| 1 | Thu Mar 30 | vs White Sox | L2-3 | 0-1 | .000 | Minute Maid Park · Houston, TX |
| 2 | Fri Mar 31 | vs White Sox | W6-3 | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 3 | Sat Apr 1 | vs White Sox | W6-4 | 2-1 | .667 | Minute Maid Park · Houston, TX |
| 4 | Sun Apr 2 | vs White Sox | L3-6 | 2-2 | .500 | Minute Maid Park · Houston, TX |
| 5 | Mon Apr 3 | vs Tigers | L6-7 (11) | 2-3 | .400 | Minute Maid Park · Houston, TX |
| 6 | Tue Apr 4 | vs Tigers | L3-6 | 2-4 | .333 | Minute Maid Park · Houston, TX |
| 7 | Wed Apr 5 | vs Tigers | W8-2 | 3-4 | .429 | Minute Maid Park · Houston, TX |
| 8 | Fri Apr 7 | at Twins | L2-3 (10) | 3-5 | .375 | Target Field · Minneapolis, MN |
| 9 | Sat Apr 8 | at Twins | L6-9 | 3-6 | .333 | Target Field · Minneapolis, MN |
| 10 | Sun Apr 9 | at Twins | W5-1 | 4-6 | .400 | Target Field · Minneapolis, MN |
| 11 | Mon Apr 10 | at Pirates | W8-2 | 5-6 | .455 | PNC Park · Pittsburgh, PA |
| 12 | Tue Apr 11 | at Pirates | L4-7 | 5-7 | .417 | PNC Park · Pittsburgh, PA |
| 13 | Wed Apr 12 | at Pirates | W7-0 | 6-7 | .462 | PNC Park · Pittsburgh, PA |
| 14 | Fri Apr 14 | vs Rangers | L2-6 | 6-8 | .429 | Minute Maid Park · Houston, TX |
| 15 | Sat Apr 15 | vs Rangers | W8-2 | 7-8 | .467 | Minute Maid Park · Houston, TX |
| 16 | Sun Apr 16 | vs Rangers | L1-9 | 7-9 | .438 | Minute Maid Park · Houston, TX |
| 17 | Mon Apr 17 | vs Blue Jays | W9-2 | 8-9 | .471 | Minute Maid Park · Houston, TX |
| 18 | Tue Apr 18 | vs Blue Jays | L2-4 | 8-10 | .444 | Minute Maid Park · Houston, TX |
| 19 | Wed Apr 19 | vs Blue Jays | W8-1 | 9-10 | .474 | Minute Maid Park · Houston, TX |
| 20 | Fri Apr 21 | at Braves | W6-4 | 10-10 | .500 | Truist Park · Cumberland, GA |
| 21 | Sat Apr 22 | at Braves | W6-3 | 11-10 | .524 | Truist Park · Cumberland, GA |
| 22 | Sun Apr 23 | at Braves | W5-2 | 12-10 | .545 | Truist Park · Cumberland, GA |
| 23 | Mon Apr 24 | at Rays | L3-8 | 12-11 | .522 | Tropicana Field · St. Petersburg, FL |
| 24 | Tue Apr 25 | at Rays | W5-0 | 13-11 | .542 | Tropicana Field · St. Petersburg, FL |
| 25 | Wed Apr 26 | at Rays | W1-0 | 14-11 | .560 | Tropicana Field · St. Petersburg, FL |
| 26 | Fri Apr 28 | vs Phillies | L1-3 | 14-12 | .538 | Minute Maid Park · Houston, TX |
| 27 | Sat Apr 29 | vs Phillies | L1-6 | 14-13 | .519 | Minute Maid Park · Houston, TX |
| 28 | Sun Apr 30 | vs Phillies | W4-3 | 15-13 | .536 | Minute Maid Park · Houston, TX |
| 29 | Mon May 1 | vs Giants | W7-3 | 16-13 | .552 | Minute Maid Park · Houston, TX |
| 30 | Tue May 2 | vs Giants | L0-2 | 16-14 | .533 | Minute Maid Park · Houston, TX |
| 31 | Wed May 3 | vs Giants | L2-4 | 16-15 | .516 | Minute Maid Park · Houston, TX |
| 32 | Fri May 5 | at Mariners | W6-4 | 17-15 | .531 | T-Mobile Park · Seattle, WA |
| 33 | Sat May 6 | at Mariners | L5-7 | 17-16 | .515 | T-Mobile Park · Seattle, WA |
| 34 | Sun May 7 | at Mariners | L1-3 | 17-17 | .500 | T-Mobile Park · Seattle, WA |
| 35 | Mon May 8 | at Angels | L4-6 | 17-18 | .486 | Angel Stadium · Anaheim, CA |
| 36 | Tue May 9 | at Angels | W3-1 | 18-18 | .500 | Angel Stadium · Anaheim, CA |
| 37 | Wed May 10 | at Angels | W5-4 | 19-18 | .514 | Angel Stadium · Anaheim, CA |
| 38 | Fri May 12 | at White Sox | W5-1 | 20-18 | .526 | Guaranteed Rate Field · Chicago, IL |
| 39 | Sat May 13 | at White Sox | L1-3 | 20-19 | .513 | Guaranteed Rate Field · Chicago, IL |
| 40 | Sun May 14 | at White Sox | W4-3 | 21-19 | .525 | Guaranteed Rate Field · Chicago, IL |
| 41 | Mon May 15 | vs Cubs | W6-4 | 22-19 | .537 | Minute Maid Park · Houston, TX |
| 42 | Tue May 16 | vs Cubs | W7-3 | 23-19 | .548 | Minute Maid Park · Houston, TX |
| 43 | Wed May 17 | vs Cubs | W7-6 | 24-19 | .558 | Minute Maid Park · Houston, TX |
| 44 | Fri May 19 | vs Athletics | W5-1 | 25-19 | .568 | Minute Maid Park · Houston, TX |
| 45 | Sat May 20 | vs Athletics | W3-2 | 26-19 | .578 | Minute Maid Park · Houston, TX |
| 46 | Sun May 21 | vs Athletics | W2-0 | 27-19 | .587 | Minute Maid Park · Houston, TX |
| 47 | Mon May 22 | at Brewers | W12-2 | 28-19 | .596 | American Family Field · Milwaukee, WI |
| 48 | Tue May 23 | at Brewers | L0-6 | 28-20 | .583 | American Family Field · Milwaukee, WI |
| 49 | Wed May 24 | at Brewers | L0-4 | 28-21 | .571 | American Family Field · Milwaukee, WI |
| 50 | Fri May 26 | at Athletics | W5-2 | 29-21 | .580 | RingCentral Coliseum · Oakland, CA |
| 51 | Sat May 27 | at Athletics | W6-3 | 30-21 | .588 | RingCentral Coliseum · Oakland, CA |
| 52 | Sun May 28 | at Athletics | W10-1 | 31-21 | .596 | RingCentral Coliseum · Oakland, CA |
| 53 | Mon May 29 | vs Twins | L5-7 (10) | 31-22 | .585 | Minute Maid Park · Houston, TX |
| 54 | Tue May 30 | vs Twins | W5-1 | 32-22 | .593 | Minute Maid Park · Houston, TX |
| 55 | Wed May 31 | vs Twins | L2-8 | 32-23 | .582 | Minute Maid Park · Houston, TX |
| 56 | Thu Jun 1 | vs Angels | W5-2 | 33-23 | .589 | Minute Maid Park · Houston, TX |
| 57 | Fri Jun 2 | vs Angels | W6-2 | 34-23 | .596 | Minute Maid Park · Houston, TX |
| 58 | Sat Jun 3 | vs Angels | W9-6 | 35-23 | .603 | Minute Maid Park · Houston, TX |
| 59 | Sun Jun 4 | vs Angels | L1-2 | 35-24 | .593 | Minute Maid Park · Houston, TX |
| 60 | Mon Jun 5 | at Blue Jays | W11-4 | 36-24 | .600 | Rogers Centre · Toronto, ON |
| 61 | Tue Jun 6 | at Blue Jays | L1-5 | 36-25 | .590 | Rogers Centre · Toronto, ON |
| 62 | Wed Jun 7 | at Blue Jays | L2-3 | 36-26 | .581 | Rogers Centre · Toronto, ON |
| 63 | Thu Jun 8 | at Blue Jays | L2-3 | 36-27 | .571 | Rogers Centre · Toronto, ON |
| 64 | Fri Jun 9 | at Guardians | L9-10 (14) | 36-28 | .563 | Progressive Field · Cleveland, OH |
| 65 | Sat Jun 10 | at Guardians | W6-4 | 37-28 | .569 | Progressive Field · Cleveland, OH |
| 66 | Sun Jun 11 | at Guardians | L0-5 | 37-29 | .561 | Progressive Field · Cleveland, OH |
| 67 | Tue Jun 13 | vs Nationals | W6-1 | 38-29 | .567 | Minute Maid Park · Houston, TX |
| 68 | Wed Jun 14 | vs Nationals | W5-4 | 39-29 | .574 | Minute Maid Park · Houston, TX |
| 69 | Thu Jun 15 | vs Nationals | L1-4 (10) | 39-30 | .565 | Minute Maid Park · Houston, TX |
| 70 | Fri Jun 16 | vs Reds | L1-2 | 39-31 | .557 | Minute Maid Park · Houston, TX |
| 71 | Sat Jun 17 | vs Reds | L3-10 | 39-32 | .549 | Minute Maid Park · Houston, TX |
| 72 | Sun Jun 18 | vs Reds | L7-9 (10) | 39-33 | .542 | Minute Maid Park · Houston, TX |
| 73 | Mon Jun 19 | vs Mets | L1-11 | 39-34 | .534 | Minute Maid Park · Houston, TX |
| 74 | Tue Jun 20 | vs Mets | W4-2 | 40-34 | .541 | Minute Maid Park · Houston, TX |
| 75 | Wed Jun 21 | vs Mets | W10-8 | 41-34 | .547 | Minute Maid Park · Houston, TX |
| 76 | Fri Jun 23 | at Dodgers | L2-3 | 41-35 | .539 | Dodger Stadium · Los Angeles, CA |
| 77 | Sat Jun 24 | at Dodgers | L7-8 | 41-36 | .532 | Dodger Stadium · Los Angeles, CA |
| 78 | Sun Jun 25 | at Dodgers | W6-5 (11) | 42-36 | .538 | Dodger Stadium · Los Angeles, CA |
| 79 | Tue Jun 27 | at Cardinals | L2-4 | 42-37 | .532 | Busch Stadium · St. Louis, MO |
| 80 | Wed Jun 28 | at Cardinals | W10-7 | 43-37 | .537 | Busch Stadium · St. Louis, MO |
| 81 | Thu Jun 29 | at Cardinals | W14-0 | 44-37 | .543 | Busch Stadium · St. Louis, MO |
| 82 | Fri Jun 30 | at Rangers | W5-3 | 45-37 | .549 | Globe Life Field · Arlington, TX |
| 83 | Sat Jul 1 | at Rangers | L2-5 | 45-38 | .542 | Globe Life Field · Arlington, TX |
| 84 | Sun Jul 2 | at Rangers | W5-3 | 46-38 | .548 | Globe Life Field · Arlington, TX |
| 85 | Mon Jul 3 | at Rangers | W12-11 | 47-38 | .553 | Globe Life Field · Arlington, TX |
| 86 | Tue Jul 4 | vs Rockies | W4-1 | 48-38 | .558 | Minute Maid Park · Houston, TX |
| 87 | Wed Jul 5 | vs Rockies | W6-4 | 49-38 | .563 | Minute Maid Park · Houston, TX |
| 88 | Thu Jul 6 | vs Mariners | L1-5 | 49-39 | .557 | Minute Maid Park · Houston, TX |
| 89 | Fri Jul 7 | vs Mariners | L1-10 | 49-40 | .551 | Minute Maid Park · Houston, TX |
| 90 | Sat Jul 8 | vs Mariners | W3-2 | 50-40 | .556 | Minute Maid Park · Houston, TX |
| 91 | Sun Jul 9 | vs Mariners | L1-3 | 50-41 | .549 | Minute Maid Park · Houston, TX |
| 92 | Fri Jul 14 | at Angels | W7-5 | 51-41 | .554 | Angel Stadium · Anaheim, CA |
| 93 | Sat Jul 15 | at Angels | L12-13 (10) | 51-42 | .548 | Angel Stadium · Anaheim, CA |
| 94 | Sun Jul 16 | at Angels | W9-8 | 52-42 | .553 | Angel Stadium · Anaheim, CA |
| 95 | Tue Jul 18 | at Rockies | L3-4 | 52-43 | .547 | Coors Field · Denver, CO |
| 96 | Wed Jul 19 | at Rockies | W4-1 | 53-43 | .552 | Coors Field · Denver, CO |
| 97 | Thu Jul 20 | at Athletics | W3-1 | 54-43 | .557 | RingCentral Coliseum · Oakland, CA |
| 98 | Fri Jul 21 | at Athletics | W6-4 | 55-43 | .561 | RingCentral Coliseum · Oakland, CA |
| 99 | Sat Jul 22 | at Athletics | L1-4 | 55-44 | .556 | RingCentral Coliseum · Oakland, CA |
| 100 | Sun Jul 23 | at Athletics | W3-2 | 56-44 | .560 | RingCentral Coliseum · Oakland, CA |
| 101 | Mon Jul 24 | vs Rangers | W10-9 | 57-44 | .564 | Minute Maid Park · Houston, TX |
| 102 | Tue Jul 25 | vs Rangers | W4-3 | 58-44 | .569 | Minute Maid Park · Houston, TX |
| 103 | Wed Jul 26 | vs Rangers | L5-13 | 58-45 | .563 | Minute Maid Park · Houston, TX |
| 104 | Fri Jul 28 | vs Rays | L3-4 | 58-46 | .558 | Minute Maid Park · Houston, TX |
| 105 | Sat Jul 29 | vs Rays | W17-4 | 59-46 | .562 | Minute Maid Park · Houston, TX |
| 106 | Sun Jul 30 | vs Rays | L2-8 | 59-47 | .557 | Minute Maid Park · Houston, TX |
| 107 | Mon Jul 31 | vs Guardians | W7-3 | 60-47 | .561 | Minute Maid Park · Houston, TX |
| 108 | Tue Aug 1 | vs Guardians | W2-0 | 61-47 | .565 | Minute Maid Park · Houston, TX |
| 109 | Wed Aug 2 | vs Guardians | W3-2 | 62-47 | .569 | Minute Maid Park · Houston, TX |
| 110 | Thu Aug 3 | at Yankees | L3-4 | 62-48 | .564 | Yankee Stadium · The Bronx, NY |
| 111 | Fri Aug 4 | at Yankees | W7-3 | 63-48 | .568 | Yankee Stadium · The Bronx, NY |
| 112 | Sat Aug 5 | at Yankees | L1-3 | 63-49 | .563 | Yankee Stadium · The Bronx, NY |
| 113 | Sun Aug 6 | at Yankees | W9-7 | 64-49 | .566 | Yankee Stadium · The Bronx, NY |
| 114 | Tue Aug 8 | at Orioles | W7-6 | 65-49 | .570 | Camden Yards · Baltimore, MD |
| 115 | Wed Aug 9 | at Orioles | W8-2 | 66-49 | .574 | Camden Yards · Baltimore, MD |
| 116 | Thu Aug 10 | at Orioles | L4-5 | 66-50 | .569 | Camden Yards · Baltimore, MD |
| 117 | Fri Aug 11 | vs Angels | W11-3 | 67-50 | .573 | Minute Maid Park · Houston, TX |
| 118 | Sat Aug 12 | vs Angels | W11-3 | 68-50 | .576 | Minute Maid Park · Houston, TX |
| 119 | Sun Aug 13 | vs Angels | L1-2 | 68-51 | .571 | Minute Maid Park · Houston, TX |
| 120 | Mon Aug 14 | at Marlins | L1-5 | 68-52 | .567 | LoanDepot Park · Miami, FL |
| 121 | Tue Aug 15 | at Marlins | W6-5 | 69-52 | .570 | LoanDepot Park · Miami, FL |
| 122 | Wed Aug 16 | at Marlins | W12-5 | 70-52 | .574 | LoanDepot Park · Miami, FL |
| 123 | Fri Aug 18 | vs Mariners | L0-2 | 70-53 | .569 | Minute Maid Park · Houston, TX |
| 124 | Sat Aug 19 | vs Mariners | L3-10 | 70-54 | .565 | Minute Maid Park · Houston, TX |
| 125 | Sun Aug 20 | vs Mariners | L6-7 | 70-55 | .560 | Minute Maid Park · Houston, TX |
| 126 | Mon Aug 21 | vs Red Sox | W9-4 | 71-55 | .563 | Minute Maid Park · Houston, TX |
| 127 | Tue Aug 22 | vs Red Sox | W7-3 | 72-55 | .567 | Minute Maid Park · Houston, TX |
| 128 | Wed Aug 23 | vs Red Sox | L5-7 (10) | 72-56 | .563 | Minute Maid Park · Houston, TX |
| 129 | Thu Aug 24 | vs Red Sox | L1-17 | 72-57 | .558 | Minute Maid Park · Houston, TX |
| 130 | Fri Aug 25 | at Tigers | L1-4 | 72-58 | .554 | Comerica Park · Detroit, MI |
| 131 | Sat Aug 26 | at Tigers | W9-2 | 73-58 | .557 | Comerica Park · Detroit, MI |
| 132 | Sun Aug 27 | at Tigers | W17-4 | 74-58 | .561 | Comerica Park · Detroit, MI |
| 133 | Mon Aug 28 | at Red Sox | W13-5 | 75-58 | .564 | Fenway Park · Boston, MA |
| 134 | Tue Aug 29 | at Red Sox | W6-2 | 76-58 | .567 | Fenway Park · Boston, MA |
| 135 | Wed Aug 30 | at Red Sox | W7-4 | 77-58 | .570 | Fenway Park · Boston, MA |
| 136 | Fri Sep 1 | vs Yankees | L2-6 | 77-59 | .566 | Minute Maid Park · Houston, TX |
| 137 | Sat Sep 2 | vs Yankees | L4-5 | 77-60 | .562 | Minute Maid Park · Houston, TX |
| 138 | Sun Sep 3 | vs Yankees | L1-6 | 77-61 | .558 | Minute Maid Park · Houston, TX |
| 139 | Mon Sep 4 | at Rangers | W13-6 | 78-61 | .561 | Globe Life Field · Arlington, TX |
| 140 | Tue Sep 5 | at Rangers | W14-1 | 79-61 | .564 | Globe Life Field · Arlington, TX |
| 141 | Wed Sep 6 | at Rangers | W12-3 | 80-61 | .567 | Globe Life Field · Arlington, TX |
| 142 | Fri Sep 8 | vs Padres | L2-11 | 80-62 | .563 | Minute Maid Park · Houston, TX |
| 143 | Sat Sep 9 | vs Padres | W7-5 | 81-62 | .566 | Minute Maid Park · Houston, TX |
| 144 | Sun Sep 10 | vs Padres | W12-2 | 82-62 | .569 | Minute Maid Park · Houston, TX |
| 145 | Mon Sep 11 | vs Athletics | L0-4 | 82-63 | .566 | Minute Maid Park · Houston, TX |
| 146 | Tue Sep 12 | vs Athletics | L2-6 | 82-64 | .562 | Minute Maid Park · Houston, TX |
| 147 | Wed Sep 13 | vs Athletics | W6-2 | 83-64 | .565 | Minute Maid Park · Houston, TX |
| 148 | Fri Sep 15 | at Royals | L2-4 | 83-65 | .561 | Kauffman Stadium · Kansas City, MO |
| 149 | Sat Sep 16 | at Royals | L8-10 | 83-66 | .557 | Kauffman Stadium · Kansas City, MO |
| 150 | Sun Sep 17 | at Royals | W7-1 | 84-66 | .560 | Kauffman Stadium · Kansas City, MO |
| 151 | Mon Sep 18 | vs Orioles | L7-8 | 84-67 | .556 | Minute Maid Park · Houston, TX |
| 152 | Tue Sep 19 | vs Orioles | L5-9 | 84-68 | .553 | Minute Maid Park · Houston, TX |
| 153 | Wed Sep 20 | vs Orioles | W2-1 | 85-68 | .556 | Minute Maid Park · Houston, TX |
| 154 | Fri Sep 22 | vs Royals | L5-7 | 85-69 | .552 | Minute Maid Park · Houston, TX |
| 155 | Sat Sep 23 | vs Royals | L2-3 | 85-70 | .548 | Minute Maid Park · Houston, TX |
| 156 | Sun Sep 24 | vs Royals | L5-6 | 85-71 | .545 | Minute Maid Park · Houston, TX |
| 157 | Mon Sep 25 | at Mariners | W5-1 | 86-71 | .548 | T-Mobile Park · Seattle, WA |
| 158 | Tue Sep 26 | at Mariners | L2-6 | 86-72 | .544 | T-Mobile Park · Seattle, WA |
| 159 | Wed Sep 27 | at Mariners | W8-3 | 87-72 | .547 | T-Mobile Park · Seattle, WA |
| 160 | Fri Sep 29 | at D-backs | W2-1 | 88-72 | .550 | Chase Field · Phoenix, AZ |
| 161 | Sat Sep 30 | at D-backs | W1-0 | 89-72 | .553 | Chase Field · Phoenix, AZ |
| 162 | Sun Oct 1 | at D-backs | W8-1 | 90-72 | .556 | Chase Field · Phoenix, AZ |
| 163 | Sat Oct 7 | vs Twins | W6-4 | 1-0 | 1.000 | Minute Maid Park · Houston, TX |
| 164 | Sun Oct 8 | vs Twins | L2-6 | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 165 | Tue Oct 10 | at Twins | W9-1 | 2-1 | .667 | Target Field · Minneapolis, MN |
| 166 | Wed Oct 11 | at Twins | W3-2 | 3-1 | .750 | Target Field · Minneapolis, MN |
| 167 | Sun Oct 15 | vs Rangers | L0-2 | 0-1 | .000 | Minute Maid Park · Houston, TX |
| 168 | Mon Oct 16 | vs Rangers | L4-5 | 0-2 | .000 | Minute Maid Park · Houston, TX |
| 169 | Wed Oct 18 | at Rangers | W8-5 | 1-2 | .333 | Globe Life Field · Arlington, TX |
| 170 | Thu Oct 19 | at Rangers | W10-3 | 2-2 | .500 | Globe Life Field · Arlington, TX |
| 171 | Fri Oct 20 | at Rangers | W5-4 | 3-2 | .600 | Globe Life Field · Arlington, TX |
| 172 | Sun Oct 22 | vs Rangers | L2-9 | 3-3 | .500 | Minute Maid Park · Houston, TX |
| 173 | Mon Oct 23 | vs Rangers | L4-11 | 3-4 | .429 | Minute Maid Park · Houston, TX |