| 1 | Mon Nov 4 | at Troy | L74-84 | 0-1 | .000 | - | ESPN+ | Trojan Arena · Troy, AL |
| 2 | Sat Nov 9 | at Marshall | W90-80 | 1-1 | .500 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 3 | Wed Nov 13 | vs Wright St | W86-77 | 2-1 | .667 | - | ESPN+ | Savage Arena · Toledo, OH |
| 4 | Sat Nov 16 | at Detroit Mercy | W82-67 | 3-1 | .750 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 5 | Thu Nov 21 | at Stetson | W103-78 | 4-1 | .800 | - | | Edmunds Center · Deland, FL |
| 6 | Fri Nov 22 | at J'Ville St | W82-80 | 5-1 | .833 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 7 | Sat Nov 23 | at UC San Diego | L45-80 | 5-2 | .714 | - | | University Credit Union Center · Davis, CA |
| 8 | Sat Nov 30 | vs Oakland | L52-85 | 5-3 | .625 | - | ESPN+ | Savage Arena · Toledo, OH |
| 9 | Sat Dec 7 | vs TBD | W111-49 | 6-3 | .667 | - | ESPN+ | Savage Arena · Toledo, OH |
| 10 | Sat Dec 14 | at Youngstown St | L87-93 | 6-4 | .600 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 11 | Wed Dec 18 | at #15Houston | L49-78 | 6-5 | .545 | - | ESPN+ | Fertitta Center · Houston, TX |
| 12 | Sun Dec 29 | at #21Purdue | L64-83 | 6-6 | .500 | - | BTN | Mackey Arena · West Lafayette, IN |
| 13 | Sat Jan 4 | at W Michigan | W76-70 | 7-6 | .538 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 14 | Tue Jan 7 | vs E Michigan | W90-87 | 8-6 | .571 | - | ESPN+ | Savage Arena · Toledo, OH |
| 15 | Fri Jan 10 | vs C Michigan | W69-67 | 9-6 | .600 | - | CBS | Savage Arena · Toledo, OH |
| 16 | Tue Jan 14 | at Akron | L78-85 | 9-7 | .563 | - | ESPN+ | James A. Rhodes Arena · Akron, OH |
| 17 | Sat Jan 18 | at Ball State | W93-75 | 10-7 | .588 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 18 | Tue Jan 21 | vs Kent State | L64-83 | 10-8 | .556 | - | ESPN+ | Savage Arena · Toledo, OH |
| 19 | Fri Jan 24 | at Bowling Green | W84-71 | 11-8 | .579 | - | CBS | Stroh Center · Bowling Green, OH |
| 20 | Tue Jan 28 | at Ohio | W86-83 | 12-8 | .600 | - | ESPN2 | Convocation Center (OH) · Athens, OH |
| 21 | Sat Feb 1 | vs N Illinois | W89-85 | 13-8 | .619 | - | ESPN+ | Savage Arena · Toledo, OH |
| 22 | Tue Feb 4 | vs Buffalo | W87-74 | 14-8 | .636 | - | ESPN+ | Savage Arena · Toledo, OH |
| 23 | Sat Feb 8 | vs JMU | W72-69 | 15-8 | .652 | - | ESPN+ | Savage Arena · Toledo, OH |
| 24 | Tue Feb 11 | at Miami OH | L80-92 | 15-9 | .625 | - | ESPN+ | Millett Hall · Oxford, OH |
| 25 | Sat Feb 15 | atE Michigan | L73-80 | 15-10 | .600 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 26 | Tue Feb 18 | vsBall State | W67-66 | 16-10 | .615 | - | ESPN+ | Savage Arena · Toledo, OH |
| 27 | Fri Feb 21 | vsBowling Green | L68-69 | 16-11 | .593 | - | CBS | Savage Arena · Toledo, OH |
