| 1 | Thu Mar 28 | vs Twins | L1-4 | 0-1 | .000 | Kauffman Stadium · Kansas City, MO |
| 2 | Sat Mar 30 | vs Twins | L1-5 | 0-2 | .000 | Kauffman Stadium · Kansas City, MO |
| 3 | Sun Mar 31 | vs Twins | W11-0 | 1-2 | .333 | Kauffman Stadium · Kansas City, MO |
| 4 | Mon Apr 1 | at Orioles | L4-6 | 1-3 | .250 | Camden Yards · Baltimore, MD |
| 5 | Tue Apr 2 | at Orioles | W4-1 | 2-3 | .400 | Camden Yards · Baltimore, MD |
| 6 | Wed Apr 3 | at Orioles | L3-4 | 2-4 | .333 | Camden Yards · Baltimore, MD |
| 7 | Thu Apr 4 | vs White Sox | W10-1 | 3-4 | .429 | Kauffman Stadium · Kansas City, MO |
| 8 | Fri Apr 5 | vs White Sox | W2-1 | 4-4 | .500 | Kauffman Stadium · Kansas City, MO |
| 9 | Sat Apr 6 | vs White Sox | W3-0 | 5-4 | .556 | Kauffman Stadium · Kansas City, MO |
| 10 | Sun Apr 7 | vs White Sox | W5-3 | 6-4 | .600 | Kauffman Stadium · Kansas City, MO |
| 11 | Tue Apr 9 | vs Astros | W4-3 (10) | 7-4 | .636 | Kauffman Stadium · Kansas City, MO |
| 12 | Wed Apr 10 | vs Astros | W11-2 | 8-4 | .667 | Kauffman Stadium · Kansas City, MO |
| 13 | Thu Apr 11 | vs Astros | W13-3 | 9-4 | .692 | Kauffman Stadium · Kansas City, MO |
| 14 | Fri Apr 12 | at Mets | L1-6 | 9-5 | .643 | Citi Field · Queens, NY |
| 15 | Sat Apr 13 | at Mets | W11-7 | 10-5 | .667 | Citi Field · Queens, NY |
| 16 | Sun Apr 14 | at Mets | L1-2 | 10-6 | .625 | Citi Field · Queens, NY |
| 17 | Mon Apr 15 | at White Sox | W2-0 | 11-6 | .647 | Guaranteed Rate Field · Chicago, IL |
| 18 | Wed Apr 17 | at White Sox | W4-2 | 12-6 | .667 | Guaranteed Rate Field · Chicago, IL |
| 19 | Wed Apr 17 | at White Sox | L1-2 | 12-7 | .632 | Guaranteed Rate Field · Chicago, IL |
| 20 | Fri Apr 19 | vs Orioles | W9-4 | 13-7 | .650 | Kauffman Stadium · Kansas City, MO |
| 21 | Sat Apr 20 | vs Orioles | L7-9 | 13-8 | .619 | Kauffman Stadium · Kansas City, MO |
| 22 | Sun Apr 21 | vs Orioles | L0-5 | 13-9 | .591 | Kauffman Stadium · Kansas City, MO |
| 23 | Mon Apr 22 | vs Blue Jays | L3-5 | 13-10 | .565 | Kauffman Stadium · Kansas City, MO |
| 24 | Tue Apr 23 | vs Blue Jays | W3-2 | 14-10 | .583 | Kauffman Stadium · Kansas City, MO |
| 25 | Wed Apr 24 | vs Blue Jays | W3-2 | 15-10 | .600 | Kauffman Stadium · Kansas City, MO |
| 26 | Thu Apr 25 | vs Blue Jays | W2-1 | 16-10 | .615 | Kauffman Stadium · Kansas City, MO |
| 27 | Fri Apr 26 | at Tigers | W8-0 | 17-10 | .630 | Comerica Park · Detroit, MI |
| 28 | Sat Apr 27 | at Tigers | L5-6 | 17-11 | .607 | Comerica Park · Detroit, MI |
| 29 | Sun Apr 28 | at Tigers | L1-4 | 17-12 | .586 | Comerica Park · Detroit, MI |
| 30 | Mon Apr 29 | at Blue Jays | L5-6 | 17-13 | .567 | Rogers Centre · Toronto, ON |
| 31 | Tue Apr 30 | at Blue Jays | W4-1 | 18-13 | .581 | Rogers Centre · Toronto, ON |
| 32 | Wed May 1 | at Blue Jays | W6-1 | 19-13 | .594 | Rogers Centre · Toronto, ON |
| 33 | Fri May 3 | vs Rangers | W7-1 | 20-13 | .606 | Kauffman Stadium · Kansas City, MO |
| 34 | Sat May 4 | vs Rangers | L4-15 | 20-14 | .588 | Kauffman Stadium · Kansas City, MO |
| 35 | Sun May 5 | vs Rangers | L2-3 (10) | 20-15 | .571 | Kauffman Stadium · Kansas City, MO |
| 36 | Mon May 6 | vs Brewers | W3-2 | 21-15 | .583 | Kauffman Stadium · Kansas City, MO |
| 37 | Tue May 7 | vs Brewers | L5-6 | 21-16 | .568 | Kauffman Stadium · Kansas City, MO |
| 38 | Wed May 8 | vs Brewers | W6-4 | 22-16 | .579 | Kauffman Stadium · Kansas City, MO |
| 39 | Thu May 9 | at Angels | W10-4 | 23-16 | .590 | Angel Stadium · Anaheim, CA |
| 40 | Fri May 10 | at Angels | W2-1 | 24-16 | .600 | Angel Stadium · Anaheim, CA |
| 41 | Sat May 11 | at Angels | L3-9 | 24-17 | .585 | Angel Stadium · Anaheim, CA |
| 42 | Sun May 12 | at Angels | W4-2 | 25-17 | .595 | Angel Stadium · Anaheim, CA |
| 43 | Mon May 13 | at Mariners | L2-6 | 25-18 | .581 | T-Mobile Park · Seattle, WA |
| 44 | Tue May 14 | at Mariners | W4-2 | 26-18 | .591 | T-Mobile Park · Seattle, WA |
| 45 | Wed May 15 | at Mariners | L2-4 | 26-19 | .578 | T-Mobile Park · Seattle, WA |
| 46 | Fri May 17 | vs Athletics | W6-2 | 27-19 | .587 | Kauffman Stadium · Kansas City, MO |
| 47 | Sat May 18 | vs Athletics | W5-3 | 28-19 | .596 | Kauffman Stadium · Kansas City, MO |
| 48 | Sun May 19 | vs Athletics | W8-4 | 29-19 | .604 | Kauffman Stadium · Kansas City, MO |
| 49 | Mon May 20 | vs Tigers | W8-3 | 30-19 | .612 | Kauffman Stadium · Kansas City, MO |
| 50 | Tue May 21 | vs Tigers | W10-3 | 31-19 | .620 | Kauffman Stadium · Kansas City, MO |
| 51 | Wed May 22 | vs Tigers | W8-3 | 32-19 | .627 | Kauffman Stadium · Kansas City, MO |
| 52 | Fri May 24 | at Rays | W8-1 | 33-19 | .635 | Tropicana Field · St. Petersburg, FL |
| 53 | Sat May 25 | at Rays | W7-4 (11) | 34-19 | .642 | Tropicana Field · St. Petersburg, FL |
| 54 | Sun May 26 | at Rays | L1-4 | 34-20 | .630 | Tropicana Field · St. Petersburg, FL |
| 55 | Mon May 27 | at Twins | L5-6 | 34-21 | .618 | Target Field · Minneapolis, MN |
| 56 | Tue May 28 | at Twins | L2-4 | 34-22 | .607 | Target Field · Minneapolis, MN |
| 57 | Wed May 29 | at Twins | W6-1 | 35-22 | .614 | Target Field · Minneapolis, MN |
| 58 | Thu May 30 | at Twins | L6-7 | 35-23 | .603 | Target Field · Minneapolis, MN |
| 59 | Fri May 31 | vs Padres | L8-11 | 35-24 | .593 | Kauffman Stadium · Kansas City, MO |
| 60 | Sat Jun 1 | vs Padres | L3-7 | 35-25 | .583 | Kauffman Stadium · Kansas City, MO |
| 61 | Sun Jun 2 | vs Padres | W4-3 | 36-25 | .590 | Kauffman Stadium · Kansas City, MO |
| 62 | Tue Jun 4 | at Guardians | L5-8 | 36-26 | .581 | Progressive Field · Cleveland, OH |
| 63 | Thu Jun 6 | at Guardians | W4-3 | 37-26 | .587 | Progressive Field · Cleveland, OH |
| 64 | Fri Jun 7 | vs Mariners | W10-9 | 38-26 | .594 | Kauffman Stadium · Kansas City, MO |
| 65 | Sat Jun 8 | vs Mariners | W8-4 | 39-26 | .600 | Kauffman Stadium · Kansas City, MO |
| 66 | Sun Jun 9 | vs Mariners | L5-6 (10) | 39-27 | .591 | Kauffman Stadium · Kansas City, MO |
| 67 | Mon Jun 10 | vs Yankees | L2-4 | 39-28 | .582 | Kauffman Stadium · Kansas City, MO |
| 68 | Tue Jun 11 | vs Yankees | L1-10 | 39-29 | .574 | Kauffman Stadium · Kansas City, MO |
| 69 | Wed Jun 12 | vs Yankees | L5-11 | 39-30 | .565 | Kauffman Stadium · Kansas City, MO |
| 70 | Thu Jun 13 | vs Yankees | W4-3 | 40-30 | .571 | Kauffman Stadium · Kansas City, MO |
| 71 | Fri Jun 14 | at Dodgers | L3-4 | 40-31 | .563 | Dodger Stadium · Los Angeles, CA |
| 72 | Sat Jun 15 | at Dodgers | W7-2 | 41-31 | .569 | Dodger Stadium · Los Angeles, CA |
| 73 | Sun Jun 16 | at Dodgers | L0-3 | 41-32 | .562 | Dodger Stadium · Los Angeles, CA |
| 74 | Tue Jun 18 | at Athletics | L5-7 | 41-33 | .554 | RingCentral Coliseum · Oakland, CA |
| 75 | Wed Jun 19 | at Athletics | L1-5 | 41-34 | .547 | RingCentral Coliseum · Oakland, CA |
| 76 | Thu Jun 20 | at Athletics | W3-2 | 42-34 | .553 | RingCentral Coliseum · Oakland, CA |
| 77 | Fri Jun 21 | at Rangers | L2-6 | 42-35 | .545 | Globe Life Field · Arlington, TX |
| 78 | Sat Jun 22 | at Rangers | L0-6 | 42-36 | .538 | Globe Life Field · Arlington, TX |
| 79 | Sun Jun 23 | at Rangers | L0-4 | 42-37 | .532 | Globe Life Field · Arlington, TX |
| 80 | Mon Jun 24 | vs Marlins | W4-1 | 43-37 | .537 | Kauffman Stadium · Kansas City, MO |
| 81 | Tue Jun 25 | vs Marlins | L1-2 | 43-38 | .531 | Kauffman Stadium · Kansas City, MO |
| 82 | Wed Jun 26 | vs Marlins | W5-1 | 44-38 | .537 | Kauffman Stadium · Kansas City, MO |
| 83 | Thu Jun 27 | vs Guardians | W2-1 | 45-38 | .542 | Kauffman Stadium · Kansas City, MO |
| 84 | Fri Jun 28 | vs Guardians | W10-3 | 46-38 | .548 | Kauffman Stadium · Kansas City, MO |
| 85 | Sat Jun 29 | vs Guardians | L2-7 | 46-39 | .541 | Kauffman Stadium · Kansas City, MO |
| 86 | Sun Jun 30 | vs Guardians | W6-2 | 47-39 | .547 | Kauffman Stadium · Kansas City, MO |
| 87 | Tue Jul 2 | vs Rays | L1-5 | 47-40 | .540 | Kauffman Stadium · Kansas City, MO |
| 88 | Wed Jul 3 | vs Rays | W4-2 | 48-40 | .545 | Kauffman Stadium · Kansas City, MO |
| 89 | Thu Jul 4 | vs Rays | L8-10 | 48-41 | .539 | Kauffman Stadium · Kansas City, MO |
| 90 | Fri Jul 5 | at Rockies | L2-4 | 48-42 | .533 | Coors Field · Denver, CO |
| 91 | Sat Jul 6 | at Rockies | L1-3 | 48-43 | .527 | Coors Field · Denver, CO |
| 92 | Sun Jul 7 | at Rockies | W10-1 | 49-43 | .533 | Coors Field · Denver, CO |
| 93 | Wed Jul 10 | at Cardinals | W6-4 | 50-43 | .538 | Busch Stadium · St. Louis, MO |
| 94 | Wed Jul 10 | at Cardinals | W8-5 | 51-43 | .543 | Busch Stadium · St. Louis, MO |
| 95 | Fri Jul 12 | at Red Sox | W6-1 | 52-43 | .547 | Fenway Park · Boston, MA |
| 96 | Sat Jul 13 | at Red Sox | L0-5 | 52-44 | .542 | Fenway Park · Boston, MA |
| 97 | Sun Jul 14 | at Red Sox | L4-5 | 52-45 | .536 | Fenway Park · Boston, MA |
| 98 | Fri Jul 19 | vs White Sox | W7-1 | 53-45 | .541 | Kauffman Stadium · Kansas City, MO |
| 99 | Sat Jul 20 | vs White Sox | W6-1 | 54-45 | .545 | Kauffman Stadium · Kansas City, MO |
| 100 | Sun Jul 21 | vs White Sox | W4-1 | 55-45 | .550 | Kauffman Stadium · Kansas City, MO |
| 101 | Mon Jul 22 | vs D-backs | W10-4 | 56-45 | .554 | Kauffman Stadium · Kansas City, MO |
| 102 | Tue Jul 23 | vs D-backs | L2-6 | 56-46 | .549 | Kauffman Stadium · Kansas City, MO |
| 103 | Wed Jul 24 | vs D-backs | L6-8 | 56-47 | .544 | Kauffman Stadium · Kansas City, MO |
| 104 | Fri Jul 26 | vs Cubs | W6-0 | 57-47 | .548 | Kauffman Stadium · Kansas City, MO |
| 105 | Sat Jul 27 | vs Cubs | L4-9 | 57-48 | .543 | Kauffman Stadium · Kansas City, MO |
| 106 | Sun Jul 28 | vs Cubs | L3-7 | 57-49 | .538 | Kauffman Stadium · Kansas City, MO |
| 107 | Mon Jul 29 | at White Sox | W8-5 | 58-49 | .542 | Guaranteed Rate Field · Chicago, IL |
| 108 | Tue Jul 30 | at White Sox | W4-3 | 59-49 | .546 | Guaranteed Rate Field · Chicago, IL |
| 109 | Wed Jul 31 | at White Sox | W10-3 | 60-49 | .550 | Guaranteed Rate Field · Chicago, IL |
| 110 | Thu Aug 1 | at Tigers | W7-1 | 61-49 | .555 | Comerica Park · Detroit, MI |
| 111 | Fri Aug 2 | at Tigers | W9-2 | 62-49 | .559 | Comerica Park · Detroit, MI |
| 112 | Sat Aug 3 | at Tigers | L5-6 (11) | 62-50 | .554 | Comerica Park · Detroit, MI |
| 113 | Sun Aug 4 | at Tigers | W3-2 | 63-50 | .558 | Comerica Park · Detroit, MI |
| 114 | Mon Aug 5 | vs Red Sox | L5-9 | 63-51 | .553 | Kauffman Stadium · Kansas City, MO |
| 115 | Tue Aug 6 | vs Red Sox | L5-6 | 63-52 | .548 | Kauffman Stadium · Kansas City, MO |
| 116 | Wed Aug 7 | vs Red Sox | W8-4 | 64-52 | .552 | Kauffman Stadium · Kansas City, MO |
| 117 | Fri Aug 9 | vs Cardinals | L5-8 | 64-53 | .547 | Kauffman Stadium · Kansas City, MO |
| 118 | Sat Aug 10 | vs Cardinals | W8-3 | 65-53 | .551 | Kauffman Stadium · Kansas City, MO |
| 119 | Mon Aug 12 | at Twins | L3-8 | 65-54 | .546 | Target Field · Minneapolis, MN |
| 120 | Tue Aug 13 | at Twins | L3-13 | 65-55 | .542 | Target Field · Minneapolis, MN |
| 121 | Wed Aug 14 | at Twins | W4-1 | 66-55 | .545 | Target Field · Minneapolis, MN |
| 122 | Fri Aug 16 | at Reds | W7-1 | 67-55 | .549 | Great American Ball Park · Cincinnati, OH |
| 123 | Sat Aug 17 | at Reds | W13-1 | 68-55 | .553 | Great American Ball Park · Cincinnati, OH |
| 124 | Sun Aug 18 | at Reds | W8-1 | 69-55 | .556 | Great American Ball Park · Cincinnati, OH |
| 125 | Mon Aug 19 | vs Angels | W5-3 | 70-55 | .560 | Kauffman Stadium · Kansas City, MO |
| 126 | Tue Aug 20 | vs Angels | L5-9 | 70-56 | .556 | Kauffman Stadium · Kansas City, MO |
| 127 | Wed Aug 21 | vs Angels | W3-0 | 71-56 | .559 | Kauffman Stadium · Kansas City, MO |
| 128 | Fri Aug 23 | vs Phillies | W7-4 | 72-56 | .563 | Kauffman Stadium · Kansas City, MO |
| 129 | Sat Aug 24 | vs Phillies | L2-11 | 72-57 | .558 | Kauffman Stadium · Kansas City, MO |
| 130 | Sun Aug 25 | vs Phillies | L3-11 | 72-58 | .554 | Kauffman Stadium · Kansas City, MO |
| 131 | Mon Aug 26 | at Guardians | W4-3 | 73-58 | .557 | Progressive Field · Cleveland, OH |
| 132 | Mon Aug 26 | at Guardians | W9-4 | 74-58 | .561 | Progressive Field · Cleveland, OH |
| 133 | Tue Aug 27 | at Guardians | W6-1 | 75-58 | .564 | Progressive Field · Cleveland, OH |
| 134 | Wed Aug 28 | at Guardians | L5-7 | 75-59 | .560 | Progressive Field · Cleveland, OH |
| 135 | Thu Aug 29 | at Astros | L3-6 | 75-60 | .556 | Minute Maid Park · Houston, TX |
| 136 | Fri Aug 30 | at Astros | L2-3 | 75-61 | .551 | Minute Maid Park · Houston, TX |
| 137 | Sat Aug 31 | at Astros | L2-5 | 75-62 | .547 | Minute Maid Park · Houston, TX |
| 138 | Sun Sep 1 | at Astros | L2-7 | 75-63 | .543 | Minute Maid Park · Houston, TX |
| 139 | Mon Sep 2 | vs Guardians | L2-4 | 75-64 | .540 | Kauffman Stadium · Kansas City, MO |
| 140 | Tue Sep 3 | vs Guardians | L1-7 | 75-65 | .536 | Kauffman Stadium · Kansas City, MO |
| 141 | Wed Sep 4 | vs Guardians | W4-1 | 76-65 | .539 | Kauffman Stadium · Kansas City, MO |
| 142 | Fri Sep 6 | vs Twins | W5-0 | 77-65 | .542 | Kauffman Stadium · Kansas City, MO |
| 143 | Sat Sep 7 | vs Twins | W4-2 | 78-65 | .545 | Kauffman Stadium · Kansas City, MO |
| 144 | Sun Sep 8 | vs Twins | W2-0 | 79-65 | .549 | Kauffman Stadium · Kansas City, MO |
| 145 | Mon Sep 9 | at Yankees | L4-10 | 79-66 | .545 | Yankee Stadium · The Bronx, NY |
| 146 | Tue Sep 10 | at Yankees | W5-0 | 80-66 | .548 | Yankee Stadium · The Bronx, NY |
| 147 | Wed Sep 11 | at Yankees | L3-4 (11) | 80-67 | .544 | Yankee Stadium · The Bronx, NY |
| 148 | Fri Sep 13 | at Pirates | W8-3 | 81-67 | .547 | PNC Park · Pittsburgh, PA |
| 149 | Sat Sep 14 | at Pirates | W5-1 | 82-67 | .550 | PNC Park · Pittsburgh, PA |
| 150 | Sun Sep 15 | at Pirates | L3-4 | 82-68 | .547 | PNC Park · Pittsburgh, PA |
| 151 | Mon Sep 16 | vs Tigers | L6-7 | 82-69 | .543 | Kauffman Stadium · Kansas City, MO |
| 152 | Tue Sep 17 | vs Tigers | L1-3 (10) | 82-70 | .539 | Kauffman Stadium · Kansas City, MO |
| 153 | Wed Sep 18 | vs Tigers | L2-4 | 82-71 | .536 | Kauffman Stadium · Kansas City, MO |
| 154 | Fri Sep 20 | vs Giants | L1-2 | 82-72 | .532 | Kauffman Stadium · Kansas City, MO |
| 155 | Sat Sep 21 | vs Giants | L0-9 | 82-73 | .529 | Kauffman Stadium · Kansas City, MO |
| 156 | Sun Sep 22 | vs Giants | L0-2 | 82-74 | .526 | Kauffman Stadium · Kansas City, MO |
| 157 | Tue Sep 24 | at Nationals | W1-0 (10) | 83-74 | .529 | Nationals Park · Washington, D.C. |
| 158 | Wed Sep 25 | at Nationals | W3-0 | 84-74 | .532 | Nationals Park · Washington, D.C. |
| 159 | Thu Sep 26 | at Nationals | W7-4 | 85-74 | .535 | Nationals Park · Washington, D.C. |
| 160 | Fri Sep 27 | at Braves | L0-3 | 85-75 | .531 | Truist Park · Cumberland, GA |
| 161 | Sat Sep 28 | at Braves | L1-2 | 85-76 | .528 | Truist Park · Cumberland, GA |
| 162 | Sun Sep 29 | at Braves | W4-2 | 86-76 | .531 | Truist Park · Cumberland, GA |
| 163 | Tue Oct 1 | at Orioles | W1-0 | 1-0 | 1.000 | Camden Yards · Baltimore, MD |
| 164 | Wed Oct 2 | at Orioles | W2-1 | 2-0 | 1.000 | Camden Yards · Baltimore, MD |
| 165 | Sat Oct 5 | at Yankees | L5-6 | 0-1 | .000 | Yankee Stadium · The Bronx, NY |
| 166 | Mon Oct 7 | at Yankees | W4-2 | 1-1 | .500 | Yankee Stadium · The Bronx, NY |
| 167 | Wed Oct 9 | vs Yankees | L2-3 | 1-2 | .333 | Kauffman Stadium · Kansas City, MO |
| 168 | Thu Oct 10 | vs Yankees | L1-3 | 1-3 | .250 | Kauffman Stadium · Kansas City, MO |