| 1 | Wed Nov 25 | at Indiana | L59-89 | 0-1 | .000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 2 | Mon Nov 30 | vsChattanooga | L54-62 | 0-2 | .000 | - | | Hooper Eblen Center · Cookeville, TN |
| 3 | Wed Dec 2 | atXavier | L48-79 | 0-3 | .000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 4 | Thu Dec 3 | atN Kentucky | L65-74 | 0-4 | .000 | - | | Truist Arena · Highland Heights, KY |
| 5 | Sun Dec 6 | atW Carolina | L75-76 (OT) | 0-5 | .000 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 6 | Sun Dec 13 | vsJ'Ville St | L67-73 | 0-6 | .000 | - | | Hooper Eblen Center · Cookeville, TN |
| 7 | Wed Dec 16 | atJ'Ville St | L50-74 | 0-7 | .000 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 8 | Fri Dec 18 | at10Tennessee | L49-103 | 0-8 | .000 | - | | Thompson-Boling Arena · Knoxville, TN |
| 9 | Tue Dec 22 | atWestern KY | L68-88 | 0-9 | .000 | - | ESPNU | E. A. Diddle Arena · Bowling Green, KY |
| 10 | Wed Dec 30 | vsSE Missouri St | W72-63 | 1-9 | .100 | - | | Hooper Eblen Center · Cookeville, TN |
| 11 | Sat Jan 2 | atE Illinois | L81-87 | 1-10 | .091 | - | | Lantz Arena · Charleston, IL |
| 12 | Thu Jan 7 | atMorehead St | L54-57 | 1-11 | .083 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 13 | Sat Jan 9 | atE Kentucky | L80-90 | 1-12 | .077 | - | | McBrayer Arena · Richmond, KY |
| 14 | Thu Jan 14 | vsBelmont | L67-88 | 1-13 | .071 | - | | Hooper Eblen Center · Cookeville, TN |
| 15 | Sat Jan 16 | vsTennessee St | W74-71 | 2-13 | .133 | - | | Hooper Eblen Center · Cookeville, TN |
| 16 | Thu Jan 21 | atAustin Peay | L69-72 | 2-14 | .125 | - | | Winfield Dunn Center · Clarksville, TN |
| 17 | Sat Jan 23 | atMurray St | L63-72 | 2-15 | .118 | - | | CFSB Center · Murray, KY |
| 18 | Thu Jan 28 | vsE Kentucky | PPD | 5-22 | .185 | - | | Hooper Eblen Center · Cookeville, TN |
| 19 | Sat Jan 30 | vsMorehead St | L55-74 | 2-16 | .111 | - | | Hooper Eblen Center · Cookeville, TN |
| 20 | Thu Feb 4 | atSE Missouri St | L64-68 | 2-17 | .105 | - | | Show Me Center · Cape Girardeau, MO |
| 21 | Sat Feb 6 | atUT Martin | L64-66 | 2-18 | .100 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 22 | Thu Feb 11 | vsSIUE | L63-81 | 2-19 | .095 | - | | Hooper Eblen Center · Cookeville, TN |
| 23 | Sat Feb 13 | vsE Illinois | W80-67 | 3-19 | .136 | - | | Hooper Eblen Center · Cookeville, TN |
| 24 | Mon Feb 15 | vsE Kentucky | L72-83 | 3-20 | .130 | - | | Hooper Eblen Center · Cookeville, TN |
| 25 | Thu Feb 18 | atTennessee St | L86-91 | 3-21 | .125 | - | | Gentry Center · Nashville, TN |
| 26 | Sat Feb 20 | atBelmont | L66-90 | 3-22 | .120 | - | | Curb Event Center Arena · Nashville, TN |
| 27 | Thu Feb 25 | vsAustin Peay | W81-76 | 4-22 | .154 | - | | Hooper Eblen Center · Cookeville, TN |
| 28 | Sat Feb 27 | vsMurray St | W71-61 | 5-22 | .185 | - | | Hooper Eblen Center · Cookeville, TN |
