| 1 | Mon Nov 4 | vs Northeastern | L72-80 | 0-1 | .000 | - | ESPN+ | Case Gym · Boston, MA |
| 2 | Fri Nov 8 | atSan Diego | L60-74 | 0-2 | .000 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 3 | Mon Nov 11 | atUCLA | L40-71 | 0-3 | .000 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 4 | Sat Nov 16 | vsDartmouth | W78-50 | 1-3 | .250 | - | ESPN+ | Case Gym · Boston, MA |
| 5 | Tue Nov 19 | vsWagner | L58-60 | 1-4 | .200 | - | ESPN+ | Case Gym · Boston, MA |
| 6 | Sat Nov 23 | atUMBC | W75-71 | 2-4 | .333 | - | ESPN+ | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 7 | Sun Nov 24 | atHoward | W69-62 | 3-4 | .429 | - | | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 8 | Sun Dec 1 | vsSacred Heart | L65-73 | 3-5 | .375 | - | ESPN+ | Case Gym · Boston, MA |
| 9 | Sat Dec 7 | vsAlbany | W80-74 (OT) | 4-5 | .444 | - | ESPN+ | Case Gym · Boston, MA |
| 10 | Mon Dec 9 | vsTBD | W113-75 | 5-5 | .500 | - | ESPN+ | Case Gym · Boston, MA |
| 11 | Fri Dec 13 | atMerrimack | L61-64 | 5-6 | .455 | - | ESPN+ | placeholder · sf, ca |
| 12 | Sat Dec 21 | atUMass Lowell | L71-83 | 5-7 | .417 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 13 | Sun Dec 29 | atMaine | W59-56 | 6-7 | .462 | - | ESPN+ | Cross Insurance Center · Bangor, ME |
| 14 | Thu Jan 2 | atLafayette | L46-60 | 6-8 | .429 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 15 | Sun Jan 5 | vsArmy | W71-63 | 7-8 | .467 | - | ESPN+ | Case Gym · Boston, MA |
| 16 | Wed Jan 8 | vsAmerican | W60-54 | 8-8 | .500 | - | ESPN+ | Case Gym · Boston, MA |
| 17 | Sat Jan 11 | atColgate | L50-87 | 8-9 | .471 | - | ESPN+ | Cotterell Court · Hamilton, NY |
| 18 | Wed Jan 15 | vsLehigh | W63-58 | 9-9 | .500 | - | ESPN+ | Case Gym · Boston, MA |
| 19 | Sat Jan 18 | atArmy | L62-68 | 9-10 | .474 | - | ESPN+ | Christl Arena · West Point, NY |
| 20 | Wed Jan 22 | atNavy | L47-62 | 9-11 | .450 | - | ESPN+ | Alumni Hall (Navy) · Annapolis, MD |
| 21 | Sat Jan 25 | vsBucknell | W85-82 (OT) | 10-11 | .476 | - | ESPN+ | Case Gym · Boston, MA |
| 22 | Mon Jan 27 | vsHoly Cross | W69-59 | 11-11 | .500 | - | CBSSN | Case Gym · Boston, MA |
| 23 | Sat Feb 1 | atLoyola MD | L67-69 | 11-12 | .478 | - | ESPN+ | Reitz Arena · Baltimore, MD |
| 24 | Wed Feb 5 | vsNavy | W87-65 | 12-12 | .500 | - | ESPN+ | Case Gym · Boston, MA |
| 25 | Sat Feb 8 | atHoly Cross | L52-72 | 12-13 | .480 | - | ESPN+ | Hart Center · Worcester, MA |
| 26 | Wed Feb 12 | atBucknell | L60-76 | 12-14 | .462 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 27 | Sat Feb 15 | vsColgate | W93-91 (2OT) | 13-14 | .481 | - | ESPN+ | Case Gym · Boston, MA |
| 28 | Wed Feb 19 | vsLoyola MD | W68-66 | 14-14 | .500 | - | ESPN+ | Case Gym · Boston, MA |
| 29 | Sat Feb 22 | atAmerican | L44-48 | 14-15 | .483 | - | ESPN+ | Bender Arena · Washington, D.C. |
| 30 | Wed Feb 26 | atLehigh | W79-68 | 15-15 | .500 | - | ESPN+ | Stabler Arena · Bethlehem, PA |
| 31 | Sat Mar 1 | vsLafayette | W66-64 | 16-15 | .516 | - | ESPN+ | Case Gym · Boston, MA |
| 32 | Thu Mar 6 | vsNavy | L78-86 | 16-16 | .500 | - | ESPN+ | Case Gym · Boston, MA |
