| 73 | Tue Jun 16 | at Astros | 8:10 PM | 33-41 | .446 | Minute Maid Park · Houston, TX |
| 74 | Wed Jun 17 | at Astros | 2:10 PM | 33-41 | .446 | Minute Maid Park · Houston, TX |
| 75 | Fri Jun 19 | vs White Sox | 6:40 PM | 38-32 | .543 | Comerica Park · Detroit, MI |
| 76 | Sat Jun 20 | vs White Sox | 1:10 PM | 38-32 | .543 | Comerica Park · Detroit, MI |
| 77 | Sun Jun 21 | vs White Sox | 1:40 PM | 38-32 | .543 | Comerica Park · Detroit, MI |
| 78 | Mon Jun 22 | vs Yankees | 6:40 PM | 43-27 | .614 | Comerica Park · Detroit, MI |
| 79 | Tue Jun 23 | vs Yankees | 6:40 PM | 43-27 | .614 | Comerica Park · Detroit, MI |
| 80 | Wed Jun 24 | vs Yankees | 6:40 PM | 43-27 | .614 | Comerica Park · Detroit, MI |
| 81 | Thu Jun 25 | vs Astros | 6:40 PM | 33-41 | .446 | Comerica Park · Detroit, MI |
| 82 | Fri Jun 26 | vs Astros | 6:40 PM | 33-41 | .446 | Comerica Park · Detroit, MI |
| 83 | Sat Jun 27 | vs Astros | 1:10 PM | 33-41 | .446 | Comerica Park · Detroit, MI |
| 84 | Sun Jun 28 | vs Astros | 1:40 PM | 33-41 | .446 | Comerica Park · Detroit, MI |
| 85 | Mon Jun 29 | at Yankees | 7:05 PM | 43-27 | .614 | Yankee Stadium · The Bronx, NY |
| 86 | Tue Jun 30 | at Yankees | 7:05 PM | 43-27 | .614 | Yankee Stadium · The Bronx, NY |
| 87 | Wed Jul 1 | at Yankees | 1:35 PM | 43-27 | .614 | Yankee Stadium · The Bronx, NY |
| 88 | Thu Jul 2 | at Rangers | 8:05 PM | 35-37 | .486 | Globe Life Field · Arlington, TX |
| 89 | Sat Jul 4 | at Rangers | 4:05 PM | 35-37 | .486 | Globe Life Field · Arlington, TX |
| 90 | Sun Jul 5 | at Rangers | 3:30 PM | 35-37 | .486 | Globe Life Field · Arlington, TX |
| 91 | Tue Jul 7 | vs Athletics | 6:40 PM | 36-36 | .500 | Comerica Park · Detroit, MI |
| 92 | Wed Jul 8 | vs Athletics | 6:40 PM | 36-36 | .500 | Comerica Park · Detroit, MI |
| 93 | Thu Jul 9 | vs Athletics | 6:40 PM | 36-36 | .500 | Comerica Park · Detroit, MI |
| 94 | Fri Jul 10 | vs Phillies | 6:40 PM | 39-33 | .542 | Comerica Park · Detroit, MI |
| 95 | Sat Jul 11 | vs Phillies | 6:10 PM | 39-33 | .542 | Comerica Park · Detroit, MI |
| 96 | Sun Jul 12 | vs Phillies | 1:40 PM | 39-33 | .542 | Comerica Park · Detroit, MI |
| 97 | Fri Jul 17 | at Angels | 9:38 PM | 29-44 | .397 | Angel Stadium · Anaheim, CA |
| 98 | Sat Jul 18 | at Angels | 10:07 PM | 29-44 | .397 | Angel Stadium · Anaheim, CA |
| 99 | Sun Jul 19 | at Angels | 4:07 PM | 29-44 | .397 | Angel Stadium · Anaheim, CA |
| 100 | Mon Jul 20 | at Cubs | 8:05 PM | 38-35 | .521 | Wrigley Field · Chicago, IL |
| 101 | Tue Jul 21 | at Cubs | 8:05 PM | 38-35 | .521 | Wrigley Field · Chicago, IL |
| 102 | Wed Jul 22 | at Cubs | 8:05 PM | 38-35 | .521 | Wrigley Field · Chicago, IL |
| 103 | Thu Jul 23 | vs Royals | 6:40 PM | 29-44 | .397 | Comerica Park · Detroit, MI |
| 104 | Fri Jul 24 | vs Royals | 6:40 PM | 29-44 | .397 | Comerica Park · Detroit, MI |
| 105 | Sat Jul 25 | vs Royals | 1:10 PM | 29-44 | .397 | Comerica Park · Detroit, MI |
| 106 | Sun Jul 26 | vs Royals | 1:40 PM | 29-44 | .397 | Comerica Park · Detroit, MI |
| 107 | Mon Jul 27 | vs Orioles | 6:40 PM | 34-39 | .466 | Comerica Park · Detroit, MI |
| 108 | Tue Jul 28 | vs Orioles | 6:40 PM | 34-39 | .466 | Comerica Park · Detroit, MI |
| 109 | Wed Jul 29 | vs Orioles | 1:10 PM | 34-39 | .466 | Comerica Park · Detroit, MI |
| 110 | Fri Jul 31 | at Athletics | 9:40 PM | 36-36 | .500 | Sutter Health Park · West Sacramento, CA |
| 111 | Sat Aug 1 | at Athletics | 9:40 PM | 36-36 | .500 | Sutter Health Park · West Sacramento, CA |
| 112 | Sun Aug 2 | at Athletics | 4:05 PM | 36-36 | .500 | Sutter Health Park · West Sacramento, CA |
| 113 | Tue Aug 4 | at Mariners | 9:40 PM | 37-36 | .507 | T-Mobile Park · Seattle, WA |
| 114 | Wed Aug 5 | at Mariners | 9:40 PM | 37-36 | .507 | T-Mobile Park · Seattle, WA |
| 115 | Thu Aug 6 | at Mariners | 4:10 PM | 37-36 | .507 | T-Mobile Park · Seattle, WA |
| 116 | Fri Aug 7 | at Giants | 10:15 PM | 29-43 | .403 | Oracle Park · San Francisco, CA |
| 117 | Sat Aug 8 | at Giants | 7:15 PM | 29-43 | .403 | Oracle Park · San Francisco, CA |
| 118 | Sun Aug 9 | at Giants | 4:05 PM | 29-43 | .403 | Oracle Park · San Francisco, CA |
| 119 | Tue Aug 11 | vs Guardians | 6:40 PM | 39-33 | .542 | Comerica Park · Detroit, MI |
| 120 | Wed Aug 12 | vs Guardians | 6:40 PM | 39-33 | .542 | Comerica Park · Detroit, MI |
| 121 | Thu Aug 13 | vs Guardians | 1:10 PM | 39-33 | .542 | Comerica Park · Detroit, MI |
| 122 | Fri Aug 14 | vs White Sox | 6:40 PM | 38-32 | .543 | Comerica Park · Detroit, MI |
| 123 | Sat Aug 15 | vs White Sox | 1:10 PM | 38-32 | .543 | Comerica Park · Detroit, MI |
| 124 | Sun Aug 16 | vs White Sox | 1:40 PM | 38-32 | .543 | Comerica Park · Detroit, MI |
| 125 | Mon Aug 17 | at Pirates | 7:05 PM | 36-37 | .493 | PNC Park · Pittsburgh, PA |
| 126 | Tue Aug 18 | at Pirates | 6:40 PM | 36-37 | .493 | PNC Park · Pittsburgh, PA |
| 127 | Wed Aug 19 | at Pirates | 12:35 PM | 36-37 | .493 | PNC Park · Pittsburgh, PA |
| 128 | Fri Aug 21 | at Royals | 8:10 PM | 29-44 | .397 | Kauffman Stadium · Kansas City, MO |
| 129 | Sat Aug 22 | at Royals | 7:15 PM | 29-44 | .397 | Kauffman Stadium · Kansas City, MO |
| 130 | Sun Aug 23 | at Royals | 2:10 PM | 29-44 | .397 | Kauffman Stadium · Kansas City, MO |
| 131 | Mon Aug 24 | vs Rays | 6:40 PM | 41-28 | .594 | Comerica Park · Detroit, MI |
| 132 | Tue Aug 25 | vs Rays | 6:40 PM | 41-28 | .594 | Comerica Park · Detroit, MI |
| 133 | Wed Aug 26 | vs Rays | 1:10 PM | 41-28 | .594 | Comerica Park · Detroit, MI |
| 134 | Fri Aug 28 | vs Dodgers | 6:40 PM | 46-27 | .630 | Comerica Park · Detroit, MI |
| 135 | Sat Aug 29 | vs Dodgers | 1:10 PM | 46-27 | .630 | Comerica Park · Detroit, MI |
| 136 | Sun Aug 30 | vs Dodgers | 1:40 PM | 46-27 | .630 | Comerica Park · Detroit, MI |
| 137 | Mon Aug 31 | at Twins | 7:40 PM | 34-40 | .459 | Target Field · Minneapolis, MN |
| 138 | Tue Sep 1 | at Twins | 7:40 PM | 34-40 | .459 | Target Field · Minneapolis, MN |
| 139 | Wed Sep 2 | at Twins | 7:40 PM | 34-40 | .459 | Target Field · Minneapolis, MN |
| 140 | Fri Sep 4 | at Guardians | 2:10 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 141 | Fri Sep 4 | at Guardians | 7:10 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 142 | Sat Sep 5 | at Guardians | 7:15 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 143 | Sun Sep 6 | at Guardians | 1:40 PM | 39-33 | .542 | Progressive Field · Cleveland, OH |
| 144 | Mon Sep 7 | vs Twins | 1:10 PM | 34-40 | .459 | Comerica Park · Detroit, MI |
| 145 | Tue Sep 8 | vs Twins | 6:40 PM | 34-40 | .459 | Comerica Park · Detroit, MI |
| 146 | Wed Sep 9 | vs Twins | 1:10 PM | 34-40 | .459 | Comerica Park · Detroit, MI |
| 147 | Fri Sep 11 | vs Rockies | 6:40 PM | 27-46 | .370 | Comerica Park · Detroit, MI |
| 148 | Sat Sep 12 | vs Rockies | 1:10 PM | 27-46 | .370 | Comerica Park · Detroit, MI |
| 149 | Sun Sep 13 | vs Rockies | 1:40 PM | 27-46 | .370 | Comerica Park · Detroit, MI |
| 150 | Mon Sep 14 | at Blue Jays | 7:07 PM | 34-38 | .472 | Rogers Centre · Toronto, ON |
| 151 | Tue Sep 15 | at Blue Jays | 7:07 PM | 34-38 | .472 | Rogers Centre · Toronto, ON |
| 152 | Wed Sep 16 | at Blue Jays | 3:07 PM | 34-38 | .472 | Rogers Centre · Toronto, ON |
| 153 | Thu Sep 17 | at White Sox | 7:40 PM | 38-32 | .543 | Guaranteed Rate Field · Chicago, IL |
| 154 | Fri Sep 18 | at White Sox | 7:40 PM | 38-32 | .543 | Guaranteed Rate Field · Chicago, IL |
| 155 | Sat Sep 19 | at White Sox | 7:10 PM | 38-32 | .543 | Guaranteed Rate Field · Chicago, IL |
| 156 | Sun Sep 20 | at White Sox | 2:10 PM | 38-32 | .543 | Guaranteed Rate Field · Chicago, IL |
| 157 | Mon Sep 21 | vs Nationals | 6:40 PM | 38-35 | .521 | Comerica Park · Detroit, MI |
| 158 | Tue Sep 22 | vs Nationals | 6:40 PM | 38-35 | .521 | Comerica Park · Detroit, MI |
| 159 | Wed Sep 23 | vs Nationals | 1:10 PM | 38-35 | .521 | Comerica Park · Detroit, MI |
| 160 | Fri Sep 25 | vs Pirates | 6:40 PM | 36-37 | .493 | Comerica Park · Detroit, MI |
| 161 | Sat Sep 26 | vs Pirates | 1:10 PM | 36-37 | .493 | Comerica Park · Detroit, MI |
| 162 | Sun Sep 27 | vs Pirates | 3:10 PM | 36-37 | .493 | Comerica Park · Detroit, MI |