| 1 | Fri Apr 1 | at Phillies | L4-5 | 0-1 | .000 | Citizens Bank Park · Philadelphi, PA |
| 2 | Sat Apr 2 | at Phillies | L4-9 | 0-2 | .000 | Citizens Bank Park · Philadelphi, PA |
| 3 | Sun Apr 3 | at Phillies | L3-7 | 0-3 | .000 | Citizens Bank Park · Philadelphi, PA |
| 4 | Tue Apr 5 | at Reds | L2-8 | 0-4 | .000 | Great American Ball Park · Cincinnati, OH |
| 5 | Wed Apr 6 | at Reds | L4-12 | 0-5 | .000 | Great American Ball Park · Cincinnati, OH |
| 6 | Thu Apr 7 | at Reds | W3-2 | 1-5 | .167 | Great American Ball Park · Cincinnati, OH |
| 7 | Fri Apr 8 | vs Marlins | L3-4 | 1-6 | .143 | Minute Maid Park · Houston, TX |
| 8 | Sat Apr 9 | vs Marlins | L5-7 | 1-7 | .125 | Minute Maid Park · Houston, TX |
| 9 | Sun Apr 10 | vs Marlins | W7-1 | 2-7 | .222 | Minute Maid Park · Houston, TX |
| 10 | Mon Apr 11 | vs Cubs | L4-5 | 2-8 | .200 | Minute Maid Park · Houston, TX |
| 11 | Tue Apr 12 | vs Cubs | W11-2 | 3-8 | .273 | Minute Maid Park · Houston, TX |
| 12 | Wed Apr 13 | vs Cubs | L5-9 | 3-9 | .250 | Minute Maid Park · Houston, TX |
| 13 | Thu Apr 14 | vs Padres | W1-0 | 4-9 | .308 | Minute Maid Park · Houston, TX |
| 14 | Fri Apr 15 | vs Padres | L2-4 | 4-10 | .286 | Minute Maid Park · Houston, TX |
| 15 | Sat Apr 16 | vs Padres | W5-3 | 5-10 | .333 | Minute Maid Park · Houston, TX |
| 16 | Sun Apr 17 | vs Padres | L6-8 | 5-11 | .313 | Minute Maid Park · Houston, TX |
| 17 | Tue Apr 19 | at Mets | W6-1 | 6-11 | .353 | Citi Field · Queens, NY |
| 18 | Wed Apr 20 | at Mets | W4-3 | 7-11 | .389 | Citi Field · Queens, NY |
| 19 | Thu Apr 21 | at Mets | L1-9 | 7-12 | .368 | Citi Field · Queens, NY |
| 20 | Fri Apr 22 | at Brewers | L7-14 | 7-13 | .350 | American Family Field · Milwaukee, WI |
| 21 | Sat Apr 23 | at Brewers | W9-6 (10) | 8-13 | .381 | American Family Field · Milwaukee, WI |
| 22 | Sun Apr 24 | at Brewers | L1-4 | 8-14 | .364 | American Family Field · Milwaukee, WI |
| 23 | Tue Apr 26 | vs Cardinals | W6-5 | 9-14 | .391 | Minute Maid Park · Houston, TX |
| 24 | Wed Apr 27 | vs Cardinals | L5-6 | 9-15 | .375 | Minute Maid Park · Houston, TX |
| 25 | Thu Apr 28 | vs Cardinals | L7-11 | 9-16 | .360 | Minute Maid Park · Houston, TX |
| 26 | Fri Apr 29 | vs Brewers | L0-5 | 9-17 | .346 | Minute Maid Park · Houston, TX |
| 27 | Sat Apr 30 | vs Brewers | W2-1 | 10-17 | .370 | Minute Maid Park · Houston, TX |
| 28 | Sun May 1 | vs Brewers | W5-0 | 11-17 | .393 | Minute Maid Park · Houston, TX |
| 29 | Tue May 3 | at Reds | W10-4 | 12-17 | .414 | Great American Ball Park · Cincinnati, OH |
| 30 | Wed May 4 | at Reds | L2-3 | 12-18 | .400 | Great American Ball Park · Cincinnati, OH |
| 31 | Thu May 5 | at Reds | L4-10 | 12-19 | .387 | Great American Ball Park · Cincinnati, OH |
| 32 | Fri May 6 | at Pirates | W3-2 | 13-19 | .406 | PNC Park · Pittsburgh, PA |
| 33 | Sat May 7 | at Pirates | L1-6 | 13-20 | .394 | PNC Park · Pittsburgh, PA |
| 34 | Sun May 8 | at Pirates | L4-5 | 13-21 | .382 | PNC Park · Pittsburgh, PA |
| 35 | Mon May 9 | vs Reds | L1-6 | 13-22 | .371 | Minute Maid Park · Houston, TX |
| 36 | Tue May 10 | vs Reds | L3-7 | 13-23 | .361 | Minute Maid Park · Houston, TX |
| 37 | Wed May 11 | vs Reds | W4-3 | 14-23 | .378 | Minute Maid Park · Houston, TX |
| 38 | Fri May 13 | vs Mets | L4-6 | 14-24 | .368 | Minute Maid Park · Houston, TX |
| 39 | Sat May 14 | vs Mets | W7-3 | 15-24 | .385 | Minute Maid Park · Houston, TX |
| 40 | Sun May 15 | vs Mets | L4-7 | 15-25 | .375 | Minute Maid Park · Houston, TX |
| 41 | Mon May 16 | at Braves | L2-3 | 15-26 | .366 | Truist Park · Cumberland, GA |
| 42 | Tue May 17 | at Braves | L1-3 (11) | 15-27 | .357 | Truist Park · Cumberland, GA |
| 43 | Wed May 18 | at Cardinals | L1-5 | 15-28 | .349 | Busch Stadium · St. Louis, MO |
| 44 | Thu May 19 | at Cardinals | L2-4 | 15-29 | .341 | Busch Stadium · St. Louis, MO |
| 45 | Fri May 20 | at Blue Jays | W5-2 | 16-29 | .356 | Rogers Centre · Toronto, ON |
| 46 | Sat May 21 | at Blue Jays | L5-7 | 16-30 | .348 | Rogers Centre · Toronto, ON |
| 47 | Sun May 22 | at Blue Jays | W3-2 | 17-30 | .362 | Rogers Centre · Toronto, ON |
| 48 | Mon May 23 | vs Dodgers | W4-3 | 18-30 | .375 | Minute Maid Park · Houston, TX |
| 49 | Tue May 24 | vs Dodgers | L4-5 | 18-31 | .367 | Minute Maid Park · Houston, TX |
| 50 | Wed May 25 | vs Dodgers | W2-1 | 19-31 | .380 | Minute Maid Park · Houston, TX |
| 51 | Fri May 27 | vs D-backs | L6-7 | 19-32 | .373 | Minute Maid Park · Houston, TX |
| 52 | Sat May 28 | vs D-backs | L3-11 | 19-33 | .365 | Minute Maid Park · Houston, TX |
| 53 | Sun May 29 | vs D-backs | L2-4 | 19-34 | .358 | Minute Maid Park · Houston, TX |
| 54 | Mon May 30 | at Cubs | W12-7 | 20-34 | .370 | Wrigley Field · Chicago, IL |
| 55 | Tue May 31 | at Cubs | W7-3 | 21-34 | .382 | Wrigley Field · Chicago, IL |
| 56 | Wed Jun 1 | at Cubs | W3-1 | 22-34 | .393 | Wrigley Field · Chicago, IL |
| 57 | Thu Jun 2 | at Padres | W7-4 | 23-34 | .404 | Petco Park · San Diego, CA |
| 58 | Fri Jun 3 | at Padres | L1-3 | 23-35 | .397 | Petco Park · San Diego, CA |
| 59 | Sat Jun 4 | at Padres | L3-6 | 23-36 | .390 | Petco Park · San Diego, CA |
| 60 | Sun Jun 5 | at Padres | L2-7 | 23-37 | .383 | Petco Park · San Diego, CA |
| 61 | Tue Jun 7 | vs Cardinals | L4-7 | 23-38 | .377 | Minute Maid Park · Houston, TX |
| 62 | Wed Jun 8 | vs Cardinals | W4-1 | 24-38 | .387 | Minute Maid Park · Houston, TX |
| 63 | Thu Jun 9 | vs Cardinals | L2-9 | 24-39 | .381 | Minute Maid Park · Houston, TX |
| 64 | Fri Jun 10 | vs Braves | L4-11 | 24-40 | .375 | Minute Maid Park · Houston, TX |
| 65 | Sat Jun 11 | vs Braves | L3-6 (10) | 24-41 | .369 | Minute Maid Park · Houston, TX |
| 66 | Sun Jun 12 | vs Braves | L1-4 | 24-42 | .364 | Minute Maid Park · Houston, TX |
| 67 | Mon Jun 13 | vs Braves | W8-3 | 25-42 | .373 | Minute Maid Park · Houston, TX |
| 68 | Tue Jun 14 | vs Pirates | L0-1 | 25-43 | .368 | Minute Maid Park · Houston, TX |
| 69 | Wed Jun 15 | vs Pirates | L3-7 | 25-44 | .362 | Minute Maid Park · Houston, TX |
| 70 | Thu Jun 16 | vs Pirates | L4-5 | 25-45 | .357 | Minute Maid Park · Houston, TX |
| 71 | Fri Jun 17 | at Dodgers | W7-3 | 26-45 | .366 | Dodger Stadium · Los Angeles, CA |
| 72 | Sat Jun 18 | at Dodgers | W7-0 | 27-45 | .375 | Dodger Stadium · Los Angeles, CA |
| 73 | Sun Jun 19 | at Dodgers | L0-1 | 27-46 | .370 | Dodger Stadium · Los Angeles, CA |
| 74 | Mon Jun 20 | at Rangers | L3-8 | 27-47 | .365 | Globe Life Field · Arlington, TX |
| 75 | Tue Jun 21 | at Rangers | L4-5 (11) | 27-48 | .360 | Globe Life Field · Arlington, TX |
| 76 | Wed Jun 22 | at Rangers | W5-3 | 28-48 | .368 | Globe Life Field · Arlington, TX |
| 77 | Fri Jun 24 | vs Rays | L1-5 | 28-49 | .364 | Minute Maid Park · Houston, TX |
| 78 | Sat Jun 25 | vs Rays | L2-7 | 28-50 | .359 | Minute Maid Park · Houston, TX |
| 79 | Sun Jun 26 | vs Rays | L10-14 | 28-51 | .354 | Minute Maid Park · Houston, TX |
| 80 | Tue Jun 28 | vs Rangers | L3-7 | 28-52 | .350 | Minute Maid Park · Houston, TX |
| 81 | Wed Jun 29 | vs Rangers | L2-3 | 28-53 | .346 | Minute Maid Park · Houston, TX |
| 82 | Thu Jun 30 | vs Rangers | W7-0 | 29-53 | .354 | Minute Maid Park · Houston, TX |
| 83 | Fri Jul 1 | vs Red Sox | L5-7 | 29-54 | .349 | Minute Maid Park · Houston, TX |
| 84 | Sat Jul 2 | vs Red Sox | L4-10 | 29-55 | .345 | Minute Maid Park · Houston, TX |
| 85 | Sun Jul 3 | vs Red Sox | L1-2 | 29-56 | .341 | Minute Maid Park · Houston, TX |
| 86 | Mon Jul 4 | at Pirates | L3-5 | 29-57 | .337 | PNC Park · Pittsburgh, PA |
| 87 | Tue Jul 5 | at Pirates | L1-5 | 29-58 | .333 | PNC Park · Pittsburgh, PA |
| 88 | Wed Jul 6 | at Pirates | W8-2 | 30-58 | .341 | PNC Park · Pittsburgh, PA |
| 89 | Thu Jul 7 | at Marlins | L0-5 | 30-59 | .337 | MVP Arena · Albany, NY |
| 90 | Fri Jul 8 | at Marlins | L3-6 | 30-60 | .333 | MVP Arena · Albany, NY |
| 91 | Sat Jul 9 | at Marlins | L1-6 | 30-61 | .330 | MVP Arena · Albany, NY |
| 92 | Sun Jul 10 | at Marlins | L4-5 | 30-62 | .326 | MVP Arena · Albany, NY |
| 93 | Fri Jul 15 | vs Pirates | L0-4 | 30-63 | .323 | Minute Maid Park · Houston, TX |
| 94 | Sat Jul 16 | vs Pirates | W6-4 | 31-63 | .330 | Minute Maid Park · Houston, TX |
| 95 | Sun Jul 17 | vs Pirates | L5-7 (11) | 31-64 | .326 | Minute Maid Park · Houston, TX |
| 96 | Mon Jul 18 | vs Nationals | L2-5 | 31-65 | .323 | Minute Maid Park · Houston, TX |
| 97 | Tue Jul 19 | vs Nationals | W7-6 | 32-65 | .330 | Minute Maid Park · Houston, TX |
| 98 | Wed Jul 20 | vs Nationals | W3-2 (11) | 33-65 | .337 | Minute Maid Park · Houston, TX |
| 99 | Fri Jul 22 | at Cubs | L2-4 | 33-66 | .333 | Wrigley Field · Chicago, IL |
| 100 | Sat Jul 23 | at Cubs | L1-5 | 33-67 | .330 | Wrigley Field · Chicago, IL |
| 101 | Sun Jul 24 | at Cubs | L4-5 (10) | 33-68 | .327 | Wrigley Field · Chicago, IL |
| 102 | Mon Jul 25 | at Cardinals | L5-10 | 33-69 | .324 | Busch Stadium · St. Louis, MO |
| 103 | Tue Jul 26 | at Cardinals | L1-3 | 33-70 | .320 | Busch Stadium · St. Louis, MO |
| 104 | Wed Jul 27 | at Cardinals | W4-2 | 34-70 | .327 | Busch Stadium · St. Louis, MO |
| 105 | Thu Jul 28 | at Cardinals | W5-3 | 35-70 | .333 | Busch Stadium · St. Louis, MO |
| 106 | Fri Jul 29 | at Brewers | L0-4 | 35-71 | .330 | American Family Field · Milwaukee, WI |
| 107 | Sat Jul 30 | at Brewers | L2-6 | 35-72 | .327 | American Family Field · Milwaukee, WI |
| 108 | Sun Jul 31 | at Brewers | L4-5 | 35-73 | .324 | American Family Field · Milwaukee, WI |
| 109 | Mon Aug 1 | vs Reds | W4-3 (10) | 36-73 | .330 | Minute Maid Park · Houston, TX |
| 110 | Tue Aug 2 | vs Reds | L1-5 | 36-74 | .327 | Minute Maid Park · Houston, TX |
| 111 | Wed Aug 3 | vs Reds | W5-4 | 37-74 | .333 | Minute Maid Park · Houston, TX |
| 112 | Fri Aug 5 | vs Brewers | L1-8 | 37-75 | .330 | Minute Maid Park · Houston, TX |
| 113 | Sat Aug 6 | vs Brewers | L5-7 | 37-76 | .327 | Minute Maid Park · Houston, TX |
| 114 | Sun Aug 7 | vs Brewers | L3-7 | 37-77 | .325 | Minute Maid Park · Houston, TX |
| 115 | Mon Aug 8 | at D-backs | W9-1 | 38-77 | .330 | Chase Field · Phoenix, AZ |
| 116 | Tue Aug 9 | at D-backs | L9-11 | 38-78 | .328 | Chase Field · Phoenix, AZ |
| 117 | Wed Aug 10 | at D-backs | L3-6 | 38-79 | .325 | Chase Field · Phoenix, AZ |
| 118 | Thu Aug 11 | at D-backs | L5-8 (10) | 38-80 | .322 | Chase Field · Phoenix, AZ |
| 119 | Fri Aug 12 | at Dodgers | L0-1 (10) | 38-81 | .319 | Dodger Stadium · Los Angeles, CA |
| 120 | Sat Aug 13 | at Dodgers | L1-6 | 38-82 | .317 | Dodger Stadium · Los Angeles, CA |
| 121 | Sun Aug 14 | at Dodgers | L0-7 | 38-83 | .314 | Dodger Stadium · Los Angeles, CA |
| 122 | Mon Aug 15 | vs Cubs | L3-4 | 38-84 | .311 | Minute Maid Park · Houston, TX |
| 123 | Tue Aug 16 | vs Cubs | W6-5 | 39-84 | .317 | Minute Maid Park · Houston, TX |
| 124 | Wed Aug 17 | vs Cubs | W4-3 | 40-84 | .323 | Minute Maid Park · Houston, TX |
| 125 | Fri Aug 19 | vs Giants | W6-0 | 41-84 | .328 | Minute Maid Park · Houston, TX |
| 126 | Sat Aug 20 | vs Giants | W7-5 | 42-84 | .333 | Minute Maid Park · Houston, TX |
| 127 | Sun Aug 21 | vs Giants | L4-6 (11) | 42-85 | .331 | Minute Maid Park · Houston, TX |
| 128 | Mon Aug 22 | at Rockies | L5-9 | 42-86 | .328 | Coors Field · Denver, CO |
| 129 | Tue Aug 23 | at Rockies | L6-8 | 42-87 | .326 | Coors Field · Denver, CO |
| 130 | Wed Aug 24 | at Rockies | L6-7 (10) | 42-88 | .323 | Coors Field · Denver, CO |
| 131 | Thu Aug 25 | at Giants | W3-1 | 43-88 | .328 | Oracle Park · San Francisco, CA |
| 132 | Fri Aug 26 | at Giants | L1-2 | 43-89 | .326 | Oracle Park · San Francisco, CA |
| 133 | Sat Aug 27 | at Giants | L1-2 (10) | 43-90 | .323 | Oracle Park · San Francisco, CA |
| 134 | Sun Aug 28 | at Giants | W4-3 (11) | 44-90 | .328 | Oracle Park · San Francisco, CA |
| 135 | Mon Aug 29 | vs Pirates | W7-4 | 45-90 | .333 | Minute Maid Park · Houston, TX |
| 136 | Tue Aug 30 | vs Pirates | W8-2 | 46-90 | .338 | Minute Maid Park · Houston, TX |
| 137 | Wed Aug 31 | vs Pirates | W2-0 | 47-90 | .343 | Minute Maid Park · Houston, TX |
| 138 | Fri Sep 2 | vs Brewers | L2-8 | 47-91 | .341 | Minute Maid Park · Houston, TX |
| 139 | Sat Sep 3 | vs Brewers | L2-8 | 47-92 | .338 | Minute Maid Park · Houston, TX |
| 140 | Sun Sep 4 | vs Brewers | L0-4 | 47-93 | .336 | Minute Maid Park · Houston, TX |
| 141 | Mon Sep 5 | at Pirates | L1-3 | 47-94 | .333 | PNC Park · Pittsburgh, PA |
| 142 | Tue Sep 6 | at Pirates | W4-1 | 48-94 | .338 | PNC Park · Pittsburgh, PA |
| 143 | Wed Sep 7 | at Pirates | L4-5 | 48-95 | .336 | PNC Park · Pittsburgh, PA |
| 144 | Fri Sep 9 | at Nationals | L3-4 (11) | 48-96 | .333 | Nationals Park · Washington, D.C. |
| 145 | Sat Sep 10 | at Nationals | W9-3 | 49-96 | .338 | Nationals Park · Washington, D.C. |
| 146 | Sun Sep 11 | at Nationals | L2-8 | 49-97 | .336 | Nationals Park · Washington, D.C. |
| 147 | Mon Sep 12 | vs Phillies | W5-1 | 50-97 | .340 | Minute Maid Park · Houston, TX |
| 148 | Tue Sep 13 | vs Phillies | W5-2 | 51-97 | .345 | Minute Maid Park · Houston, TX |
| 149 | Wed Sep 14 | vs Phillies | L0-1 | 51-98 | .342 | Minute Maid Park · Houston, TX |
| 150 | Fri Sep 16 | at Cubs | L3-4 (12) | 51-99 | .340 | Wrigley Field · Chicago, IL |
| 151 | Sat Sep 17 | at Cubs | L1-2 | 51-100 | .338 | Wrigley Field · Chicago, IL |
| 152 | Sun Sep 18 | at Cubs | W3-2 | 52-100 | .342 | Wrigley Field · Chicago, IL |
| 153 | Mon Sep 19 | at Reds | W3-2 | 53-100 | .346 | Great American Ball Park · Cincinnati, OH |
| 154 | Tue Sep 20 | at Reds | L4-6 | 53-101 | .344 | Great American Ball Park · Cincinnati, OH |
| 155 | Wed Sep 21 | at Reds | L0-2 | 53-102 | .342 | Great American Ball Park · Cincinnati, OH |
| 156 | Thu Sep 22 | vs Rockies | W9-6 | 54-102 | .346 | Minute Maid Park · Houston, TX |
| 157 | Fri Sep 23 | vs Rockies | W11-2 | 55-102 | .350 | Minute Maid Park · Houston, TX |
| 158 | Sat Sep 24 | vs Rockies | L2-4 (13) | 55-103 | .348 | Minute Maid Park · Houston, TX |
| 159 | Sun Sep 25 | vs Rockies | L3-19 | 55-104 | .346 | Minute Maid Park · Houston, TX |
| 160 | Mon Sep 26 | vs Cardinals | W5-4 (10) | 56-104 | .350 | Minute Maid Park · Houston, TX |
| 161 | Tue Sep 27 | vs Cardinals | L6-13 | 56-105 | .348 | Minute Maid Park · Houston, TX |
| 162 | Wed Sep 28 | vs Cardinals | L0-8 | 56-106 | .346 | Minute Maid Park · Houston, TX |