| 1 | Mon Nov 4 | vs Portland St | W100-92 | 1-0 | 1.000 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 2 | Fri Nov 8 | vsBradley | W91-74 | 2-0 | 1.000 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 3 | Mon Nov 11 | vsIdaho | W90-67 | 3-0 | 1.000 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 4 | Fri Nov 15 | atIowa | L66-76 | 3-1 | .750 | - | BTN | Scotiabank Saddledome · Calgary, Alberta |
| 5 | Mon Nov 18 | vsN Colorado | W83-69 | 4-1 | .800 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 6 | Thu Nov 21 | vsE Washington | W96-81 | 5-1 | .833 | - | | Friel Court at Beasley Coliseum · Pullman, WA |
| 7 | Tue Nov 26 | vsFresno St | W84-73 | 6-1 | .857 | - | truTV | Friel Court at Beasley Coliseum · Pullman, WA |
| 8 | Wed Nov 27 | vsSMU | L60-77 | 6-2 | .750 | - | | Friel Court at Beasley Coliseum · Pullman, WA |
| 9 | Mon Dec 2 | atNevada | W68-57 | 7-2 | .778 | - | | Barclays Center · Brooklyn, NY |
| 10 | Sat Dec 7 | atBoise St | W74-69 | 8-2 | .800 | - | CBS | ExtraMile Arena · Boise, ID |
| 11 | Sat Dec 14 | vsMissouri St | W91-78 | 9-2 | .818 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 12 | Wed Dec 18 | atWashington | L73-89 | 9-3 | .750 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 13 | Sat Dec 21 | atNorthern Iowa | W76-68 | 10-3 | .769 | - | | Orleans Arena · Las Vegas, NV |
| 14 | Sat Dec 28 | atPortland | W89-73 | 11-3 | .786 | - | ESPN+ | Chiles Center · Portland, OR |
| 15 | Mon Dec 30 | vsLMU | W73-59 | 12-3 | .800 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 16 | Sat Jan 4 | vsSan Francisco | W91-82 | 13-3 | .813 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 17 | Thu Jan 9 | vsPacific | L94-95 (OT) | 13-4 | .765 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 18 | Sat Jan 11 | at18Gonzaga | L75-88 | 13-5 | .722 | - | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 19 | Thu Jan 16 | atSan Diego | W65-61 | 14-5 | .737 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 20 | Sat Jan 18 | vsPortland | W92-70 | 15-5 | .750 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 21 | Thu Jan 23 | atSanta Clara | L65-93 | 15-6 | .714 | - | CBSSN | Leavey Center · Santa Clara, CA |
| 22 | Sat Jan 25 | vsSaint Mary's | L75-80 | 15-7 | .682 | - | CBSSN | Friel Court at Beasley Coliseum · Pullman, WA |
| 23 | Thu Jan 30 | atPacific | L68-70 | 15-8 | .652 | - | ESPN+ | Alex G. Spanos Center · Stockton, CA |
| 24 | Sat Feb 1 | atSan Francisco | L51-75 | 15-9 | .625 | - | ESPN+ | War Memorial at the Sobrato Center · San Francisco, CA |
| 25 | Thu Feb 6 | atOregon St | L74-82 | 15-10 | .600 | - | ESPN2 | Gill Coliseum · Corvallis, OR |
| 26 | Sat Feb 8 | vsPepperdine | W87-86 | 16-10 | .615 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 27 | Sat Feb 15 | atSaint Mary's | L56-77 | 16-11 | .593 | - | ESPN2 | University Credit Union Pavilion · Moraga, CA |
| 28 | Wed Feb 19 | vsGonzaga | L63-84 | 16-12 | .571 | - | ESPN2 | Friel Court at Beasley Coliseum · Pullman, WA |
| 29 | Sat Feb 22 | vsSanta Clara | L79-109 | 16-13 | .552 | - | CBSSN | Friel Court at Beasley Coliseum · Pullman, WA |
| 30 | Thu Feb 27 | vsSan Diego | W93-86 | 17-13 | .567 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 31 | Sat Mar 1 | atPepperdine | W90-83 | 18-13 | .581 | - | ESPN+ | Firestone Fieldhouse · Malibu, CA |
| 32 | Sat Mar 8 | vsLMU | W94-77 | 19-13 | .594 | - | ESPN+ | Orleans Arena · Las Vegas, NV |
| 33 | Sun Mar 9 | atSan Francisco | L75-86 | 19-14 | .576 | - | ESPN2 | Orleans Arena · Las Vegas, NV |
| 34 | Mon Mar 31 | vsGeorgetown | L82-85 | 19-15 | .559 | - | FS1 | Friel Court at Beasley Coliseum · Pullman, WA |
