| 1 | Tue Nov 9 | at Saint Mary's | L68-87 | 0-1 | .000 | - | | University Credit Union Pavilion · Moraga, CA |
| 2 | Thu Nov 11 | atSan Francisco | L76-92 | 0-2 | .000 | - | | War Memorial at the Sobrato Center · San Francisco, CA |
| 3 | Sat Nov 13 | atMichigan | L49-77 | 0-3 | .000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 4 | Sun Nov 14 | atOklahoma St | L59-72 | 0-4 | .000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Mon Nov 15 | atTexas Tech | L49-84 | 0-5 | .000 | - | | United Supermarkets Arena · Lubbock, TX |
| 6 | Wed Nov 17 | atGrand Canyon | L64-91 | 0-6 | .000 | - | | GCU Arena · Phoenix, AZ |
| 7 | Sat Nov 27 | atLMU | L80-83 | 0-7 | .000 | - | | Gersten Pavilion · Los Angeles, CA |
| 8 | Tue Nov 30 | atS Dakota St | L90-99 | 0-8 | .000 | - | | Frost Arena · Brookings, SD |
| 9 | Fri Dec 10 | atBoise St | L60-97 | 0-9 | .000 | - | | ExtraMile Arena · Boise, ID |
| 10 | Wed Dec 22 | atWichita St | L66-102 | 0-10 | .000 | - | | Charles Koch Arena · Wichita, KS |
| 15 | Sat Jan 8 | vsMiss Valley St | L82-84 (OT) | 0-11 | .000 | - | | William Nicks Building · Prairie View, TX |
| 16 | Mon Jan 10 | vsAR-Pine Bluff | W75-58 | 1-11 | .083 | - | | William Nicks Building · Prairie View, TX |
| 17 | Sat Jan 15 | atJackson St | L64-75 | 1-12 | .077 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 18 | Mon Jan 17 | atAlcorn St | W74-73 | 2-12 | .143 | - | | Davey L. Whitney Complex · Lorman, MS |
| 19 | Sat Jan 22 | vsAlabama St | W70-67 | 3-12 | .200 | - | | William Nicks Building · Prairie View, TX |
| 20 | Mon Jan 24 | vsAlabama A&M | W72-48 | 4-12 | .250 | - | | William Nicks Building · Prairie View, TX |
| 21 | Sat Jan 29 | vsTexas So | L74-75 (OT) | 4-13 | .235 | - | ESPNU | William Nicks Building · Prairie View, TX |
| 22 | Sat Feb 5 | atBethune | L67-68 | 4-14 | .222 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 23 | Mon Feb 7 | atFAMU | L60-61 | 4-15 | .211 | - | | Al Lawson Center · Tallahassee, FL |
| 24 | Sat Feb 12 | vsSouthern | W84-77 | 5-15 | .250 | - | | William Nicks Building · Prairie View, TX |
| 25 | Mon Feb 14 | vsGrambling | W71-70 | 6-15 | .286 | - | | William Nicks Building · Prairie View, TX |
| 26 | Sat Feb 19 | atAR-Pine Bluff | W92-84 | 7-15 | .318 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 27 | Mon Feb 21 | atMiss Valley St | W69-64 | 8-15 | .348 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 28 | Sat Feb 26 | vsAlcorn St | L69-72 | 8-16 | .333 | - | | William Nicks Building · Prairie View, TX |
| 29 | Mon Feb 28 | vsJackson St | L53-59 | 8-17 | .320 | - | ESPNU | William Nicks Building · Prairie View, TX |
| 30 | Sat Mar 5 | atTexas So | L77-78 | 8-18 | .308 | - | | H&PE Arena · Houston, TX |
| 31 | Wed Mar 9 | atAlcorn St | L63-64 (OT) | 8-19 | .296 | - | | Bartow Arena · Birmingham, AL |
