| 1 | Mon Nov 3 | at Northeastern | W76-75 (OT) | 1-0 | 1.000 | - | | Matthews Arena · Boston, MA |
| 2 | Fri Nov 7 | atNorthwestern | L52-76 | 1-1 | .500 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 3 | Wed Nov 12 | vsBrown | W90-77 | 2-1 | .667 | - | ESPN+ | Case Gym · Boston, MA |
| 4 | Sat Nov 15 | vsMerrimack | L79-91 | 2-2 | .500 | - | ESPN+ | Case Gym · Boston, MA |
| 5 | Tue Nov 18 | atColumbia | L49-54 | 2-3 | .400 | - | ESPN+ | Francis S. Levien Gymnasium · New York, NY |
| 6 | Sat Nov 22 | vsHarvard | W75-74 | 3-3 | .500 | - | | Case Gym · Boston, MA |
| 7 | Tue Nov 25 | atPenn State | L87-96 | 3-4 | .429 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 8 | Sat Nov 29 | atN Kentucky | L65-74 | 3-5 | .375 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 9 | Wed Dec 3 | vsTBD | W104-57 | 4-5 | .444 | - | ESPN+ | Case Gym · Boston, MA |
| 10 | Sat Dec 6 | atNew Hampshire | L82-88 (OT) | 4-6 | .400 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 11 | Wed Dec 10 | vsMaine | L59-69 | 4-7 | .364 | - | ESPN+ | Case Gym · Boston, MA |
| 12 | Sat Dec 13 | atDartmouth | L64-77 | 4-8 | .333 | - | ESPN+ | Edward Leede Arena · Hanover, NH |
| 13 | Sun Dec 21 | vsUMass Lowell | W88-76 | 5-8 | .385 | - | ESPN+ | Case Gym · Boston, MA |
| 14 | Wed Dec 31 | atNavy | L77-82 | 5-9 | .357 | - | ESPN+ | Alumni Hall (Navy) · Annapolis, MD |
| 15 | Sat Jan 3 | vsAmerican | L62-64 | 5-10 | .333 | - | ESPN+ | Case Gym · Boston, MA |
| 16 | Wed Jan 7 | atLafayette | W83-67 | 6-10 | .375 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 17 | Sat Jan 10 | vsArmy | W100-91 | 7-10 | .412 | - | ESPN+ | Case Gym · Boston, MA |
| 18 | Wed Jan 14 | vsLehigh | L91-93 (OT) | 7-11 | .389 | - | ESPN+ | Case Gym · Boston, MA |
| 19 | Sat Jan 17 | atLoyola MD | L57-74 | 7-12 | .368 | - | ESPN+ | Reitz Arena · Baltimore, MD |
| 20 | Wed Jan 21 | vsLafayette | W77-73 (OT) | 8-12 | .400 | - | ESPN+ | Case Gym · Boston, MA |
| 21 | Sat Jan 24 | atColgate | L79-80 (OT) | 8-13 | .381 | - | ESPN+ | Cotterell Court · Hamilton, NY |
| 22 | Wed Jan 28 | vsNavy | L50-58 | 8-14 | .364 | - | ESPN+ | Case Gym · Boston, MA |
| 23 | Sat Jan 31 | atBucknell | L97-103 (2OT) | 8-15 | .348 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 24 | Mon Feb 2 | atHoly Cross | W72-64 | 9-15 | .375 | - | CBSSN | Hart Center · Worcester, MA |
| 25 | Sat Feb 7 | vsLoyola MD | W78-69 | 10-15 | .400 | - | ESPN+ | Case Gym · Boston, MA |
| 26 | Wed Feb 11 | atArmy | W85-68 | 11-15 | .423 | - | ESPN+ | Christl Arena · West Point, NY |
| 27 | Sat Feb 14 | vsBucknell | W82-69 | 12-15 | .444 | - | ESPN+ | Case Gym · Boston, MA |
| 28 | Mon Feb 16 | vsColgate | W85-58 | 13-15 | .464 | - | CBSSN | Case Gym · Boston, MA |
| 29 | Sun Feb 22 | atLehigh | L67-70 | 13-16 | .448 | - | CBSSN | Stabler Arena · Bethlehem, PA |
| 30 | Wed Feb 25 | vsHoly Cross | W78-63 | 14-16 | .467 | - | ESPN+ | Case Gym · Boston, MA |
| 31 | Sat Feb 28 | atAmerican | W68-65 | 15-16 | .484 | - | CBSSN | Bender Arena · Washington, D.C. |
