| 1 | Wed Nov 25 | vs Bradley | L59-61 | 0-1 | .000 | - | | Cintas Center · Cincinnati, OH |
| 2 | Thu Nov 26 | atOakland | W80-53 | 1-1 | .500 | - | | Cintas Center · Cincinnati, OH |
| 3 | Fri Nov 27 | atXavier | L73-76 | 1-2 | .333 | - | | Cintas Center · Cincinnati, OH |
| 4 | Tue Dec 1 | vsCleveland St | W70-61 | 2-2 | .500 | - | | Savage Arena · Toledo, OH |
| 5 | Fri Dec 4 | atE Michigan | W91-74 | 3-2 | .600 | - | | Convocation Center (MI) · Ypsilanti, MI |
| 6 | Wed Dec 9 | atMichigan | L71-91 | 3-3 | .500 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 7 | Sat Dec 12 | vsKansas City | W64-57 | 4-3 | .571 | - | | Savage Arena · Toledo, OH |
| 8 | Wed Dec 16 | atMarshall | W96-87 (OT) | 5-3 | .625 | - | | Cam Henderson Center · Huntington, WV |
| 9 | Sat Dec 19 | vsValparaiso | W71-57 | 6-3 | .667 | - | | Savage Arena · Toledo, OH |
| 10 | Tue Dec 22 | vsN Illinois | W78-55 | 7-3 | .700 | - | | Savage Arena · Toledo, OH |
| 11 | Sat Jan 2 | atW Michigan | W70-59 | 8-3 | .727 | - | | University Arena (MI) · Kalamazoo, MI |
| 12 | Tue Jan 5 | atKent State | W84-82 | 9-3 | .750 | - | | M.A.C. Center · Kent, OH |
| 13 | Fri Jan 8 | vsOhio | W95-78 | 10-3 | .769 | - | CBSSN | Savage Arena · Toledo, OH |
| 14 | Tue Jan 12 | vsE Michigan | W96-63 | 11-3 | .786 | - | | Savage Arena · Toledo, OH |
| 15 | Sat Jan 16 | atAkron | L94-95 (OT) | 11-4 | .733 | - | | James A. Rhodes Arena · Akron, OH |
| 16 | Tue Jan 19 | vsC Michigan | W89-72 | 12-4 | .750 | - | | Savage Arena · Toledo, OH |
| 17 | Sat Jan 23 | vsKent State | W76-74 | 13-4 | .765 | - | | Savage Arena · Toledo, OH |
| 18 | Tue Jan 26 | atMiami OH | W90-81 | 14-4 | .778 | - | | Millett Hall · Oxford, OH |
| 19 | Sat Jan 30 | atBowling Green | W84-66 | 15-4 | .789 | - | | Stroh Center · Bowling Green, OH |
| 20 | Tue Feb 2 | vsAkron | W91-76 | 16-4 | .800 | - | | Savage Arena · Toledo, OH |
| 21 | Sat Feb 6 | atBall State | L67-81 | 16-5 | .762 | - | CBSSN | Worthen Arena · Muncie, IN |
| 23 | Sat Feb 13 | vsBowling Green | L81-88 | 16-6 | .727 | - | | Savage Arena · Toledo, OH |
| 24 | Tue Feb 16 | vsMiami OH | W87-75 | 17-6 | .739 | - | | Savage Arena · Toledo, OH |
| 25 | Fri Feb 19 | atBuffalo | W80-70 | 18-6 | .750 | - | ESPN2 | Alumni Arena · Buffalo, NY |
| 26 | Sat Feb 27 | vsW Michigan | W91-44 | 19-6 | .760 | - | | Savage Arena · Toledo, OH |
| 27 | Tue Mar 2 | atC Michigan | L79-81 | 19-7 | .731 | - | | McGuirk Arena · Mount Pleasant, MI |
| 28 | Fri Mar 5 | vsBall State | W89-70 | 20-7 | .741 | - | | Savage Arena · Toledo, OH |
| 29 | Thu Mar 11 | vsBall State | W91-89 (OT) | 21-7 | .750 | - | | Savage Arena · Toledo, OH |
| 30 | Fri Mar 12 | vsOhio | L80-87 | 21-8 | .724 | - | CBSSN | Savage Arena · Toledo, OH |
| 30 | Wed Mar 17 | at2Richmond | L66-76 | 21-9 | .700 | #3 | ESPN2 | The Super Pit · Denton, TX |
