| 1 | Thu Apr 1 | at Athletics | W8-1 | 1-0 | 1.000 | RingCentral Coliseum · Oakland, CA |
| 2 | Fri Apr 2 | at Athletics | W9-5 | 2-0 | 1.000 | RingCentral Coliseum · Oakland, CA |
| 3 | Sat Apr 3 | at Athletics | W9-1 | 3-0 | 1.000 | RingCentral Coliseum · Oakland, CA |
| 4 | Sun Apr 4 | at Athletics | W9-2 | 4-0 | 1.000 | RingCentral Coliseum · Oakland, CA |
| 5 | Mon Apr 5 | at Angels | L6-7 | 4-1 | .800 | Angel Stadium · Anaheim, CA |
| 6 | Tue Apr 6 | at Angels | W4-2 | 5-1 | .833 | Angel Stadium · Anaheim, CA |
| 7 | Thu Apr 8 | vs Athletics | W6-2 | 6-1 | .857 | Minute Maid Park · Houston, TX |
| 8 | Fri Apr 9 | vs Athletics | L2-6 | 6-2 | .750 | Minute Maid Park · Houston, TX |
| 9 | Sat Apr 10 | vs Athletics | L3-7 | 6-3 | .667 | Minute Maid Park · Houston, TX |
| 10 | Mon Apr 12 | vs Tigers | L2-6 | 6-4 | .600 | Minute Maid Park · Houston, TX |
| 11 | Tue Apr 13 | vs Tigers | L2-8 | 6-5 | .545 | Minute Maid Park · Houston, TX |
| 12 | Wed Apr 14 | vs Tigers | L4-6 | 6-6 | .500 | Minute Maid Park · Houston, TX |
| 13 | Fri Apr 16 | at Mariners | L5-6 | 6-7 | .462 | T-Mobile Park · Seattle, WA |
| 14 | Sat Apr 17 | at Mariners | W1-0 | 7-7 | .500 | T-Mobile Park · Seattle, WA |
| 15 | Sun Apr 18 | at Mariners | L2-7 | 7-8 | .467 | T-Mobile Park · Seattle, WA |
| 16 | Tue Apr 20 | at Rockies | L2-6 | 7-9 | .438 | Coors Field · Denver, CO |
| 17 | Wed Apr 21 | at Rockies | L3-6 | 7-10 | .412 | Coors Field · Denver, CO |
| 18 | Thu Apr 22 | vs Angels | W8-2 | 8-10 | .444 | Minute Maid Park · Houston, TX |
| 19 | Fri Apr 23 | vs Angels | W5-4 (10) | 9-10 | .474 | Minute Maid Park · Houston, TX |
| 20 | Sat Apr 24 | vs Angels | W16-2 | 10-10 | .500 | Minute Maid Park · Houston, TX |
| 21 | Sun Apr 25 | vs Angels | L2-4 | 10-11 | .476 | Minute Maid Park · Houston, TX |
| 22 | Mon Apr 26 | vs Mariners | W5-2 | 11-11 | .500 | Minute Maid Park · Houston, TX |
| 23 | Tue Apr 27 | vs Mariners | W2-0 | 12-11 | .522 | Minute Maid Park · Houston, TX |
| 24 | Wed Apr 28 | vs Mariners | W7-5 | 13-11 | .542 | Minute Maid Park · Houston, TX |
| 25 | Thu Apr 29 | vs Mariners | L0-1 | 13-12 | .520 | Minute Maid Park · Houston, TX |
| 26 | Fri Apr 30 | at Rays | W9-2 | 14-12 | .538 | Tropicana Field · St. Petersburg, FL |
| 27 | Sat May 1 | at Rays | W3-1 | 15-12 | .556 | Tropicana Field · St. Petersburg, FL |
| 28 | Sun May 2 | at Rays | L4-5 | 15-13 | .536 | Tropicana Field · St. Petersburg, FL |
| 29 | Tue May 4 | at Yankees | L3-7 | 15-14 | .517 | Yankee Stadium · The Bronx, NY |
| 30 | Wed May 5 | at Yankees | L3-6 | 15-15 | .500 | Yankee Stadium · The Bronx, NY |
| 31 | Thu May 6 | at Yankees | W7-4 | 16-15 | .516 | Yankee Stadium · The Bronx, NY |
| 32 | Fri May 7 | vs Blue Jays | W10-4 | 17-15 | .531 | Minute Maid Park · Houston, TX |
| 33 | Sat May 8 | vs Blue Jays | L4-8 | 17-16 | .515 | Minute Maid Park · Houston, TX |
| 34 | Sun May 9 | vs Blue Jays | W7-4 | 18-16 | .529 | Minute Maid Park · Houston, TX |
| 35 | Mon May 10 | vs Angels | L4-5 | 18-17 | .514 | Minute Maid Park · Houston, TX |
| 36 | Tue May 11 | vs Angels | W5-1 | 19-17 | .528 | Minute Maid Park · Houston, TX |
| 37 | Wed May 12 | vs Angels | W9-1 | 20-17 | .541 | Minute Maid Park · Houston, TX |
| 38 | Thu May 13 | vs Rangers | W4-3 (11) | 21-17 | .553 | Minute Maid Park · Houston, TX |
| 39 | Fri May 14 | vs Rangers | W10-4 | 22-17 | .564 | Minute Maid Park · Houston, TX |
| 40 | Sat May 15 | vs Rangers | W6-5 | 23-17 | .575 | Minute Maid Park · Houston, TX |
| 41 | Sun May 16 | vs Rangers | W6-2 | 24-17 | .585 | Minute Maid Park · Houston, TX |
| 42 | Tue May 18 | at Athletics | L5-6 | 24-18 | .571 | RingCentral Coliseum · Oakland, CA |
| 43 | Wed May 19 | at Athletics | W8-1 | 25-18 | .581 | RingCentral Coliseum · Oakland, CA |
| 44 | Thu May 20 | at Athletics | W8-4 | 26-18 | .591 | RingCentral Coliseum · Oakland, CA |
| 45 | Fri May 21 | at Rangers | L5-7 (10) | 26-19 | .578 | Globe Life Field · Arlington, TX |
| 46 | Sat May 22 | at Rangers | L4-8 | 26-20 | .565 | Globe Life Field · Arlington, TX |
| 47 | Sun May 23 | at Rangers | L2-3 (10) | 26-21 | .553 | Globe Life Field · Arlington, TX |
| 48 | Tue May 25 | vs Dodgers | L2-9 | 26-22 | .542 | Minute Maid Park · Houston, TX |
| 49 | Wed May 26 | vs Dodgers | W5-2 | 27-22 | .551 | Minute Maid Park · Houston, TX |
| 50 | Fri May 28 | vs Padres | L3-10 (11) | 27-23 | .540 | Minute Maid Park · Houston, TX |
| 51 | Sat May 29 | vs Padres | L8-11 (12) | 27-24 | .529 | Minute Maid Park · Houston, TX |
| 52 | Sun May 30 | vs Padres | W7-4 | 28-24 | .538 | Minute Maid Park · Houston, TX |
| 53 | Mon May 31 | vs Red Sox | W11-2 | 29-24 | .547 | Minute Maid Park · Houston, TX |
| 54 | Tue Jun 1 | vs Red Sox | W5-1 | 30-24 | .556 | Minute Maid Park · Houston, TX |
| 55 | Wed Jun 2 | vs Red Sox | W2-1 | 31-24 | .564 | Minute Maid Park · Houston, TX |
| 56 | Thu Jun 3 | vs Red Sox | L1-5 | 31-25 | .554 | Minute Maid Park · Houston, TX |
| 57 | Fri Jun 4 | at Blue Jays | W13-1 | 32-25 | .561 | Rogers Centre · Toronto, ON |
| 58 | Sat Jun 5 | at Blue Jays | L2-6 | 32-26 | .552 | Rogers Centre · Toronto, ON |
| 59 | Sun Jun 6 | at Blue Jays | W6-3 | 33-26 | .559 | Rogers Centre · Toronto, ON |
| 60 | Tue Jun 8 | at Red Sox | W7-1 | 34-26 | .567 | Fenway Park · Boston, MA |
| 61 | Wed Jun 9 | at Red Sox | W8-3 | 35-26 | .574 | Fenway Park · Boston, MA |
| 62 | Thu Jun 10 | at Red Sox | L8-12 | 35-27 | .565 | Fenway Park · Boston, MA |
| 63 | Fri Jun 11 | at Twins | W6-4 | 36-27 | .571 | Target Field · Minneapolis, MN |
| 64 | Sat Jun 12 | at Twins | L2-5 | 36-28 | .563 | Target Field · Minneapolis, MN |
| 65 | Sun Jun 13 | at Twins | W14-3 | 37-28 | .569 | Target Field · Minneapolis, MN |
| 66 | Tue Jun 15 | vs Rangers | W6-3 (10) | 38-28 | .576 | Minute Maid Park · Houston, TX |
| 67 | Wed Jun 16 | vs Rangers | W8-4 | 39-28 | .582 | Minute Maid Park · Houston, TX |
| 68 | Thu Jun 17 | vs White Sox | W10-2 | 40-28 | .588 | Minute Maid Park · Houston, TX |
| 69 | Fri Jun 18 | vs White Sox | W2-1 | 41-28 | .594 | Minute Maid Park · Houston, TX |
| 70 | Sat Jun 19 | vs White Sox | W7-3 | 42-28 | .600 | Minute Maid Park · Houston, TX |
| 71 | Sun Jun 20 | vs White Sox | W8-2 | 43-28 | .606 | Minute Maid Park · Houston, TX |
| 72 | Mon Jun 21 | at Orioles | W10-2 | 44-28 | .611 | Camden Yards · Baltimore, MD |
| 73 | Tue Jun 22 | at Orioles | W3-1 | 45-28 | .616 | Camden Yards · Baltimore, MD |
| 74 | Wed Jun 23 | at Orioles | W13-0 | 46-28 | .622 | Camden Yards · Baltimore, MD |
| 75 | Thu Jun 24 | at Tigers | W12-3 | 47-28 | .627 | Comerica Park · Detroit, MI |
| 76 | Sat Jun 26 | at Tigers | L1-3 | 47-29 | .618 | Comerica Park · Detroit, MI |
| 77 | Sat Jun 26 | at Tigers | W3-2 | 48-29 | .623 | Comerica Park · Detroit, MI |
| 78 | Sun Jun 27 | at Tigers | L1-2 (10) | 48-30 | .615 | Comerica Park · Detroit, MI |
| 79 | Mon Jun 28 | vs Orioles | L7-9 | 48-31 | .608 | Minute Maid Park · Houston, TX |
| 80 | Tue Jun 29 | vs Orioles | L3-13 | 48-32 | .600 | Minute Maid Park · Houston, TX |
| 81 | Wed Jun 30 | vs Orioles | L2-5 | 48-33 | .593 | Minute Maid Park · Houston, TX |
| 82 | Thu Jul 1 | at Guardians | W7-2 | 49-33 | .598 | Progressive Field · Cleveland, OH |
| 83 | Fri Jul 2 | at Guardians | W6-3 | 50-33 | .602 | Progressive Field · Cleveland, OH |
| 84 | Sat Jul 3 | at Guardians | W3-2 | 51-33 | .607 | Progressive Field · Cleveland, OH |
| 85 | Sun Jul 4 | at Guardians | W4-3 (10) | 52-33 | .612 | Progressive Field · Cleveland, OH |
| 86 | Tue Jul 6 | vs Athletics | W9-6 | 53-33 | .616 | Minute Maid Park · Houston, TX |
| 87 | Wed Jul 7 | vs Athletics | W4-3 | 54-33 | .621 | Minute Maid Park · Houston, TX |
| 88 | Thu Jul 8 | vs Athletics | L1-2 | 54-34 | .614 | Minute Maid Park · Houston, TX |
| 89 | Fri Jul 9 | vs Yankees | L0-4 | 54-35 | .607 | Minute Maid Park · Houston, TX |
| 90 | Sat Jul 10 | vs Yankees | L0-1 | 54-36 | .600 | Minute Maid Park · Houston, TX |
| 91 | Sun Jul 11 | vs Yankees | W8-7 | 55-36 | .604 | Minute Maid Park · Houston, TX |
| 92 | Fri Jul 16 | at White Sox | W7-1 | 56-36 | .609 | Guaranteed Rate Field · Chicago, IL |
| 93 | Sat Jul 17 | at White Sox | L1-10 | 56-37 | .602 | Guaranteed Rate Field · Chicago, IL |
| 94 | Sun Jul 18 | at White Sox | L0-4 | 56-38 | .596 | Guaranteed Rate Field · Chicago, IL |
| 95 | Mon Jul 19 | vs Guardians | W4-3 | 57-38 | .600 | Minute Maid Park · Houston, TX |
| 96 | Tue Jul 20 | vs Guardians | W9-3 | 58-38 | .604 | Minute Maid Park · Houston, TX |
| 97 | Wed Jul 21 | vs Guardians | L4-5 | 58-39 | .598 | Minute Maid Park · Houston, TX |
| 98 | Fri Jul 23 | vs Rangers | W7-3 | 59-39 | .602 | Minute Maid Park · Houston, TX |
| 99 | Sat Jul 24 | vs Rangers | W4-1 | 60-39 | .606 | Minute Maid Park · Houston, TX |
| 100 | Sun Jul 25 | vs Rangers | W3-1 | 61-39 | .610 | Minute Maid Park · Houston, TX |
| 101 | Mon Jul 26 | at Mariners | L8-11 | 61-40 | .604 | T-Mobile Park · Seattle, WA |
| 102 | Tue Jul 27 | at Mariners | W8-6 | 62-40 | .608 | T-Mobile Park · Seattle, WA |
| 103 | Wed Jul 28 | at Mariners | W11-4 | 63-40 | .612 | T-Mobile Park · Seattle, WA |
| 104 | Fri Jul 30 | at Giants | W9-6 | 64-40 | .615 | Oracle Park · San Francisco, CA |
| 105 | Sat Jul 31 | at Giants | L6-8 | 64-41 | .610 | Oracle Park · San Francisco, CA |
| 106 | Sun Aug 1 | at Giants | L3-5 | 64-42 | .604 | Oracle Park · San Francisco, CA |
| 107 | Tue Aug 3 | at Dodgers | W3-0 | 65-42 | .607 | Dodger Stadium · Los Angeles, CA |
| 108 | Wed Aug 4 | at Dodgers | L5-7 | 65-43 | .602 | Dodger Stadium · Los Angeles, CA |
| 109 | Thu Aug 5 | vs Twins | L3-5 | 65-44 | .596 | Minute Maid Park · Houston, TX |
| 110 | Fri Aug 6 | vs Twins | L4-5 (11) | 65-45 | .591 | Minute Maid Park · Houston, TX |
| 111 | Sat Aug 7 | vs Twins | W4-0 | 66-45 | .595 | Minute Maid Park · Houston, TX |
| 112 | Sun Aug 8 | vs Twins | L5-7 | 66-46 | .589 | Minute Maid Park · Houston, TX |
| 113 | Tue Aug 10 | vs Rockies | W5-0 | 67-46 | .593 | Minute Maid Park · Houston, TX |
| 114 | Wed Aug 11 | vs Rockies | W5-1 | 68-46 | .596 | Minute Maid Park · Houston, TX |
| 115 | Fri Aug 13 | at Angels | W4-1 | 69-46 | .600 | Angel Stadium · Anaheim, CA |
| 116 | Sat Aug 14 | at Angels | W8-2 | 70-46 | .603 | Angel Stadium · Anaheim, CA |
| 117 | Sun Aug 15 | at Angels | L1-3 | 70-47 | .598 | Angel Stadium · Anaheim, CA |
| 118 | Mon Aug 16 | at Royals | L6-7 | 70-48 | .593 | Kauffman Stadium · Kansas City, MO |
| 119 | Tue Aug 17 | at Royals | L1-3 | 70-49 | .588 | Kauffman Stadium · Kansas City, MO |
| 120 | Wed Aug 18 | at Royals | L2-3 | 70-50 | .583 | Kauffman Stadium · Kansas City, MO |
| 121 | Thu Aug 19 | at Royals | W6-3 (10) | 71-50 | .587 | Kauffman Stadium · Kansas City, MO |
| 122 | Fri Aug 20 | vs Mariners | W12-3 | 72-50 | .590 | Minute Maid Park · Houston, TX |
| 123 | Sat Aug 21 | vs Mariners | W15-1 | 73-50 | .593 | Minute Maid Park · Houston, TX |
| 124 | Sun Aug 22 | vs Mariners | L3-6 (11) | 73-51 | .589 | Minute Maid Park · Houston, TX |
| 125 | Mon Aug 23 | vs Royals | L1-7 | 73-52 | .584 | Minute Maid Park · Houston, TX |
| 126 | Tue Aug 24 | vs Royals | W4-0 | 74-52 | .587 | Minute Maid Park · Houston, TX |
| 127 | Wed Aug 25 | vs Royals | W6-5 (10) | 75-52 | .591 | Minute Maid Park · Houston, TX |
| 128 | Fri Aug 27 | at Rangers | W5-4 | 76-52 | .594 | Globe Life Field · Arlington, TX |
| 129 | Sat Aug 28 | at Rangers | W5-2 | 77-52 | .597 | Globe Life Field · Arlington, TX |
| 130 | Sun Aug 29 | at Rangers | L2-13 | 77-53 | .592 | Globe Life Field · Arlington, TX |
| 131 | Mon Aug 30 | at Mariners | W4-3 | 78-53 | .595 | T-Mobile Park · Seattle, WA |
| 132 | Tue Aug 31 | at Mariners | L0-4 | 78-54 | .591 | T-Mobile Park · Seattle, WA |
| 133 | Wed Sep 1 | at Mariners | L0-1 | 78-55 | .586 | T-Mobile Park · Seattle, WA |
| 134 | Fri Sep 3 | at Padres | W6-3 | 79-55 | .590 | Petco Park · San Diego, CA |
| 135 | Sat Sep 4 | at Padres | L2-10 | 79-56 | .585 | Petco Park · San Diego, CA |
| 136 | Sun Sep 5 | at Padres | L3-4 | 79-57 | .581 | Petco Park · San Diego, CA |
| 137 | Mon Sep 6 | vs Mariners | W11-2 | 80-57 | .584 | Minute Maid Park · Houston, TX |
| 138 | Tue Sep 7 | vs Mariners | W5-4 (10) | 81-57 | .587 | Minute Maid Park · Houston, TX |
| 139 | Wed Sep 8 | vs Mariners | L5-8 | 81-58 | .583 | Minute Maid Park · Houston, TX |
| 140 | Fri Sep 10 | vs Angels | W10-5 | 82-58 | .586 | Minute Maid Park · Houston, TX |
| 141 | Sat Sep 11 | vs Angels | L2-4 | 82-59 | .582 | Minute Maid Park · Houston, TX |
| 142 | Sun Sep 12 | vs Angels | W3-1 | 83-59 | .585 | Minute Maid Park · Houston, TX |
| 143 | Mon Sep 13 | at Rangers | W15-1 | 84-59 | .587 | Globe Life Field · Arlington, TX |
| 144 | Tue Sep 14 | at Rangers | L1-8 | 84-60 | .583 | Globe Life Field · Arlington, TX |
| 145 | Wed Sep 15 | at Rangers | W7-2 | 85-60 | .586 | Globe Life Field · Arlington, TX |
| 146 | Thu Sep 16 | at Rangers | W12-1 | 86-60 | .589 | Globe Life Field · Arlington, TX |
| 147 | Fri Sep 17 | vs D-backs | W4-3 (10) | 87-60 | .592 | Minute Maid Park · Houston, TX |
| 148 | Sat Sep 18 | vs D-backs | L4-6 (10) | 87-61 | .588 | Minute Maid Park · Houston, TX |
| 149 | Sun Sep 19 | vs D-backs | W7-6 | 88-61 | .591 | Minute Maid Park · Houston, TX |
| 150 | Mon Sep 20 | at Angels | W10-0 | 89-61 | .593 | Angel Stadium · Anaheim, CA |
| 151 | Tue Sep 21 | at Angels | W10-5 | 90-61 | .596 | Angel Stadium · Anaheim, CA |
| 152 | Wed Sep 22 | at Angels | W9-5 (12) | 91-61 | .599 | Angel Stadium · Anaheim, CA |
| 153 | Thu Sep 23 | at Angels | L2-3 | 91-62 | .595 | Angel Stadium · Anaheim, CA |
| 154 | Fri Sep 24 | at Athletics | L2-14 | 91-63 | .591 | RingCentral Coliseum · Oakland, CA |
| 155 | Sat Sep 25 | at Athletics | L1-2 | 91-64 | .587 | RingCentral Coliseum · Oakland, CA |
| 156 | Sun Sep 26 | at Athletics | L3-4 | 91-65 | .583 | RingCentral Coliseum · Oakland, CA |
| 157 | Tue Sep 28 | vs Rays | W4-3 | 92-65 | .586 | Minute Maid Park · Houston, TX |
| 158 | Wed Sep 29 | vs Rays | L0-7 | 92-66 | .582 | Minute Maid Park · Houston, TX |
| 159 | Thu Sep 30 | vs Rays | W3-2 | 93-66 | .585 | Minute Maid Park · Houston, TX |
| 160 | Fri Oct 1 | vs Athletics | L6-8 | 93-67 | .581 | Minute Maid Park · Houston, TX |
| 161 | Sat Oct 2 | vs Athletics | W10-4 | 94-67 | .584 | Minute Maid Park · Houston, TX |
| 162 | Sun Oct 3 | vs Athletics | W7-6 | 95-67 | .586 | Minute Maid Park · Houston, TX |
| 163 | Thu Oct 7 | vs White Sox | W6-1 | 1-0 | 1.000 | Minute Maid Park · Houston, TX |
| 164 | Fri Oct 8 | vs White Sox | W9-4 | 2-0 | 1.000 | Minute Maid Park · Houston, TX |
| 165 | Sun Oct 10 | at White Sox | L6-12 | 2-1 | .667 | Guaranteed Rate Field · Chicago, IL |
| 166 | Tue Oct 12 | at White Sox | W10-1 | 3-1 | .750 | Guaranteed Rate Field · Chicago, IL |
| 167 | Fri Oct 15 | vs Red Sox | W5-4 | 1-0 | 1.000 | Minute Maid Park · Houston, TX |
| 168 | Sat Oct 16 | vs Red Sox | L5-9 | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 169 | Mon Oct 18 | at Red Sox | L3-12 | 1-2 | .333 | Fenway Park · Boston, MA |
| 170 | Tue Oct 19 | at Red Sox | W9-2 | 2-2 | .500 | Fenway Park · Boston, MA |
| 171 | Wed Oct 20 | at Red Sox | W9-1 | 3-2 | .600 | Fenway Park · Boston, MA |
| 172 | Fri Oct 22 | vs Red Sox | W5-0 | 4-2 | .667 | Minute Maid Park · Houston, TX |
| 173 | Tue Oct 26 | vs Braves | L2-6 | 0-1 | .000 | Minute Maid Park · Houston, TX |
| 174 | Wed Oct 27 | vs Braves | W7-2 | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 175 | Fri Oct 29 | at Braves | L0-2 | 1-2 | .333 | Truist Park · Cumberland, GA |
| 176 | Sat Oct 30 | at Braves | L2-3 | 1-3 | .250 | Truist Park · Cumberland, GA |
| 177 | Sun Oct 31 | at Braves | W9-5 | 2-3 | .400 | Truist Park · Cumberland, GA |
| 178 | Tue Nov 2 | vs Braves | L0-7 | 2-4 | .333 | Minute Maid Park · Houston, TX |