| 1 | Mon Apr 5 | at Royals | W8-4 | 1-0 | 1.000 | Kauffman Stadium · Kansas City, MO |
| 2 | Wed Apr 7 | at Royals | L2-3 (11) | 1-1 | .500 | Kauffman Stadium · Kansas City, MO |
| 3 | Thu Apr 8 | at Royals | W7-3 | 2-1 | .667 | Kauffman Stadium · Kansas City, MO |
| 4 | Fri Apr 9 | vs Guardians | W5-2 | 3-1 | .750 | Comerica Park · Detroit, MI |
| 5 | Sat Apr 10 | vs Guardians | W4-2 | 4-1 | .800 | Comerica Park · Detroit, MI |
| 6 | Sun Apr 11 | vs Guardians | W9-8 | 5-1 | .833 | Comerica Park · Detroit, MI |
| 7 | Mon Apr 12 | vs Royals | L5-10 | 5-2 | .714 | Comerica Park · Detroit, MI |
| 8 | Tue Apr 13 | vs Royals | W6-5 | 6-2 | .750 | Comerica Park · Detroit, MI |
| 9 | Wed Apr 14 | vs Royals | L3-7 | 6-3 | .667 | Comerica Park · Detroit, MI |
| 10 | Fri Apr 16 | at Mariners | L3-11 | 6-4 | .600 | T-Mobile Park · Seattle, WA |
| 11 | Sat Apr 17 | at Mariners | L2-4 | 6-5 | .545 | T-Mobile Park · Seattle, WA |
| 12 | Sun Apr 18 | at Mariners | W4-2 | 7-5 | .583 | T-Mobile Park · Seattle, WA |
| 13 | Mon Apr 19 | at Angels | L0-2 | 7-6 | .538 | Angel Stadium · Anaheim, CA |
| 14 | Tue Apr 20 | at Angels | L5-6 | 7-7 | .500 | Angel Stadium · Anaheim, CA |
| 15 | Wed Apr 21 | at Angels | W4-3 | 8-7 | .533 | Angel Stadium · Anaheim, CA |
| 16 | Thu Apr 22 | at Angels | W5-4 | 9-7 | .563 | Angel Stadium · Anaheim, CA |
| 17 | Fri Apr 23 | at Rangers | L4-5 | 9-8 | .529 | Globe Life Field · Arlington, TX |
| 18 | Sat Apr 24 | at Rangers | W8-4 | 10-8 | .556 | Globe Life Field · Arlington, TX |
| 19 | Sun Apr 25 | at Rangers | L4-8 | 10-9 | .526 | Globe Life Field · Arlington, TX |
| 20 | Mon Apr 26 | at Rangers | W8-6 | 11-9 | .550 | Globe Life Field · Arlington, TX |
| 21 | Tue Apr 27 | vs Twins | L0-2 | 11-10 | .524 | Comerica Park · Detroit, MI |
| 22 | Wed Apr 28 | vs Twins | W11-6 | 12-10 | .545 | Comerica Park · Detroit, MI |
| 23 | Thu Apr 29 | vs Twins | W3-0 | 13-10 | .565 | Comerica Park · Detroit, MI |
| 24 | Fri Apr 30 | vs Angels | W10-6 | 14-10 | .583 | Comerica Park · Detroit, MI |
| 25 | Sat May 1 | vs Angels | W3-2 | 15-10 | .600 | Comerica Park · Detroit, MI |
| 26 | Sun May 2 | vs Angels | W5-1 | 16-10 | .615 | Comerica Park · Detroit, MI |
| 27 | Mon May 3 | at Twins | L4-10 | 16-11 | .593 | Target Field · Minneapolis, MN |
| 28 | Tue May 4 | at Twins | L3-4 | 16-12 | .571 | Target Field · Minneapolis, MN |
| 29 | Wed May 5 | at Twins | L4-5 | 16-13 | .552 | Target Field · Minneapolis, MN |
| 30 | Sat May 8 | at Guardians | W6-4 | 17-13 | .567 | Progressive Field · Cleveland, OH |
| 31 | Sun May 9 | at Guardians | L4-7 | 17-14 | .548 | Progressive Field · Cleveland, OH |
| 32 | Mon May 10 | vs Yankees | W5-4 | 18-14 | .563 | Comerica Park · Detroit, MI |
| 33 | Wed May 12 | vs Yankees | W2-0 | 19-14 | .576 | Comerica Park · Detroit, MI |
| 34 | Wed May 12 | vs Yankees | L0-8 | 19-15 | .559 | Comerica Park · Detroit, MI |
| 35 | Thu May 13 | vs Yankees | W6-0 | 20-15 | .571 | Comerica Park · Detroit, MI |
| 36 | Fri May 14 | vs Red Sox | L2-7 | 20-16 | .556 | Comerica Park · Detroit, MI |
| 37 | Sat May 15 | vs Red Sox | W7-6 (12) | 21-16 | .568 | Comerica Park · Detroit, MI |
| 38 | Sun May 16 | vs Red Sox | W5-1 | 22-16 | .579 | Comerica Park · Detroit, MI |
| 39 | Tue May 18 | vs White Sox | L2-6 | 22-17 | .564 | Comerica Park · Detroit, MI |
| 40 | Wed May 19 | at Athletics | W5-1 | 23-17 | .575 | RingCentral Coliseum · Oakland, CA |
| 41 | Thu May 20 | at Athletics | W5-2 | 24-17 | .585 | RingCentral Coliseum · Oakland, CA |
| 42 | Fri May 21 | at Dodgers | L1-4 | 24-18 | .571 | Dodger Stadium · Los Angeles, CA |
| 43 | Sat May 22 | at Dodgers | L4-6 | 24-19 | .558 | Dodger Stadium · Los Angeles, CA |
| 44 | Sun May 23 | at Dodgers | W6-2 | 25-19 | .568 | Dodger Stadium · Los Angeles, CA |
| 45 | Tue May 25 | at Mariners | L3-5 | 25-20 | .556 | T-Mobile Park · Seattle, WA |
| 46 | Wed May 26 | at Mariners | L4-5 | 25-21 | .543 | T-Mobile Park · Seattle, WA |
| 47 | Fri May 28 | vs Athletics | L4-5 | 25-22 | .532 | Comerica Park · Detroit, MI |
| 48 | Sat May 29 | vs Athletics | L0-6 | 25-23 | .521 | Comerica Park · Detroit, MI |
| 49 | Sun May 30 | vs Athletics | W10-2 | 26-23 | .531 | Comerica Park · Detroit, MI |
| 50 | Mon May 31 | vs Athletics | L1-4 | 26-24 | .520 | Comerica Park · Detroit, MI |
| 51 | Tue Jun 1 | vs Guardians | L2-3 | 26-25 | .510 | Comerica Park · Detroit, MI |
| 52 | Wed Jun 2 | vs Guardians | W3-0 | 27-25 | .519 | Comerica Park · Detroit, MI |
| 53 | Thu Jun 3 | vs Guardians | W12-6 | 28-25 | .528 | Comerica Park · Detroit, MI |
| 54 | Fri Jun 4 | at Royals | L3-7 | 28-26 | .519 | Kauffman Stadium · Kansas City, MO |
| 55 | Sat Jun 5 | at Royals | W4-2 | 29-26 | .527 | Kauffman Stadium · Kansas City, MO |
| 56 | Sun Jun 6 | at Royals | L2-7 | 29-27 | .518 | Kauffman Stadium · Kansas City, MO |
| 57 | Tue Jun 8 | at White Sox | W7-2 | 30-27 | .526 | Guaranteed Rate Field · Chicago, IL |
| 58 | Wed Jun 9 | at White Sox | L3-15 | 30-28 | .517 | Guaranteed Rate Field · Chicago, IL |
| 59 | Thu Jun 10 | at White Sox | L0-3 | 30-29 | .508 | Guaranteed Rate Field · Chicago, IL |
| 60 | Fri Jun 11 | vs Pirates | W6-2 | 31-29 | .517 | Comerica Park · Detroit, MI |
| 61 | Sat Jun 12 | vs Pirates | W4-3 (10) | 32-29 | .525 | Comerica Park · Detroit, MI |
| 62 | Sun Jun 13 | vs Pirates | W4-3 | 33-29 | .532 | Comerica Park · Detroit, MI |
| 63 | Tue Jun 15 | vs Nationals | W7-4 | 34-29 | .540 | Comerica Park · Detroit, MI |
| 64 | Wed Jun 16 | vs Nationals | W8-3 | 35-29 | .547 | Comerica Park · Detroit, MI |
| 65 | Thu Jun 17 | vs Nationals | W8-3 | 36-29 | .554 | Comerica Park · Detroit, MI |
| 66 | Fri Jun 18 | vs D-backs | W7-5 | 37-29 | .561 | Comerica Park · Detroit, MI |
| 67 | Sat Jun 19 | vs D-backs | L5-6 | 37-30 | .552 | Comerica Park · Detroit, MI |
| 68 | Sun Jun 20 | vs D-backs | W3-1 | 38-30 | .559 | Comerica Park · Detroit, MI |
| 69 | Tue Jun 22 | at Mets | L6-14 | 38-31 | .551 | Citi Field · Queens, NY |
| 70 | Wed Jun 23 | at Mets | L0-5 | 38-32 | .543 | Citi Field · Queens, NY |
| 71 | Thu Jun 24 | at Mets | W6-5 | 39-32 | .549 | Citi Field · Queens, NY |
| 72 | Fri Jun 25 | at Braves | L1-3 | 39-33 | .542 | Truist Park · Cumberland, GA |
| 73 | Sat Jun 26 | at Braves | L3-4 | 39-34 | .534 | Truist Park · Cumberland, GA |
| 74 | Sun Jun 27 | at Braves | W10-4 | 40-34 | .541 | Truist Park · Cumberland, GA |
| 75 | Mon Jun 28 | at Twins | W7-5 | 41-34 | .547 | Target Field · Minneapolis, MN |
| 76 | Tue Jun 29 | at Twins | L4-11 | 41-35 | .539 | Target Field · Minneapolis, MN |
| 77 | Wed Jun 30 | at Twins | L1-5 | 41-36 | .532 | Target Field · Minneapolis, MN |
| 78 | Fri Jul 2 | vs Mariners | W7-1 | 42-36 | .538 | Comerica Park · Detroit, MI |
| 79 | Sat Jul 3 | vs Mariners | W6-1 | 43-36 | .544 | Comerica Park · Detroit, MI |
| 80 | Sun Jul 4 | vs Mariners | L1-8 | 43-37 | .537 | Comerica Park · Detroit, MI |
| 81 | Mon Jul 5 | vs Orioles | W12-9 | 44-37 | .543 | Comerica Park · Detroit, MI |
| 82 | Tue Jul 6 | vs Orioles | W7-5 (11) | 45-37 | .549 | Comerica Park · Detroit, MI |
| 83 | Wed Jul 7 | vs Orioles | W4-2 | 46-37 | .554 | Comerica Park · Detroit, MI |
| 84 | Fri Jul 9 | vs Twins | W7-3 | 47-37 | .560 | Comerica Park · Detroit, MI |
| 85 | Sat Jul 10 | vs Twins | W7-4 | 48-37 | .565 | Comerica Park · Detroit, MI |
| 86 | Sun Jul 11 | vs Twins | L3-6 | 48-38 | .558 | Comerica Park · Detroit, MI |
| 87 | Fri Jul 16 | at Guardians | L2-8 | 48-39 | .552 | Progressive Field · Cleveland, OH |
| 88 | Sat Jul 17 | at Guardians | L3-4 | 48-40 | .545 | Progressive Field · Cleveland, OH |
| 89 | Sat Jul 17 | at Guardians | L1-2 (11) | 48-41 | .539 | Progressive Field · Cleveland, OH |
| 90 | Sun Jul 18 | at Guardians | L2-7 | 48-42 | .533 | Progressive Field · Cleveland, OH |
| 91 | Mon Jul 19 | vs Rangers | L6-8 (14) | 48-43 | .527 | Comerica Park · Detroit, MI |
| 92 | Tue Jul 20 | vs Rangers | L0-8 | 48-44 | .522 | Comerica Park · Detroit, MI |
| 93 | Wed Jul 21 | vs Rangers | W4-1 | 49-44 | .527 | Comerica Park · Detroit, MI |
| 94 | Thu Jul 22 | vs Blue Jays | W5-2 | 50-44 | .532 | Comerica Park · Detroit, MI |
| 95 | Sat Jul 24 | vs Blue Jays | L2-3 | 50-45 | .526 | Comerica Park · Detroit, MI |
| 96 | Sun Jul 25 | vs Blue Jays | L3-5 | 50-46 | .521 | Comerica Park · Detroit, MI |
| 97 | Sun Jul 25 | vs Blue Jays | W6-5 | 51-46 | .526 | Comerica Park · Detroit, MI |
| 98 | Mon Jul 26 | at Rays | L0-5 | 51-47 | .520 | Tropicana Field · St. Petersburg, FL |
| 99 | Tue Jul 27 | at Rays | L2-3 | 51-48 | .515 | Tropicana Field · St. Petersburg, FL |
| 100 | Wed Jul 28 | at Rays | L4-7 | 51-49 | .510 | Tropicana Field · St. Petersburg, FL |
| 101 | Thu Jul 29 | at Rays | L2-4 | 51-50 | .505 | Tropicana Field · St. Petersburg, FL |
| 102 | Fri Jul 30 | at Red Sox | W6-5 | 52-50 | .510 | Fenway Park · Boston, MA |
| 103 | Sat Jul 31 | at Red Sox | L4-5 | 52-51 | .505 | Fenway Park · Boston, MA |
| 104 | Sun Aug 1 | at Red Sox | L3-4 | 52-52 | .500 | Fenway Park · Boston, MA |
| 105 | Tue Aug 3 | vs White Sox | L2-12 | 52-53 | .495 | Comerica Park · Detroit, MI |
| 106 | Tue Aug 3 | vs White Sox | W7-1 | 53-53 | .500 | Comerica Park · Detroit, MI |
| 107 | Wed Aug 4 | vs White Sox | L1-4 | 53-54 | .495 | Comerica Park · Detroit, MI |
| 108 | Thu Aug 5 | vs White Sox | L4-6 (11) | 53-55 | .491 | Comerica Park · Detroit, MI |
| 109 | Fri Aug 6 | vs Angels | L2-4 | 53-56 | .486 | Comerica Park · Detroit, MI |
| 110 | Sat Aug 7 | vs Angels | L1-10 | 53-57 | .482 | Comerica Park · Detroit, MI |
| 111 | Sun Aug 8 | vs Angels | W9-4 | 54-57 | .486 | Comerica Park · Detroit, MI |
| 112 | Mon Aug 9 | vs Rays | L3-6 | 54-58 | .482 | Comerica Park · Detroit, MI |
| 113 | Tue Aug 10 | vs Rays | L0-8 | 54-59 | .478 | Comerica Park · Detroit, MI |
| 114 | Wed Aug 11 | vs Rays | W3-2 | 55-59 | .482 | Comerica Park · Detroit, MI |
| 115 | Fri Aug 13 | at White Sox | L4-8 | 55-60 | .478 | Guaranteed Rate Field · Chicago, IL |
| 116 | Sat Aug 14 | at White Sox | W3-2 | 56-60 | .483 | Guaranteed Rate Field · Chicago, IL |
| 117 | Sun Aug 15 | at White Sox | W13-8 | 57-60 | .487 | Guaranteed Rate Field · Chicago, IL |
| 118 | Mon Aug 16 | at Yankees | W3-1 | 58-60 | .492 | Yankee Stadium · The Bronx, NY |
| 119 | Tue Aug 17 | at Yankees | L2-6 | 58-61 | .487 | Yankee Stadium · The Bronx, NY |
| 120 | Wed Aug 18 | at Yankees | L5-9 | 58-62 | .483 | Yankee Stadium · The Bronx, NY |
| 121 | Thu Aug 19 | at Yankees | L5-11 | 58-63 | .479 | Yankee Stadium · The Bronx, NY |
| 122 | Fri Aug 20 | vs Guardians | W6-0 | 59-63 | .484 | Comerica Park · Detroit, MI |
| 123 | Sat Aug 21 | vs Guardians | W5-2 | 60-63 | .488 | Comerica Park · Detroit, MI |
| 124 | Sun Aug 22 | vs Guardians | W8-1 | 61-63 | .492 | Comerica Park · Detroit, MI |
| 125 | Mon Aug 23 | vs Royals | W12-3 | 62-63 | .496 | Comerica Park · Detroit, MI |
| 126 | Tue Aug 24 | vs Royals | W9-1 | 63-63 | .500 | Comerica Park · Detroit, MI |
| 127 | Wed Aug 25 | vs Royals | L3-4 (12) | 63-64 | .496 | Comerica Park · Detroit, MI |
| 128 | Thu Aug 26 | at Blue Jays | W7-1 | 64-64 | .500 | Rogers Centre · Toronto, ON |
| 129 | Fri Aug 27 | at Blue Jays | L2-3 (11) | 64-65 | .496 | Rogers Centre · Toronto, ON |
| 130 | Sat Aug 28 | at Blue Jays | L4-5 | 64-66 | .492 | Rogers Centre · Toronto, ON |
| 131 | Sun Aug 29 | at Blue Jays | W10-4 | 65-66 | .496 | Rogers Centre · Toronto, ON |
| 132 | Tue Aug 31 | at Twins | L3-4 | 65-67 | .492 | Target Field · Minneapolis, MN |
| 133 | Wed Sep 1 | at Twins | L1-2 (10) | 65-68 | .489 | Target Field · Minneapolis, MN |
| 134 | Thu Sep 2 | at Twins | W10-9 (13) | 66-68 | .493 | Target Field · Minneapolis, MN |
| 135 | Fri Sep 3 | at Royals | W9-5 (11) | 67-68 | .496 | Kauffman Stadium · Kansas City, MO |
| 136 | Sat Sep 4 | at Royals | W6-4 | 68-68 | .500 | Kauffman Stadium · Kansas City, MO |
| 137 | Sun Sep 5 | at Royals | L1-2 | 68-69 | .496 | Kauffman Stadium · Kansas City, MO |
| 138 | Mon Sep 6 | vs White Sox | L4-5 (10) | 68-70 | .493 | Comerica Park · Detroit, MI |
| 139 | Tue Sep 7 | vs White Sox | W9-1 | 69-70 | .496 | Comerica Park · Detroit, MI |
| 140 | Wed Sep 8 | vs White Sox | W5-1 | 70-70 | .500 | Comerica Park · Detroit, MI |
| 141 | Thu Sep 9 | vs White Sox | W6-3 | 71-70 | .504 | Comerica Park · Detroit, MI |
| 142 | Fri Sep 10 | vs Orioles | L3-6 | 71-71 | .500 | Comerica Park · Detroit, MI |
| 143 | Sat Sep 11 | vs Orioles | L3-5 | 71-72 | .497 | Comerica Park · Detroit, MI |
| 144 | Sun Sep 12 | vs Orioles | W6-2 | 72-72 | .500 | Comerica Park · Detroit, MI |
| 145 | Tue Sep 14 | at Rangers | L4-11 | 72-73 | .497 | Globe Life Field · Arlington, TX |
| 146 | Wed Sep 15 | at Rangers | L7-11 | 72-74 | .493 | Globe Life Field · Arlington, TX |
| 147 | Fri Sep 17 | at White Sox | W9-2 | 73-74 | .497 | Guaranteed Rate Field · Chicago, IL |
| 148 | Sat Sep 18 | at White Sox | W6-3 | 74-74 | .500 | Guaranteed Rate Field · Chicago, IL |
| 149 | Sun Sep 19 | at White Sox | W9-7 (11) | 75-74 | .503 | Guaranteed Rate Field · Chicago, IL |
| 150 | Mon Sep 20 | vs Royals | W7-5 | 76-74 | .507 | Comerica Park · Detroit, MI |
| 151 | Tue Sep 21 | vs Royals | L6-9 | 76-75 | .503 | Comerica Park · Detroit, MI |
| 152 | Wed Sep 22 | vs Royals | W4-2 | 77-75 | .507 | Comerica Park · Detroit, MI |
| 153 | Fri Sep 24 | vs Twins | W10-1 | 78-75 | .510 | Comerica Park · Detroit, MI |
| 154 | Sat Sep 25 | vs Twins | W11-10 (13) | 79-75 | .513 | Comerica Park · Detroit, MI |
| 155 | Sun Sep 26 | vs Twins | W5-1 | 80-75 | .516 | Comerica Park · Detroit, MI |
| 156 | Mon Sep 27 | at Guardians | L3-6 | 80-76 | .513 | Progressive Field · Cleveland, OH |
| 157 | Wed Sep 29 | at Guardians | L0-4 | 80-77 | .510 | Progressive Field · Cleveland, OH |
| 158 | Wed Sep 29 | at Guardians | L3-4 | 80-78 | .506 | Progressive Field · Cleveland, OH |
| 159 | Fri Oct 1 | at Orioles | L6-10 | 80-79 | .503 | Camden Yards · Baltimore, MD |
| 160 | Fri Oct 1 | at Orioles | L1-2 | 80-80 | .500 | Camden Yards · Baltimore, MD |
| 161 | Sat Oct 2 | at Orioles | L1-2 | 80-81 | .497 | Camden Yards · Baltimore, MD |
| 162 | Sun Oct 3 | at Orioles | W4-2 | 81-81 | .500 | Camden Yards · Baltimore, MD |