| Sun Nov 5 | at Kansas City | L1-2 | 17-12-5 | 56 PTS | Children's Mercy Park · Kansas City, KS |
| Sun Oct 29 | vsKansas City | L1-4 | 17-12-5 | 56 PTS | CITYPARK · St. Louis, MO |
| Sat Oct 21 | vs Seattle | L0-2 | 17-12-5 | 56 PTS | CITYPARK · St. Louis, MO |
| Wed Oct 4 | at Vancouver | L0-3 | 17-11-5 | 56 PTS | BC Place · Vancouver, BC |
| Sat Sep 30 | vsKansas City | W4-1 | 17-10-5 | 56 PTS | CITYPARK · St. Louis, MO |
| Sat Sep 23 | at Minnesota | W2-1 | 16-10-5 | 53 PTS | Allianz Field · Saint Paul, MN |
| Wed Sep 20 | vs LAFC | D0-0 | 15-10-5 | 50 PTS | CITYPARK · St. Louis, MO |
| Sat Sep 16 | at Houston | D1-1 | 15-10-4 | 49 PTS | Shell Energy Stadium · Houston, TX |
| Sun Sep 10 | at LA Galaxy | D2-2 | 15-10-3 | 48 PTS | Dignity Health Sports Park · Carson, CA |
| Sat Sep 2 | atKansas City | L1-2 | 15-10-2 | 47 PTS | Children's Mercy Park · Kansas City, KS |
| Wed Aug 30 | vs Dallas | W2-1 | 15-9-2 | 47 PTS | CITYPARK · St. Louis, MO |
| Sat Aug 26 | at Orlando | L1-2 | 14-9-2 | 44 PTS | Exploria Stadium · Orlando, FL |
| Sun Aug 20 | vs Austin | W6-3 | 14-8-2 | 44 PTS | CITYPARK · St. Louis, MO |
| Sat Jul 15 | vs Miami | W3-0 | 13-8-2 | 41 PTS | CITYPARK · St. Louis, MO |
| Wed Jul 12 | atLAFC | L0-3 | 12-8-2 | 38 PTS | BMO Stadium · Los Angeles, CA |
| Sat Jul 8 | at Toronto | W1-0 | 12-7-2 | 38 PTS | BMO Field · Toronto, ON |
| Sat Jul 1 | vs Colorado | W2-0 | 11-7-2 | 35 PTS | CITYPARK · St. Louis, MO |
| Sat Jun 24 | at San Jose | W2-1 | 10-7-2 | 32 PTS | PayPal Park · San Jose, CA |
| Wed Jun 21 | vs Salt Lake | L1-3 | 9-7-2 | 29 PTS | CITYPARK · St. Louis, MO |
| Sat Jun 17 | at Nashville | L1-3 | 9-6-2 | 29 PTS | GEODIS Park · Nashville, TN |
| Sun Jun 11 | vsLA Galaxy | D1-1 | 9-5-2 | 29 PTS | CITYPARK · St. Louis, MO |
| Wed Jun 7 | atDallas | L0-2 | 9-5-1 | 28 PTS | Toyota Stadium · Frisco, TX |
| Sat Jun 3 | vsHouston | W3-0 | 9-4-1 | 28 PTS | CITYPARK · St. Louis, MO |
| Sat May 27 | vsVancouver | W3-1 | 8-4-1 | 25 PTS | CITYPARK · St. Louis, MO |
| Sat May 20 | vsKansas City | W4-0 | 7-4-1 | 22 PTS | CITYPARK · St. Louis, MO |
| Sat May 13 | at Chicago | L0-1 | 6-4-1 | 19 PTS | Soldier Field · Chicago, IL |
| Sat Apr 29 | vs Portland | L1-2 | 6-3-1 | 19 PTS | CITYPARK · St. Louis, MO |
| Sat Apr 22 | atColorado | D1-1 | 6-2-1 | 19 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| Sat Apr 15 | vs Cincinnati | W5-1 | 6-2-0 | 18 PTS | CITYPARK · St. Louis, MO |
| Sat Apr 8 | atSeattle | L0-3 | 5-2-0 | 15 PTS | Lumen Field · Seattle, WA |
| Sat Apr 1 | vsMinnesota | L0-1 | 5-1-0 | 15 PTS | CITYPARK · St. Louis, MO |
| Sat Mar 25 | atSalt Lake | W4-0 | 5-0-0 | 15 PTS | America First Field · Sandy, UT |
| Sat Mar 18 | vsSan Jose | W3-0 | 4-0-0 | 12 PTS | CITYPARK · St. Louis, MO |
| Sat Mar 11 | atPortland | W2-1 | 3-0-0 | 9 PTS | Providence Park · Portland, OR |
| Sat Mar 4 | vs Charlotte | W3-1 | 2-0-0 | 6 PTS | CITYPARK · St. Louis, MO |
| Sat Feb 25 | atAustin | W3-2 | 1-0-0 | 3 PTS | Q2 Stadium · Austin, TX |
