| 1 | Thu Mar 29 | at Rangers | W4-1 | 1-0 | 1.000 | Globe Life Field · Arlington, TX |
| 2 | Fri Mar 30 | at Rangers | L1-5 | 1-1 | .500 | Globe Life Field · Arlington, TX |
| 3 | Sat Mar 31 | at Rangers | W9-3 | 2-1 | .667 | Globe Life Field · Arlington, TX |
| 4 | Sun Apr 1 | at Rangers | W8-2 | 3-1 | .750 | Globe Life Field · Arlington, TX |
| 5 | Mon Apr 2 | vs Orioles | W6-1 | 4-1 | .800 | Minute Maid Park · Houston, TX |
| 6 | Tue Apr 3 | vs Orioles | W10-6 | 5-1 | .833 | Minute Maid Park · Houston, TX |
| 7 | Wed Apr 4 | vs Orioles | W3-2 | 6-1 | .857 | Minute Maid Park · Houston, TX |
| 8 | Fri Apr 6 | vs Padres | L1-4 | 6-2 | .750 | Minute Maid Park · Houston, TX |
| 9 | Sat Apr 7 | vs Padres | W1-0 (10) | 7-2 | .778 | Minute Maid Park · Houston, TX |
| 10 | Sun Apr 8 | vs Padres | W4-1 | 8-2 | .800 | Minute Maid Park · Houston, TX |
| 11 | Mon Apr 9 | at Twins | W2-0 | 9-2 | .818 | Target Field · Minneapolis, MN |
| 12 | Tue Apr 10 | at Twins | L1-4 | 9-3 | .750 | Target Field · Minneapolis, MN |
| 13 | Wed Apr 11 | at Twins | L8-9 | 9-4 | .692 | Target Field · Minneapolis, MN |
| 14 | Fri Apr 13 | vs Rangers | W3-2 | 10-4 | .714 | Minute Maid Park · Houston, TX |
| 15 | Sat Apr 14 | vs Rangers | L5-6 (10) | 10-5 | .667 | Minute Maid Park · Houston, TX |
| 16 | Sun Apr 15 | vs Rangers | L1-3 (10) | 10-6 | .625 | Minute Maid Park · Houston, TX |
| 17 | Mon Apr 16 | at Mariners | L1-2 | 10-7 | .588 | T-Mobile Park · Seattle, WA |
| 18 | Tue Apr 17 | at Mariners | W4-1 | 11-7 | .611 | T-Mobile Park · Seattle, WA |
| 19 | Wed Apr 18 | at Mariners | W7-1 | 12-7 | .632 | T-Mobile Park · Seattle, WA |
| 20 | Thu Apr 19 | at Mariners | W9-2 | 13-7 | .650 | T-Mobile Park · Seattle, WA |
| 21 | Fri Apr 20 | at White Sox | W10-0 | 14-7 | .667 | Guaranteed Rate Field · Chicago, IL |
| 22 | Sat Apr 21 | at White Sox | W10-1 | 15-7 | .682 | Guaranteed Rate Field · Chicago, IL |
| 23 | Sun Apr 22 | at White Sox | W7-1 | 16-7 | .696 | Guaranteed Rate Field · Chicago, IL |
| 24 | Mon Apr 23 | vs Angels | L0-2 | 16-8 | .667 | Minute Maid Park · Houston, TX |
| 25 | Tue Apr 24 | vs Angels | L7-8 | 16-9 | .640 | Minute Maid Park · Houston, TX |
| 26 | Wed Apr 25 | vs Angels | W5-2 | 17-9 | .654 | Minute Maid Park · Houston, TX |
| 27 | Fri Apr 27 | vs Athletics | L1-8 | 17-10 | .630 | Minute Maid Park · Houston, TX |
| 28 | Sat Apr 28 | vs Athletics | W11-0 | 18-10 | .643 | Minute Maid Park · Houston, TX |
| 29 | Sun Apr 29 | vs Athletics | W8-4 | 19-10 | .655 | Minute Maid Park · Houston, TX |
| 30 | Mon Apr 30 | vs Yankees | W2-1 | 20-10 | .667 | Minute Maid Park · Houston, TX |
| 31 | Tue May 1 | vs Yankees | L0-4 | 20-11 | .645 | Minute Maid Park · Houston, TX |
| 32 | Wed May 2 | vs Yankees | L0-4 | 20-12 | .625 | Minute Maid Park · Houston, TX |
| 33 | Thu May 3 | vs Yankees | L5-6 | 20-13 | .606 | Minute Maid Park · Houston, TX |
| 34 | Fri May 4 | at D-backs | W8-0 | 21-13 | .618 | Chase Field · Phoenix, AZ |
| 35 | Sat May 5 | at D-backs | L3-4 | 21-14 | .600 | Chase Field · Phoenix, AZ |
| 36 | Sun May 6 | at D-backs | L1-3 | 21-15 | .583 | Chase Field · Phoenix, AZ |
| 37 | Mon May 7 | at Athletics | W16-2 | 22-15 | .595 | RingCentral Coliseum · Oakland, CA |
| 38 | Tue May 8 | at Athletics | W4-2 | 23-15 | .605 | RingCentral Coliseum · Oakland, CA |
| 39 | Wed May 9 | at Athletics | W4-1 | 24-15 | .615 | RingCentral Coliseum · Oakland, CA |
| 40 | Fri May 11 | vs Rangers | L0-1 | 24-16 | .600 | Minute Maid Park · Houston, TX |
| 41 | Sat May 12 | vs Rangers | W6-1 | 25-16 | .610 | Minute Maid Park · Houston, TX |
| 42 | Sun May 13 | vs Rangers | W6-1 | 26-16 | .619 | Minute Maid Park · Houston, TX |
| 43 | Mon May 14 | at Angels | L1-2 | 26-17 | .605 | Angel Stadium · Anaheim, CA |
| 44 | Tue May 15 | at Angels | W5-3 | 27-17 | .614 | Angel Stadium · Anaheim, CA |
| 45 | Wed May 16 | at Angels | W2-0 | 28-17 | .622 | Angel Stadium · Anaheim, CA |
| 46 | Fri May 18 | vs Guardians | W4-1 | 29-17 | .630 | Minute Maid Park · Houston, TX |
| 47 | Sat May 19 | vs Guardians | L4-5 | 29-18 | .617 | Minute Maid Park · Houston, TX |
| 48 | Sun May 20 | vs Guardians | W3-1 | 30-18 | .625 | Minute Maid Park · Houston, TX |
| 49 | Tue May 22 | vs Giants | W11-2 | 31-18 | .633 | Minute Maid Park · Houston, TX |
| 50 | Wed May 23 | vs Giants | W4-1 | 32-18 | .640 | Minute Maid Park · Houston, TX |
| 51 | Thu May 24 | at Guardians | W8-2 | 33-18 | .647 | Progressive Field · Cleveland, OH |
| 52 | Fri May 25 | at Guardians | W11-2 | 34-18 | .654 | Progressive Field · Cleveland, OH |
| 53 | Sat May 26 | at Guardians | L6-8 | 34-19 | .642 | Progressive Field · Cleveland, OH |
| 54 | Sun May 27 | at Guardians | L9-10 (14) | 34-20 | .630 | Progressive Field · Cleveland, OH |
| 55 | Mon May 28 | at Yankees | W5-1 | 35-20 | .636 | Yankee Stadium · The Bronx, NY |
| 56 | Tue May 29 | at Yankees | L5-6 (10) | 35-21 | .625 | Yankee Stadium · The Bronx, NY |
| 57 | Wed May 30 | at Yankees | L3-5 | 35-22 | .614 | Yankee Stadium · The Bronx, NY |
| 58 | Thu May 31 | vs Red Sox | W4-2 | 36-22 | .621 | Minute Maid Park · Houston, TX |
| 59 | Fri Jun 1 | vs Red Sox | W7-3 | 37-22 | .627 | Minute Maid Park · Houston, TX |
| 60 | Sat Jun 2 | vs Red Sox | L4-5 | 37-23 | .617 | Minute Maid Park · Houston, TX |
| 61 | Sun Jun 3 | vs Red Sox | L3-9 | 37-24 | .607 | Minute Maid Park · Houston, TX |
| 62 | Tue Jun 5 | vs Mariners | L1-7 | 37-25 | .597 | Minute Maid Park · Houston, TX |
| 63 | Wed Jun 6 | vs Mariners | W7-5 | 38-25 | .603 | Minute Maid Park · Houston, TX |
| 64 | Thu Jun 7 | at Rangers | W5-2 | 39-25 | .609 | Globe Life Field · Arlington, TX |
| 65 | Fri Jun 8 | at Rangers | W7-3 | 40-25 | .615 | Globe Life Field · Arlington, TX |
| 66 | Sat Jun 9 | at Rangers | W4-3 | 41-25 | .621 | Globe Life Field · Arlington, TX |
| 67 | Sun Jun 10 | at Rangers | W8-7 | 42-25 | .627 | Globe Life Field · Arlington, TX |
| 68 | Tue Jun 12 | at Athletics | W6-3 | 43-25 | .632 | RingCentral Coliseum · Oakland, CA |
| 69 | Wed Jun 13 | at Athletics | W13-5 | 44-25 | .638 | RingCentral Coliseum · Oakland, CA |
| 70 | Thu Jun 14 | at Athletics | W7-3 | 45-25 | .643 | RingCentral Coliseum · Oakland, CA |
| 71 | Fri Jun 15 | at Royals | W7-3 | 46-25 | .648 | Kauffman Stadium · Kansas City, MO |
| 72 | Sat Jun 16 | at Royals | W10-2 | 47-25 | .653 | Kauffman Stadium · Kansas City, MO |
| 73 | Sun Jun 17 | at Royals | W7-4 | 48-25 | .658 | Kauffman Stadium · Kansas City, MO |
| 74 | Mon Jun 18 | vs Rays | W5-4 | 49-25 | .662 | Minute Maid Park · Houston, TX |
| 75 | Tue Jun 19 | vs Rays | L1-2 | 49-26 | .653 | Minute Maid Park · Houston, TX |
| 76 | Wed Jun 20 | vs Rays | W5-1 | 50-26 | .658 | Minute Maid Park · Houston, TX |
| 77 | Fri Jun 22 | vs Royals | L0-1 | 50-27 | .649 | Minute Maid Park · Houston, TX |
| 78 | Sat Jun 23 | vs Royals | W4-3 (12) | 51-27 | .654 | Minute Maid Park · Houston, TX |
| 79 | Sun Jun 24 | vs Royals | W11-3 | 52-27 | .658 | Minute Maid Park · Houston, TX |
| 80 | Mon Jun 25 | vs Blue Jays | L3-6 | 52-28 | .650 | Minute Maid Park · Houston, TX |
| 81 | Tue Jun 26 | vs Blue Jays | W7-0 | 53-28 | .654 | Minute Maid Park · Houston, TX |
| 82 | Wed Jun 27 | vs Blue Jays | W7-6 | 54-28 | .659 | Minute Maid Park · Houston, TX |
| 83 | Thu Jun 28 | at Rays | W1-0 | 55-28 | .663 | Tropicana Field · St. Petersburg, FL |
| 84 | Fri Jun 29 | at Rays | L2-3 | 55-29 | .655 | Tropicana Field · St. Petersburg, FL |
| 85 | Sat Jun 30 | at Rays | L2-5 | 55-30 | .647 | Tropicana Field · St. Petersburg, FL |
| 86 | Sun Jul 1 | at Rays | L2-3 | 55-31 | .640 | Tropicana Field · St. Petersburg, FL |
| 87 | Tue Jul 3 | at Rangers | W5-3 | 56-31 | .644 | Globe Life Field · Arlington, TX |
| 88 | Wed Jul 4 | at Rangers | W5-4 (10) | 57-31 | .648 | Globe Life Field · Arlington, TX |
| 89 | Thu Jul 5 | vs White Sox | W4-3 | 58-31 | .652 | Minute Maid Park · Houston, TX |
| 90 | Fri Jul 6 | vs White Sox | W11-4 | 59-31 | .656 | Minute Maid Park · Houston, TX |
| 91 | Sat Jul 7 | vs White Sox | W12-6 | 60-31 | .659 | Minute Maid Park · Houston, TX |
| 92 | Sun Jul 8 | vs White Sox | W2-1 | 61-31 | .663 | Minute Maid Park · Houston, TX |
| 93 | Mon Jul 9 | vs Athletics | L0-2 | 61-32 | .656 | Minute Maid Park · Houston, TX |
| 94 | Tue Jul 10 | vs Athletics | W6-5 (11) | 62-32 | .660 | Minute Maid Park · Houston, TX |
| 95 | Wed Jul 11 | vs Athletics | L3-8 | 62-33 | .653 | Minute Maid Park · Houston, TX |
| 96 | Thu Jul 12 | vs Athletics | L4-6 | 62-34 | .646 | Minute Maid Park · Houston, TX |
| 97 | Fri Jul 13 | vs Tigers | W3-0 | 63-34 | .649 | Minute Maid Park · Houston, TX |
| 98 | Sat Jul 14 | vs Tigers | W9-1 | 64-34 | .653 | Minute Maid Park · Houston, TX |
| 99 | Sun Jul 15 | vs Tigers | L3-6 | 64-35 | .646 | Minute Maid Park · Houston, TX |
| 100 | Fri Jul 20 | at Angels | W3-1 | 65-35 | .650 | Angel Stadium · Anaheim, CA |
| 101 | Sat Jul 21 | at Angels | W7-0 | 66-35 | .653 | Angel Stadium · Anaheim, CA |
| 102 | Sun Jul 22 | at Angels | L5-14 | 66-36 | .647 | Angel Stadium · Anaheim, CA |
| 103 | Tue Jul 24 | at Rockies | W8-2 (10) | 67-36 | .650 | Coors Field · Denver, CO |
| 104 | Wed Jul 25 | at Rockies | L2-3 | 67-37 | .644 | Coors Field · Denver, CO |
| 105 | Fri Jul 27 | vs Rangers | L2-11 | 67-38 | .638 | Minute Maid Park · Houston, TX |
| 106 | Sat Jul 28 | vs Rangers | L3-7 | 67-39 | .632 | Minute Maid Park · Houston, TX |
| 107 | Sun Jul 29 | vs Rangers | L3-4 | 67-40 | .626 | Minute Maid Park · Houston, TX |
| 108 | Mon Jul 30 | at Mariners | L0-2 | 67-41 | .620 | T-Mobile Park · Seattle, WA |
| 109 | Tue Jul 31 | at Mariners | W5-2 | 68-41 | .624 | T-Mobile Park · Seattle, WA |
| 110 | Wed Aug 1 | at Mariners | W8-3 | 69-41 | .627 | T-Mobile Park · Seattle, WA |
| 111 | Fri Aug 3 | at Dodgers | W2-1 | 70-41 | .631 | Dodger Stadium · Los Angeles, CA |
| 112 | Sat Aug 4 | at Dodgers | W14-0 | 71-41 | .634 | Dodger Stadium · Los Angeles, CA |
| 113 | Sun Aug 5 | at Dodgers | L2-3 | 71-42 | .628 | Dodger Stadium · Los Angeles, CA |
| 114 | Mon Aug 6 | at Giants | W3-1 | 72-42 | .632 | Oracle Park · San Francisco, CA |
| 115 | Tue Aug 7 | at Giants | W2-1 | 73-42 | .635 | Oracle Park · San Francisco, CA |
| 116 | Thu Aug 9 | vs Mariners | L6-8 | 73-43 | .629 | Minute Maid Park · Houston, TX |
| 117 | Fri Aug 10 | vs Mariners | L2-5 | 73-44 | .624 | Minute Maid Park · Houston, TX |
| 118 | Sat Aug 11 | vs Mariners | L2-3 | 73-45 | .619 | Minute Maid Park · Houston, TX |
| 119 | Sun Aug 12 | vs Mariners | L3-4 (10) | 73-46 | .613 | Minute Maid Park · Houston, TX |
| 120 | Tue Aug 14 | vs Rockies | L1-5 | 73-47 | .608 | Minute Maid Park · Houston, TX |
| 121 | Wed Aug 15 | vs Rockies | W12-1 | 74-47 | .612 | Minute Maid Park · Houston, TX |
| 122 | Fri Aug 17 | at Athletics | L3-4 (10) | 74-48 | .607 | RingCentral Coliseum · Oakland, CA |
| 123 | Sat Aug 18 | at Athletics | L1-7 | 74-49 | .602 | RingCentral Coliseum · Oakland, CA |
| 124 | Sun Aug 19 | at Athletics | W9-4 | 75-49 | .605 | RingCentral Coliseum · Oakland, CA |
| 125 | Mon Aug 20 | at Mariners | L4-7 | 75-50 | .600 | T-Mobile Park · Seattle, WA |
| 126 | Tue Aug 21 | at Mariners | W3-2 | 76-50 | .603 | T-Mobile Park · Seattle, WA |
| 127 | Wed Aug 22 | at Mariners | W10-7 | 77-50 | .606 | T-Mobile Park · Seattle, WA |
| 128 | Fri Aug 24 | at Angels | W9-3 | 78-50 | .609 | Angel Stadium · Anaheim, CA |
| 129 | Sat Aug 25 | at Angels | W8-3 | 79-50 | .612 | Angel Stadium · Anaheim, CA |
| 130 | Sun Aug 26 | at Angels | W3-1 | 80-50 | .615 | Angel Stadium · Anaheim, CA |
| 131 | Mon Aug 27 | vs Athletics | W11-4 | 81-50 | .618 | Minute Maid Park · Houston, TX |
| 132 | Tue Aug 28 | vs Athletics | L3-4 | 81-51 | .614 | Minute Maid Park · Houston, TX |
| 133 | Wed Aug 29 | vs Athletics | W5-4 | 82-51 | .617 | Minute Maid Park · Houston, TX |
| 134 | Thu Aug 30 | vs Angels | L2-5 | 82-52 | .612 | Minute Maid Park · Houston, TX |
| 135 | Fri Aug 31 | vs Angels | L0-3 | 82-53 | .607 | Minute Maid Park · Houston, TX |
| 136 | Sat Sep 1 | vs Angels | W7-3 | 83-53 | .610 | Minute Maid Park · Houston, TX |
| 137 | Sun Sep 2 | vs Angels | W4-2 | 84-53 | .613 | Minute Maid Park · Houston, TX |
| 138 | Mon Sep 3 | vs Twins | W4-1 | 85-53 | .616 | Minute Maid Park · Houston, TX |
| 139 | Tue Sep 4 | vs Twins | W5-2 | 86-53 | .619 | Minute Maid Park · Houston, TX |
| 140 | Wed Sep 5 | vs Twins | W9-1 | 87-53 | .621 | Minute Maid Park · Houston, TX |
| 141 | Fri Sep 7 | at Red Sox | W6-3 | 88-53 | .624 | Fenway Park · Boston, MA |
| 142 | Sat Sep 8 | at Red Sox | W5-3 | 89-53 | .627 | Fenway Park · Boston, MA |
| 143 | Sun Sep 9 | at Red Sox | L5-6 | 89-54 | .622 | Fenway Park · Boston, MA |
| 144 | Mon Sep 10 | at Tigers | W3-2 | 90-54 | .625 | Comerica Park · Detroit, MI |
| 145 | Tue Sep 11 | at Tigers | W5-4 | 91-54 | .628 | Comerica Park · Detroit, MI |
| 146 | Wed Sep 12 | at Tigers | W5-4 | 92-54 | .630 | Comerica Park · Detroit, MI |
| 147 | Fri Sep 14 | vs D-backs | L2-4 | 92-55 | .626 | Minute Maid Park · Houston, TX |
| 148 | Sat Sep 15 | vs D-backs | W10-4 | 93-55 | .628 | Minute Maid Park · Houston, TX |
| 149 | Sun Sep 16 | vs D-backs | W5-4 | 94-55 | .631 | Minute Maid Park · Houston, TX |
| 150 | Mon Sep 17 | vs Mariners | L1-4 | 94-56 | .627 | Minute Maid Park · Houston, TX |
| 151 | Tue Sep 18 | vs Mariners | W7-0 | 95-56 | .629 | Minute Maid Park · Houston, TX |
| 152 | Wed Sep 19 | vs Mariners | L0-9 | 95-57 | .625 | Minute Maid Park · Houston, TX |
| 153 | Fri Sep 21 | vs Angels | W11-3 | 96-57 | .627 | Minute Maid Park · Houston, TX |
| 154 | Sat Sep 22 | vs Angels | W10-5 | 97-57 | .630 | Minute Maid Park · Houston, TX |
| 155 | Sun Sep 23 | vs Angels | W6-2 | 98-57 | .632 | Minute Maid Park · Houston, TX |
| 156 | Mon Sep 24 | at Blue Jays | W5-3 | 99-57 | .635 | Rogers Centre · Toronto, ON |
| 157 | Tue Sep 25 | at Blue Jays | W4-1 | 100-57 | .637 | Rogers Centre · Toronto, ON |
| 158 | Wed Sep 26 | at Blue Jays | L1-3 | 100-58 | .633 | Rogers Centre · Toronto, ON |
| 159 | Fri Sep 28 | at Orioles | W2-1 | 101-58 | .635 | Camden Yards · Baltimore, MD |
| 160 | Sat Sep 29 | at Orioles | W4-3 | 102-58 | .637 | Camden Yards · Baltimore, MD |
| 161 | Sat Sep 29 | at Orioles | W5-2 | 103-58 | .640 | Camden Yards · Baltimore, MD |
| 162 | Sun Sep 30 | at Orioles | L0-4 | 103-59 | .636 | Camden Yards · Baltimore, MD |
| 163 | Fri Oct 5 | vs Guardians | W7-2 | 1-0 | 1.000 | Minute Maid Park · Houston, TX |
| 164 | Sat Oct 6 | vs Guardians | W3-1 | 2-0 | 1.000 | Minute Maid Park · Houston, TX |
| 165 | Mon Oct 8 | at Guardians | W11-3 | 3-0 | 1.000 | Progressive Field · Cleveland, OH |
| 166 | Sat Oct 13 | at Red Sox | W7-2 | 1-0 | 1.000 | Fenway Park · Boston, MA |
| 167 | Sun Oct 14 | at Red Sox | L5-7 | 1-1 | .500 | Fenway Park · Boston, MA |
| 168 | Tue Oct 16 | vs Red Sox | L2-8 | 1-2 | .333 | Minute Maid Park · Houston, TX |
| 169 | Wed Oct 17 | vs Red Sox | L6-8 | 1-3 | .250 | Minute Maid Park · Houston, TX |
| 170 | Thu Oct 18 | vs Red Sox | L1-4 | 1-4 | .200 | Minute Maid Park · Houston, TX |