .394 | Chase Field · Phoenix, AZ |
| 72 | Sun Jun 26 | at D-backs | L7-11 | 28-44 | .389 | Chase Field · Phoenix, AZ |
| 73 | Tue Jun 28 | at Giants | L3-4 | 28-45 | .384 | Oracle Park · San Francisco, CA |
| 74 | Wed Jun 29 | at Giants | W3-2 | 29-45 | .392 | Oracle Park · San Francisco, CA |
| 75 | Fri Jul 1 | vs Royals | L1-3 | 29-46 | .387 | Comerica Park · Detroit, MI |
| 76 | Sat Jul 2 | vs Royals | W4-3 | 30-46 | .395 | Comerica Park · Detroit, MI |
| 77 | Sun Jul 3 | vs Royals | L4-7 | 30-47 | .390 | Comerica Park · Detroit, MI |
| 78 | Mon Jul 4 | vs Guardians | W4-1 | 31-47 | .397 | Comerica Park · Detroit, MI |
| 79 | Mon Jul 4 | vs Guardians | W5-3 | 32-47 | .405 | Comerica Park · Detroit, MI |
| 80 | Tue Jul 5 | vs Guardians | W11-4 | 33-47 | .412 | Comerica Park · Detroit, MI |
| 81 | Wed Jul 6 | vs Guardians | W8-2 | 34-47 | .420 | Comerica Park · Detroit, MI |
| 82 | Thu Jul 7 | at White Sox | W2-1 | 35-47 | .427 | Guaranteed Rate Field · Chicago, IL |
| 83 | Fri Jul 8 | at White Sox | W7-5 | 36-47 | .434 | Guaranteed Rate Field · Chicago, IL |
| 84 | Sat Jul 9 | at White Sox | L0-8 | 36-48 | .429 | Guaranteed Rate Field · Chicago, IL |
| 85 | Sun Jul 10 | at White Sox | L2-4 | 36-49 | .424 | Guaranteed Rate Field · Chicago, IL |
| 86 | Mon Jul 11 | at Royals | L1-3 | 36-50 | .419 | Kauffman Stadium · Kansas City, MO |
| 87 | Mon Jul 11 | at Royals | L3-7 | 36-51 | .414 | Kauffman Stadium · Kansas City, MO |
| 88 | Tue Jul 12 | at Royals | W7-5 | 37-51 | .420 | Kauffman Stadium · Kansas City, MO |
| 89 | Wed Jul 13 | at Royals | L2-5 | 37-52 | .416 | Kauffman Stadium · Kansas City, MO |
| 90 | Thu Jul 14 | at Guardians | L0-4 | 37-53 | .411 | Progressive Field · Cleveland, OH |
| 91 | Fri Jul 15 | at Guardians | L5-6 | 37-54 | .407 | Progressive Field · Cleveland, OH |
| 92 | Sat Jul 16 | at Guardians | L0-10 | 37-55 | .402 | Progressive Field · Cleveland, OH |
| 93 | Thu Jul 21 | at Athletics | W7-2 | 38-55 | .409 | RingCentral Coliseum · Oakland, CA |
| 94 | Thu Jul 21 | at Athletics | L0-5 | 38-56 | .404 | RingCentral Coliseum · Oakland, CA |
| 95 | Sat Jul 23 | vs Twins | L4-8 | 38-57 | .400 | Comerica Park · Detroit, MI |
| 96 | Sun Jul 24 | vs Twins | L1-9 | 38-58 | .396 | Comerica Park · Detroit, MI |
| 97 | Mon Jul 25 | vs Padres | W12-4 | 39-58 | .402 | Comerica Park · Detroit, MI |
| 98 | Tue Jul 26 | vs Padres | L4-6 (10) | 39-59 | .398 | Comerica Park · Detroit, MI |
| 99 | Wed Jul 27 | vs Padres | W4-3 | 40-59 | .404 | Comerica Park · Detroit, MI |
| 100 | Thu Jul 28 | at Blue Jays | L3-5 | 40-60 | .400 | Rogers Centre · Toronto, ON |
| 101 | Fri Jul 29 | at Blue Jays | W4-2 | 41-60 | .406 | Rogers Centre · Toronto, ON |
| 102 | Sat Jul 30 | at Blue Jays | L3-5 | 41-61 | .402 | Rogers Centre · Toronto, ON |
| 103 | Sun Jul 31 | at Blue Jays | L1-4 | 41-62 | .398 | Rogers Centre · Toronto, ON |
| 104 | Mon Aug 1 | at Twins | L3-5 (10) | 41-63 | .394 | Target Field · Minneapolis, MN |
| 105 | Tue Aug 2 | at Twins | W5-3 | 42-63 | .400 | Target Field · Minneapolis, MN |
| 106 | Wed Aug 3 | at Twins | L1-4 | 42-64 | .396 | Target Field · Minneapolis, MN |
| 107 | Thu Aug 4 | vs Rays | L2-6 | 42-65 | .393 | Comerica Park · Detroit, MI |
| 108 | Fri Aug 5 | vs Rays | L3-5 | 42-66 | .389 | Comerica Park · Detroit, MI |
| 109 | Sat Aug 6 | vs Rays | W9-1 | 43-66 | .394 | Comerica Park · Detroit, MI |
| 110 | Sun Aug 7 | vs Rays | L0-7 | 43-67 | .391 | Comerica Park · Detroit, MI |
| 111 | Tue Aug 9 | vs Guardians | L2-5 | 43-68 | .387 | Comerica Park · Detroit, MI |
| 112 | Wed Aug 10 | vs Guardians | L2-3 | 43-69 | .384 | Comerica Park · Detroit, MI |
| 113 | Thu Aug 11 | vs Guardians | L3-4 (10) | 43-70 | .381 | Comerica Park · Detroit, MI |
| 114 | Fri Aug 12 | at White Sox | L0-2 | 43-71 | .377 | Guaranteed Rate Field · Chicago, IL |
| 115 | Sat Aug 13 | at White Sox | L4-6 | 43-72 | .374 | Guaranteed Rate Field · Chicago, IL |
| 116 | Sun Aug 14 | at White Sox | L3-5 | 43-73 | .371 | Guaranteed Rate Field · Chicago, IL |
| 117 | Mon Aug 15 | at Guardians | L1-4 | 43-74 | .368 | Progressive Field · Cleveland, OH |
| 118 | Mon Aug 15 | at Guardians | W7-5 | 44-74 | .373 | Progressive Field · Cleveland, OH |
| 119 | Tue Aug 16 | at Guardians | W4-3 | 45-74 | .378 | Progressive Field · Cleveland, OH |
| 120 | Wed Aug 17 | at Guardians | L4-8 | 45-75 | .375 | Progressive Field · Cleveland, OH |
| 121 | Fri Aug 19 | vs Angels | L0-1 | 45-76 | .372 | Comerica Park · Detroit, MI |
| 122 | Sat Aug 20 | vs Angels | W4-3 | 46-76 | .377 | Comerica Park · Detroit, MI |
| 123 | Sun Aug 21 | vs Angels | W4-0 | 47-76 | .382 | Comerica Park · Detroit, MI |
| 124 | Tue Aug 23 | vs Giants | L1-3 | 47-77 | .379 | Comerica Park · Detroit, MI |
| 125 | Wed Aug 24 | vs Giants | W6-1 | 48-77 | .384 | Comerica Park · Detroit, MI |
| 126 | Fri Aug 26 | at Rangers | L6-7 | 48-78 | .381 | Globe Life Field · Arlington, TX |
| 127 | Sat Aug 27 | at Rangers | W11-2 | 49-78 | .386 | Globe Life Field · Arlington, TX |
| 128 | Sun Aug 28 | at Rangers | W9-8 | 50-78 | .391 | Globe Life Field · Arlington, TX |
| 129 | Tue Aug 30 | vs Mariners | L3-9 | 50-79 | .388 | Comerica Park · Detroit, MI |
| 130 | Wed Aug 31 | vs Mariners | L3-5 | 50-80 | .385 | Comerica Park · Detroit, MI |
| 131 | Thu Sep 1 | vs Mariners | L0-7 | 50-81 | .382 | Comerica Park · Detroit, MI |
| 132 | Fri Sep 2 | vs Royals | W5-4 | 51-81 | .386 | Comerica Park · Detroit, MI |
| 133 | Sat Sep 3 | vs Royals | L2-12 | 51-82 | .383 | Comerica Park · Detroit, MI |
| 134 | Sun Sep 4 | vs Royals | L2-3 | 51-83 | .381 | Comerica Park · Detroit, MI |
| 135 | Mon Sep 5 | at Angels | L0-10 | 51-84 | .378 | Angel Stadium · Anaheim, CA |
| 136 | Tue Sep 6 | at Angels | L4-5 (10) | 51-85 | .375 | Angel Stadium · Anaheim, CA |
| 137 | Wed Sep 7 | at Angels | W5-4 | 52-85 | .380 | Angel Stadium · Anaheim, CA |
| 138 | Fri Sep 9 | at Royals | W10-2 | 53-85 | .384 | Kauffman Stadium · Kansas City, MO |
| 139 | Sat Sep 10 | at Royals | W8-4 | 54-85 | .388 | Kauffman Stadium · Kansas City, MO |
| 140 | Sun Sep 11 | at Royals | L0-4 | 54-86 | .386 | Kauffman Stadium · Kansas City, MO |
| 141 | Mon Sep 12 | vs Astros | L0-7 | 54-87 | .383 | Comerica Park · Detroit, MI |
| 142 | Tue Sep 13 | vs Astros | L3-6 | 54-88 | .380 | Comerica Park · Detroit, MI |
| 143 | Wed Sep 14 | vs Astros | L1-2 | 54-89 | .378 | Comerica Park · Detroit, MI |
| 144 | Fri Sep 16 | vs White Sox | W3-2 (10) | 55-89 | .382 | Comerica Park · Detroit, MI |
| 145 | Sat Sep 17 | vs White Sox | L3-4 (11) | 55-90 | .379 | Comerica Park · Detroit, MI |
| 146 | Sun Sep 18 | vs White Sox | L5-11 | 55-91 | .377 | Comerica Park · Detroit, MI |
| 147 | Mon Sep 19 | at Orioles | W11-0 | 56-91 | .381 | Camden Yards · Baltimore, MD |
| 148 | Tue Sep 20 | at Orioles | W3-2 | 57-91 | .385 | Camden Yards · Baltimore, MD |
| 149 | Wed Sep 21 | at Orioles | L1-8 | 57-92 | .383 | Camden Yards · Baltimore, MD |
| 150 | Fri Sep 23 | at White Sox | W5-3 | 58-92 | .387 | Guaranteed Rate Field · Chicago, IL |
| 151 | Sat Sep 24 | at White Sox | W7-2 | 59-92 | .391 | Guaranteed Rate Field · Chicago, IL |
| 152 | Sun Sep 25 | at White Sox | W4-1 | 60-92 | .395 | Guaranteed Rate Field · Chicago, IL |
| 153 | Tue Sep 27 | vs Royals | W4-3 (10) | 61-92 | .399 | Comerica Park · Detroit, MI |
| 154 | Wed Sep 28 | vs Royals | W2-1 | 62-92 | .403 | Comerica Park · Detroit, MI |
| 155 | Thu Sep 29 | vs Royals | W10-3 | 63-92 | .406 | Comerica Park · Detroit, MI |
| 156 | Fri Sep 30 | vs Twins | L0-7 | 63-93 | .404 | Comerica Park · Detroit, MI |
| 157 | Sat Oct 1 | vs Twins | W3-2 | 64-93 | .408 | Comerica Park · Detroit, MI |
| 158 | Sun Oct 2 | vs Twins | W5-2 | 65-93 | .411 | Comerica Park · Detroit, MI |
| 159 | Mon Oct 3 | at Mariners | W4-3 | 66-93 | .415 | T-Mobile Park · Seattle, WA |
| 160 | Tue Oct 4 | at Mariners | L6-7 (10) | 66-94 | .412 | T-Mobile Park · Seattle, WA |
| 161 | Tue Oct 4 | at Mariners | L6-9 | 66-95 | .410 | T-Mobile Park · Seattle, WA |
| 162 | Wed Oct 5 | at Mariners | L4-5 | 66-96 | .407 | T-Mobile Park · Seattle, WA |